Didaktische Maßnahmen zur Lernstandskontrolle und Aktivierung

Wie können Studierende beim Lernen unterstützt werden? Eine Studie der Technischen Hochschule Ostwestfalen-Lippe zeigt, dass die Verschmelzung von Vorlesung und Übung sowie kontinuierliche Lernstandskontrollen und Übungsaufgaben zur Eigenarbeit hilfreich sind. Auch Videoaufzeichnungen der Vorlesung und Erläuterungsvideos zu Übungsaufgaben sowie Lerngruppen mit Betreuung durch Lernscouts können den Lernprozess unterstützen. Die Ergebnisse der Studie zeigen, dass diese Maßnahmen von den Studierenden positiv bewertet wurden und zu einem besseren Lernerfolg beitragen können. (Herausgeber)How can students be supported in their learning? A study by the Ostwestfalen-Lippe University of Applied Sciences and Arts shows that merging lectures and exercises, as well as continuous learning level checks and exercises for independent work, are helpful. Video recordings of the lecture and explanatory videos for exercises as well as learning groups with supervision by learning scouts can also support the learning process. The results of the study show that these measures were positively evaluated by the students and can contribute to better learning success. (Editor

Erklärvideos: Chancen und Risiken Zwischen fachlicher Korrektheit und didaktischen Zielen

Der aktuelle Hype um Erklärvideos sollte nicht verdecken, dass ein erfolgreicher Einsatz auf soliden fachdidaktischen und fachlichen Prinzipien ruhen sollte. Der Beitrag diskutiert einige dazu nützliche Grundlagen und illustriert diese an ausgewählten Beispielen

Experience with the introduction of dry, urine-diverting sanitation systems in Ethiopia

To overcome the drawbacks of conventional sanitation systems, new approaches to sanitation are necessary. Human faeces and urine as well as greywater represent potential resources requiring efficient management. Thus, source-separating systems, which safe water and allow the recycling of nutrients to agriculture, can provide an alternative. These systems can even be integrated into multistorey houses, therefore addressing the need for resource efficient sanitation in condominium housing programmes. Several urine separating facilities are implemented in Ethiopia showing a high acceptance by their users. The cost comparison between source-separating systems and the conventional system for condominium houses shows an advantage for the new approach due to savings of water for toilet flushing as well as reduced costs for the treatment of the wastewater in septic tanks. The use of human urine as fertiliser in several trials resulted in significant benefits in terms of improved crop growth

Design of the HEM-POWR study:A prospective, observational study of real-world treatment with damoctocog alfa pegol in patients with haemophilia A

INTRODUCTION: Haemophilia A is a rare bleeding disorder caused by defects in coagulation factor VIII (FVIII). Damoctocog alfa pegol (BAY 94–9027, Jivi, Bayer, Germany) is a site-specifically PEGylated, extended-half-life, recombinant FVIII, approved for use in previously treated patients (PTPs) aged ≥12 years with haemophilia A. However, a real-world evidence regarding routine clinical use of damoctocog alfa pegol is limited. METHODS AND ANALYSIS: HEM-POWR is a multinational, multicentre, non-interventional, prospective, postmarketing cohort study evaluating the effectiveness and safety of real-world treatment with damoctocog alfa pegol. Estimated enrolment is ≥200 PTPs with haemophilia A, receiving damoctocog alfa pegol (on-demand, prophylaxis or intermittent prophylaxis (as per local label)), observed for 36 months. Primary outcomes are total bleeding events and annualised bleeding rate; secondary outcomes include long-term safety, joint health, pharmacokinetics, patient-reported outcomes (PROs) from validated questionnaires and perioperative haemostasis. Where applicable, reasons for switching to damoctocog alfa pegol, choice of treatment regimen and dose will also be captured. Exploratory and descriptive statistical analyses will be performed, and will be stratified by parameters including, but not limited to, prophylaxis regimen and haemophilia severity. Patients can record bleeds and consumption in electronic (e) Diaries, ePROs, and can access non-promotional study information (videos explaining study procedures) via an online patient portal. Optionally, patients can enrol in the LIFE-ACTIVE substudy designed to investigate the relationship between activity (measured by the ActiGraph CP Insight watch) and effectiveness parameters collected from HEM-POWR. ETHICS AND DISSEMINATION: Study approval was obtained by local independent ethics committees and authorities in participating study centres across Europe, the Americas and Asia. Informed consent from patients or their legal representative is a requirement for participation. The study results will be submitted for publication in a peer-reviewed scientific journal and presented at scientific conferences. TRIAL REGISTRATION NUMBERS: NCT03932201, EUPAS26416. PROTOCOL VERSION AND DATE: V.1.2, 27 September 2019

Decomposition numbers for the cyclotomic Brauer algebras in characteristic zero

We study the representation theory of the cyclotomic Brauer algebra via truncation to idempotent subalgebras which are isomorphic to a product of walled and classical Brauer algebras. In particular, we determine the block structure and decomposition numbers in characteristic zero.Comment: 20 pages, 12 figure

Gentherapie der Hämophilie: Empfehlung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH).

Gene therapy has recently become a realistic treatment perspective for patients with haemophilia. Reviewing the literature and our personal experience from clinical trials, we discuss key aspects of haemophilia A and B gene therapy with vectors derived from adeno-associated virus (AAV), including predictable results, risks, adverse events, and patient-reported outcomes. Patient selection, informed consent, administration, and monitoring of gene therapy as well as data collection are explained. We also discuss the need for interdisciplinary cooperation with hepatology and other specialties. We emphasize structural and organizational requirements for treatment centres according to the hub-and-spoke model and recommend the use of electronic diaries to ensure safe and timely collection and exchange of data. Electronic diaries will play a key role as primary source of data for pharmacovigilance, post-marketing clinical studies, national and international registries, as well as health technology and benefit assessment. Reimbursement aspects and the future of gene therapy in adolescents and children are also considered. In a rapidly evolving scientific environment, these recommendations aim to support treatment providers and payers to prepare for the implementation of gene therapy following marketing authorization

Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial.

BACKGROUND: Biannual mass azithromycin administration to preschool children reduces all-cause mortality, but the mechanism for the effect is not understood. Azithromycin has activity against malaria parasites, and malaria is a leading cause of child mortality in the Sahel. The effect of biannual versus annual azithromycin distribution for trachoma control on serological response to merozoite surface protein 1 (MSP-119), a surrogate for malaria incidence, was evaluated among children in Niger. METHODS: Markers of malaria exposure were measured in two arms of a factorial randomized controlled trial designed to evaluate targeted biannual azithromycin distribution to children under 12 years of age compared to annual azithromycin to the entire community for trachoma control (N = 12 communities per arm). Communities were treated for 36 months (6 versus 3 distributions). Dried blood spots were collected at 36 months among children ages 1-5 years, and MSP-119 antibody levels were assessed using a bead-based multiplex assay to measure malaria seroprevalence. RESULTS: Antibody results were available for 991 children. MSP-119 seropositivity was 62.7% in the biannual distribution arm compared to 68.7% in the annual arm (prevalence ratio 0.91, 95% CI 0.83 to 1.00). Mean semi-quantitative antibody levels were lower in the biannual distribution arm compared to the annual arm (mean difference - 0.39, 95% CI - 0.05 to - 0.72). CONCLUSIONS: Targeted biannual azithromycin distribution was associated with lower malaria seroprevalence compared to that in a population that received annual distribution. Trial Registration Clinicaltrials.gov NCT00792922