184 research outputs found

    A Conversation with Philip Roth

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    PHILIP ROTH\u27s books are: Goodbye, Columbus (1959); Letting Go (1962); When She Was Good (1967); Portnoy\u27s Complaint (1969); Our Gang (1971); The Breast (1972); The Great American Novel (1973); and My Life as a Man (1974). He is currently working on a group of essays that will probably be called Reading Myself and Others, and which deal, among other things, with some of his contemporaries—Bellow, Malamud—and the predicament of fame. Since 1965 he has been on the English faculty of the University of Pennsylvania, where he teaches two courses in literature during the fall semester. In 1970 he was elected to the National Institute of Arts and Letters.JOYCE CAROL OATES has recently published a collection of satiric academic stories, The Hungry Ghosts (Black Sparrow Press, 1974), and a collection of critical essays, New Heaven, New Earth: The Visionary Experience in Literature (Vanguard Press, 1974)

    Joyce Carol Oates: 10-30-1980

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    In an interview conducted the week before Ronald Reagan was elected president, Joyce Carol Oates discusses her novels Wonderland, Bellefleur, and Angel of Light; the process of writing a short story or novel; and political terrorism.https://digitalcommons.brockport.edu/writers_videos/1030/thumbnail.jp

    Inferior vena cava filters (IVCFs): A review of uses and application to international guidelines at a single Australian center; implications of venous thromboembolism associated with malignancy

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    Venous thromboembolism (VTE) is a potentially lethal event. Anticoagulation is the cornerstone of treatment. Inferior vena cava filters (IVCFs) may be used in circumstances when anticoagulation is contraindicated or as an adjunct to anticoagulation. IVCF use is not without controversy due to concerns over their safety profile, differences in guidelines from international societies, and a limited randomized control trial evidence. We retrospectively undertook a review of IVCF use over a three-year period (2014–2016) at our center, which has a large oncology service but no trauma unit. There were 44 patients with successful IVCF insertion and one patient with an unsuccessful attempt. Indications for insertion included: a contraindication to anticoagulation (n¼28); recurrent VTE on anticoagulation (n¼10); and extensive VTE (n¼7). There were 13 retrieval attempts, of which ten were successful. There were five documented IVCF complications (tilting: n¼2, IVC thrombus: n¼3) with one episode of IVCF failure and two episodes of deep vein thrombosis during the follow-up period. Of the patients, 71% had an active malignancy (of whom 71% had metastatic disease). Seventeen patients died due to progressive malignancy during the study period. There were no life-threatening VTEs or IVCF associated mortalities. Adherence with published international guidelines was variable. Patients with malignancy were less likely to undergo IVCF retrieval and had a reduced rate of retrieval success. None of the international guidelines comment on the use of IVCFs in patients with malignancy despite being commonly used. IVCF use may be an underappreciated tool in this group

    Evolution of the calcium-based intracellular signalling system

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    To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain proteins that have undergone duplication, recombination, sequence divergence, and selection. The picture of evolution, considering the repertoire of proteins in the toolkit of both extant organisms and ancestors, is radically different from that of other systems. In eukaryotes, the repertoire increased in both abundance and diversity at a far greater rate than general genomic expansion. We describe how calcium-based intracellular signaling evolution differs not only in rate but in nature, and how this correlates with the disparity of plants and animals

    Revealing the insoluble metasecretome of lignocellulosedegrading microbial communities

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    AbstractMicrobial communities metabolize plant biomass using secreted enzymes; however, identifying extracellular proteins tightly bound to insoluble lignocellulose in these microbiomes presents a challenge, as the rigorous extraction required to elute these proteins also lyses the microbes associated with the plant biomass releasing intracellular proteins that contaminate the metasecretome. Here we describe a technique for targeting the extracellular proteome, which was used to compare the metasecretome and meta-surface-proteome of two lignocellulose-degrading communities grown on wheat straw and rice straw. A combination of mass spectrometry-based proteomics coupled with metatranscriptomics enabled the identification of a unique secretome pool from these lignocellulose-degrading communities. This method enabled us to efficiently discriminate the extracellular proteins from the intracellular proteins by improving detection of actively secreted and transmembrane proteins. In addition to the expected carbohydrate active enzymes, our new method reveals a large number of unknown proteins, supporting the notion that there are major gaps in our understanding of how microbial communities degrade lignocellulosic substrates.</jats:p
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