1,327 research outputs found
Probing optically silent superfluid stripes in cuprates
Unconventional superconductivity in the cuprates emerges from, or coexists
with, other types of electronic order. However, these orders are sometimes
invisible because of their symmetry. For example, the possible existence of
superfluid charge stripes in the normal state of single layer cuprates cannot
be validated with infrared optics, because interlayer tunneling fluctuations
vanish on average. Similarly, it is not easy to establish if charge orders are
responsible for dynamical decoupling of the superconducting layers over broad
ranges of doping and temperatures. Here, we show that TeraHertz pulses can
excite nonlinear tunneling currents between linearly de-coupled charge-ordered
planes. A giant TeraHertz third harmonic signal is observed in
La1.885Ba0.115CuO4 far above Tc=13 K and up to the charge ordering temperature
TCO = 55 K. We model these results by considering large order-parameter-phase
oscillations in a pair density wave condensate, and show how nonlinear mixing
of optically silent tunneling modes can drive large dipole-carrying
super-current oscillations. Our results provide compelling experimental support
for the presence of hidden superfluid order in the normal state of cuprates.
These experiments also underscore the power of nonlinear TeraHertz optics as a
sensitive probe of frustrated excitations in quantum solids.Comment: 9 pages main text, 5 figures, 12 page supplementar
Interaction-driven dynamical quantum phase transitions in a strongly correlated bosonic system
We study dynamical quantum phase transitions (DQPTs) in the extended
Bose-Hubbard model after a sudden quench of the nearest-neighbor interaction
strength. Using the time-dependent density matrix renormalization group, we
demonstrate that interaction-driven DQPTs can appear after quenches between two
topologically trivial insulating phases -- a phenomenon that has so far only
been studied between gapped and gapless phases. These DQPTs occur when the
interaction strength crosses a certain threshold value that does not coincide
with the equilibrium phase boundaries, which is in contrast to quenches that
involve a change of topology. In order to elucidate the nonequilibrium
excitations during the time evolution, we define a new set of string and parity
order parameters. We find a close connection between DQPTs and these newly
defined order parameters for both types of quenches. In the interaction-driven
case, the order parameter exhibits a singularity at the time of the DQPT only
when the quench parameter is close to the threshold value. Finally, the
timescales of DQPTs are scrutinized and different kinds of power laws are
revealed for the topological and interaction-driven cases.Comment: 6 pages, 4 figures, and supplemental materia
Evolution of Preprofessional Pharmacy Curricula
Objectives. To examine changes in preprofessional pharmacy curricular requirements and trends, and determine rationales for and implications of modifications. Methods. Prerequisite curricular requirements compiled between 2006 and 2011 from all doctor of pharmacy (PharmD) programs approved by the Accreditation Council of Pharmacy Education were reviewed to ascertain trends over the past 5 years. An online survey was conducted of 20 programs that required either 3 years of prerequisite courses or a bachelor’s degree, and a random sample of 20 programs that required 2 years of prerequisites. Standardized telephone interviews were then conducted with representatives of 9 programs. Results. In 2006, 4 programs required 3 years of prerequisite courses and none required a bachelor’s degree; by 2011, these increased to 18 programs and 7 programs, respectively. Of 40 programs surveyed, responses were received from 28 (70%), 9 (32%) of which reported having increased the number of prerequisite courses since 2006. Reasons given for changes included desire to raise the level of academic achievement of students entering the PharmD program, desire to increase incoming student maturity, and desire to add clinical sciences and experiential coursework to the pharmacy curriculum. Some colleges and schools experienced a temporary decrease in applicants. Conclusions. The preprofessional curriculum continues to evolve, with many programs increasing the number of course prerequisites. The implications of increasing prerequisites were variable and included a perceived increase in maturity and quality of applicants and, for some schools, a temporary decrease in the number of applicants
Improved Bounds for Wireless Localization
We consider a novel class of art gallery problems inspired by wireless localization that has recently been introduced by Eppstein, Goodrich, and Sitchinava. Given a simple polygonP, place and orient guards each of which broadcasts a unique key within a fixed angular range. In contrast to the classical art gallery setting, broadcasts are not blocked by the edges ofP. At any point in the plane one must be able to tell whether or not one is located inside P only by looking at the set of keys received. In other words, the interior of the polygon must be described by a monotone Boolean formula composed from the keys. We improve both upper and lower bounds for the general problem where guards may be placed anywhere by showing that the maximum number of guards to describe any simple polygon on n vertices is between roughly and . Aguarding that uses at most guards can be obtained in O(nlog n) time. For the natural setting where guards may be placed aligned to one edge or two consecutive edges ofP only, we prove that n−2 guards are always sufficient and sometimes necessar
Emergence of Micronuclei and Their Effects on the Fate of Cells under Replication Stress
The presence of micronuclei in mammalian cells is related to several mutagenetic stresses. In order to understand how micronuclei emerge, behave in cells, and affect cell fate, we performed extensive time-lapse microscopy of HeLa H2B-GFP cells in the presence of hydroxyurea at low concentration. Micronuclei formed after mitosis from lagging chromatids or chromatin bridges between anaphase chromosomes and were stably maintained in the cells for up to one cell cycle. Nuclear buds also formed from chromatin bridges or during interphase. If the micronuclei-bearing cells entered mitosis, they either produced daughter cells without micronuclei or, more frequently, produced cells with additional micronuclei. Low concentrations of hydroxyurea efficiently induced multipolar mitosis, which generated lagging chromatids or chromatin bridges, and also generated multinuclear cells that were tightly linked to apoptosis. We found that the presence of micronuclei is related to apoptosis but not to multipolar mitosis. Furthermore, the structural heterogeneity among micronuclei, with respect to chromatin condensation or the presence of lamin B, derived from the mechanism of micronuclei formation. Our study reinforces the notion that micronucleation has important implications in the genomic plasticity of tumor cells
Impact of regioregularity on thin-film transistor and photovoltaic cell performances of pentacene-containing polymers
Regioregular pentacene-containing polymers were synthesized with alkylated bithiophene (BT) and cyclopentadithiophene (CPDT) as comonomers. Among them, 2,9-conjugated polymers PnBT-2,9 and PnCPDT-2,9 achieved the best performance in transistor and photovoltaic devices respectively. The former achieved the most highly ordered structures in thin films, yielding ambipolar transistor behavior with hole and electron mobilities up to 0.03 and 0.02 cm(2) V-1 s(-1) on octadecylsilane-treated substrates. The latter achieved photovoltaic power conversion efficiencies up to 0.33%. The impact of regioregularity and direction of conjugation-extension (2,9 vs. 2,10), on thin-film order and device performance has been demonstrated for the pentacene-containing polymers for the first time, providing insight towards future functional material design.close101
Novel Therapies in Glioblastoma
Conventional treatment of glioblastoma has advanced only incrementally in the last 30 years and still yields poor outcomes. The current strategy of surgery, radiation, and chemotherapy has increased median survival to approximately 15 months. With the advent of molecular biology and consequent improved understanding of basic tumor biology, targeted therapies have become cornerstones for cancer treatment. Many pathways (RTKs, PI3K/AKT/mTOR, angiogenesis, etc.) have been identified in GBM as playing major roles in tumorigenesis, treatment resistance, or natural history of disease. Despite the growing understanding of the complex networks regulating GBM tumors, many targeted therapies have fallen short of expectations. In this paper, we will discuss novel therapies and the successes and failures that have occurred. One clear message is that monotherapies yield minor results, likely due to functionally redundant pathways. A better understanding of underlying tumor biology may yield insights into optimal targeting strategies which could improve the overall therapeutic ratio of conventional treatments
- …