247 research outputs found
Physiological and histopathological responses following closed rotational head injury depend on direction of head motion
Rotational inertial forces are thought to be the underlying mechanism for most severe brain injuries. However, little is known about the effect of head rotation direction on injury outcomes, particularly in the pediatric population. Neonatal piglets were subjected to a single non-impact head rotation in the horizontal, coronal, or sagittal direction, and physiological and histopathological responses were observed. Sagittal rotation produced the longest duration of unconsciousness, highest incidence of apnea, and largest intracranial pressure increase, while coronal rotation produced little change, and horizontal rotation produced intermediate and variable derangements. Significant cerebral blood flow reductions were observed following sagittal but not coronal or horizontal injury compared to sham. Subarachnoid hemorrhage, ischemia, and brainstem pathology were observed in the sagittal and horizontal groups but not in a single coronal animal. Significant axonal injury occurred following both horizontal and sagittal rotations. For both groups, the distribution of injury was greater in the frontal and parietotemporal lobes than in the occipital lobes, frequently occurred in the absence of ischemia, and did not correlate with regional cerebral blood flow reductions. We postulate that these direction-dependent differences in injury outcomes are due to differences in tissue mechanical loading produced during head rotation
Biomechanics of Traumatic Brain Injury: Influences of the Morphologic Heterogeneities of the Cerebral Cortex
Voxel-based statistical analysis of thalamic glucose metabolism in traumatic brain injury: relationship with consciousness and cognition
Objective: To study the relationship between thalamic glucose metabolism and neurological outcome after severe traumatic
brain injury (TBI).
Methods: Forty-nine patients with severe and closed TBI and 10 healthy control subjects with 18F-FDG PET were studied.
Patients were divided into three groups: MCS&VS group (n ¼ 17), patients in a vegetative or a minimally conscious state;
In-PTA group (n ¼ 12), patients in a state of post-traumatic amnesia (PTA); and Out-PTA group (n ¼ 20), patients who
had emerged from PTA. SPM5 software implemented in MATLAB 7 was used to determine the quantitative differences
between patients and controls. FDG-PET images were spatially normalized and an automated thalamic ROI mask was
generated. Group differences were analysed with two sample voxel-wise t-tests.
Results: Thalamic hypometabolism was the most prominent in patients with low consciousness (MCS&VS group) and the
thalamic hypometabolism in the In-PTA group was more prominent than that in the Out-PTA group. Healthy control
subjects showed the greatest thalamic metabolism. These differences in metabolism were more pronounced in the internal
regions of the thalamus.
Conclusions: The results confirm the vulnerability of the thalamus to suffer the effect of the dynamic forces generated during
a TBI. Patients with thalamic hypometabolism could represent a sub-set of subjects that are highly vulnerable to
neurological disability after TBI.Lull Noguera, N.; Noé, E.; Lull Noguera, JJ.; Garcia Panach, J.; Chirivella, J.; Ferri, J.; López-Aznar, D.... (2010). Voxel-based statistical analysis of thalamic glucose metabolism in traumatic brain injury: relationship with consciousness and cognition. Brain Injury. 24(9):1098-1107. doi:10.3109/02699052.2010.494592S10981107249Gallagher, C. N., Hutchinson, P. J., & Pickard, J. D. (2007). Neuroimaging in trauma. Current Opinion in Neurology, 20(4), 403-409. doi:10.1097/wco.0b013e32821b987bWoischneck, D., Klein, S., Rei�berg, S., D�hring, W., Peters, B., & Firsching, R. (2001). Classification of Severe Head Injury Based on Magnetic Resonance Imaging. Acta Neurochirurgica, 143(3), 263-271. doi:10.1007/s007010170106Grados, M. A. (2001). Depth of lesion model in children and adolescents with moderate to severe traumatic brain injury: use of SPGR MRI to predict severity and outcome. 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Consensus statement on abusive head trauma in infants and young children
Abusive head trauma (AHT) is the leading cause of fatal head injuries in children younger than 2 years. A multidisciplinary team bases this diagnosis on history, physical examination, imaging and laboratory findings. Because the etiology of the injury is multifactorial (shaking, shaking and impact, impact, etc.) the current best and inclusive term is AHT. There is no controversy concerning the medical validity of the existence of AHT, with multiple components including subdural hematoma, intracranial and spinal changes, complex retinal hemorrhages, and rib and other fractures that are inconsistent with the provided mechanism of trauma. The workup must exclude medical diseases that can mimic AHT. However, the courtroom has become a forum for speculative theories that cannot be reconciled with generally accepted medical literature. There is no reliable medical evidence that the following processes are causative in the constellation of injuries of AHT: cerebral sinovenous thrombosis, hypoxic-ischemic injury, lumbar puncture or dysphagic choking/vomiting. There is no substantiation, at a time remote from birth, that an asymptomatic birth-related subdural hemorrhage can result in rebleeding and sudden collapse. Further, a diagnosis of AHT is a medical conclusion, not a legal determination of the intent of the perpetrator or a diagnosis of murder. We hope that this consensus document reduces confusion by recommending to judges and jurors the tools necessary to distinguish genuine evidence-based opinions of the relevant medical community from legal arguments or etiological speculations that are unwarranted by the clinical findings, medical evidence and evidence-based literature
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