Proposal of a virtual collaborative news environment: an interdisciplinary study

The main objective of this work is to demonstrate the advances made by the CATI research group with regard to the proposal to create a virtual collaborative news environment (AVNC) , to be initially implemented at the Northern Fluminense Darcy Ribeiro State University(UENF) through the Postgraduate Program in Cognition and Language. This interdisciplinary environment involves concepts from the area of communication, administration and information technology and seeks to meet the demands of generation, storage, retrieval, processing and transmission of information in this digital age. The AVNC involves three research fronts: rethinking the logic of news production, structuring a platform that is collaborative and defining what a business and management model should be that can give sustainability to this environment. In today\u27s world, it is important to consider the reader\u27s increasingly active participation in journalism, through information and communication technologies, thanks to the social changes that come with them. In times of cyberspace and cyberculture, it is necessary to rethink the dynamics of journalistic production. For this, authors like Pierre Lévy, Lúcia Santaella, Henry Jenkins, Caio Túlio Costa, among others were searched. In an era in which forms of collaborative ownership prevail, the platform being considered in this research follows the 3C collaboration model, according to Michalsky, Mamani, and Gerosa. A global platform where individuals interact, communicate, collaborate and gather information requires a business model and management that assists in managing the collaborative virtual news environment. For this, we used authors such as Alex Osterwalder, Eric Flamholtz, Siqueira and Crispim, Campos, among others. With this, an increasingly intelligent and collaborative environment is expected, with the active participation of all the agents involved. That is, what is proposed is the total interaction of the Internet user-reader

Plasmonic/magnetic liposomes based on nanoparticles with multicore-shell architecture for chemo/thermotherapy

In this work, multicore magnetic nanoparticles (NPs) of manganese ferrite were prepared using carboxymethyl-dextran and melamine as agglutinating agents.Magnetoliposome-like structures containing the multicore NPs exhibit sizes in the range 250 – 400 nm, being suitable for biomedical applications.FCT under Strategic funding of CF-UM-UP (UIDB/04650/2020

Factor Analysis and the Social Capital Index: A Study at the Brazil / Bolivia Border

Objective: The study aimed to build the level of social capital by neighborhoods Guajará-Mirim border region between the State of Rondônia, Brazil and the Republic of Bolivia, which in recent years has been showing signs of social fragility due advance not virtuous practices. Method: This work made use of research in secondary bases as well as in primary bases. The tabulation of qualitative and quantitative data was performed in Excel (2010) and for their processing performance index construction purposes were calculated following the factorial analysis techniques presented by Hair et al. [19] Santana [20, 21]; and Choi [22]. For this, we made use of the statistical tool SPSS (Statistical Package for Social Sciences) for the construction of the indices of social capital. The correlation analysis process was done in Excel. results: It was observed that the capital reached regular levels in Guajará-Mirim neighborhoods not observable, so correlations between the studied parameters, however, it needs to be further studied as factors such as the flooding of the Mamore river may have interfered in any way in the implementation process of the field survey to the residents of the city. It became clear that the municipality of Guajará-Mirim suffers from serious social problems and that most problems are correlated with the increase in alcoholic beverage market in the city and use drugs. However, was not observed as the institutional arrangements are dealing with this problem, that is, as public bodies are relating to discuss actions for concrete solutions to this evil that plagues large portion of the population of Guajará-Mirim, mainly young teenagers residents of Guajá-Mamim. However, we hope to continue this work in order to better understand this mechanism of social network between the actors of this process in the region

Local Power as the Basis of the Understanding of the Federative Pact

The research aimed to describe the existing problems in the relationship between City, State and Federal Government, through the Brazilian Federative Pact, mainly for municipalities with population of less than 50,000 inhabitants. The research is structured from a qualitative perspective. The theoretical framework was built from the local power of the discussion based on the understanding of the federal pact and local interest and the municipality in Brazil. The paper argues that the federal pact is little debated, discussed, much less questioned by society in general, it only strengthens the lack of a legal and institutional framework for coordination and cooperation among federal entities in the country, which results in public policy fragmented the territory and without direction, causing waste of public resources

Rectosigmoidectomy in a patient with a prolapsed sigmoid tumor: case report

Modelo de estudo: Relato de caso. Objetivo do estudo: Relatar o caso de uma paciente com prolapso de tumor colorretal localizado no sigmóide. Metodologia: Relato de caso obtido de prontuário. Resultados: É relatado o caso de uma paciente que aguardava cirurgia para ressecção oncológica de um tumor colorretal, quando foi encaminhada ao serviço de urgências médicas com episódio de prolapso retal contendo massa tumoral pós-evacuação, sem redução espontânea. A paciente foi encaminhada à cirurgia de urgência e submetida a uma abordagem transabdominal, na qual o prolapso foi reduzido, em seguida realizada retossigmoidectomia segundo procedimento de Hartamann com colostomia terminal no cólon descendente. Conclusões: No caso relatado, por tratar-se de um paciente portador de tumor de sigmóide prolapsado, a abordagem de escolha foi a retosigmoidectomia abdominal, seguindo os preceitos oncológicos, com ligadura da artéria mesentérica inferior em sua origem. Importância do problema: O prolapso de tumor de sigmóide, uma situação clínica relativamente incomum na população adulta, e uma complicação mais rara quando se trata dos tumores colorretais, deve ser tratado imediatamente após o diagnóstico para se diminuir o risco de isquemia do segmento prolapsado e sempre que possível oferecer a cirurgia que siga os preceitos oncológicos de tratamento. Comentários: No caso relatado, foi necessário uma abordagem cirúrgica de urgência, sendo a via abdominal escolhida por respeito aos princípios da cirurgia oncológica e ao menor tempo cirúrgicoDesign of the study: Case report. Objectives: To report a case of a patient with colorectal tumor prolapse located in the sigmoid. Methodology: A retrospective case report obtained from medical records. Results: We report a case of a patient awaiting surgery for tumor resection of a colorectal tumor, when she was sent to the service of medical emergencies with an episode of post-evacuation rectal prolapse with a tumor without spontaneous reduction. The patient was referred to emergency surgery and underwent a transabdominal approach, in which the prolapse was reduced then followed by Hartmann's rectosigmodectomy surgical procedure. Conclusions: Sigmoid tumor prolapse require a surgical approach, the approach of choice was abdominal retosigmoidectomy, following the oncological principles, with ligation of the inferior mesenteric artery at its origin. Relevance: Sigmoid tumor prolapse, a relatively unusual clinical situation in adults, and more rare complication when it comes to colorectal tumors, it must be treated immediately after diagnosis to reduce the risk of ischemia prolapsed segment, and whenever possible offer surgery to follow the precepts of cancer treatment. Comments: In the case reported, an emergency surgical approach was necessary, and the abdominal route was chosen following the principles of cancer surgery and shorter surgical tim

Magnetoliposomes containing multicore nanoparticles and a new antitumor thienopyridine compound with potential application in chemo/thermotherapy

Multicore magnetic nanoparticles of manganese ferrite were prepared using carboxymethyl dextran as an agglutinating compound or by an innovative method using melamine as a cross-coupling agent. The nanoparticles prepared using melamine exhibited a flower-shape structure, a saturation magnetization of 6.16 emu/g and good capabilities for magnetic hyperthermia, with a specific absorption rate (SAR) of 0.14 W/g. Magnetoliposome-like structures containing the multicore nanoparticles were prepared, and their bilayer structure was confirmed by FRET (Förster Resonance Energy Transfer) assays. The nanosystems exhibited sizes in the range of 250–400 nm and a low polydispersity index. A new antitumor thienopyridine derivative, 7-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridine, active against HeLa (cervical carcinoma), MCF-7 (breast adenocarcinoma), NCI-H460 (non-small-cell lung carcino-ma) and HepG2 (hepatocellular carcinoma) cell lines, was loaded in these nanocarriers, obtaining a high encapsulation efficiency of 98% ± 2.6%. The results indicate that the new magnetoliposomes can be suitable for dual cancer therapy (combined magnetic hyperthermia and chemotherapy).This research was funded by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UIDB/04650/2020) and through the research project PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020), financed by the European Fund of Regional Development (FEDER), COMPETE2020, and Portugal2020. J.M.R. acknowledges FCT, ESF (European Social Fund—North Portugal Regional Operational Program) and HCOP (Human Capital Operational Program) for a PhD grant (SFRH/BD/115844/2016)

role of female sex hormone receptors

Funding Information: Funding: This study was supported by grant IECT-FAPEMA-05796/18 and FAPEMA IECT 30/2018-IECT Saúde, by the Research Center of the Portuguese Oncology Institute of Porto (project no. PI86-CI-IPOP-66-2017); by European Investment Funds by FEDER/COMPETE/POCI—Operational Competitiveness and Internationalization Program, and national funds by FCT—Portuguese Foundation for Science and Technology under projects UID/AGR/04033/2020, UIDB/CVT/00772/2020 and by Base Funding-UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology, and Energy—LEPABE—funded by national funds through the FCT/MCTES (PID-DAC); Project 2SMART-engineered Smart materials for Smart citizens, with reference NORTE-01-0145-FEDER-000054, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.A growing proportion of oropharyngeal squamous cell carcinomas (OPSCC) are associated with infection by high-risk human papillomavirus (HPV). For reasons that remain largely unknown, HPV+OPSCC is significantly more common in men than in women. This study aims to determine the incidence of OPSCC in male and female HPV16-transgenic mice and to explore the role of female sex hormone receptors in the sexual predisposition for HPV+ OPSCC. The tongues of 30-weeks-old HPV16-transgenic male (n = 80) and female (n = 90) and matched wild-type male (n = 10) and female (n = 10) FVB/n mice were screened histologically for intraepithelial and invasive lesions in 2017 at the Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Por-tugal. Expression of estrogen receptors alpha (ERα) and beta (ERβ), progesterone receptors (PR) and matrix metalloproteinase 2 (MMP2) was studied immunohistochemically. Collagen remodeling was studied using picrosirius red. Female mice showed robust ERα and ERβ expression in intraepithelial and invasive lesions, which was accompanied by strong MMP2 expression and marked collagen remodeling. Male mice showed minimal ERα, ERβ and MMP2 expression and unaltered collagen patterns. These results confirm the association of HPV16 with tongue base cancer in both sexes. The higher cancer incidence in female versus male mice contrasts with data from OPSCC patients and is associated with enhanced ER expression via MMP2 upregulation.publishersversionpublishe

Triagem Inteligente: O Uso da Internet das Coisas na Classificação dos Riscos nas Emergências

Este artigo tem como objetivo apresentar a automação do processo de triagem de pacientes utilizando o atuador Arduino. O processo de triagem determina o nível de risco do paciente e sua execução pode tornar-se desnecessariamente complexa, sendo que, aproximadamente, 80% dos pacientes em serviços de emergência não necessitam de atendimento urgente. Portanto, a automatização deste processo pode provar-se bastante benéfica: os dados do paciente são analisados em tempo real, provendo um resultado seguro e em alta velocidade, garantindo prioridade a pacientes em risco e reduzindo o tempo de admissão dele