Chronic ethanol consumption in mice does not induce DNA damage in somatic or germ cells, evaluated by the bone marrow micronucleous assay and the dominant lethal mutation assay

Indexación: Web of Science; ScieloAlthough alcohol is known to be a carcinogen for humans, ethanol-genotoxicity studies are incomplete. Ethanol seems not to be a bacterial mutagen, but the results are conflicting in rodent assays. We investigate the genotoxicity in the bone marrow micronucleus (MN) test and in the dominant lethal mutation (DLM) assay using two long-term ethanol exposure protocols. In the MN test, mice consumed three doses (5, 10 and 15% v/v) for 32 weeks. MN induction was compared to two control groups of 5- and 38-week-old mice (the ages of the treated mice when the treatment was initiated and when they were killed, respectively). For the three groups treated with ethanol there was no significant increase in MN induction as compared to the first control group, but observed MN frequencies were significantly lower than in the 38-week-old control group. This suggests a protective effect against genotoxic damage caused by aging, probably due to ethanol action as a hydroxyl radical scavenger. In the DLM assay, male mice drank ethanol at 15% or 30% (v/v) for 20 weeks. In both groups the number of dead implants was similar to the control, but there was a significant reduction in total implants, indicating a pre-implantation loss.http://ref.scielo.org/7b9mt

Algo viejo, algo nuevo, algo prestado: La construcción de Nueva España en el siglo XVI

Moya Olmedo, P. (2013). Algo Viejo, algo nuevo, algo prestado: La construcción de Nueva España en el siglo XVI. En S. Huerta Fernández (Ed.), Octavo Congreso Nacional de Historia de la Construcción (pp. 747-756). Escuela Superior de Arquitectura de la Universidad Politécnica de Madrid, Madrid, España. ISBN 978-84-9728-476-9 (obra completa dos volúmenes

El testigo menos sobornable de la historia...

Moya Olmedo, P. (2014). El testigo menos sobornable de la historia? En A. Melián García (Ed.), 15 Congreso Internacional de Expresión Gráfica Arquitectónica El dibujo de viaje de los arquitectos (pp. 531-539). Escuela de Arquitectura de la Universidad de Las Palmas de Gran Canaria, Las palmas de Gran Canaria, España. ISBN 978-84-9042-099-

Algunos dibujos de la primera arquitectura de Nueva España: mapas, planos y proyectos de arquitectura del siglo XVI

Moya Olmedo, P. (2014). Algunos dibujos de la primera arquitectura de Nueva España: mapas, planos y proyectos de arquitectura del siglo XVI. P+C: proyecto y ciudad: revista de temas de arquitectura (5), 75-88. ISSN 2172-9220 (ISOC; LATINDEX; DIALNET; RESH; DICE; MIAR

Analysis of assessment tools of Engineering degrees

This work presents an analysis of the assessment tools used by professors at the Universitat Politécnica de Catalunya to assess the generic competencies introduced in the Bachelor’s Degrees in Engineering. In order to conduct this study, a survey was designed and administered anonymously to a sample of the professors most receptive to educational innovation at their own university. All total, 80 professors responded to this survey, of whom 26% turned out to be members of the university’s own evaluation innovation group (https://www.upc.edu/rima/grups/grapa), GRAPA. This percentage represents 47% of the total GRAPA membership, meaning that nearly half of the professors most concerned about evaluation at the university chose to participate. The analysis of the variables carried out using the statistical program SPSS v19 shows that for practically 49% of those surveyed, rubrics are the tools most commonly used to assess generic competencies integrated in more specific ones. Of those surveyed, 60% use them either frequently or always. The most frequently evaluated generic competencies were teamwork (28%), problem solving (26%), effective oral and written communication (24%) and autonomous learning (13%), all of which constitute commonly recognized competencies in the engineering profession. A two-dimensional crosstabs analysis with SPSS v19 shows a significant correlation (Asymp. Sig. 0.001) between the type of tool used and the competencies assessed. However, no significant correlation was found between the type of assessment tool used and the type of subject, type of evaluation (formative or summative), frequency of feedback given to the students or the degree of student satisfaction, and thus none of these variables can be considered to have an influence on the kind of assessment tool used. In addition, the results also indicate that there are no significant differences between the instructors belonging to GRAPA and the rest of those surveyed.Preprin

El aprendizaje de inglés y su relación con los deberes para casa en educación primaria

Many factors are involved in the learning of a language, and homework is one such example to be taken into account. The main objective of this descriptive and correlational study is to study and analyze variables that can be related to homework and the learning of English in Primary Education, to ascertain and analyze the situation and offer proposals for improvement. The study sample was composed of 747 students, 679 families and 57 teachers of 4th, 5th and 6th grade of Primary Education and the respondents answered three ad-hoc questionnaires. The perceived difficulty of homework, the need for help, the frequency, marks and the effort spent on homework, can be found among the analyzed variables. The main results show that students spent more time doing English homework, but that homework for this subject was also the most difficult and required more effort and help. These findings correlate with the difficulty that families have in helping their children and, in line with other studies, suggests that further guidance on homework from teachers is necessary to minimize difficulties. After having analyzed the results, the authors’ general conclusion is that careful homework design is crucial for its optimal autonomous development.En el aprendizaje de un idioma intervienen muchos factores y los deberes para casa son una herramienta a tener en cuenta. Esta investigación de carácter descriptivo y correlacional tiene como objetivo estudiar y analizar variables que pueden tener relación entre los deberes y el aprendizaje del Inglés en Educación Primaria, para conocer y analizar la situación y ofrecer propuestas de mejora. La muestra de estudio ha estado compuesta por 747 alumnos, 679 familias y 57 docentes de 4º, 5º y 6º de Educación Primaria. Los informantes han respondido a tres cuestionarios construidos ad hoc. Entre las variables analizadas están la dificultad percibida de los deberes, si hay necesidad de ayuda, la frecuencia, las calificaciones y el esfuerzo empleado en los deberes. Entre los principales resultados se ha obtenido que a los deberes de Inglés se les dedica más tiempo y son los más difíciles para los alumnos, concluyéndose que requieren de más esfuerzo y ayuda. Esto se correlaciona con la dificultad que encuentran las familias para ayudar, haciéndose necesarias orientaciones sobre los deberes por parte de los docentes para reducir esta situación de dificultad y en consonancia con otros estudios. Se concluye que es crucial cómo los deberes estén diseñados para su óptimo desarrollo de forma autónoma

El aprendizaje de inglés y su relación con los deberes para casa en educación primaria

Many factors are involved in the learning of a language, and homework is one such example to be taken into account. The main objective of this descriptive and cor-relational study is to study and analyze variables that can be related to homework and the learning of English in Primary Education, to ascertain and analyze the situation and offer proposals for improvement. The study sample was composed of 747 students, 679 families and 57 teachers of 4th, 5th and 6th grade of Primary Education and the respondents answered three ad-hoc questionnaires. The perceived difficulty of homework, the need for help, the frequency, marks and the effort spent on homework, can be found among the analyzed vari-ables. The main results show that students spent more time doing English homework, but that homework for this subject was also the most difficult and required more effort and help. These findings correlate with the difficulty that families have in helping their children and, in line with other studies, suggests that further guidance on homework from teachers is ne-cessary to minimize difficulties. After having analyzed the results, the authors’ general con-clusion is that careful homework design is crucial for its optimal autonomous development.En el aprendizaje de un idioma intervienen muchos factores y los deberes para casa son una herramienta a tener en cuenta. Esta investigación de carácter descriptivo y co-rrelacional tiene como objetivo estudiar y analizar variables que pueden tener relación entre los deberes y el aprendizaje del Inglés en Educación Primaria, para conocer y analizar la situación y ofrecer propuestas de mejora. La muestra de estudio ha estado compuesta por 747 alumnos, 679 familias y 57 docentes de 4º, 5º y 6º de Educación Primaria. Los informantes han respondido a tres cuestionarios construidos ad hoc. Entre las variables analizadas están la dificultad percibida de los deberes, si hay necesidad de ayuda, la frecuencia, las califica-ciones y el esfuerzo empleado en los deberes. Entre los principales resultados se ha obtenido que a los deberes de Inglés se les dedica más tiempo y son los más difíciles para los alumnos, concluyéndose que requieren de más esfuerzo y ayuda. Esto se correlaciona con la dificultad que encuentran las familias para ayudar, haciéndose necesarias orientaciones sobre los debe-res por parte de los docentes para reducir esta situación de dificultad y en consonancia con otros estudios. Se concluye que es crucial cómo los deberes estén diseñados para su óptimo desarrollo de forma autónoma

Prolonged quiescence delays somatic stem cell-like divisions in Caenorhabditis elegans and is controlled by insulin signaling

Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. Here, we show that a similar process happens during Caenorhabditis elegans development, providing an in vivo model to study proliferative capacity after quiescence. Hatching under starvation provokes the arrest of blast cell divisions that normally take place during the first larval stage (L1). We have used a novel method to precisely quantify each stage of postembryonic development to analyze the consequences of prolonged L1 quiescence. We report that prolonged L1 quiescence delays the reactivation of blast cell divisions in C. elegans, leading to a delay in the initiation of postembryonic development. The transcription factor DAF‐16/FOXO is necessary for rapid recovery after extended arrest, and this effect is independent from its role as a suppressor of cell proliferation. Instead, the activation of DAF‐16 by decreased insulin signaling reduces the rate of L1 aging, increasing proliferative potential. We also show that yolk provisioning affects the proliferative potential after L1 arrest modulating the rate of L1 aging, providing a possible mechanistic link between insulin signaling and the maintenance of proliferative potential. Furthermore, variable yolk provisioning in embryos is one of the sources of interindividual variability in recovery after quiescence of genetically identical animals. Our results support the relevance of L1 arrest as an in vivo model to study stem cell‐like aging and the mechanisms for maintenance of proliferation potential after quiescence.Spanish Ministerio de Economía y Competitividad (BFU2016-74949-P and BFU2012- 35509)European Research Council (ERC-2011-StG-281691)Marie-Curie Intra-European Fellowship (FP7-PEOPLE-2013- IEF/GA Nr: 627263

Analysis and Modelling of Groundwater Salinity Dynamics in the Gaza strip

The Gaza Strip suffers from an acute problem in the water quality and quantity. Groundwater is used as drinking water, for agricultural uses, and industrial processes. Salinity is increasing in groundwater in the Gaza Strip. Seawater intrusion is the main source of salinity. A chloride ion-selective is used as indicator of salinity for analysis and modelling of salinity of groundwater in the Gaza Strip by 2023. Research depends on three models for prediction of chloride concentration in groundwater: Forecasting, Linear regression and Multiple regression for the year 2023. The result of three models showed water salinity will increase in all areas in the Gaza Strip by the year 2023. Only a small area in the North Governorate will keep less than 250 mg/L of chloride concentration in fresh water, which represents 4.56 % of the total of the Gaza Strip area. The analysis of seawater intrusion within the cross sections is clear along the coastline and outspreads from the Mediterranean Sea to the East part of the Gaza Strip.La Franja de Gaza sufre un grave problema relacionado con la calidad y cantidad del agua. El agua subterránea se utiliza como agua potable, para usos agrícolas y para procesos industriales. La salinidad del agua está aumentando en la Franja de Gaza, siendo la intrusión de agua de mar la principal fuente de salinidad. En este trabajo, los iones selectivos de cloruro se utilizan, como indicador de la salinidad, para el análisis y modelización de la salinidad del agua subterránea en la Franja de Gaza para el horizonte 2023. Tres modelos de previsión del aumento de cloruros en las aguas subterráneas son considerados para 2023: el modelo basado en pronóstico, la regresión lineal y la regresión múltiple. El resultado de estos tres modelos muestra que la salinidad del agua aumentará en todas las áreas de la Franja de Gaza para el año 2023. Solo una pequeña zona en la provincia del norte tendrá menos de 250 mg/l de concentración de cloruro en agua dulce, lo que representa 4.56% del total del área de la Franja de Gaza. La intrusión de agua de mar se pone de manifiesto en los cortes transversales a lo largo de la costa, extendiéndose desde el Mar Mediterráneo hasta el este de la Franja de Gaza

From Smart Cities to Smart Human Cities: digital inclusion in app's

Las Smart Human cities, tienen como objetivos mejorar y facilitar la vida a los ciudadanos con la ayuda de las aplicaciones TICs (Apps, en adelante). El estudio que se presenta tiene como finalidad analizar las Apps, en cuanto a su accesibilidad y usabilidad para ciudadanos con disfuncionalidad visual, ya que esta dificultad es la que más influye en el uso eficaz y eficiente de las mismas. La muestra la constituyen 19 Apps cuyo criterios de selección son; los rankings de aplicaciones más empleadas en el año 2014 (google play, app store y iTunes Store) y aplicaciones desarrolladas por algunas Smart cities españolas (Gijón, Logroño, Madrid y Murcia). Para su análisis se construye una escala descriptiva en base a indicadores extraídos mediantes un proceso deductivo-inductivo. Un primer resultado es el “Sistema de indicadores para el análisis de la accesibilidad y usabilidad de las Apps” como modelo a aplicar. De los cuatro entornos en los que se aglutinan las Apps más usadas, el social y más concretamente las aplicaciones de redes sociales, son las que más atiende a la accesibilidad; son muy demandadas y rentables para la industria de las telecomunicaciones. Sin embargo, el resto de aplicaciones son evaluadas como totalmente inaccesibles para estos usuarios.Smart cities have as goals to Improve and to make an easier life for their citizens throw ICT applications (Apps, hereinafter). The study aim to analyse Apps, abut its accessibility and usability for people with visual dysfunction, because this is the greatest disability with influence on the effective and efficient use of them. The sample constitutes 19 Apps whose selection criteria are; the rankings of most used applications in 2014 (google play, app store and iTunes Store) and some applications developed by some Spanish Smart Cities (Gijon, Logroño, Madrid and Murcia). To analyse these data is made a descriptive scale based on indicators retrieved from a deductive-inductive process. First result is the "System of indicators for analysis accessibility and usability of Apps" as a model to apply. On the four groups of most used Apps, social and social networking applications specifically, pay attention to better accessibility; they have a high demand by costumers and a high cost-profit rates to communications companies. However, other applications are evaluated as completely inaccessible to these special users