A Case of Primary Colonic Signet Ring Cell Carcinoma in a Young Man which Preoperatively Mimicked Phlebosclerotic Colitis

A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely similar to phlebosclerotic colitis in clinical findings; surgical resection was required for correct diagnosis

A study of the curriculum development for fostering children's thinking ability : Focusing on the music classes of the lower grades of elementary school

本研究の目的は,児童一人ひとりの自発的な音楽表現を起点として音楽科の特性に応じた思考を発展させ,さまざまな音楽文化に能動的・主体的にかかわっていけるような,音楽科における次世代のカリキュラムの開発を行うことにある。初年度の取り組みとして,生活の中での子どもたちの学びの履歴と,学校における教育課程との接点を探りながら,学びの総体としてカリキュラムを捉え,「児童の音楽的思考を育む」ことを目標に授業を行い,児童の表現を分析・検討した。自分にとって価値のある表現を見出していくプロセスは,どのような表現をするかを思考する上で重要な環境づくりとなるが,母語を出発点とし,発達段階に応じた適切な制約を設け,楽譜を介在させない活動のなかで,児童はそれぞれに「なじみのある」音楽とのかかわり方を模索し,音楽的思考を働かせ,多様な表現を生み出した。考察を通して,児童が実感を伴って感情移入できる題材,心地よく意欲を喚起されるような約束,学年進行に応じた手だてや難易度の設定,拡散的思考や発想による音楽的な工夫への肯定的評価など,児童の音楽的思考を促すために有効な題材設定,学習過程,働きかけを見出すことができた

EFFECTS OF HINDLINB SUSPENSION ON PATTERNS OF MYOSIN ISOFORMS IN RAT SOLEUS MUSCLE

Using several electrophoretic techniques, this study examined the efeicts of 3 weeks hindlimb suspension on the patterns of isomyosins, myosin heavy chain(HC)isoforms and myosin light chain (LC)isoforms in the soleus muscle of the rat. The suspended soleus showed a shift in the HC isoform distribution with a marked increase in fast HC isoforms and a commensurate decrease in HCI. In addition, the change in the fast HC isoforms consisted of the expression of HCIId and HC IIb absent in the normal soleus. In contrast to HC isoforms, suspension did not lead to appreciable changes in LC isoform distribution. Analyses of electrophoresis under nondenaturing conditions demonstrated that the normal soleus expressing HCI and HCIIa isoforms contained two isomysoins. Although, of the two isomyosins observed in the normal soleus, the faster migrating band most likely represented the HCIIa-based one(FMas), its mobility was not identical with that of the HCIIa-based isomyosin(FMaf)found in fast-twitch muscles, migrating in the order FMaf>FMas. FMas was designated as intermediate isomyosin(IM). Some of the suspended soleus contained slow isomyosin(SM)and IM whereas the others comprised FM3 and/or FM2 as well as SM and IM. In spite of the expression of HCIIb and HCIId in the suspended soleus, FM3 and FM2 observed in these muscles exhibited distinct mobilities from either HCIId-based or HCIIb-based isomyosins comprised in fast-twitch muscles. These results suggest that some of newly expressed HCIId and /or HCIIb isoforms in the suspoended soleus are associated with not only fast but also slow LC isoforms and function as a constitutive elemet of the myosin molecule

尾部懸垂によるラットヒラメ筋におけるミオシンアイソフォームの分布の変化

Using several electrophoretic techniques, this study examined the efeicts of 3 weeks hindlimb suspension on the patterns of isomyosins, myosin heavy chain(HC)isoforms and myosin light chain (LC)isoforms in the soleus muscle of the rat. The suspended soleus showed a shift in the HC isoform distribution with a marked increase in fast HC isoforms and a commensurate decrease in HCI. In addition, the change in the fast HC isoforms consisted of the expression of HCIId and HC IIb absent in the normal soleus. In contrast to HC isoforms, suspension did not lead to appreciable changes in LC isoform distribution. Analyses of electrophoresis under nondenaturing conditions demonstrated that the normal soleus expressing HCI and HCIIa isoforms contained two isomysoins. Although, of the two isomyosins observed in the normal soleus, the faster migrating band most likely represented the HCIIa-based one(FMas), its mobility was not identical with that of the HCIIa-based isomyosin(FMaf)found in fast-twitch muscles, migrating in the order FMaf>FMas. FMas was designated as intermediate isomyosin(IM). Some of the suspended soleus contained slow isomyosin(SM)and IM whereas the others comprised FM3 and/or FM2 as well as SM and IM. In spite of the expression of HCIIb and HCIId in the suspended soleus, FM3 and FM2 observed in these muscles exhibited distinct mobilities from either HCIId-based or HCIIb-based isomyosins comprised in fast-twitch muscles. These results suggest that some of newly expressed HCIId and /or HCIIb isoforms in the suspoended soleus are associated with not only fast but also slow LC isoforms and function as a constitutive elemet of the myosin molecule