Infrared Imaging of z=2.43 Radio Galaxy B3 0731+438 with the Subaru Telescope - Detection of Hα\alpha Ionization Cones of a Powerful Radio Galaxy

We report on infrared imaging observations of the z=2.429 radio galaxy B3 0731+438 with the Subaru telescope. The images were taken with the K'-band filter and the 2.25 um narrow-band filter to examine the structure and properties of the Ha+[N II] 6548,6583 emission-line components. The Ha+[N II] emission-line image shows biconical lobes with an extent of 40 kpc, which are aligned with the radio axis. The rest-frame equivalent widths of the emission lines at these cones are as large as 1100 AA, and can be well explained by a gas-cloud model photoionized by power-law continuum radiation. The isotropic ionizing photon luminosity necessary to ionize the hydrogen gas in these cones amounts to 1e57(photons/s), which is larger than that in the majority of radio-loud QSOs. From these results, we propose that the Ha alignment effect in this object is produced by biconical gas clouds, which are swept up by the passage of radio jets, and are ionized by strong UV radiation from a hidden AGN. The continuum image consists of two components, a stellar-like point source and an extended diffuse galaxy. These are supposed to be a type-2 AGN and its host galaxy. The SED is fitted by a combination of spectra of a reddened dust-scattered AGN and an instantaneous starburst population of 500 Myr old. The stellar mass of the galaxy is estimated to be 3e11 M_solar, which is as large as that of typical 3C radio galaxies at z=1.Comment: 12 pages, 4 Postscript figures, uses PASJ2.sty, PASJ95.sty, PASJadd.sty. Accepted for publication in PASJ (2000

Anti-glycopeptide mAb LpMab-21 against Podoplanin

Human podoplanin (hPDPN), which binds to C‐type lectin‐like receptor‐2 (CLEC‐2), is involved in platelet aggregation and cancer metastasis. The expression of hPDPN in cancer cells or cancer‐associated fibroblasts indicates poor prognosis. Human lymphatic endothelial cells, lung‐type I alveolar cells, and renal glomerular epithelial cells express hPDPN. Although numerous monoclonal antibodies (mA bs) against hPDPN are available, they recognize peptide epitopes of hPDPN. Here, we generated a novel anti‐hPDPN mA b, LpMab‐21. To characterize the hPDPN epitope recognized by the LpMab‐21, we established glycan‐deficient CHO‐S and HEK‐293T cell lines, using the CRISPR/Cas9 or TALEN. Flow cytometric analysis revealed that the minimum hPDPN epitope, in which sialic acid is linked to Thr76, recognized by LpMab‐21 is Thr76–Arg79. LpMab‐21 detected hPDPN expression in glioblastoma, oral squamous carcinoma, and seminoma cells as well as in normal lymphatic endothelial cells. However, LpMab‐21 did not react with renal glomerular epithelial cells or lung type I alveolar cells, indicating that sialylation of hPDPN Thr76 is cell‐type‐specific. LpMab‐21 combined with other anti‐hPDPN antibodies that recognize different epitopes may therefore be useful for determining the physiological function of sialylated hPDPN

SDSSp J104433.04−-012502.2 at z=5.74z=5.74 is Gravitationally Magnified by an Intervening Galaxy

During the course of our optical deep survey program on L$\alpha$ emitters at $z \approx 5.7$ in the sky area surrounding the quasar SDSSp J104433.04$-$012502.2 at $z=5.74$, we found that a faint galaxy with $m_B$(AB) $\approx 25$ is located at \timeform{1".9} southwest of the quasar. Its broad-band color properties from $B$ to $z^\prime$ suggest that the galaxy is located at a redshift of $z \sim 1.5$ -- 2.5. This is consistent with no strong emission line in our optical spectroscopy. Since the counter image of the quasar cannot be seen in our deep optical images, the magnification factor seems not to be very high. Our modest estimate is that this quasar is gravitationally magnified by a factor of 2.Comment: 11 pages, 5 figures, PASJ, in pres

The Discovery of a Very Narrow-Line Star Forming Obat a Redshift of 5.66ject

We report on the discovery of a very narrow-line star forming object beyond redshift of 5. Using the prime-focus camera, Suprime-Cam, on the 8.2 m Subaru telescope together with a narrow-passband filter centered at $\lambda_{\rm c}$ = 8150 \AA with passband of $\Delta\lambda$ = 120 \AA, we have obtained a very deep image of the field surrounding the quasar SDSSp J104433.04$-$012502.2 at a redshift of 5.74. Comparing this image with optical broad-band images, we have found an object with a very strong emission line. Our follow-up optical spectroscopy has revealed that this source is at a redshift of $z=5.655\pm0.002$, forming stars at a rate $\sim 13 ~ h_{0.7}^{-2} ~ M_\odot$ yr$^{-1}$. Remarkably, the velocity dispersion of Ly$\alpha$-emitting gas is only 22 km s$^{-1}$. Since a blue half of the Ly$\alpha$ emission could be absorbed by neutral hydrogen gas, perhaps in the system, a modest estimate of the velocity dispersion may be $\gtrsim$ 44 km s$^{-1}$. Together with a linear size of 7.7 $h_{0.7}^{-1}$ kpc, we estimate a lower limit of the dynamical mass of this object to be $\sim 2 \times 10^9 M_\odot$. It is thus suggested that LAE J1044$-$0123 is a star-forming dwarf galaxy (i.e., a subgalactic object or a building block) beyond redshift 5 although we cannot exclude a possibility that most Ly$\alpha$ emission is absorbed by the red damping wing of neutral intergalactic matter.Comment: 6 pages, 2 figures. ApJ Letters, in pres

Superwind-Driven Intense H_2 Emission in NGC 6240

We have performed a long-slit K band spectroscopic observation of the luminous infrared galaxy NGC 6240. The peak position of the H_2 v=1-0 S(1) emission in the slit is located ~0.3" - 0.4" north of the southern nucleus. It is almost the midpoint between the southern nucleus and the peak position of the ^12CO J=1-0 emission. Based on the line-ratio analyses, we suggest the excitation mechanism of H_2 is pure thermal at most positions. In the southern region we find the following three velocity components in the H_2 emission: the blueshifted shell component (~-250 km s^-1 with respect to V_sys) which is recognized as a distinct C-shape distortion in the velocity field around the southern nucleus, the high-velocity blueshifted ``wing'' component (~-1000 km s^-1 with respect to V_sys), and the component indicating possible line splitting of ~500 km s^-1. The latter two components are extended to the south from the southern nucleus. We show that the kinematic properties of these three components can be reproduced by expanding motion of a shell-like structure around the southern nucleus. The offset peak position of the H_2 emission can be understood if we assume that the shell expanding to the north interacts with the extragalactic molecular gas. At the interface between the shell and the molecular gas concentration the cloud-crushing mechanism proposed by Cowie et al. (1981) may work efficiently, and the intense H_2 emission is thus expected there. All these findings lead us to propose a model that the most H_2 emission is attributed to the shock excitation driven by the superwind activity of the southern nucleus.Comment: 33 pages, 9 figures, accepted for publication in PAS

Current Performance and On-Going Improvements of the 8.2 m Subaru Telescope

An overview of the current status of the 8.2 m Subaru Telescope constructed and operated at Mauna Kea, Hawaii, by the National Astronomical Observatory of Japan is presented. The basic design concept and the verified performance of the telescope system are described. Also given are the status of the instrument package offered to the astronomical community, the status of operation, and some of the future plans. The status of the telescope reported in a number of SPIE papers as of the summer of 2002 are incorporated with some updates included as of 2004 February. However, readers are encouraged to check the most updated status of the telescope through the home page, http://subarutelescope.org/index.html, and/or the direct contact with the observatory staff.Comment: 18 pages (17 pages in published version), 29 figures (GIF format), This is the version before the galley proo

Down-Sizing in Galaxy Formation at z~1 in the Subaru/XMM-Newton Deep Survey (SXDS)

We use the deep wide-field optical imaging data of the Subaru/XMM-Newton Deep Survey (SXDS) to discuss the luminosity (mass) dependent galaxy colours down to z'=25.0 (5 x 10^9 h_{70}^{-2} Msun) for z~1 galaxies in colour-selected high density regions. We find an apparent absence of galaxies on the red colour-magnitude sequence below z'~24.2, corresponding to ~M*+2 (~10^{10} Msun) with respect to passively evolving galaxies at z~1. Galaxies brighter than M*-0.5 (8 x 10^{10} Msun), however, are predominantly red passively evolving systems, with few blue star forming galaxies at these magnitudes. This apparent age gradient, where massive galaxies are dominated by old stellar populations while less massive galaxies have more extended star formation histories, supports the `down-sizing' idea where the mass of galaxies hosting star formation decreases as the Universe ages. Combined with the lack of evolution in the shape of the stellar mass function for massive galaxies since at least z~1, it appears that galaxy formation processes (both star formation and mass assembly) should have occurred in an accelerated way in massive systems in high density regions, while these processes should have been slower in smaller systems. This result provides an interesting challenge for modern CDM-based galaxy formation theories which predict later formation epochs of massive systems, commonly referred to as ``bottom-up''.Comment: proof corrected version (MNRAS in press), 10 pages, 12 figures (of which 3 are in jpg format

A Bayesian Network-Based Browsing Model for Patients Seeking Radiology-Related Information on Hospital Websites : Development and Usability Study

Background: An increasing number of people are visiting hospital websites to seek better services and treatments compared to the past. It is therefore important for hospitals to develop websites to meet the needs of their patients. However, few studies have investigated whether and how the current hospital websites meet the patient's needs. Above all, in radiation departments, it may be difficult for patients to obtain the desired information regarding modality and diagnosis because such information is subdivided when described on a website. Objective: The purpose of this study is to suggest a hospital website search behavior model by analyzing the browsing behavior model using a Bayesian network from the perspective of one-to-one marketing. Methods: First, we followed the website access log of Hokkaido University Hospital, which was collected from September 1, 2016, to August 31, 2017, and analyzed the access log using Google Analytics. Second, we specified the access records related to radiology from visitor browsing pages and keywords. Third, using these resources, we structured 3 Bayesian network models based on specific patient needs: radiotherapy, nuclear medicine examination, and radiological diagnosis. Analyzing each model, this study considered why some visitors could not reach their desired page and improvements to meet the needs of visitors seeking radiology-related information. Results: The radiotherapy model showed that 74% (67/90) of the target visitors could reach their requested page, but only 2% (2/90) could reach the Center page where inspection information, one of their requested pages, is posted. By analyzing the behavior of the visitors, we clarified that connecting with the radiotherapy and radiological diagnosis pages is useful for increasing the proportion of patients reaching their requested page. Conclusions: We proposed solutions for patient web-browsing accessibility based on a Bayesian network. Further analysis is necessary to verify the accuracy of the proposed model in comparison to other models. It is expected that information provided on hospital websites will be improved using this method

LpMab-12 Established by CasMab Technology Specifically Detects Sialylated O-Glycan on Thr52 of Platelet Aggregation-Stimulating Domain of Human Podoplanin

Podoplanin (PDPN), also known as Aggrus, possesses three tandem repeat of platelet aggregation-stimulating (PLAG) domains in its N-terminus. Among the PLAG domains, sialylated O-glycan on Thr52 of PLAG3 is essential for the binding to C-type lectin-like receptor-2 (CLEC-2) and the platelet-aggregating activity of human PDPN (hPDPN). Although various anti-hPDPN monoclonal antibodies (mAbs) have been generated, no specific mAb has been reported to target the epitope containing glycosylated Thr52. We recently established CasMab technology to develop mAbs against glycosylated membrane proteins. Herein, we report the development of a novel anti-glycopeptide mAb (GpMab), LpMab-12. LpMab-12 detected endogenous hPDPN by flow cytometry. Immunohistochemical analyses also showed that hPDPN-expressing lymphatic endothelial and cancer cells were clearly labeled by LpMab-12. The minimal epitope of LpMab-12 was identified as Asp49–Pro53 of hPDPN. Furthermore, LpMab-12 reacted with the synthetic glycopeptide of hPDPN, corresponding to 38–54 amino acids (hpp3854: 38-EGGVAMPGAEDDVVTPG-54), which carries α2–6 sialylated N-acetyl-D-galactosamine (GalNAc) on Thr52. LpMab-12 did not recognize non-sialylated GalNAc-attached glycopeptide, indicating that sialylated GalNAc on Thr52 is necessary for the binding of LpMab-12 to hPDPN. Thus, LpMab-12 could serve as a new diagnostic tool for determining whether hPDPN possesses the sialylation on Thr52, a site-specific post-translational modification critical for the hPDPN association with CLEC-2