1,981 research outputs found
Magnetic spectra analysis of dielectrics
Method of magnetic spectroscopy is used to analyze and to interpret the experimental data obtained by magnetic
measurement of the complex permeability spectra of Mg ferrite and NiZn ferritepolymers. Ferritepolymers were prepared
from various concentration of NiZn ferrite particles as a soft magnetic fillers dispersed in PVC polymer matrix. Effect of the
filler content on the permeability spectra of NiZn ferritepolymers was examined and compared with presented sintered ferrite
samples. The variations of permeability and relaxation frequency due to ferrite filler concentration in composite are presented
and discussed from point of view the magnetization processes in samples
Improving Interpretability for Computer-aided Diagnosis tools on Whole Slide Imaging with Multiple Instance Learning and Gradient-based Explanations
Deep learning methods are widely used for medical applications to assist
medical doctors in their daily routines. While performances reach expert's
level, interpretability (highlight how and what a trained model learned and why
it makes a specific decision) is the next important challenge that deep
learning methods need to answer to be fully integrated in the medical field. In
this paper, we address the question of interpretability in the context of whole
slide images (WSI) classification. We formalize the design of WSI
classification architectures and propose a piece-wise interpretability
approach, relying on gradient-based methods, feature visualization and multiple
instance learning context. We aim at explaining how the decision is made based
on tile level scoring, how these tile scores are decided and which features are
used and relevant for the task. After training two WSI classification
architectures on Camelyon-16 WSI dataset, highlighting discriminative features
learned, and validating our approach with pathologists, we propose a novel
manner of computing interpretability slide-level heat-maps, based on the
extracted features, that improves tile-level classification performances by
more than 29% for AUC.Comment: 8 pages (references excluded), 3 figures, presented in iMIMIC
Workshop at MICCAI 202
Arene oxidation with malonoyl peroxides
Malonoyl peroxide 7, prepared in a single step from the commercially available diacid, is an effective reagent for the
oxidation of aromatics. Reaction of an arene with peroxide 7 at room temperature leads to the corresponding protected phenol
which can be unmasked by aminolysis. An ionic mechanism consistent with the experimental findings and supported by isotopic
labeling, Hammett analysis, EPR investigations and reactivity profile studies is proposed
Bayesian approach to cyclic activity of CF Oct
Bayesian statistical methods of Gregory-Loredo and the Bretthorst
generalization of the Lomb-Scargle periodogram have been applied for studying
activity cycles of the early K-type subgiant star CF Oct. We have used a ~45
year long dataset derived from archival photographic observations, published
photoelectric photometry, Hipparcos data series and All Sky Automated Survey
archive. We have confirmed the already known rotational period for the star of
20.16 d and have shown evidences that it has exhibited changes from 19.90 d to
20.45 d. This is an indication for stellar surface differential rotation.The
Bayesian magnitude and time--residual analysis reveals clearly at least one
long-term cycle. The cycle lenght's posterior distributions appear to be
multimodal with a pronounced peak at a period of 7.1 y with FWHM of 54 d for
time-residuals and at a period of 9.8 y with FWHM of 184 d for magitude data.
These results are consistent with the previously postulated cycle of 9+/-3
years.Comment: The paper contains 6 figures and 3 tables. Accepted for publication
in Monthly Notices of the Royal Astronomical Society Main Journa
Synthesis of Highly Substituted Adamantanones from Bicyclo[3.3.1]nonanes
Trifluoromethanesulfonic acid and other electrophiles promote formation of the adamantanone core from the readily accessible 1,5-dimethyl-3,7-dimethylenebicyclo[3.3.1]nonan-9-one 2. Because adamantyl cation 3 can be trapped by a range of nucleophiles, including aromatic and heteroaromatic rings, alcohol, nitriles, and halides, access to a wide variety of functionality at the newly formed tertiary position is provided
Anti-calmodulins and Tricyclic Adjuvants in Pain Therapy Block the TRPV1 Channel
Ca2+-loaded calmodulin normally inhibits multiple Ca2+-channels upon dangerous elevation of intracellular Ca2+ and protects cells from Ca2+-cytotoxicity, so blocking of calmodulin should theoretically lead to uncontrolled elevation of intracellular Ca2+. Paradoxically, classical anti-psychotic, anti-calmodulin drugs were noted here to inhibit Ca2+-uptake via the vanilloid inducible Ca2+-channel/inflamatory pain receptor 1 (TRPV1), which suggests that calmodulin inhibitors may block pore formation and Ca2+ entry. Functional assays on TRPV1 expressing cells support direct, dose-dependent inhibition of vanilloid-induced 45Ca2+-uptake at µM concentrations: calmidazolium (broad range)≥trifluoperazine (narrow range)>chlorpromazine/amitriptyline>fluphenazine>>W-7 and W-13 (only partially). Most likely a short acidic domain at the pore loop of the channel orifice functions as binding site either for Ca2+ or anti-calmodulin drugs. Camstatin, a selective peptide blocker of calmodulin, inhibits vanilloid-induced Ca2+-uptake in intact TRPV1+ cells, and suggests an extracellular site of inhibition. TRPV1+, inflammatory pain-conferring nociceptive neurons from sensory ganglia, were blocked by various anti-psychotic and anti-calmodulin drugs. Among them, calmidazolium, the most effective calmodulin agonist, blocked Ca2+-entry by a non-competitive kinetics, affecting the TRPV1 at a different site than the vanilloid binding pocket. Data suggest that various calmodulin antagonists dock to an extracellular site, not found in other Ca2+-channels. Calmodulin antagonist-evoked inhibition of TRPV1 and NMDA receptors/Ca2+-channels was validated by microiontophoresis of calmidazolium to laminectomised rat monitored with extracellular single unit recordings in vivo. These unexpected findings may explain empirically noted efficacy of clinical pain adjuvant therapy that justify efforts to develop hits into painkillers, selective to sensory Ca2+-channels but not affecting motoneurons
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