167 research outputs found
Delivery of animal health services in extensive livestock production systems: Report of a stakeholder workshop, Nairobi, 9‐10 March 2017
Relative fitness contribution of BoLA alleles in T.parva immune cattle: Interface with parasite genetic diversity
Schistosoma mansoni infection and the associated antibody immune response amongst residents of Kigungu Entebbe, Uganda
Background: There are many foci endemic for Schistosoma (S.) mansoni in Uganda. The immune responses to infection with the parasites in these areas have been found to vary with host sex, age and infection intensity.Objective: To determine the profile of antibody isotypes responses against S. mansoni crude soluble egg antigens (SEA) and soluble adult worm protein (SWAP) antigens that determine the host resistance or susceptibility to reinfection.Design: Cross Sectional, cohort study.Setting: Kigugu fishing village in Entebbe, Uganda.Subjects: Nine hundred and forty five (945) Kigungu residents reported for pre-treatment screening and enrolment and 626 cohorts report for post-treatment screening and enrolment 18 months later.Results: Pearson’s Chi-sq2 showed that increase in titres of anti (SWAP IgE, SEA IgE, and SEA IgG2) was not significant, but increase in anti SEA IgG3 was significant. Decrease in titres of anti (SWAP IgG1, SEA IgG1, and SEA IgG4) was not significant but decrease of anti (SWAP IgG2, SWAP IgG3 and SWAP IgG4) was significant. Positive correlation existed between age and anti SWAP IgE in before and after treatment sera. On the contrary, age was positively correlated with anti SWAP IgG4 in pre-treatment sera but was negatively correlated with anti SWAP IgG4 in the post-treatment sera. In addition there were positive correlation between higher egg counts and the immunoglobulin levels of anti SWAP IgG4 and anti SEA IgG4 but negative correlations were observed between anti SWAP IgE and anti SEA IgE. Conversely low egg counts were associated with high levels of anti SWAP IgE. Furthermore, IgG1-4, IgE antibody to SEA and SWAP antigens did not differ significantly according to sex.Conclusion: We concluded that praziquantel treatment of S. mansoni infected persons alter the immune responses that are influenced by age and intensity. A phenomenon that is useful in the effort to produce vaccine against schistosome
Evidence of Long Term Benefit of Praziquantel Treatment Against Schistosoma mansoni in Kigungu Fishing Village of Entebbe, Uganda
Praziquantel (PZQ) is efficacious against all species of schistosome: Schistosoma mansoni; Schistosoma haematobium; Schistosoma japonicum and other parasites like the Taenia species. This cross-sectional cohorts study was carried out in Kigungu fishing village along Lake Victoria shore in Entebbe Uganda. Our analysis was based on examining microscopically three slides from a single stool specimen from each of base line cohorts 945.These included children and adults, participants from both sexes in Kigungu fishing village in Entebbe Uganda. Nine hundred and one (901) of the cohorts were re-examined after six months and 625 of the same cohorts who were examined at the baseline and after six months were re-examined 18 months later. The slides were prepared using modified Kato/Katz (Odongo-Aginya) method. The infection proportion with Schistosoma mansoni at baseline was 448 (47.5%) but this was reduced to 244 (25.8%) 18 months after treatment with a single oral dose of praziquantel at 40mg/kg. However 495 (52.5%) were negative at the baseline study. The cure proportion after six was significant {(P=0.00), (OR4.63) CI at 95% (3.53-6.06)}. Similarly the cure proportion after 18 months was significant {(P=0.00), (OR2.2) CI at 95% (1.87-3.34)}. The force of re-infection after six months was significant {(P=0.0001), (OR 0.47) CI at 95% (0.31-0.71)}. Nevertheless the force of re-infection was not significant after 18 months {(P=0.766), (OR 0.95) CI at 95% (0.68-1.34)} eggs excretion did not reach the level of the pre-treatment intensity. The egg reduction was 69.3%. This was associated with age and pre-treatment intensity < 400 eggs per gram (epg) of faeces and age groups ≥ 30 years. The egg reduction also resulted in marked decrease in clinical symptoms in the participants. Our study suggests evidence of long-term benefit of praziquantel in Kigungu and that the re-infection occurred more commonly in younger age group than in the older patients.Key words: Praziquantel; Schistosoma mansoni; Kigungu; Entebbe; Uganda
The Rhipicephalus appendiculatus tick vector of Theileria parva is absent from cape buffalo (Syncerus caffer) populations and associated ecosystems in northern Uganda
Rhipicephalus appendiculatus is the major tick vector of Theileria parva, an apicomplexan protozoan parasite that causes the most economically important and lethal disease of cattle in East and central Africa. The African cape buffalo (Syncerus caffer) is the major wildlife host of T. parva from southern Uganda and Kenya to southern Africa. We show herein that R. appendiculatus appears to be absent from the two largest national parks in northern Uganda. Syncerus caffer is common in both of these national parks, specifically Murchison falls (MFNP) and Kidepo Valley (KVNP). We re-confirmed the previously reported absence of T. parva in buffalo sampled in the two northern parks based on RLB data using a nested PCR based on the T. parva p104 gene. By contrast, T. parva-infected R. appendiculatus ticks and parasite-infected buffalo were present in Lake Mburo (LMNP) in South central Uganda. This suggests that the distribution of R. appendiculatus, which is predicted to include the higher rainfall regions of northern Uganda, may be limited by additional, as yet unknown factors
Role of power in supply chain performance: Evidence from agribusiness SMEs in Uganda
Purpose: This paper examined the role of power on supply chain performance in the context of small and medium sized agribusiness enterprises (SMEs). Contrary to most of previous studies, which collect and analyze data from one side of a relationship dyad using a focal firm approach, a matched triad approach was employed in data collection and analysis in this study.
Methodology: Empirical data was collected from 150 agribusiness supply chain members from the maize supply chain in Uganda. Analysis was done using multi-group analysis and structural equations modelling. Findings: Results highlights the differences in the perception of power use and how it influences supply chain performance. The differences in perception suggest the existence of power asymmetry amongst supply chain members. This work contributes to the ongoing debate concerning the use of triad as a unit of analysis as opposed to a firm or a dyad.
Limitations: This study only focused on one commodity chain in one country, which can limit the broad application of the findings. Managerial implications: A practical implication of the finding is that managers of agribusiness supply chains should be aware of their power positions and appropriately influence the supply chain based on their relative power positions. Originality: The novelty of this work lies in fact that we assess perception of power amongst supply chain members in a triadic context, a perspective that has not been adequately tested in agribusiness supply chain management studies before
Sweetpotato selection releases: Lessons learnt from Uganda
The National Sweetpotato Programme of the National Agricultural Research Organisation (NARO) in Uganda released 14 sweetpotato cultivars between 1994 and 2005. Of the released cultivars, six have gained importance in local Ugandan markets and in export trade to Europe and two are being used as parental sources for high drymatter (>30%), sweetpotato virus disease (SPVD) and nematode resistance in hybridization schemes, and in the genetic mapping work in joint international collaborative research. Two orange-fleshed sweetpotato (OFSP) cultivars, namely, Ejumula, and SPK004 (Kakamega), high in beta-carotene (the precursor for vitamin A) arespreading rapidly for combating widespread vitamin A deficiency in Uganda. The major steps leading to the release of Kakemega and Ejumula are used to illustrate the experience of the Ugandan sweetpotato breeding programme sustained activities for a decade, and lessons learnt are highlighted. The sustained breeding activitieshave led to a vibrant and robust program, increased international and south to south collaboration, increased partnership and alliances; shifted research focus from production to production per se and quality (nutrition), resulting into significant and relevant agricultural research. The lesson here is that it takes a long time to develop technologies, disseminate and commercialize them. It also requires commitment by the donor, government, scientists, farmers and other stakeholders for effective commercialization of the developed technologies
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