Organizaciones matemáticas y didácticas en torno al objeto de "límite de función" : una propuesta metodológica para el análisis

Our research falls within the general field of the analysis of the teacher's activity and focuses on the specific case of teaching the concept of "limit to the function" in the Spanish secondary school system. Using the anthropological focus of didactics (Chevallard, 1998) as a general theoretical frame, we propose an investigative methodology for the analysis of mathematical organizations recreated by the teacher in the classroom in collaboration with his/her pupils and the respective didactic organizations that allow their reconstruction

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.We thank S. Lecher, S. Li and J. Zallet for technical support. Calculations were performed at the sciCORE scientific computing core facility at the University of Basel. This work was supported by the Swiss National Science Foundation (grants 310030_166687 (S.G.) and 320030_153442 (M.E.) and Swiss HIV Cohort Study grant 740 to L.F.), the European Research Council (309540-EVODRTB to S.G.), TB-PAN-NET (FP7-223681 to S.N.), PathoNgenTrace projects (FP7-278864-2 to S.N.), SystemsX.ch (S.G.), the German Center for Infection Research (DZIF; S.N.), the Novartis Foundation (S.G.), the Natural Science Foundation of China (91631301 to Q.G.), and the National Institute of Allergy and Infectious Diseases (5U01-AI069924-05) of the US National Institutes of Health (M.E.)

Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study

BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN, PATIENTS AND SETTING: This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries.MAIN OUTCOME MEASURES: Women and men were compared with respect to use of LTVV, defined as VT of 8 ml kg-1 or less predicted bodyweight (PBW). A VT was deemed 'default' if the set VT was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation.RESULTS: This analysis includes 9864 patients, of whom 5425 (55%) were women. A default VT was often set, both in women and men; mode VT was 500 ml. Median [IQR] VT was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] ml kg-1 PBW, P < 0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), P < 0.001]. In the mediation analysis, patients' height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default VT.CONCLUSION: In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher VT than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV.TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov, NCT01601223

Energy consumption analysis of video streaming to Android mobile devices

Energy conservation has become a critical issue around the world. In smart phones, battery power capabilities are not keeping up with the advances in other technologies (e.g., processing and memory) and are rapidly becoming a concern, especially in view of the growth in usage of energy-hungry mobile multimedia streaming. The deficiency in battery power and the need for reduced energy consumption provides motivation for researchers to develop energy efficient techniques in order to manage the power consumption in next-generation wireless networks. As there is little analysis in the literature on the relationship between the wireless environment and the mobile device energy consumption, this paper investigates the impact of network-related factors (e.g., network load and signal quality level) on the power consumption of the mobile device in the context of video delivery. This paper analyzes the energy consumption of an Android device and the efficiency of the system in several scenarios while performing video delivery (over UDP or TCP) on an IEEE 802.11g network. The results show that the network load and the signal quality level have a combined significant impact on the energy consumption. This analysis can be further used when proposing energy efficient adaptive multimedia and handover mechanisms

Characterization polyethylene terephthalate nanocomposites mixing with nano-silica and titanium oxide

Polyethylene terephthalate (PET) based nanocomposites containing nano-silica (Aerosil (Degusa)) and titanium oxide (TiO2 (Merk)) were prepared by melt compounding. Influence of nano-silica and titanium oxide on properties of the resulting nanocomposites was investigated by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM). The possible interaction between nano-silica and titanium oxide particles with PET functional groups at bulk and surface was elucidated by transmission of FTIR-ATR spectroscopy. AFM studies of the resulting nanocomposites showed an increased surface roughness compared to pure PET. SEM images illustrated that nano-silica particles have tendency to migrate to the surface of the PET matrix much more than titanium oxide powder

Characterization polyethylene terephthalate nanocomposites mixing with nano-silica and titanium oxide

Polyethylene terephthalate (PET) based nanocomposites containing nano-silica (Aerosil (Degusa)) and titanium oxide (TiO2 (Merk)) were prepared by melt compounding. Influence of nano-silica and titanium oxide on properties of the resulting nanocomposites was investigated by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM). The possible interaction between nano-silica and titanium oxide particles with PET functional groups at bulk and surface was elucidated by transmission of FTIR-ATR spectroscopy. AFM studies of the resulting nanocomposites showed an increased surface roughness compared to pure PET. SEM images illustrated that nano-silica particles have tendency to migrate to the surface of the PET matrix much more than titanium oxide powder

Ferroptosis Involvement in Glioblastoma Treatment

Glioblastoma multiforme (GBM) is one of the deadliest brain tumors. Current standard therapy includes tumor resection surgery followed by radiotherapy and chemotherapy. Due to the tumors invasive nature, recurrences are almost a certainty, giving the patients after diagnosis only a 12–15 months average survival time. Therefore, there is a dire need of finding new therapies that could potentially improve patient outcomes. Ferroptosis is a newly described form of cell death with several implications in cancer, among which GBM. Agents that target different molecules involved in ferroptosis and that stimulate this process have been described as potentially adjuvant anti-cancer treatment options. In GBM, ferroptosis stimulation inhibits tumor growth, improves patient survival, and increases the efficacy of radiation and chemotherapy. This review provides an overview of the current knowledge regarding ferroptosis modulation in GBM

Microfabrication of freestanding metal structures released from graphite substrates,

Abstract A novel method of fabricating freestanding electroformed metal structures using a rigid porous graphite substrate is reported. Polymethylmethacrylate's adhesion to graphite is much stronger compared with metal-coated silicon or graphite, because of graphite's high porosity and microroughness. Another advantage of graphite is its easy sacrificial removal by abrasion. Results are presented on the fabrication of high-aspect-ratio freestanding copper grids used as collimators in mammography and medical imaging. The method can be used in the production of micromolds for hot embossing and injection mold fabrication of microelectromechanical systems (MEMSs) and for fabrication of arrays of microparts on pick-and-place carriers for assembly into MEMS. Published by Elsevier Science B.V

Varietal Differences in Juice, Pomace and Root Biochemical Characteristics of Four Rhubarb (Rheum rhabarbarum L.) Cultivars

The complex evaluation of varietal biochemical differences in rhubarb juice, pomace and roots is highly useful to develop an efficient processing technology. Research was carried out to compare four rhubarb cultivars (Malakhit, Krupnochereshkovy, Upryamets and Zaryanka) in terms of the quality and antioxidant parameters of juice, pomace and roots. The laboratory analyses showed a high juice yield (75–82%) with a relatively high content of ascorbic acid (125–164 mg L−1) and other organic acids (16–21 g L−1). Citric, oxalic and succinic acids accounted for 98% of the total acids amount. The juice of the cultivar Upryamets demonstrated high levels of the natural preservatives sorbic (36.2 mg L−1) and benzoic acids (11.7 mg L−1), which are highly valuable in juice production. The juice pomace proved to be an excellent source of pectin and dietary fiber, whose concentrations reached 21–24% and 59–64%, respectively. The total antioxidant activity decreased according to the following sequence: root pulp (161–232 mg GAE g−1 d.w.) > root peel (115–170 mg GAE g−1 d.w.) > juice pomace (28.3–34.4 mg GAE g−1 d.w.) > juice (4.4–7.6 mg GAE g−1 f.w.), suggesting that root pulp is a highly valuable antioxidant source. The results of this research highlight the interesting prospects of the complex rhubarb plant processing for the production of juice, containing a wide spectrum of organic acids and natural stabilizers (sorbic and benzoic acids), dietary fiber and pectin (juice pomace) and natural antioxidants (roots)