A retrospective analysis of colorectal serrated lesions from 2005 to 2014 in a single center: importance of the establishment of diagnostic patterns

sem informaçãoSerrated colorectal lesions are increasingly recognized as an important process in the development of colorectal cancer. Endoscopic and histological diagnosis may be difficult, and knowledge of the serrated lesions is important for the establishment of stsem informaçãosem informaçãosem informaçã

Chagasic Megacolon And Large Bowel Neoplasms: Case Series And Literature Review

There is a clear association between chagasic megaesophagus and the esophageal cancer. On the other hand, the association between chagasic megacolon and intestinal neoplasm is uncommon. There are only a few cases described in literature. We selected two cases of colorectal adenocarcinoma associated with adenoma from 2000 to 2011, which are added to the four patients already described by this group. The mean age of the patients, was 68.5 years. Both had been submitted to surgical resection of the neoplasm. Survival rates ranged and were directly related to tumor staging at the time of diagnosis. In this context, we report our case series and reviwed the corresponding literature, especially the clinical and epidemiological aspects of this rare association.314372377Adad, S.J., Etchebehere, R.M., Araújo, J.R., Madureira, A.B., Lima, V.G.F., Silva, A.A., Association of chagasic megacolon and cancer of the colon: Case report and review of the literature (2002) Rev Soc Bras Med Trop, 35, pp. 63-68Abreu, R.B., Quaglieri, P., Ribeiro, M.F., Corsi, P.R., Castro, L.T., Gagliardi, D., Megaesôfago: Doença precursora do câncer de esôfago (1990) Rev Bras Cirur, 80, pp. 91-94Brandalise, N.A., Andreollo, N.A., Leonardi, L.S., Callejas, N.F., Carcinoma associado a megaesôfago chagásico (1985) Rev Col Bras Cir, 12, pp. 196-199Huggins, D., Carcinoma do esôfago associado ao megaesôfago chagásico (relato de um caso) (1976) An Inst Hig Med Trop, 4, pp. 57-62Livstone, E.M., Skinner, D.B., Tumors of the esophagus (1985) Bockus Gastroenterology, pp. 814-840. , In: Berr JE, 4th ed. Philadelphia: WB Saunders CoLopes, E.R., Megaesôfago, megacólon e câncer (1988) Rev Soc Bras Med Trop, 21, pp. 91-94Lustig, E.S., Puricelli, L., Lansetti, J.C., Association of Chagas' disease and cancer (1980) Medicina, 40, pp. 43-46Oliveira, E.C., Associação Entre Infecção Crônica Pelo Trypanosoma Cruzi E Câncer De Cólon (1998) Estudo Experimental Em Ratos [Dissertação De Mestrado], , Goiânia (GO): Universidade Federal de GoiásRezende, J.M., Rosa, H., Vaz, M.G.M., Andrade-Sá, N., Porto, J.D., Neves, N.J., Endoscopia no megaesôfago. Estudo prospectivo de 600 casos (1985) Arq Gastroenterol, 22, pp. 53-62Rocha, A., Almeida, H.O., Esper, F.E., Moraes, D.M., Santos, E.P., Teixeira, V.P.A., Associação entre megaesôfago e carcinoma de esôfago (1983) Rev Soc Bras Med Trop, 16, pp. 94-97Pinotti, H.W., Pollara, W.M., Gemperi, R., Raia, A.A., O problema do câncer no megaesôfago (1980) Rev Ass Méd Bras, 26, pp. 379-381Fagundes, J.J., Góes, J.R.N., Coy, C.S.R., Ayrizono, M.L.S., Mochizuki, M., Chadu, M., Associação entre megacólon chagásico e câncer do intestino grosso: Apresentação de casos e revisão da literatura (2002) J Coloproctol, 22, pp. 252-256Garcia, S.B., (1995) O Câncer No Megacólon: Estudos Da Incidência No Homem E Experimental Em Ratos [Tese De Doutorado], , Ribeirão Preto (SP): Faculdade de Medicina da Universidade de São PauloGarcia, S.B., Oliveira, J.S.M., Pinto, L.Z., Muccillo, G., Zucoloto, S., The relationship between megacolon and carcinoma of the colon: An experimental approach (1996) Carcinogenesis, 17, pp. 1777-1796Oliveira, E.C., Leite, M.S.B., Miranda, J.A., Andrade, A.L., Garcia, S.B., Luquetti, A.O., Chronic Trypanosoma cruzi infection associated with low incidence of 1,2-dimethylhydrazine-induced colon cancer in rats (2001) Carcinogenesis, 22, pp. 737-740Meneses, A.C.O., Lopes, M.A.B., Rocha, A., Fatureto, M.C., Lopes, G.P., Lopes, E.R., Megas e câncer. Câncer de intestino grosso em chagásicos com megacólon (1989) Arq Gastroenterol, 26, pp. 13-16Gabella, G., Size of neurons and glial cells in the intramural ganglia of the hypertrophic intestine of the guinea-pig (1984) J Neurocyt, 13, pp. 73-84Gabriel-Neto, S., Oliveira, E.C., Carmo, F.V., Conceição, D.C., Mendonça, G.G., Leite, M.S.B., Megacólon chagásico associado à adenocarcinoma de cólon (1998) Rev Soc Bras Med Trop, 31, pp. 46-49Crema, E., Lima, V.G.F., Madureira, A.B., Adad, S.J., Silva, A.A., Oliveira, C.B., Associação de neoplasia obstrutiva com megacólon chagásico (1999) J Coloproctol, 19, pp. 87-8

Unusual Finding After Resection Of Rectal Adenocarcinoma: Report Of Two Cases [achado Incomum Após Ressecção De Adenocarcinoma Do Reto: Relato De Dois Casos]

Pelvic recurrence after resection of rectal adenocarcinoma is a feared complication and is associated with a worse prognosis and low resectability rates. The differential diagnosis is diff cult, as biopsy is seldom performed preoperatively. We report two cases of desmoid pelvic tumor after resection of rectal adenocarcinoma. Therapeutic options and literature review are described. © 2013 Elsevier Editora Ltda. All rights reserved.333157160Leal, R.F., Ayrizono, M.L.S., Fagundes, J.J., Oliveira, P.S.P., Ângelo, S.N., Coy, C.S.R., Góes, J.R.N., Recidiva Pélvica de Adenocarcinoma de Reto - Abordagem Cirúrgica (2008) Rev Bras Coloproct, 28 (1), pp. 040-045Shinagare, A.B., Ramaya, N.H., Jagannathan, J.P., Krajewski, K.M., Giardino, A.A., Butrynski, J.E., A to Z of Desmoid Tumors (2011) Am J Roentegnol, 197 (6), pp. 1008-1014Sakorafas, G.H., Nissotakis, C., Peros, G., Abdominal Desmoid Tumors (2007) Surg Oncol, 16 (2), pp. 131-142Escobar, C., Munker, R., Thomas, J.O., Li, B.D., Burton, G.V., Update on desmoid tumors (2012) Ann Oncol, 23 (3), pp. 562-569Wanjeri, J.K., Opeya, C.J.O., A massive abdominal wall desmoid tumor occurring in a laparotomy scar: A case report (2011) World J Surg Oncol, 9 (35), pp. 1-4Kasper, B., Strbel, P., Hohenberger, A., Desmoid tumors: Clinical features and treatment options for advanced disease (2011) Oncologist, 16 (5), pp. 682-693Bertani, E., Chiappa, A., Testori, A., Mazzarol, G., Biff, R., Martella, S., Desmoid Tumors of the Anterior Abdominal Wall: Results from a Monocentric Surgical Experience and Review of the Literature (2009) Ann Surg Oncol, 16 (6), pp. 1642-1649Spiridakis, K., Panagiotakis, G., Grigoraki, M., Kokinnos, I., Papadakis, T., Kokkinakis, T., Isolated giant mesenteric f bromatosis (intra-abdominal desmoid tumors) (2008) Case Report. G Chir, 29 (10), pp. 413-416Bonvalot, S., Desai, A., Coppola, S., Pechoux, C.L., Terrier, P., Domont, J., The treatment of desmoid tumors: A stepwise clinical approach (2012) Ann Oncol, 22 (10), pp. 158-166Leal, R.F., Silva, P.V., Ayrizono, M.L.S., Fagundes, J.J., Amstalden, E.M., Coy, C.S., Desmoid tumor in patients with familial adenomatous polyposis (2010) Arq Gastroenterol, 47 (4), pp. 373-378Valejo, F.A.M., Tiezzi, D.G., Nai, G.A., Tumor desmoide abdomino-pélvico (2008) Rev Bras Ginecol Obstet, 31 (1), pp. 35-40Duggal, A., Dickinson, I.C., Sommerville, S., Gallie, P., The management of extra-abdominal desmoids tumours (2004) Int Orthop, 28 (4), pp. 252-256Camargo, V.P., Keohan, M.L., Adamo, D.R., Antonescu, C.R., Brennan, M.F., Singer, S., (2010) Cancer, 116 (9), pp. 2258-2265Oguz, M., Bedirli, A., Gultekin, A., Dursun, A., Mentes, B.B., (2006) Dis Colon Rectum, 49 (9), pp. 1445-1448Lee, J.C., Thomas, J.M., Phillips, S., Fisher, C., Moskovic, E., (2006) Am J Roentgenol, 186 (1), pp. 247-254Sinha, A., Hansmann, A., Bhandari, S., Gupta, A., Burling, D., Rana, S., Imaging assessment of desmoid tumours in familial adenomatous polyposis: Is state-of-the-art 1.5 T MRI better than 64-MDCT? (2012) Br J Radiol, 85 (1015), pp. 254-261Kasper, B., Dimitrakopoulou-Strauss, A., Strauss, L.G., Hohenberger, P., Positron emission tomography in patients with aggressive f bromatosis/desmoid tumours undergoing therapy with imatinib (2010) Eur J Ncl Med Mol Imaging, 37 (10), pp. 1876-1882Melis, M., Zager, J.S., Sondak, V., Multimodality Management of Desmoid Tumors: How Important Is a Negative Surgical Margin? (2008) J Surg Oncol, 98 (8), pp. 594-602Middleton, S.B., Phillips, R.K.S., Surgery for Large Intra-Abdominal Desmoid Tumors (2000) Dis Colon Rectum, 43 (12), pp. 1759-1762Merchant, B.N., Lewis, J.J., Woodruff, J.M., Leung, D.H., Brennan, M.F., Extremity and trunk desmoid tumors: A multifacial analysis of outcome (1999) Cancer, 86 (10), pp. 2045-205

Characterization Of Langmuir-blodgett Films Of Parent Polyaniline

Conducting Langmuir-Blodgett (LB) films have been fabricated from parent polyaniline (PAni) which was doped with functionalized acids. In order to optimize experimental conditions for the formation of stable Langmuir monolayers and their subsequent transfer onto solid substrates, PAni was dissolved in ten different combinations of chloroform solutions. Use was made of camphor sulfonic acid, dodecyl benzene sulfonic acid, and toluenesulfonic acid, and of the solvents N-methyl pyrrolidine and m-cresol as processing agents. Because acidic subphases have been employed, as-deposited LB films were already doped, which was confirmed by the appearance of a polaronic band in the UV-Vis absorption spectra. The absorbance peak increases with the number of deposited layers indicating that a suitable multilayer buildup is accomplished. When analysed by atomic force microscopy, PAni LB films show a fibrillar structure with the fibril width ranging from ≈ 60 to 160 nm.284-285177180Cao, Y., Smith, P., Heeger, A.J., (1993) Synth. Met., 55-57, p. 3514Riul A., Jr., Mattoso, L.H.C., Mello, S.V., Telles, G.D., Oliveira O.N., Jr., (1995) Synth. Met., 71, p. 2067Mattoso, L.H.C., MacDiarmid, A.G., Epstein, A.J., (1994) Synth. Met., 68, p. 1Mattoso, L.H.C., Mello, S.V., Riul A., Jr., Oliveira O.N., Jr., Faria, R.M., (1994) Thin Solid Films, 244, p. 714Cheung, J.H., Rubner, M.F., (1994) Thin Solid Films, 244, p. 990Agbor, M.E., Petty, M.C., Monkman, A.P., Harris, M., (1993) Synth. Met., 55-57, p. 3789Punkka, E., Laakso, K., Stubb, H., Levon, K., Zheng, W.-Y., (1994) Thin Solid Films, 515-520, p. 243MacDiarmid, A.C., Epstein, A.J., (1994) Synth. Met., 65, p. 103Morgan, H., Taylor, D.M., Oliveira O.N., Jr., (1991) Biochim. Biophys. Acta, 1062, p. 149Cheung, J.H., (1993), Ph.D. Thesis, Massachusetts Institute of Technology, EUAMacDiarmid, A.G., Epstein, A.J., (1993) Brazilian Conf. on Polymers, p. 544. , São Paulo, Brazil, October Brazilian Polymer Association, São Carlos, BrazilMantovani, J.G., Warmack, R.J., Annis, B.K., MacDiarmid, A.G., Scherr, E., (1990) J. Appl. Polym. Sci., 40, p. 169

Quality Of Life In Patients With Ileal Pouch For Ulcerative Colitis [qualidade De Vida Em Portadores De Reservatório Ileal Por Retocolite Ulcerative]

Introduction: proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the standard surgical procedure for the treatment of ulcerative colitis (UC) and is associated with the prospect of cure. Experience gained over the years has demonstrated the occurrence of a high number of complications as well as bowel disorders that can compromise quality of life (QoL). Objective: evaluate QoL in patients with IPAA for ulcerative colitis. Patients and methods: the Inflammatory Bowel Disease Questionnaire (IBDQ) was used to assess QoL in patients with IPAA after its validation in Portuguese. Results: thirty-one patients submitted to IPAA by the same group of professionals were evaluated. QoL was classified as regular in all domains evaluated (intestinal and systemic symptoms and emotional and social aspects). There were no differences in relation to gender, type of pouch or postoperative time. However, elderly patients showed a tendency toward lower scores. Having a professional activity was associated with higher scores in systemic symptoms and social aspects (p < 0.05). Patients with ileostomy showed lower values in the domains of systemic symptoms, emotional and social aspects (p <0.05). Conclusion: in all domains assessed, patients with IPAA for UC had QoL classif ed as regular. Ileostomy and lack of professional activity negatively inluenced QoL. © 2013 Elsevier Editora Ltda. All rights reserved.333113117Parks, A.G., Nicholls, R.J., Proctocolectomy without ileostomy for ulcerative colitis (1978) Br Med J, 2, pp. 85-88Góes, J.N.R., (2001) Preservação Da Arcada Vascular Marginal Do Cólon Direito Como Via Suplementar De Irrigação Sanguínea Ao Reservatório Ileal Em Posição Pélvica, , estudos de dissecção em cadáveres e de observação clínica. Tese de livre docência. FCM- UNICAMPNeumann, P.A., Mennigen, R.B., Senninger, N., Bruewer, M., Rijcken, E., Timing of restorative proctocolectomy in patients with medically refractory ulcerative colitis: The patient's point of view (2012) Dis Colon Rectum, 55, pp. 756-761van Balkom, K.A., Beld, M.P., Visschers, R.G., van Gemert, W.G., Breuking, S.O., Long-term results after restorative proctocolectomy with ileal pouch-anal anastomosis at a yong age (2012) Dis Colon Rectum, 55 (9), pp. 939-947Jota, G., Karadzov, Z., Panovski, M., Joksimovic, N., Kartalov, A., Gelevski, R., Functional outcome and quality of life after restorative proctocolectomy and ileal pouch-anal anastomosis (2011) Prilozi, 32 (2), pp. 221-230Bennis, M., Tiret, E., Surgical management of ulcerative colitis (2012) Langenbeecks Arch Surg, 397, pp. 11-17Mennigen, R., Senninger, N., Bruewer, M., Rijcken, E., Pouch function and quality of life after successful management of pouch-related septic complications in patients with ulcerative colitis (2012) Langenbeeks Arch Surg, 397, pp. 37-44Bengtsson, J., Lindholm, E., Nordgren, S., Berndtsson, I., Oresland, T., Börjesson, L., Sexual function after failed ileal pouch-anal anastomosis (2011) J Crohns Colitis, 5, pp. 407-414Leowardi, C., Hinz, U., Tariverdian, M., Kienle, P., Herfarth, C., Ulrich, A., Long-term outcome 10 years or more after restorative proctocolectomy and ileal pouch-anal anastomosis in patients with ulcerative colitis (2010) Langenbecks Arch Surg, 395, pp. 49-56Meyer, A.L.M., Teixeira, M.G., Almeida, M.G., Kiss, D.R., Nahas, S.C., Cecconello, I., Quality of life in the late follow-up of ulcerative colitis patients submitted to restorative proctocolectomy with sphincter preservation over ten years ago (2009) Clinics (São Paulo), 64, pp. 877-883Heikens, J.T., Vries, J., van Laarhoven, C.J.H.M., Quality of Life, health-related quality of life and health status in patients having restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis: A systematic review (2012) Colorectal Dis, 14, pp. 536-544Wuthrich, P., Gervaz, P., Ambrosetti, P., Soravia, C., Morel, P., Functional outcome and quality of life after restorative proctocolectomy and ileo-anal pouch anastomosis (2009) Swiss Med WKLY, 139, pp. 193-19

Minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis : predictive model based on machine learning

Very few data are available on predictors of minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis (PsA). Such data are crucial, since the therapeutic measures used to change the adverse course of PsA are more likely to succeed if we intervene early. In the present study, we used predictive models based on machine learning to detect variables associated with achieving MDA in patients with recent-onset PsA. We performed a multicenter observational prospective study (2-year follow-up, regular annual visits). The study population comprised patients aged ≥18 years who fulfilled the CASPAR criteria and less than 2 years since the onset of symptoms. The dataset contained data for the independent variables from the baseline visit and from follow-up visit number 1. These were matched with the outcome measures from follow-up visits 1 and 2, respectively. We trained a random forest-type machine learning algorithm to analyze the association between the outcome measure and the variables selected in the bivariate analysis. In order to understand how the model uses the variables to make its predictions, we applied the SHAP technique. We used a confusion matrix to visualize the performance of the model. The sample comprised 158 patients. 55.5% and 58.3% of the patients had MDA at the first and second follow-up visit, respectively. In our model, the variables with the greatest predictive ability were global pain, impact of the disease (PsAID), patient global assessment of disease, and physical function (HAQ-Disability Index). The percentage of hits in the confusion matrix was 85.94%. A key objective in the management of PsA should be control of pain, which is not always associated with inflammatory burden, and the establishment of measures to better control the various domains of PsA