70 research outputs found
Comparison of the human immune responses to recombinant proteins representing three distinct surface proteins of Plasmodium vivax merozoites
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/03/2000
- Field of study
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Departamento de Microbiologia, Imunologia e ParasitologiaUniversidade Federal do Pará Departamento de PatologiaCenters for Disease Control and Prevention Division of Parasitic DiseasesInstituto Evandro ChagasUniversidade Federal de Minas Gerais Departamento de ParasitologiaUNIFESP, EPM, Depto. de Microbiologia, Imunologia e ParasitologiaSciEL
Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzalez
- Alessandro Filla
- Alex Fondaw
- Alexandre Guerreiro
- Alexandre Guerreiro
- Ali Malekniazi
- Aline de Cassia Santos
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral de Andrade
- Ana Lazaro
- Ana Paula Macagnan
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Ardoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hont
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Booth H. D. E.
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Byoung Joon Kim
- Byung-Jo Kim
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chae Won Shin
- Chafic Karam
- Chafic Karam
- Chang Nyoung Lee
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Da Yoon Koh
- Dae Lim Koo
- Dai Matsuse
- Daiane da Cruz Pacheco
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Diego Lopergolo
- Donna Carnes
- Doreen Ho
- Délphine Mahieu
- Edina Varga
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Elena Giacomelli
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emanuela Onesti
- Emiko Tsuda
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Eun Bi Hwang
- Eun Bin Cho
- Eun Haw Choi
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco Saccà
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fujita K. P.
- Fumie Meguro
- Gabor Lovas
- Gabor Lovasamela César
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Gedeonne Jakab
- Giannis Sokratous
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Graziela Pinto
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H James Jones
- Ha Young Shin
- Ha-Neul Jeong
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Henrique Mohr
- Hidekazu Suzuki
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Hoo Nam Kang
- Howard J. F.
- Hui Gong
- Huned Patwa
- Hung Youl Seok
- Husnu Efendi
- HyeJin Ra
- HyeLim Lee
- Hyung Seok Lee
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jae-Sung Lim
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jasmine Hewlett
- Jaya Trivedi
- Jayashri Srinivasan
- Jeffery Statland
- Jeffrey Guptill
- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelbach
- Jeri Sieren
- Jerry Locheke
- Ji Ye Hwang
- JiEun Lee
- Jinmyoung Seok
- JinWoo Jung
- Jiri Pitha
- Joan Højgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josef Bednarik
- Josep Gamez Carbonell
- Joseph Chad Hoyle
- Ju-Hong Min
- Judit Matolcsi
- Juha-Pekka Erälinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- JuYoung Kwon
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kendrick Henderson
- Kenichi Tsukita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Polaka
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laszlo Vecsei
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Lauren Wheeler
- Laurie Gutmann
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Livia Dezsi
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Ferreira
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutiérrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maeda Yasuko
- Magda Chmelikova
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Mantegazza R.
- Marcela Silva
- Marcela Wolfova
- Marcelo Annes
- Marcelo Chaves
- Marcelo Rugiero
- Marek Cierny
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
- Maria Gabriele
- Maria Gori
- Maria Pasanisi
- Maria Salvado Figueras
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
- Masako Tsurumaru
- Masanori Takahashi
- Masayuki Nakamori
- Matteo Garibaldi
- Maureen Walsh
- Maurer Pereira Martins
- Maurizio Inghilleri
- Maurício AndréGheller Friedrich
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
- Megumi Koga
- Meinoshin Okumura
- Melanie Glenn
- Melinda Horvath
- Michael Benatar
- Michael Hehir
- Michael Pulley
- Michael Weiss
- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Miju Shin
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Mireya Fernandez-Fournier
- Miri Kim
- Miriam Freimer
- Misa Shimpo
- MiSong Choi
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammed Salajegheh
- Mohammed Sanjak
- Mollie Vanderhook
- Mona Elsayed
- Monika Konyane
- Muppidi S.
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- Natália Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- O'Brien F. L.
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Paolo Emilio Alboini
- Patricia Padilla
- Patrícia Fernandes
- Pedro Lopez Ruiz
- Petra Tilkin
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Rekha Pillai
- Renata Martins Ribeiro
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- SangAe Park
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Seung Min Kim
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Sharon Nations
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- So-Hyun Ahn
- Soichiro Funaka
- Sonia Garcia
- Stanislav Vohanka
- Stanislava Toncrova
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Steve Hopkins
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Miyazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Arnold
- Thomas Cochrane
- Thomas Harbo
- Tierney Scott
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- Tomás Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tulio Bertorini
- Tuula Harrison
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Vittorio Frasca
- Vittorio Frasca
- Waqar Waheed
- Wiendl H.
- Wladimir Pinto
- Wolfe G. I.
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasmeen Shabbir
- Yasushi Suzuki
- Ye Liu
- Yoko Ishiyama
- Yoko Kaneko
- Yong Seo Koo
- Yool-Hee Kim
- Yoon-Ho Hong
- Yoshiko Sano
- Yuen T So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
- Yumiko Nakamura
- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo
Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab
- Author
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- André Gheller Friedrich Maurício
- Annes Marcelo
- Antonia Alberti Aguilo Maria
- Antonini Giovanni
- Antonio Querol Gutiérrez Luis
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis Natália
- Augusto da Silva Luiz
- Augusto Suriane Fialho Tomás
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsah
- Beck Kate
- Bednarik Josef
- Benatar Michael
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bi Hwang Eun
- Bilsker Martin
- Bin Cho Eun
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carolina Amaral de Andrade Ana
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chad Hoyle Joseph
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cristina Gomes da Silva Tamires
- Cunningham Scott
- César Pamela
- D'Amato Valentina
- D'Hont Ann
- da Cruz Pacheco Daiane
- da Penha Ananias Morita Maria
- Dada Martineli Torres Debora
- Dalila Garcia Alejandra
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- De Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- De Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- Di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- Ebru Bekircan-Kurt Can
- Echevarria Laura
- Eduardo Pazetto Lucas
- Efendi Husnu
- Elsayed Mona
- Emilio Alboini Paolo
- Emmons Kelley
- Engel Marguerite
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Erälinna Juha-Pekka
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernanda Butinhao Cristiani
- Fernandes Patrícia
- Fernandez-Fournier Mireya
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Filla Alessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Fujii Yuko
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriel Mazia Claudio
- Gabriele Maria
- Gamez Carbonell Josep
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gori Maria Cristina
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guinrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Haw Choi Eun
- Hayashi Takashi
- Hehir Michael
- Henderson Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
- Homedes-Pedret Christian
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Howard Jr James
- Huynh Kristin
- Højgaard Joan
- Illa Isabel
- Imai Tomihiro
- Imai Tomihiro
- Inghilleri Maurizio
- Iorio Raffaele
- Ishiyama Naoko
- Ishiyama Yoko
- Jacob Saiju
- Jakab Gedeonne
- James Jones H
- Jara Jordan
- Javier Rodriguez de Rivera Francisco
- Jeffery Dennis
- Jenci Nicole
- Jeong Ha-Neul
- Jerath Nivedita
- Jingu Maki
- Johns Kathryn
- Jones Floyd
- Joon Kim Byoung
- Juel Vern
- Julia Palacios Natalia
- Jung JinWoo
- Junkerova Barbora Kurkova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kanai Tetsuya
- Kaneko Yoko
- Kanzaki Akiko
- Karam Chafic
- Karam Chafic
- Karimi Sanaz
- Katz Jonathan
- Katzin Lara
- Kaur Harpreet
- Kawaguchi Naoki
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Kazim Onar Musa
- Kelley Andrea
- Keung Benison
- Khoury Julie
- Kikutake Keiko
- Kim Bryan
- Kim Byung-Jo
- Kim Miri
- Kim Yool-Hee
- Kincaid John
- Kirbas Cavdar Tugce
- Kissel John
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Kohlrus Stephanie
- Konyane Monika
- Kramer Megan
- Kressin Nicole
- Krogh Susanne
- Kumar Aditya
- Kurihara Rikako
- Kutlu Ayse
- Kwan Justin
- Kwon JuYoung
- Laaksonen Mikko
- Lazaro Ana
- Lee HyeLim
- Lee JiEun
- Lim Koo Dae
- Lim Jae-Sung
- Lin Frank
- Liu Tina
- Liu Ye
- Locatelli Alberta
- Locheke Jerry
- Lokaitis Barbara
- Loor John
- Lopergolo Diego
- Lopez Ruiz Pedro
- Lovas Gabor
- Lu Liang
- Lucy Shannon
- Maeda Yasuko
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu Délphine
- Maier Gal
- Makamori Masayuki
- Malekniazi Ali
- Mallon Ashley
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
- Marsili Angela
- Martins Ribeiro Renata
- Masaki Katsuhisa
- Massey Janice
- Mathew Veena
- Matolcsi Judit
- Matsuse Dai
- Matsushita Takuya
- Mazuela Gonzalo
- McClain Terry
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
- McVey April
- Meguro Fumie
- Meherremova Arzu
- Mercelis Rudy
- Mette Ostergaard Autzen Anne
- Mezache Louisa
- Micheels Angela
- Michon Sara-Claude
- Miller Robert
- Min Kim Seung
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Mitazaki Teiichiro
- Miyawaki Eriko
- Mizugami Aya
- Mogensen Anita
- Mohr Henrique
- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamura Yumiko
- Nam Kang Hoo
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nogueira Coelho Erica
- Norwood Fiona
- Noshiro Mayuko
- Novakova Iveta
- Nowak Richard
- Nozaki Kenkichi
- Nye Joan
- Nyoung Lee Chang
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
- Onesti Emanuela
- Orsel Gulsah
- Osakada Kaori
- Otavio Maia Gonçalves Luiz
- Ozawa Yukiko
- Ozcelik Pinar
- Padilla Patricia
- Paiva Gabriel
- Park SangAe
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Patrick Kara
- Patwa Huned
- Paula Macagnan Ana
- Paula Melo Ana
- Paulose Shirley
- Pedersen Jane
- Pereira Martins Maurer
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pinar Acar Nazire
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pol Sabrina
- Polaka Krishna
- Pozo Marina
- Prando Natalia
- Previous
- Previous
- Previous
- Pulley Michael
- Puorro Giorgia
- Ra HyeJin
- Reguliova Katarina
- Renata Cubas Volpe Luciana
- Reyes Eliana
- Rico Gabrielle
- Robeson Kimberly
- Rocha Rosana
- Roderus Rikki
- Roe Kristen
- Rojas Garcia Ricardo
- Rosenfeld Jeffrey
- Ross Berger Alan
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Saba Juliet
- Saccà Francesco
- Sadalage Girija
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salvado Figueras Maria
- Samukawa Makoto
- Sanjak Mohammad
- Sanjak Mohammed
- Sano Yoshiko
- Santos Engel Murilo
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Seddigh Arshira
- Seelbach Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seo Koo Yong
- Seok Lee Hyung
- Seok Jinmyoung
- Shabbir Yasmeen
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimohama Shun
- Shimpo Misa
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- Sohail Faisal
- Sokratous Giannis
- Souza Bulle Oliveira Acary
- Souza Duca Luciana
- Souza Iandra
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
- Strom Susan
- Sub-Investigators
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- T So Yuen
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
- Tano Ohito
- Terzi Murat
- Tilkin Petra
- Tinerney Scott
- Tobon Gonzalez Alejandro
- Toncrova Stanislava
- Torane Pravin
- Toska Shirli
- Tran Anh
- Traub Rebecca
- Trivedi Jaya
- Troili Fernanda
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- Van Daele Sien
- Van Damme Philip
- Van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Velez Santamaria Valentina
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vohanka Stanislav
- Vu Hong
- Vu Tuan
- Vynckier Jan
- Vytopil Michael
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Yunxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Won Shin Chae
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Ye Hwang Ji
- Yilmaz Ezgi
- Yoon Koh Da
- Yoshida Seiko
- Yoshida Seiko
- Yoshimura Shunsuke
- Youl Seok Hung
- Young Shin Ha
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana G.
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
- Gattinoni Luciano
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonz Á Lez Raquel Montiel
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Rojas Manuel A.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
- Gosselin Ryan J.
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O.
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K.
- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking Danielle J.
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J.
- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
- Huff Nidhi G.
- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
- Hutchison Robyn A.
- Hutton Paula J.
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P.
- Imperio María C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou Nicholas
- Iotti Giorgio A.
- Irvine Donald A.
- Ismail Dina
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves D.
- Jassal Mandeep
- Javeed Areej
- Javier-Blanco
- Jhamatthew Thomas Rajeev R.
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio G.
- Jochmans S. bastien
- Jog Sameer A.
- Jovanovic Bojan
- Judy Claine
- Jurado M. . Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kansuke-Koyama
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch Barrett T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon H.
- Laake Jon Henrik
- Labarca Eduardo F.
- Laffey John
- Laffey John G.
- Laffey John G.
- Lamb Keith D.
- Lanspa Michael J.
- Larsson Anders
- Larsson Niklas
- le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana S.
- Leon Yoshido Hector H.
- Li Bin
- Li Qingdong
- Li Qiong J.
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan Y.
- Li-Xin Zhou
- Liew Kong Y.
- Ling Long L.
- Liu Haitao
- Liu Jian
- Liu Jing L.
- Liu Ling
- Llano Miguel
- Llinares Moya David D.
- Lohner Ralph
- Loiacono Flavia A.
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado Juan C.
- Lora Fredy S.
- Lora Pilar
- Lorente Jose A.
- Losada Elena Perez
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa Juan B.
- Maazouzi Wajdi
- MacFadyen Rosaleen
- MacFie Caroline C.
- Madotto Fabiana
- Maeyama Hiroki N.
- Maghrabi Khalid A.
- Magret Monica
- Mahto Heera L.
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego Pastor
- Marcu Alexandra
- Maria Villa
- Marin Julien
- Marin Maria C.
- Martinez Felipe T.
- Martinho Aurelia M.
- Marum Susan M.
- Massa Eleni V.
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin M.
- McArthur Colin
- McAuley Daniel F.
- McAuley Daniel F.
- McAuley Danny
- McCalman Katie H.
- McKechnie Stuart
- McKee Raymond
- McKenna Toni E.
- McLeod Alex
- McNamee Lia
- McNicholas Bairbre
- Meaney Edel A.
- Meco Basak Ceyda
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco Javier Flores
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António M.
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca T.
- Miller Jennene J.
- Miller Russel R.
- Mirabella Lucia
- Miryam-Prieto-González
- Mizuguchi Ichiko
- Mochizuki Katsunori
- Mohr Nicholas M.
- Mojoli Francesco
- Moles Silvia Iglesias
- Molin Alexandre
- Montanha Gustavo M.
- Monteiro Jorge M.
- Montero Laura Alvarez
- Montes Oscanoa Fredy A.
- Monti Giacomo
- Montini Luca M.
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni K.
- Mukkera Satyanarayana Reddy
- Mustafa Ghanem M.
- Muthuchellappan Radhakrishnan
- Myra-Rinia
- Máca Jan
- Nagy Eva O.
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Antonio P.
- Nasu Michitaka
- Navalpotro Miguel Angel Blasco
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius Ioan
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolas
- Nin Nicolás
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark Kim Andre L.
- Nunci Lordian
- Nunes Silvia L.
- Nutt Christopher
- Nuñez Edgardo
- Nygren Ingela
- O'Croinin Donall
- O'Kane Sinead C.
- O'Muircheartaigh Aogan C.
- O'Neill Orla
- Occhipinti Giovanna
- Oetting Trevor W.
- Ogino Yasuaki
- Oikonomou Marina A.
- Okuda Nao
- Oldroyd Matthew G.
- Olga Moreno F.
- Oliveira Bruno S.
- Ortiz Claudia A.
- Osman Emilio M.
- Oss Peteris
- Ouanes Islem
- Ourailogloy Vasilis
- Owens Robert L.
- Ozcelik Menekse
- Palaniswamy Vijayanand
- Palma Daniela M.
- Palmese Salvatore
- Palo Jose Emmanuel
- Panarello Giovanna
- Panwar Rakshit
- Papanikolaou Metaxia N.
- Papavasilopoulou Theonymfi G.
- Papazian Laurent
- Papurica Marius
- Para Luis Herrera
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim Rossini Abbie B.
- Patroniti Nicolò
- Pattarino Pierpaolo Terragni Ilaria
- Pecci Elisabetta
- Pellegrini Carlos A.
- Pelletier Nicolas
- Pellicer Ana M.
- Penuelas Oscar
- Pereira Carlos S.
- Perez Cesar P.
- Perez Manuel P.
- Persson Linnea
- Pesenti Antonio
- Pg Hj Ismail Dk Maizatul Aiman B.
- Pham T. i
- Pham T. i
- Pham Tai
- Phan Nga T.
- Piacentini Enrique A.
- Pillai Suresh
- Pintado Maria C.
- Piquilloud Lise
- Piras Claudio
- Pittini Gustavo
- Plotnikow Gustavo A.
- Poblano Manuel
- Poli Michela M.
- Pota Vincenzo
- Pozo Norberto C.
- Pozzi Matteo
- Preez Pieter D.
- Pronovost Antoine
- Protti Alessandro
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu H.
- Qin Tie H.
- Qiu Haibo
- Raaijmakers Monique
- Rafael S. nchez I.
- Raimondi Ferdinando
- Raj Ashok S.
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J.
- Ramirez-Alfaro Christian M.
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton M.
- Ranero Jorge Luis
- Ranieri Marco
- Raponi Francesco
- Recio Noelia N.
- Reschreiter Henrik
- Reske Andreas W.
- Reuter Danielle
- Reynolds Claire
- Rezoagli Emanuele
- Rhayakar Rachana V.
- Rialp Gemma
- Richecoeur Jack R.
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rios Fernando
- Riss Katharina C.
- Rittayamai Nuttapol
- Roberts Brigit L.
- Robine Adrien
- Robles Joanne B.
- Roche-Campo Ferran
- Rodgers Helen J.
- Rodriguez Lucia L.
- Rodriguez Ruben
- Rosa Jonas I.
- Roser Tomas P.
- Rossi Anna
- Roux Damien
- Rubenfeld Gordon
- Rugonfalvi Szabolcs
- Ruiz Silvia Rodriguez
- Ruiz-Aguilar Antonio L.
- Rylander Christian C.
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal D.
- Saenz María G.
- Saez Alejandro A.
- Sagar Sudha V.
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier E.
- Sales Vanessa M.
- Samkaoui Nacer
- Sanchez Roberto Jimenez
- Sanchez-Hurtado Luis A.
- Sanchez-Medina Jorge R.
- Sandesc Dorel
- Santoli Francesco L.
- Santos Cristina
- Sauvadet Elise P.
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam B.
- Schmidt Marcello
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen A.
- Schuetz Michael
- Schultz Marcus J.
- Schäfer Susanne
- Scott Christopher J.
- Seasman Colette
- Seethala Raghu
- Sellors Gareth P.
- Seoane-Quiroga Leticia
- Serra Carolina
- Serra Isabel M.
- Setten Mariano G.
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shin-Nunomiya
- Shindhe Suresh
- Shinn John O.
- Shiozaki Kyoko
- Silesky Jimenez Juan I.
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne D.
- Sivashanmugavel Mageswaran
- Sjøbø Brit Å.
- Sklienka Peter
- Slutsky Arthur S.
- Smith Mark J.
- Smith Oliver
- Soler Juan Alfonso
- Solis-Quesada Jaime E.
- Sotillo Diaz Juan Carlos J.
- Sottiaux T.
- Souissi Asma Ben
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E.
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Susana-Temprano
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío Manzano
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tabhan Edgardo E.
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tallet Alfonso Alec A.
- Tan Beatriz C.
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Terzi Nicolas
- Theresa Uhc Mother
- Thibault Sandrine
- Thompson B. Taylor
- Thompson Marlus M.
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana R.
- Toribio D. Á Cil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T. John
- Trinidad Olivia A.
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- van Haren Frank
- van Haren Frank
- van Wezel Hellen M.
- Vargas Monica P.
- Vascotto Ettore R.
- Vasquez Daniela N.
- Vega Luis D.
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villagomez Asisclo J.
- Villamagua Boris G.
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua X.
- Wang Shou H.
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D.
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L.
- Williams Alexandra J.
- Williams Karen E.
- Wise Matt P.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David W.
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
The evolution of lung cancer and impact of subclonal selection in TRACERx
- Author
- Abbosh Christopher
- AbdulJabbar Khalid
- Aerts Hugo J. W. L.
- Ahmad Tanya
- Ahmed Asia
- Al Bakir Maise
- Al-Sawaf Othman
- Alzetani Aiman
- Ambrose Lyn
- Ang Keng
- Angelova Mihaela
- Ashford Paul
- Asif Mo
- Athanasopoulou Foteini
- Austin Silvia
- Bailey Chris
- Bajaj Amrita
- Bandula Steve
- Barbè Vittorio
- Beck Stephan
- Begum Sofina
- Benafif Sarah
- Bentham Robert
- Bhakhri Kunal
- Bhayani Harshil
- Bilancia Rocco
- Birkbak Nicolai J.
- Bishop Paul
- Biswas Dhruva
- Black James R. M.
- Blackhall Fiona H.
- Blyth Kevin G.
- Boeing Stefan
- Bola Supreet Kaur
- Boleti Ekaterini
- Booth Sarah
- Borg Elaine
- Boyles Rebecca
- Brown Kate
- Buderi Silviu I.
- Bunkum Abigail
- Campbell Brittany B.
- Carter Mathew
- Castignani Carla
- Cave Judith
- Chain Benny
- Chan Kitty
- Chaturvedi Anshuman
- Chavan Hema
- Chee Serena
- Chen Kezhong
- Chervova Olga
- Cheyne Heather
- Choudhary Junaid
- Chowdhry Mohammed Fiyaz
- Chuter David
- Clark Tristan
- Clipson Alexandra
- Collins-Fekete Charles-Antoine
- Colliver Emma
- Cook Daniel E.
- Crosbie Philip
- Cruickshank Tracey
- Danson Sarah
- De Sousa Paulo
- Demeulemeester Jonas
- Denner Tamara
- Devaraj Anand
- Dhanda Harjot Kaur
- Dick Craig
- Dietzen Michelle
- Dijkstra Krijn
- Diossy Miklos
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Dulloo Sean
- Enfield Katey S. S.
- Ensell Leah
- Escudero Mickael
- Falzon Mary
- Fennell Dean A.
- Fernandes Nadia
- Fontaine Eustace
- Forster Martin D.
- Fraioli Francesco
- Frankell Alexander M.
- Gamble Samuel
- Gilbert Kayleigh
- Gimeno-Valiente Francisco
- Goldman Jacki
- Gomes Fabio
- Gorman Pat
- Gower Nicole
- Granato Felice
- Grapa Anca
- Grigoriadis Kristiana
- Grönroos Eva
- Gálvez-Cancino Felip
- Hackshaw Allan
- Hartley John A.
- Hayward Martin
- Herrero Javier
- Hessey Sonya
- Hewish Madeleine
- Hiley Crispin T.
- Hill Mark S.
- Hill William
- Hobson Philip
- Hodgkinson Jack Davies
- Holding James W.
- Hoxha Elena
- Huebner Ariana
- Hynds Robert E.
- Ingram Papawadee
- Jamal-Hanjani Mariam
- Janes Sam M.
- Jordan Simon
- Joseph Leena
- Joshi Vijay
- Kadiri Salma
- Kaniu Daniel
- Kanu Nnennaya
- Karagianni Despoina
- Karamani Angeliki
- Karasaki Takahiro
- Kassiotis George
- Kaufmann Tom L.
- Kerr Alastair
- Kerr Keith M.
- Khalil Mohammed
- Khiroya Reena
- Kilgour Elaine
- Kirk Alan
- Kisistok Judit
- Kostoulas Nikos
- Krebs Matthew G.
- Lacson Christer
- Lam Jie Min
- Langman Gerald
- Larose Cadieux Elizabeth
- Lawrence David
- Le Quesne John
- Le Quesne John
- Lee Claudia
- Lee Siow Ming
- Leek Angela
- Leslie Rachel
- Lester Jason F.
- Leung Michelle
- Levi Dina
- Lim Emilia L.
- Lim Eric
- Lindsay Colin R.
- Litchfield Kevin
- Litovchenko Maria
- Liu Wing Kin
- Lowe Helen L.
- Lu Wei-Ting
- Lucas Olivia
- López Saioa
- MacKenzie Mairead
- Magness Alastair
- Malima Mpho
- Marafioti Teresa
- Marrone Domenic
- Martinoni Hoogenboom Emilie
- Martínez-Ruiz Carlos
- Mastrokalos Gerasimos
- Matharu Gurdeep
- Matos Ignacio
- McGranahan Nicholas
- Middleton Gary
- Miedema Daniël M.
- Monk Fleur
- Montero Angeles
- Moore David A.
- Moss Stuart
- Mourikis Thanos P.
- Naceur-Lombardelli Cristina
- Naidu Babu
- Nair Arjun
- Naito Yutaka
- Nakas Apostolos
- Navani Neal
- Ng Kevin W.
- Nicholson Andrew G.
- Nicod Jerome
- Novasio Juliette
- Nye Emma
- Oliveira Pedro
- Osman Aya
- Pan Xiaoxi
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Patel Akshay J.
- Patrini Davide
- Pawlik Piotr
- Pearce David R.
- Peggs Karl S.
- Pich Oriol
- Pilotti Camilla
- Price Gillian
- Priest Lynsey
- Primrose Lindsay
- Procter Alexander James
- Proli Chiara
- Prymas Paulina
- Puttick Clare
- Quezada Sergio A.
- Rammohan Kendadai
- Ramsden Zoe
- Rane Jayant K.
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Reading James L.
- Rice Alexandra
- Richard Corentin
- Richards Jennifer
- Richardson Shirley
- Riley Joan
- Robinson Lily
- Rosenthal Rachel
- Rothwell Dominic G.
- Rowan Andrew
- Royle Gary
- Russell Peter
- Saghafinia Sadegh
- Salgado Roberto
- Scarci Marco
- Scarlett Lydia
- Schwarz Roland F.
- Scotland Molly
- Selvaraju Kayalvizhi
- Shackcloth Michael J.
- Shackleford Helen
- Shah Mansi
- Shah Pratibha
- Shah Rajesh
- Sharp Abigail
- Shaw Jacqui A.
- Sivakumar Monica
- Smith Elaine
- Smith Jon
- Smith Sean
- Sodha-Ramdeen Azmina
- Sokac Mateo
- Spanswick Victoria
- Stavrou Georgia
- Stephens Robert CM.
- Stewart Aengus
- Stone Richard Kevin
- Summers Yvonne
- Swanton Charles
- Szallasi Zoltan
- Tanić Miljana
- Taylor Magali N.
- Thakkar Krupa
- Thakrar Ricky M.
- Thol Kerstin
- Thomas Mathew
- Toncheva Antonia
- Totten Nicola
- Tufail Mohamad
- Tugwood Jonathan
- Ung Seng Kuong Anakin
- Van Loo Peter
- Van Loo Peter
- Vanloo Sharon
- Vasquez Marcos
- Veeriah Selvaraju
- Veiga Catarina
- Vendramin Roberto
- Ward Sophia
- Watkins Thomas B. K.
- Weeden Clare E.
- Werner Sunderland Mariana
- Wilson Claire
- Wilson Gareth A.
- Wilson James
- Wong Yien Ning Sophia
- Wu Yin
- Xing Wei
- Yuan Yinyin
- Zaccaria Simone
- Zhai Haoran
- Zhang Hanyun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/04/2023
- Field of study
Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relationship between intratumour heterogeneity and clinical outcome. In lung adenocarcinoma, mutations in 22 out of 40 common cancer genes were under significant subclonal selection, including classical tumour initiators such as TP53 and KRAS. We defined evolutionary dependencies between drivers, mutational processes and whole genome doubling (WGD) events. Despite patients having a history of smoking, 8% of lung adenocarcinomas lacked evidence of tobacco-induced mutagenesis. These tumours also had similar detection rates for EGFR mutations and for RET, ROS1, ALK and MET oncogenic isoforms compared with tumours in never-smokers, which suggests that they have a similar aetiology and pathogenesis. Large subclonal expansions were associated with positive subclonal selection. Patients with tumours harbouring recent subclonal expansions, on the terminus of a phylogenetic branch, had significantly shorter disease-free survival. Subclonal WGD was detected in 19% of tumours, and 10% of tumours harboured multiple subclonal WGDs in parallel. Subclonal, but not truncal, WGD was associated with shorter disease-free survival. Copy number heterogeneity was associated with extrathoracic relapse within 1 year after surgery. These data demonstrate the importance of clonal expansion, WGD and copy number instability in determining the timing and patterns of relapse in non-small cell lung cancer and provide a comprehensive clinical cancer evolutionary data resource
Genomic–transcriptomic evolution in lung cancer and metastasis
- Author
- Abbosh Christopher
- AbdulJabbar Khalid
- Aerts Hugo J. W. L.
- Ahmad Tanya
- Ahmed Asia
- Al Bakir Maise
- Al-Rashed Ali M.
- Al-Sawaf Othman
- Alzetani Aiman
- Ambrose Lyn
- Ang Keng
- Angelova Mihaela
- Ashford Paul
- Asif Mo
- Athanasopoulou Foteini
- Austin Silvia
- Bailey Chris
- Bajaj Amrita
- Bakir Maise Al
- Bandula Steve
- Barbè Vittorio
- Beck Stephan
- Begum Sofina
- Benafif Sarah
- Bentham Robert
- Bhakhri Kunal
- Bhayani Harshil
- Bilancia Rocco
- Birkbak Nicolai J.
- Birkbak Nicolai J.
- Bishop Paul
- Biswas Dhruva
- Black James R. M.
- Blackhall Fiona H.
- Blyth Kevin G.
- Boeing Stefan
- Bola Supreet Kaur
- Boleti Ekaterini
- Booth Sarah
- Borg Elaine
- Boyles Rebecca
- Brown Kate
- Buderi Silviu I.
- Bunkum Abigail
- Campbell Brittany B.
- Carter Mathew
- Castignani Carla
- Cave Judith
- Chain Benny
- Chan Kitty
- Chaturvedi Anshuman
- Chavan Hema
- Chee Serena
- Chen Kezhong
- Chervova Olga
- Cheyne Heather
- Choudhary Junaid
- Chowdhry Mohammed Fiyaz
- Chuter David
- Clark Tristan
- Clements James
- Clipson Alexandra
- Collins-Fekete Charles-Antoine
- Colliver Emma
- Cook Daniel E.
- Crosbie Philip
- Cruickshank Tracey
- Cubitt Laura
- Danson Sarah
- de Carné Trécesson Sophie
- De Sousa Paulo
- Demeulemeester Jonas
- Denner Tamara
- Devaraj Anand
- Dhanda Harjot Kaur
- Dick Craig
- Dietzen Michelle
- Dijkstra Krijn
- Diossy Miklos
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Dulloo Sean
- Duran Marcos Vasquez
- East Philip
- Enfield Katey S. S.
- Ensell Leah
- Escudero Mickael
- Falzon Mary
- Fennell Dean A.
- Fernandes Nadia
- Fontaine Eustace
- Forster Martin D.
- Fraioli Francesco
- Frankell Alexander M.
- Frankell Alexander M.
- Gamble Samuel
- Gilbert Kayleigh
- Gimeno-Valiente Francisco
- Goldman Jacki
- Gomes Fabio
- Gorman Pat
- Gower Nicole
- Granato Felice
- Grapa Anca
- Grigoriadis Kristiana
- Grönroos Eva
- Gálvez-Cancino Felip
- Hackshaw Allan
- Hartley John A.
- Hayward Martin
- Herrero Javier
- Hessey Sonya
- Hewish Madeleine
- Hiley Crispin T.
- Hill Mark S.
- Hill William
- Hobson Philip
- Hodgkinson Jack Davies
- Holding James W.
- Hoogenboom Emilie Martinoni
- Hoxha Elena
- Huebner Ariana
- Hynds Robert E.
- Ingram Papawadee
- Jamal-Hanjani Mariam
- Janes Sam M.
- Jones Thomas P.
- Jordan Simon
- Joseph Leena
- Joshi Vijay
- Kadiri Salma
- Kaniu Daniel
- Kanu Nnennaya
- Karagianni Despoina
- Karamani Angeliki
- Karasaki Takahiro
- Kassiotis George
- Kaufmann Tom L.
- Kerr Alastair
- Kerr Keith M.
- Khalil Mohammed
- Khiroya Reena
- Kilgour Elaine
- Kirk Alan
- Kisistok Judit
- Kostoulas Nikos
- Krebs Matthew G.
- Lacson Christer
- Lam Jie Min
- Lang Danny
- Langman Gerald
- Larose Cadieux Elizabeth
- Lawrence David
- Le Quesne John
- Lee Claudia
- Lee Siow Ming
- Leek Angela
- Leslie Rachel
- Lester Jason F.
- Leung Michelle
- Levi Dina
- Lim Emilia L.
- Lim Emilia L.
- Lim Eric
- Lindsay Colin R.
- Litchfield Kevin
- Litchfield Kevin
- Litovchenko Maria
- Liu Wing Kin
- Lowe Helen L.
- Lu Wei-Ting
- Lucas Olivia
- López Saioa
- MacKenzie Mairead
- Magness Alastair
- Malima Mpho
- Marafioti Teresa
- Marrone Domenic
- Martínez-Ruiz Carlos
- Mastrokalos Gerasimos
- Matharu Gurdeep
- Matos Ignacio Garcia
- McGranahan Nicholas
- McGranahan Nicholas
- Middleton Gary
- Monk Fleur
- Montero Angeles
- Moore David A.
- Moss Stuart
- Mourikis Thanos P.
- Naceur-Lombardelli Cristina
- Naidu Babu
- Nair Arjun
- Naito Yutaka
- Nakas Apostolos
- Navani Neal
- Ng Kevin W.
- Nicholson Andrew G.
- Nicod Jerome
- Novasio Juliette
- Nye Emma
- Oliveira Pedro
- Osman Aya
- Pan Xiaoxi
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Patel Akshay J.
- Patrini Davide
- Pawlik Piotr
- Pearce David R.
- Peggs Karl S.
- Pich Oriol
- Pilotti Camilla
- Price Gillian
- Priest Lynsey
- Primrose Lindsay
- Procter Alexander James
- Proli Chiara
- Prymas Paulina
- Puttick Clare
- Quezada Sergio A.
- Rammohan Kendadai
- Ramsden Zoe
- Rane Jayant K.
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Reading James L.
- Rice Alexandra
- Richard Corentin
- Richards Jennifer
- Richardson Shirley
- Riley Joan
- Robinson Lily
- Rosenthal Rachel
- Rothwell Dominic G.
- Rowan Andrew
- Royle Gary
- Russell Peter
- Saghafinia Sadegh
- Salgado Roberto
- Scarci Marco
- Scarlett Lydia
- Schwarz Roland F.
- Scotland Molly
- Selvaraju Kayalvizhi
- Shackcloth Michael J.
- Shackleford Helen
- Shah Mansi
- Shah Pratibha
- Shah Rajesh
- Sharp Abigail
- Shaw Jacqui A.
- Sivakumar Monica
- Smith Elaine
- Smith Sean
- Sodha-Ramdeen Azmina
- Sokac Mateo
- Spanswick Victoria
- Stavrou Georgia
- Stephens Robert C. M.
- Stewart Aengus
- Stone Richard Kevin
- Summers Yvonne
- Sunderland Mariana Werner
- Swanton Charles
- Swanton Charles
- Szallasi Zoltan
- Tanić Miljana
- Taylor Magali N.
- Thakkar Krupa
- Thakrar Ricky M.
- Thol Kerstin
- Thomas Mathew
- Toncheva Antonia
- Totten Nicola
- Tufail Mohamad
- Tugwood Jonathan
- Ung Seng Kuong Anakin
- Van Loo Peter
- Van Loo Peter
- Vanloo Sharon
- Veeriah Selvaraju
- Veiga Catarina
- Vendramin Roberto
- Ward Sophia
- Watkins Thomas B. K.
- Weeden Clare E.
- Wilson Claire
- Wilson Gareth A.
- Wilson James
- Wong Yien Ning Sophia
- Wu Yin
- Yuan Yinyin
- Zaccaria Simone
- Zhai Haoran
- Zhang Hanyun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/04/2023
- Field of study
Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell lung cancer tumours from 347 out of the first 421 patients prospectively recruited into the TRACERx study. Analyses of 947 tumour regions, representing both primary and metastatic disease, alongside 96 tumour-adjacent normal tissue samples implicate the transcriptome as a major source of phenotypic variation. Gene expression levels and ITH relate to patterns of positive and negative selection during tumour evolution. We observe frequent copy number-independent allele-specific expression that is linked to epigenomic dysfunction. Allele-specific expression can also result in genomic–transcriptomic parallel evolution, which converges on cancer gene disruption. We extract signatures of RNA single-base substitutions and link their aetiology to the activity of the RNA-editing enzymes ADAR and APOBEC3A, thereby revealing otherwise undetected ongoing APOBEC activity in tumours. Characterizing the transcriptomes of primary–metastatic tumour pairs, we combine multiple machine-learning approaches that leverage genomic and transcriptomic variables to link metastasis-seeding potential to the evolutionary context of mutations and increased proliferation within primary tumour regions. These results highlight the interplay between the genome and transcriptome in influencing ITH, lung cancer evolution and metastasis
The evolution of non-small cell lung cancer metastases in TRACERx
- Author
- Abbosh Christopher
- AbdulJabbar Khalid
- Aerts Hugo J. W. L.
- Ahmad Tanya
- Ahmed Asia
- Akther Mita
- Al Bakir Maise
- Al-Sawaf Othman
- Alzetani Aiman
- Ambrose Lyn
- Ang Keng
- Angelova Mihaela
- Ashford Paul
- Asif Mo
- Athanasopoulou Foteini
- Austin Silvia
- Bailey Chris
- Bajaj Amrita
- Bandula Steve
- Barbè Vittorio
- Beck Stephan
- Begum Sofina
- Benafif Sarah
- Bentham Robert
- Bhakhri Kunal
- Bhayani Harshil
- Bilancia Rocco
- Birkbak Nicolai J.
- Bishop Paul
- Biswas Dhruva
- Black James R. M.
- Blackhall Fiona H.
- Blyth Kevin G.
- Boeing Stefan
- Bola Supreet Kaur
- Boleti Ekaterini
- Booth Sarah
- Borg Elaine
- Boyles Rebecca
- Brown Kate
- Buderi Silviu I.
- Bunkum Abigail
- Campbell Brittany B.
- Carter Mathew
- Castignani Carla
- Cave Judith
- Chain Benny
- Chan Kitty
- Chaturvedi Anshuman
- Chavan Hema
- Chee Serena
- Chen Kezhong
- Chervova Olga
- Cheyne Heather
- Choudhary Junaid
- Chowdhry Mohammed Fiyaz
- Chuter David
- Clark Tristan
- Clipson Alexandra
- Collins-Fekete Charles-Antoine
- Colliver Emma
- Cook Daniel E.
- Crosbie Philip
- Cruickshank Tracey
- Danson Sarah
- De Sousa Paulo
- Demeulemeester Jonas
- Denner Tamara
- Devaraj Anand
- Dhanda Harjot Kaur
- Dick Craig
- Dietzen Michelle
- Dijkstra Krijn
- Diossy Miklos
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Dulloo Sean
- Enfield Katey S. S.
- Ensell Leah
- Escudero Mickael
- Falzon Mary
- Fennell Dean A.
- Fernandes Nadia
- Fontaine Eustace
- Forster Martin D.
- Fraioli Francesco
- Frankell Alexander M.
- Gamble Samuel
- Gilbert Kayleigh
- Gimeno-Valiente Francisco
- Goldman Jacki
- Gomes Fabio
- Gorman Pat
- Gower Nicole
- Granato Felice
- Grapa Anca
- Grigoriadis Kristiana
- Grönroos Eva
- Gálvez-Cancino Felip
- Hackshaw Allan
- Hartley John A.
- Hayward Martin
- Herrero Javier
- Hessey Sonya
- Hewish Madeleine
- Hiley Crispin T.
- Hill Mark S.
- Hill William
- Hobson Philip
- Hodgkinson Jack Davies
- Holding James W.
- Hoxha Elena
- Huebner Ariana
- Hynds Robert E.
- Ingram Papawadee
- Jamal-Hanjani Mariam
- Janes Sam M.
- Johnson Diana
- Jordan Simon
- Joseph Leena
- Joshi Vijay
- Kadiri Salma
- Kaniu Daniel
- Kanu Nnennaya
- Karagianni Despoina
- Karamani Angeliki
- Karasaki Takahiro
- Kassiotis George
- Kaufmann Tom L.
- Kerr Alastair
- Kerr Keith M.
- Khalil Mohammed
- Khiroya Reena
- Kilgour Elaine
- Kirk Alan
- Kisistok Judit
- Kostoulas Nikos
- Krebs Matthew G.
- Lacson Christer
- Lam Jie Min
- Langman Gerald
- Larose Cadieux Elizabeth
- Lawrence David
- Laycock Joanne
- Le Quesne John
- Lee Claudia
- Lee Siow Ming
- Leek Angela
- Leslie Rachel
- Lester Jason F.
- Leung Michelle
- Levi Dina
- Lim Emilia L.
- Lim Eric
- Lindsay Colin R.
- Litchfield Kevin
- Litovchenko Maria
- Liu Wing Kin
- Lowe Helen L.
- Lu Wei-Ting
- Lucas Olivia
- López Saioa
- MacKenzie Mairead
- Magness Alastair
- Malima Mpho
- Marafioti Teresa
- Marrone Domenic
- Martinoni Hoogenboom Emilie
- Martínez-Ruiz Carlos
- Mastrokalos Gerasimos
- Matharu Gurdeep
- Matos Ignacio
- McGranahan Nicholas
- Middleton Gary
- Monk Fleur
- Montero Angeles
- Moore David A.
- Moss Stuart
- Mourikis Thanos P.
- Naceur-Lombardelli Cristina
- Naidu Babu
- Nair Arjun
- Naito Yutaka
- Nakas Apostolos
- Navani Neal
- Ng Kevin W.
- Nicholson Andrew G.
- Nicod Jerome
- Novasio Juliette
- Nye Emma
- Oliveira Pedro
- Osman Aya
- Pan Xiaoxi
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Patel Akshay J.
- Patrini Davide
- Pawlik Piotr
- Pearce David R.
- Peggs Karl S.
- Pich Oriol
- Pilotti Camilla
- Price Gillian
- Priest Lynsey
- Primrose Lindsay
- Procter Alexander James
- Proli Chiara
- Prymas Paulina
- Puttick Clare
- Quezada Sergio A.
- Rammohan Kendadai
- Ramsden Zoe
- Rane Jayant K.
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Razaq Maryam
- Reading James L.
- Rice Alexandra
- Richard Corentin
- Richards Jennifer
- Richardson Shirley
- Riley Joan
- Robinson Lily
- Rosenthal Rachel
- Rothwell Dominic G.
- Rowan Andrew
- Royle Gary
- Russell Peter
- Saghafinia Sadegh
- Salgado Roberto
- Scarci Marco
- Scarlett Lydia
- Schwarz Roland F.
- Scotland Molly
- Selvaraju Kayalvizhi
- Shackcloth Michael J.
- Shackleford Helen
- Shah Mansi
- Shah Pratibha
- Shah Rajesh
- Sharp Abigail
- Shaw Jacqui A.
- Sivakumar Monica
- Smith Elaine
- Smith Sean
- Sodha-Ramdeen Azmina
- Sokac Mateo
- Spanswick Victoria
- Stavrou Georgia
- Stephens Robert C. M.
- Stewart Aengus
- Stone Richard Kevin
- Summers Yvonne
- Swanton Charles
- Szallasi Zoltan
- Tanić Miljana
- Taylor Magali N.
- Thakkar Krupa
- Thakrar Ricky M.
- Thol Kerstin
- Thomas Mathew
- Toncheva Antonia
- Totten Nicola
- Tufail Mohamad
- Tugwood Jonathan
- Ung Seng Kuong Anakin
- Van Loo Peter
- Vanloo Sharon
- Vasquez Marcos
- Veeriah Selvaraju
- Veiga Catarina
- Vendramin Roberto
- Ward Sophia
- Watkins Thomas B. K.
- Weeden Clare E.
- Werner Sunderland Mariana
- Wilson Claire
- Wilson Gareth A.
- Wilson James
- Wong Yien Ning Sophia
- Wu Yin
- Yuan Yinyin
- Zaccaria Simone
- Zhai Haoran
- Zhang Hanyun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/04/2023
- Field of study
Metastatic disease is responsible for the majority of cancer-related deaths. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before the last clonal sweep in the primary tumour, and early divergence was enriched for patients who were smokers at the time of initial diagnosis. Simulations suggested that early metastatic divergence more frequently occurred at smaller tumour diameters (less than 8 mm). Single-region primary tumour sampling resulted in 83% of late divergence cases being misclassified as early, highlighting the importance of extensive primary tumour sampling. Polyclonal dissemination, which was associated with extrathoracic disease recurrence, was found in 32% of cases. Primary lymph node disease contributed to metastatic relapse in less than 20% of cases, representing a hallmark of metastatic potential rather than a route to subsequent recurrences/disease progression. Metastasis-seeding subclones exhibited subclonal expansions within primary tumours, probably reflecting positive selection. Our findings highlight the importance of selection in metastatic clone evolution within untreated primary tumours, the distinction between monoclonal versus polyclonal seeding in dictating site of recurrence, the limitations of current radiological screening approaches for early diverging tumours and the need to develop strategies to target metastasis-seeding subclones before relapse
Antibodies against endogenous retroviruses promote lung cancer immunotherapy
- Author
- Abbosh Christopher
- AbdulJabbar Khalid
- Aerts Hugo J. W. L.
- Ahmad Tanya
- Ahmed Asia
- Al Bakir Maise
- Al-Sawaf Othman
- Almagro Jorge
- Alzetani Aiman
- Ambrose Lyn
- Anastasiou Panayiotis
- Ang Keng
- Angelova Mihaela
- Ashford Paul
- Asif Mo
- Athanasopoulou Foteini
- Attig Jan
- Au Lewis
- Austin Silvia
- Bailey Chris
- Bajaj Amrita
- Bandula Steve
- Banerjee Susana
- Barbè Vittorio
- Beck Stephan
- Begum Sofina
- Behrens Axel
- Benafif Sarah
- Bentham Robert
- Bhakhri Kunal
- Bhayani Harshil
- Bilancia Rocco
- Birkbak Nicolai J.
- Bishop Paul
- Biswas Dhruva
- Black James R. M.
- Blackhall Fiona H.
- Blyth Kevin G.
- Boeing Stefan
- Bola Supreet Kaur
- Boleti Ekaterini
- Boos Laura Amanda
- Booth Sarah
- Borg Elaine
- Boumelha Jesse
- Boyles Rebecca
- Brown Kate
- Buderi Silviu I.
- Bunkum Abigail
- Byrne Fiona
- Campbell Brittany B.
- Carter Mathew
- Castignani Carla
- Cave Judith
- Cha Hongui
- Chain Benny
- Chan Kitty
- Chaturvedi Anshuman
- Chau Ian
- Chavan Hema
- Chee Serena
- Chen Kezhong
- Chervova Olga
- Cheyne Heather
- Choudhary Junaid
- Chowdhry Mohammed Fiyaz
- Chuter David
- Clark Tristan
- Clipson Alexandra
- Collins-Fekete Charles-Antoine
- Colliver Emma
- Cook Daniel E.
- Crosbie Philip
- Cruickshank Tracey
- Cunningham David
- Danson Sarah
- de Carné Trécesson Sophie
- De Sousa Paulo
- Demeulemeester Jonas
- Denner Tamara
- Devaraj Anand
- Dhanda Harjot Kaur
- Dick Craig
- Dietzen Michelle
- Dijkstra Krijn
- Diossy Miklos
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Downward Julian
- Droney Joanne
- Dulloo Sean
- Enfield Katey S. S.
- Ensell Leah
- Escudero Mickael
- Falzon Mary
- Faulkner Nikhil
- Fendler Annika
- Fennell Dean A.
- Fernandes Nadia
- Fontaine Eustace
- Forster Martin D.
- Fraioli Francesco
- Frankell Alexander M.
- Furness Andrew J. S.
- Gamble Samuel
- Gerard Camille L.
- Gilbert Kayleigh
- Gimeno-Valiente Francisco
- Goldman Jacki
- Gomes Fabio
- Gorman Pat
- Gower Nicole
- Granato Felice
- Grapa Anca
- Grigoriadis Kristiana
- Grönroos Eva
- Gálvez-Cancino Felip
- Hackshaw Allan
- Harrington Kevin
- Hartley John A.
- Hayward Martin
- Herrero Javier
- Hessey Sonya
- Hewish Madeleine
- Hiley Crispin T.
- Hill Mark S.
- Hill William
- Hobson Philip
- Hodgkinson Jack Davies
- Holding James W.
- Hoxha Elena
- Huebner Ariana
- Hynds Robert E.
- Ingram Papawadee
- Jamal-Hanjani Mariam
- Janes Sam M.
- Jhanji Shaman
- Jones Robin L.
- Jordan Simon
- Joseph Leena
- Joshi Vijay
- Kadiri Salma
- Kaniu Daniel
- Kanu Nnennaya
- Karagianni Despoina
- Karamani Angeliki
- Karasaki Takahiro
- Kassiotis George
- Kaufmann Tom L.
- Kerr Alastair
- Kerr Keith M.
- Khalil Mohammed
- Khiroya Reena
- Kilgour Elaine
- Kim Hyemin
- Kirk Alan
- Kisistok Judit
- Kostoulas Nikos
- Krebs Matthew G.
- Kumar Sacheen
- Lacson Christer
- Lam Jie Min
- Langman Gerald
- Larkin James
- Larose Cadieux Elizabeth
- Lawrence David
- Le Quesne John
- Lee Claudia
- Lee Se-Hoon
- Lee Siow Ming
- Leek Angela
- Leslie Rachel
- Lester Jason F.
- Leung Michelle
- Levi Dina
- Lim Emilia L.
- Lim Eric
- Lindsay Colin R.
- Litchfield Kevin
- Litovchenko Maria
- Liu Wing Kin
- Lowe Helen L.
- Lu Wei-Ting
- Lucas Olivia
- López Saioa
- MacKenzie Mairead
- Magness Alastair
- Magno Neil
- Malima Mpho
- Marafioti Teresa
- Marrone Domenic
- Martinoni Hoogenboom Emilie
- Martínez-Ruiz Carlos
- Mastrokalos Gerasimos
- Matharu Gurdeep
- Matos Ignacio
- McGranahan Nicholas
- Messiou Christina
- Middleton Gary
- Molina-Arcas Miriam
- Monk Fleur
- Montero Angeles
- Moore David A.
- Moss Stuart
- Mourikis Thanos P.
- Naceur-Lombardelli Cristina
- Naidu Babu
- Nair Arjun
- Naito Yutaka
- Nakas Apostolos
- Navani Neal
- Ng Kevin W.
- Nicholson Andrew G.
- Nicholson Emma
- Nicod Jerome
- Novasio Juliette
- Nye Emma
- Okines Alicia
- Oliveira Pedro
- Osman Aya
- Pan Xiaoxi
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Patel Akshay J.
- Patrini Davide
- Pawlik Piotr
- Pearce David R.
- Peggs Karl S.
- Pich Oriol
- Pickering Lisa
- Pilotti Camilla
- Popat Sanjay
- Price Gillian
- Priest Lynsey
- Primrose Lindsay
- Procter Alexander James
- Proli Chiara
- Prymas Paulina
- Puttick Clare
- Quezada Sergio A.
- Rammohan Kendadai
- Ramsden Zoe
- Rane Jayant K.
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Reading James L.
- Reid Alison
- Rice Alexandra
- Richard Corentin
- Richards Jennifer
- Richardson Shirley
- Riley Joan
- Robinson Lily
- Rosenthal Rachel
- Rothwell Dominic G.
- Rowan Andrew
- Royle Gary
- Russell Peter
- Saghafinia Sadegh
- Salgado Roberto
- Scarci Marco
- Scarlett Lydia
- Schmitt Andreas M.
- Schwarz Roland F.
- Scotland Molly
- Selvaraju Kayalvizhi
- Shackcloth Michael J.
- Shackleford Helen
- Shah Mansi
- Shah Pratibha
- Shah Rajesh
- Sharp Abigail
- Shaw Jacqui A.
- Shepherd Scott T. C.
- Shim Seohee
- Shum Benjamin
- Sivakumar Monica
- Smith Elaine
- Smith Sean
- Sodha-Ramdeen Azmina
- Sokac Mateo
- Spanswick Victoria
- Starling Naureen
- Stavrou Georgia
- Stephens Robert C. M.
- Stewart Aengus
- Stone Richard Kevin
- Summers Yvonne
- Swanton Charles
- Swerdlow Anthony
- Szallasi Zoltan
- Tanić Miljana
- Tatham Kate C.
- Taylor Magali N.
- Thakkar Krupa
- Thakrar Ricky M.
- Thol Kerstin
- Thomas Mathew
- Toncheva Antonia
- Totten Nicola
- Tufail Mohamad
- Tugwood Jonathan
- Turajlic Samra
- Turner Nicholas
- Ung Seng Kuong Anakin
- Van Loo Peter
- Vanloo Sharon
- Vasquez Marcos
- Veeriah Selvaraju
- Veiga Catarina
- Vendramin Roberto
- Ward Sophia
- Watkins Thomas B. K.
- Weeden Clare E.
- Welsh Liam
- Werner Sunderland Mariana
- Wilkinson Katalin A.
- Wilkinson Robert J.
- Wilson Claire
- Wilson Gareth A.
- Wilson James
- Wong Yien Ning Sophia
- Wu Yin
- Young George
- Young Kate
- Yousaf Nadia
- Yuan Yinyin
- Zaccaria Simone
- Zhai Haoran
- Zhang Hanyun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/04/2023
- Field of study
B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS). Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive. Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma. We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies, and further identify endogenous retrovirus (ERV) envelope glycoproteins as a dominant anti-tumour antibody target. ERV-targeting B cell responses are amplified by ICB in both humans and mice, and by targeted inhibition of KRAS(G12C) in the mouse model. ERV-reactive antibodies exert anti-tumour activity that extends survival in the mouse model, and ERV expression predicts the outcome of ICB in human lung adenocarcinoma. Finally, we find that effective immunotherapy in the mouse model requires CXCL13-dependent TLS formation. Conversely, therapeutic CXCL13 treatment potentiates anti-tumour immunity and synergizes with ICB. Our findings provide a possible mechanistic basis for the association of TLS with immunotherapy response
Recommended from our members
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
- Binda Filipo
- Birgisdottir Hrönn
- Birgisdóttir Hrönn
- Bispo Bruno Miguel
- Biston Patrick
- Bjorgen Hege
- Blackwood Bronagh
- Blanc Agnès
- Blanco Daniel
- Blanco Maria Pilar Sogues
- Blasco Maria Luisa
- Bliksted Inger Abildgaard
- Blondal Asbjorn
- Bloos Frank
- Blot Stijn I.
- Bo Qi
- Bocui Nie
- Boedjawan Naraindath N.
- Bogarin Javier
- Bogoevska-Miteva Zaneta
- Bonaccorso Luciano
- Bongiorno Benjamin
- Bonsignore Pablo Julio Maldonaldo
- Borgognoni Cinzia
- Borin Christophe
- Borkowska Marta
- Bormans Laura
- Boroli Filippo
- Borys Michal
- Boschetto Margherita
- Bossolasco Matteo
- Bota Marc
- Boulanger Carole
- Boulton Karen
- Bowes Bonnie
- Boyer Laetitia
- Bozbay Suha
- Bozena Armanda
- Bratsberg Bjorn
- Bravo Silvina
- Brett Carole
- Brett Stephen
- Brett Stephen J.
- Briva Arturo
- Brizio Elisabetta
- Brizuela Patricia
- Broadhurst Phil
- Brown Wendy
- Browne Troy
- Bruel Cédric
- Bruhn Louise
- Brumwell Sarah
- Bruni Andrea
- Bruno Anna Vita
- Buckley Sarah
- Bull Rhian
- Bumbasirevic Vesna
- Buregeya Egide
- Burns Karen
- Butcher Rand
- Byers Heather
- Bösl Kathrin
- Cabral Dolly Mabel Bordon
- Cabral João
- Cabrita Paula
- Caddell Paul
- Caicedo Nestor
- Calamai Italo
- Calili Duygu Kayar
- Caliskan Gulbahar
- Calleja Pablo Lopez-Arcas
- Calpe Neus
- Calvino-Gunther Silvia
- Campanili Ticiane
- Campbell Elizabeth
- Campos Pierina Arias
- Campos-Perez Margarita
- Camputaro Luis
- Camsooksai Julie
- Canales Julieta
- Canete Fidelina
- Cani Alma
- Cano Anastasio Espejo
- Cao Deyan
- Cao Wenzhen
- Cao Ying
- Cao Zu Qing
- Capuzzi Fabio
- Cardenas Yenny
- Carey Annette
- Carney Dominic
- Carter Charlotte
- Casaioli Simona
- Castelain Vincent
- Castiglione Giacomo
- Cata Juan
- Cavaco Raquel
- Cengiz Melike
- Cerezo Franklin Dean
- Cesar Helena
- Cespedes Laura
- Chaboyer Wendy
- Chadwick Llesley
- Chang Shu Chuan
- Chang Youjin
- Chantziara Vasiliki
- Chao Yu
- Chaparro Javiera
- Chaparro Silvia
- Chapeta Edwin
- Chapman Carmel
- Charalabous Iwy
- Chatzis Marinos
- Chee Hyun Keun
- Chen Feifei
- Chen Haiyan
- Chen Hongjuan
- Chen Jingfang
- Chen Lei
- Chen Meili
- Chen Tianfei
- Chen Wenmin
- Chen Xiaoyan
- Chen Zhihong
- Cheng
- Cheng Jiyin
- Chime Christiana
- Chimunda Tim
- Chinardet Benoît
- Chovas Achilleas
- Christ Martin
- Christofis Christos
- Chueca Ramon Molina
- Chunhua Gao
- Cinel İsmail
- Ciorba Paolo
- Clark Michele
- Clement Ana Isabel
- Clesi Tara
- Cody Caitriona
- Collet Marie
- Collins Amy
- Coman Mary
- Conde Belen Burgos
- Conejo Isabel
- Constantinou Constantina
- Corcoran Ailesh
- Coremans Stefano
- Correia Malcolm C.
- Corso Amalia
- Cortegiani Andrea
- Cortellazi Paolo
- Cosano Rosario
- Cossu Maria
- Costa Humberto
- Cotoia Antonella
- Coyer Fiona
- Craig Geraldine
- Craig Jayne
- Cranmer Karen
- Cranshaw Julius
- Creber Peter
- Crone Petra
- Cui Xia
- Cummings Donna
- Cupitt Jason
- Curilen Veronica
- Czuczwar Miroslaw
- Dagooc Rica
- Dai Zhaoxing
- Dal Hayriye Cankar
- Dallaire Julie
- Das Sasidharan Nair Vishnu
- Daubin Cédric
- Davidow Jon
- Davidson Cheryl
- Dawn Frances
- Dayan Meneses
- de Almeida Angelica Olivetto
- de Anda Gilberto Felipe Vazquez
- De Bels David
- de Ceballos José Peral Gutierrez
- De Decker Koen
- De Haan Marina
- de Jesús Ortiz Alberto
- de la Ventana Ana Belén Sánchez
- De lange Dylan
- De Lange Dylan
- de Molina Serrano José Ivan Rodriguez
- De Montmollin Etienne
- De Pablo Ana María
- De Rosa Silvia
- De Sanctis Francesca
- De Schryver Nicolas
- De Wit Irene
- Dean Emiliano
- Debue Anne-Sophie
- Del Bosque Diez Rosa
- del Cotillo Mercedes
- del Mar Diaz Salcedo Maria
- Del Moral Armengol Mario
- Del Rio Cabajo Lorena
- del Rosario Villar Redondo M.
- del Valle Gimenez Graciela
- Delgado Carlos Castro
- Delgado Patricia
- Dellafiore Federica
- Delossantos Shella
- Delve Peter
- Demarré Liesbet
- Demirkiran Oktay
- Dendane Tarek
- Deng Xiaoqiong
- Depuydt Tanja
- Derbyshire Claire
- Derrick Helen
- Deschepper Mieke
- Deva Shanti Rudra
- Dhaliwal Jasdeep
- Di Gravio Valentina
- Di Risio Alessandro
- Di Yanhong
- Diakaki Chrisi
- Dias Sofia
- Diaz Ana
- Diaz Anna
- Diaz Monica Garcia
- Dieperink Willem
- Diers Anja
- Dikmen Yalım
- Dikmen Yalim
- Dilek Ozcengiz
- Dimoula Aikaterini
- Dimski Thomas
- Ding Min
- Ding Xinran
- Ding Yajun
- Ding Yanming
- Dlamini-Sserumaga Lomangisi
- Dobric Milena
- Dolenc Simon
- Dolgusevs Mihails
- Domenech Laura Claramunt
- Dong Jingwen
- Dong Yunchun
- Donvito Maria
- Dormans Tom
- Douschan Philipp
- Doyle Deirdre
- Dragoumanis Christos
- Du Guifang
- Duan Huan
- Dugernier Thierry
- Duggal Abhijit
- Dullenkopf Alexander
- Dungca Adonis
- Dunne Lisa
- Duran Karely
- Déserts Marc Danguy des
- D’Ambrosio Francesco
- D’Ambrosio Paolo
- Ebaid Maie
- Ebaid Maie Salem
- Efe Serdar
- Efthimiou Aikaterini
- Efthymiou Anna
- Egi Moritoki
- Egorova Natalya
- Ei Poe Poe
- Elatrous Souheil
- Elay Gülseren
- Elgammudi Mala
- Elhadi Ahmed
- Elhadi Muhammed
- Elhechmi Youssef Zied
- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
- Enamorado Judy Enamorado
- Eneas Antony
- Eng Timothy
- Erdivanli Başar
- Erdogan Elif
- Eroglu Ahmet
- Ershova Olga
- Escalante Rosana Gabriela
- Espinosa Cristina Paños
- Esposito Romina
- Essardy Fatiha
- Etourneau Fabienne
- Evers Mirjam
- Fadeeva Liudmila
- Fan Limei
- Fang Xiuhua
- Farkas Jean-christophe
- Farmakis Epaminontas
- Farnell-Ward Sarah
- Farre Olga
- Fartoukh Muriel
- Favre René
- Feghaly Michel El
- Fei Qin
- Feng ZhangXia
- Feng Zhaoxia
- Feranandes Ana Margarida
- Fernadez Inmaculada Lorenzo
- Fernandes Fatima
- Fernandez Alejandra Azahara Marguello
- Fernandez Maria Alejandra
- Fernandez Maria Cristina Iglesias
- Fernandez Oscar
- Fernandez Ruben
- Fernandez Silvia
- Fernández Ana Wensell
- Ferreira Amelia
- Ferreira Fatima
- Ferreira Hilaryano
- Ferreira Susana
- Ferretti Christian
- Ffarcsi Madiha Hashmi
- Fiedler Christine
- Fielding Clare
- Fielding Mark
- Figaro-Barclay Dianne
- Figueiredo Margarida Ferreira
- Fijen Jan-Willem
- Filipescu Daniela Carmen
- Filipović-Grčić Ina
- Finn Damien O’Connell Rosemary
- Finnstrom Inger Johanne
- Fioretti Audrey
- Firment Peter
- Fischer Susanne
- Fishman Anne
- Fister Misa
- Fitzpatrick Gerry
- Fivecoat Pauline
- Flessel Nadine
- Fletcher Kelly
- Fleury Yvan
- Flevari Aikaterini
- Flores Leah
- Foka Maria
- Fonseca Imelda Perdomo
- Foong Kit Weng
- Fores Meritxell Tapia
- Fox Natalie
- Fox Nathalie
- Fraipont Vincent
- Franco Natalia
- Frandsen Tine Melgaard
- François Guy
- Frey Christian
- From Mette
- Fu Jing
- Fujimoto Koji
- Galaaen Britt
- Galazzi Alessandro
- Galiana Maria
- Galishevskiy Dmitriy
- Gallart Elisabet
- Gallegos-Perez Humberto
- Gallion Marc
- Gama Luz Marina Silva
- Ganeshalingam Vaarisan
- Gao Guangyuan
- Gao Jie
- Gao Li
- Gao Yan
- Garcia Amilcar
- Garcia Barbara
- Garcia Paulo Carlos
- Garcia Rosa
- García Maria Fernanda
- Garofalo Eugenio
- Garzón-Tovar Carolina
- Gatti Chiara
- Gautam Prabha
- Gautheret Nathalie
- Gavrilovic Srđan
- Gawda Ryszard
- Ge Liuyan
- Geijer Sebastian
- Georgakas Ioannis
- George Shaly
- Georgiev Carmel
- Georgiou Marios
- Gerretsen Benjamin
- Gerritsen Rik T.
- Gharios Elie
- Ghioldi Davide Massimo
- Ghosh Rishi
- Ghula Mohamed Abdurazzag Ali
- Giacardi Christophe
- Giampaoletti Andrea
- Gievski Vanja
- Gilder Eileen
- Gill Sirley
- Gils Fränk
- Girianni Salvatore
- Girona Mercè
- Giusti Gian Domenico
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- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
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- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
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- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
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- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
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- Yang Yanping
- Yang YongXia
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- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
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- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
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- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
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- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
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- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
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- Eng Timothy
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- Khwannimit Bodin
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- Kim Je Hyeong
- Kim Junghyun
- Kim Kyung Chan
- Kim Seok Chan
- Kindgen-Milles Detlef
- Kiselev Alexander
- Kjærgård Inger Ebbesen
- Kleanthous Pavlina
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- Krastins Ivasr
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- Kubisz-Pudelko Agnieszka
- Kuijpers Paul
- Kulakov Vladimir
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- Kusi-Appiah Anita-Chrysolyte
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- Kütimets Martin
- Labeau Sonia O.
- Lacaden Grace
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- Lagerhäll Caroline
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- Navarro José Alejandro
- Negro Alessandra
- Nestora Konstantina
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- Ngo Delphine
- Ni Dongshu
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- Nikolaou Charikleia
- Nishime Yoshimasa
- Noblezada-Uy Debbie
- Nocheretti Mariangeles Gabriela
- Noguchi Ayako
- Nogueira Paula Cristina
- Nor Basri Mat
- Nor Mohd Basri Mat
- North Samantha
- Nshimyumuremyi Isaac
- Nunes Catarina
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- Pan Fuqun
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- Parag Nivisha
- Parente Isabel
- Park Jisoo
- Park Seung Yong
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- Parkin Emma
- Parsons Leanne
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- Pascual-Bielsa Ana
- Pastore Beatrice
- Pastores Stephen M.
- Pathak Sabina Dhakal
- Patrichi Tatiana
- Patsalos Artemis
- Patsiou Eirini-Chysovalanto
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- Pedersen Anne Sofie Bomholt
- Pedersen Karin Rehnholt
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- Peterson Jessica
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- Pečenković Suzana
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- Piergentili Federica
- Pili-Floury Sébastien
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- Pineda Ana Alícia Velarde
- Pinheiro Cristiana Mota
- Pinto Susana
- Pinto Vitor Manuel Vaz
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- Prowle John
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- Pulak Paul
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- Putruele Sofia
- Qawasmeh Khaled Al
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- Quagliotto Catia
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- Rabarova Daria
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- Rahim Azmin Huda Abdul
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- Reece-Anthony Rosie
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- Remor Natalie
- Ren Aiua
- Reyes Amylkar Garay
- Reyes Amylkar José Garay
- Reyes Laura Martinez
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- Rodriguez Gabriel Enrique
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- Roller Martin
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- Romero-Gonzalez Juan P.
- Ronchini Ana Lucia Vitti
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- Rubulotta Francesca
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- Salazar Janel
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- Sanchez-Hurtado Luis Alejandro
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- Sankar-Maharaj Sasha
- Sankey Babangida John
- Santiago Eleanor
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- Sawawiboon Chaiwut
- Schaller Stefan
- Schallom Marilyn
- Schefold Joerg C.
- Schmidt Raysa Cristina
- Schmollgruber Shelley
- Schmukler Armando
- Schmutz René
- Schulze Tobias
- Schüppel Sebastian
- Scire Giovanni
- Scutariu Monica Adriana
- Sellami Walid
- Sepulveda Maria Idalia
- Sergeev Dmitry
- Serin Sibel Ocak
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- Sertznig Claude
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- Shi Zeya
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- Shosholcheva Mirjana
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- Thankamma Bindu
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- Thompson Amy
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- Thomsen Tina Damgaar
- Thorpe Elaine
- Tian Eryun
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- Timsit Jean-Francois
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- Tirado Celia
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- Tokareva Ekaterina
- Tokur Murat Emre
- Tole Eunice
- Tomescu Dana
- Tong Jenny May Geok
- Tonkovic Dinko
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- Traina Lidia
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- Tribulev Maksim
- Tridente Ascanio
- Triki Ahmed Ramadan
- Tripathy Swagata
- Trongtrakul Konlawij
- Trongtratul Konlawij
- Trposak Angela
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- Trueman-Dawkins Treiza
- Tsarev Alexander
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- Tsujimoto Mayumi
- Tubacka Marta
- Tuinstra Binny
- Tuo Lili
- Turan Can
- Turan Sema
- Turc Jean
- Turner Sarah Jane
- Turčan Anton
- Tutillo Diego Rolando Morocho
- Twagirumugabe Theogene
- Twiggs Hilary
- Uba Stella
- Uccelli Francesco
- Udiljak Nikolina
- Ugwu Innocent
- Umek Nejc
- Undar Hasan Nabi
- Vakalos Aristeidis
- Valerio Idália
- Valgolio Emanuel
- Valta Maija
- Valta Maija Anniina
- van Axel Alisha
- Van Cotthem Ilse
- Van de Velde Stijn
- Van Den Berg Lettie
- Van Den Brink Mark
- Van Den Elst Arlette
- van der Kuil Mark
- Van Gulik Laura
- Van Regenmortel Niels
- Van Vliet Peter
- Vanroest Margijske
- Varela Maria
- Vaschetto Rosanna
- Vasquez Alexandra
- Vaughan-Jones Nicola
- Velickovic Jelena
- Veličković Dejan
- Ventour Dale
- Vermeijden Jan Wytze
- Vieira João
- Villa Robert
- Villafuerte Missael Vladimir Espinoza
- Villanueva Ximena
- Villegas Paula
- Viveiros Abel
- Vizcaychipi Marcela
- Vlaovic Janko
- Vochin Ana
- Volta Carlo Alberto
- von der Osten Ingrid
- Von Der Osten Ingrid
- von Lewinski Dirk
- Vosylius Saulius
- Vuković Anita
- Vullum Sylvi
- Vymazal Tamas
- Vymazal Tomas
- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
- Wang Damei
- Wang Fanglan
- Wang GuoXian
- Wang Hai Yun
- Wang Haiyan
- Wang Jing
- Wang Kefang
- Wang LingLing
- Wang RuiXia
- Wang Shuhui
- Wang Shuo
- Wang Wei
- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
- Williams Anne
- Williams Ged
- Williams Helen
- Williams Karen
- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
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