The Role of mTORC1 in Autophagy as it Relates to Cancer

The mammalian target of rapamycin complex 1, mTORC1, is composed of several subunit proteins with many cellular responsibilities including participation in a complex cell signaling cascade leading to autophagy, which is the regulated degradation of cell components. mTORC1 is frequently mutated or dysregulated within human cancer. Normally, mTORC1 functions to provide efficient regulation of autophagy according to intracellular levels of growth factors, amino acids, nutrients, oxygen levels, and more that can either inhibit mTORC1 and upregulate autophagy or activate mTORC1 and downregulate autophagy. A better understanding of mTORC1 is imperative to preparing cancer therapy treatments. Various cancerous tissue types require specific mTORC1 inhibitors based on the area of dysregulation in the autophagy cell signaling pathway

Capital Offense: The Rhetorical Importance of Identifiers

I aim to deconstruct the limits of rhetorical racial identifiers for people of the African diaspora, particularly within the context of the modern-day United States. The purpose of this essay is to analyze the terminology which enslaved Africans and their descendants have been subjected to in Anglo-Saxon media and the general American English lexicon. Additionally, its purpose is to discuss the efforts of Black people to standardize their own racial identifiers. I will define identifiers and discuss their purpose within racial systems. Within the framework of rhetorical hermeneutics, I will then explore the need for autonomy in selecting identifiers. Finally, I will examine the rhetorical relationship between identifiers and identity. My goal with this piece is that readers will understand the importance of a people group’s autonomy to establish their own racial identifiers. Considering the arguments of modern Black thinkers and assessing through the rhetorical framework set forth in the writings of Steven Mailloux, this paper will unpack nomenclature as a means of redemption

Towards a declamatory performance in Schubert Lieder

This study reconsiders declamation in Schubert lieder performance in light of emerging historical evidence. Johann Michael Vogl’s reputedly declamatory approach has arguably been captured in surviving Diabelli editions that document his rhetorically motivated alterations and ornamentations. Similarly, Gustav Anton von Seckendorff has detailed song-like spoken declamation that manipulates pitch, rhythm and accentuation. Recordings of five modern German speakers were transcribed, analysed and used to model effective declamation in the recitation of Johann Wolfgang von Goethe’s poems ‘Erster Verlust’ and ‘Geistes Gruß.’ PRAAT speech analysis software was used to analyse the recordings. The participants’ use of stress, emphasis and rubato was extrapolated and used (in combination with the historical evidence) to speculatively recreate several declamatory performances of Schubert lieder

Forty voices

What does it mean to have a voice? For twenty-one year-old Linnet, her voice is all she has. Since she was young, singing has been the lens through which she interprets the world. But at the beginning of her third year of university, her voice fails her and she has to learn what it might be like to live without it. Through her relationships with the women in her life, Linnet tries to come to terms with what the loss of her voice means for her future. Set over the course of one week, with flashbacks to earlier in her life, Linnet deals with the immediate aftermath of losing her voice and tries to decide whether to remain in Ottawa with her girlfriend or return home to Prince Edward Island

Women seafarers’ health and welfare survey

Background: This is a collaborative study from the International Maritime Health Association, International Seafarers’ Welfare and Assistance Network, International Transport Workers’ Federation and the Seafarers Hospital Society. The aim of the study was to look at the health and welfare needs of women seafarers and how organisations can best make or campaign for improvements to the health information and services available to women seafarers. Materials and methods: A pilot study was conducted in July 2014 and following review of the data and revision of the questionnaire the study was launched in December 2014, running until the middle of March 2015. Results collected from the survey are also supported by qualitative data obtained from two focus groups run during February and March. Results: 595 responses were received from a range of nationalities, ages and positions on board ships. The findings suggest that joint/back pain, stress/depression/anxiety and headache seem to be the most common symptoms reported by women seafarers and that 55% felt that they are related to their work. 48% state that they have problems with seeking medical care and offer suggestions to improve this. Routine wellness checks, nutrition and information on joint and back pain are the main areas that women seafarers stated health screening/services/information would be most useful to improve their health and wellbeing. They suggested this could best be received directly from health professionals, or alternatively by reading leaflets or from online websites/an app. Significantly 37% of women seafarers also stated that they do not have access to sanitary bins within the toilet and 18% say that sexual harassment is an issue. Conclusions: The responses received highlight a small number of areas where relatively simple and low-cost interventions might improve the health and welfare of women seafarers. Specifically these include the production and appropriate, distribution of gender — specific information on back pain, mental health and nutrition in addition to gynaecological complaints, to all women seafarers; the introduction of means for disposing of sanitary waste for all female crew on all ships and the improved availability of female specific products e.g. sanitary products in port shops and welfare centres worldwide. Additional work is needed to investigate these areas more fully and to look at the issue of confidence in medically trained staff, medical confidentiality and sexual harassment. Any further work and interventions will require the support of all of the main stakeholders and we plan a briefing meeting to publicise the findings to date and to identify support for further work in this area

Medieval Convent Drama: Translating Scripture and Transforming the Liturgy

This article examines a vernacular Nativity play from the convent at Huy, in modern- day Belgium. The play includes liturgical citations that would have been sung in Latin, alongside the Walloon French lines that translate generically -- scriptural narrative into verse drama -- as well as linguistically. Scriptural narrative is also expanded through the addition of apocryphal material and especially female characters. The Huy play survives in a manuscript of the 15th century, and in a seventeenth-century manuscript that reveals further processes of revision and adaptation by the nuns who composed, copied and performed it. This paper describes these various processes of translation and adaptation for performance by and for female religious, and comments on theatrical translation and the relationship of drama to liturgy