Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury

Autosomal dominant polycystic kidney disease (ADPKD) results from mutations in either PKD1 or PKD2 and accounts for 10% of all patients on renal replacement therapy. The kidney disease phenotype is primarily characterized by cyst formation, but there are also prominent interstitial changes (inflammation, apoptosis, proliferation, and fibrosis). Using a model of unilateral ischemia-reperfusion injury, we tested the hypothesis that Pkd2 heterozygous kidneys are more sensitive to injury and that this could lead to interstitial inflammation and fibrosis. Baseline tubular proliferation in heterozygous kidneys was twofold higher than in wild-type kidneys. The magnitude and duration of tubular and interstitial proliferative responses was consistently greater in injured heterozygous compared with wild-type kidneys at all time points. Conversely, tubular p21 expression in heterozygotes was lower at baseline and following injury at all time points. Significantly more neutrophils and macrophages were detected in injured Pkd2 heterozygous kidneys at 2 days, correlating with increased expression of the cytokines interleukin (IL)-1 beta and keratinocyte-derived chemokine and resulting in interstitial fibrosis at 28 days. We conclude that Pkd2 dosage influences both susceptibility and nature of the repair responses following injury. Polycystin-2 is therefore likely to play multiple roles in regulating tubular cell viability, repair, and remodeling in the mature kidney

Linking the exotic structure of 17{}^{17}C to its unbound mirror 17{}^{17}Na

The structure of ${}^{17}$C is used to define a nuclear interaction that, when used in a multichannel algebraic scattering theory for the $n+{}^{16}$C system, gives a credible definition of the (compound) excitation spectra. When couplings to the low-lying collective excitations of the ${}^{16}$C-core are taken into account, both sub-threshold and resonant states about the $n+{}^{16}$C threshold are found. Adding Coulomb potentials to that nuclear interaction, the method is used for the mirror system of $p+{}^{16}$Ne to specify the low-excitation spectrum of the particle unstable $^{17}$Na. We compare the results with those of a microscopic cluster model. A spectrum of low excitation resonant states in ${}^{17}$Na is found with some differences to that given by the microscopic-cluster model. The calculated resonance half-widths (for proton emission) range from $\sim 2$ to $\sim 672$ keV.Comment: 13 pages, 5 figure

In-Plane Magnetic Anisotropy In RF Sputtered Fe-N Thin Films

We have fabricated Fe(N) thin films with varied N2 partial pressure and studied the microstructure, morphology, magnetic properties and resistivity by using X-ray diffraction, atomic force microscopy, transmission electron microscopy, vibrating-sample magnetometer and angle-resolved M-H hysteresis Loop tracer and standard four-point probe method. In the presence of low N2 partial pressure, Fe(N) films showed a basic bcc a-Fe structure with a preferred (110) texture. A variation of in-plane magnetic anisotropy of the Fe(N) films was observed with the changing of N component. The evolution of in-plane anisotropy in the films was attributed to the directional order mechanism. Nitrogen atoms play an important role in refining the a-Fe grains and inducing uniaxial anisotropy.Comment: 11 pages, 6 figure

Spin density wave dislocation in chromium probed by coherent x-ray diffraction

We report on the study of a magnetic dislocation in pure chromium. Coherent x-ray diffraction profiles obtained on the incommensurate Spin Density Wave (SDW) reflection are consistent with the presence of a dislocation of the magnetic order, embedded at a few micrometers from the surface of the sample. Beyond the specific case of magnetic dislocations in chromium, this work may open up a new method for the study of magnetic defects embedded in the bulk.Comment: 8 pages, 7 figure

The effect of collisions on wave-breaking in a cold plasma

The effect of electron collisions on reducing the wave-breaking amplitude of resonantly-driven electrostatic fields in a cold plasma is investigated. By means of a simple theory collisions are shown to compete with wave-breaking in dissipating wave energy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47032/1/339_2004_Article_BF00899888.pd

Formation of two-dimensional weak localization in conducting Langmuir-Blodgett films

We report the magnetotransport properties up to 7 T in the organic highly conducting Langmuir-Blodgett(LB) films formed by a molecular association of the electroactive donor molecule bis(ethylendioxy)tetrathiafulvalene (BEDO-TTF) and stearic acid CH$_3$(CH$_2$)$_{16}$COOH. We show the logarithmic decrease of dc conductivity and the negative transverse magnetoresistance at low temperature. They are interpreted in the weak localization of two-dimensional (2D) electronic system based on the homogeneous conducting layer with the molecular size thickness of BEDO-TTF. The electronic length with phase memory is given at the mesoscopic scale, which provides for the first time evidence of the 2D coherent charge transport in the conducting LB films.Comment: 5 pages, 1 Table and 5 figure

Supervised selective kernel fusion for membrane protein prediction

Membrane protein prediction is a significant classification problem, requiring the integration of data derived from different sources such as protein sequences, gene expression, protein interactions etc. A generalized probabilistic approach for combining different data sources via supervised selective kernel fusion was proposed in our previous papers. It includes, as particular cases, SVM, Lasso SVM, Elastic Net SVM and others. In this paper we apply a further instantiation of this approach, the Supervised Selective Support Kernel SVM and demonstrate that the proposed approach achieves the top-rank position among the selective kernel fusion variants on benchmark data for membrane protein prediction. The method differs from the previous approaches in that it naturally derives a subset of “support kernels” (analogous to support objects within SVMs), thereby allowing the memory-efficient exclusion of significant numbers of irrelevant kernel matrixes from a decision rule in a manner particularly suited to membrane protein prediction

Gamma-ray Observations Under Bright Moonlight with VERITAS

Imaging atmospheric Cherenkov telescopes (IACTs) are equipped with sensitive photomultiplier tube (PMT) cameras. Exposure to high levels of background illumination degrades the efficiency of and potentially destroys these photo-detectors over time, so IACTs cannot be operated in the same configuration in the presence of bright moonlight as under dark skies. Since September 2012, observations have been carried out with the VERITAS IACTs under bright moonlight (defined as about three times the night-sky-background (NSB) of a dark extragalactic field, typically occurring when Moon illumination > 35%) in two observing modes, firstly by reducing the voltage applied to the PMTs and, secondly, with the addition of ultra-violet (UV) bandpass filters to the cameras. This has allowed observations at up to about 30 times previous NSB levels (around 80% Moon illumination), resulting in 30% more observing time between the two modes over the course of a year. These additional observations have already allowed for the detection of a flare from the 1ES 1727+502 and for an observing program targeting a measurement of the cosmic-ray positron fraction. We provide details of these new observing modes and their performance relative to the standard VERITAS observations

The First VERITAS Telescope

The first atmospheric Cherenkov telescope of VERITAS (the Very Energetic Radiation Imaging Telescope Array System) has been in operation since February 2005. We present here a technical description of the instrument and a summary of its performance. The calibration methods are described, along with the results of Monte Carlo simulations of the telescope and comparisons between real and simulated data. The analysis of TeV $\gamma$-ray observations of the Crab Nebula, including the reconstructed energy spectrum, is shown to give results consistent with earlier measurements. The telescope is operating as expected and has met or exceeded all design specifications.Comment: Accepted by Astroparticle Physic