8 research outputs found
Instruction in ethics: influences on undergraduate business students' academic dishonesty
- Author
- Publication venue
- Colorado State University. Libraries
- Publication date
- 01/01/2011
- Field of study
2011 Summer.Includes bibliographical references.The primary purposes of the study were to assess the relationships between ethics instruction and academic conduct among undergraduate business students, to determine the reasons why they cheat, the extent to which students' conduct may be influenced by their parents' background (i.e., education, career, religious belief, and support), and the impact of self-esteem on students' conduct. Responses were solicited from students attending nine institutions of higher learning; five were located in the state of Georgia in the United States, while four were from the Caribbean (i.e., Jamaica and Grand Cayman). The regional profile (i.e., where the students were enrolled) included 41% (n = 418) from the United States and 59% (n = 599) from the Caribbean locations. The responses were collected from a questionnaire completed at each selected college/university. Of the 1,029 questionnaires administered, 12 were disqualified. There were 1,017 qualified respondents; approximately 37% (n = 377) were male, and 62% (n = 627) were female. The remaining 1% (n = 13) did not identify their gender. In every case, only items with valid responses were included in the various statistical computations. The findings indicated that (a) there was no statistical significance on academic misconduct between students who did complete a course of instruction in ethics and those who did not complete a course; (b) about 40% (n = 400) of the students surveyed showed positive responses to awareness of academic conduct; (c) several students admitted having engaged in academic dishonesty for various reasons (e.g., to get a better grade); (d) for perception of academic conduct, character traits and honor code appeared to have some impact on academic dishonesty; (e) parents' background (e.g., education, careers/occupation) did play a role on students' academic conduct; (f) self-esteem appeared to have some influence on academic dishonesty; (g) having an honor code did not significantly improve academic honesty within the AACSB accredited and non-AACSB institutions; (h) for the most part, it seems more female students were involved in academic dishonesty than male students for given practices; and (i) younger students particularly in the 18-22 age group seems to be more involved in academic dishonesty than older students. The overall implications of this study raise some concerns because this, like other studies, has confirmed that academic dishonesty is a menace to the education system. Therefore, academic dishonesty is not confined to one university/college but appears to be omnipresent in the aggregate grouping of the nine institutions studied. The findings suggest colleges/universities need to do more, perhaps, by being more vigilant to address students' awareness of academic misconduct, and how such actions could influence both creativity and the value of scholarship
Rheumatoid arthritis - treatment: 180. Utility of Body Weight Classified Low-Dose Leflunomide in Japanese Rheumatoid Arthritis
- Author
- Ahmad Yasmeen
- Al-Kashi Adam
- Alten Rieke
- Andres Roman Ivorra Jose
- Aranda Richard
- Aranda Richard
- Ashcroft Darren M.
- Atkinson Francesca
- Atzeni Fabiola
- Baker D.
- Baraf Herbert
- Baratelle A.
- Bathon J.
- Bathon Joan
- Becker Jean-Claude
- Becker Jean-Claude
- Behrens Frank
- Beirne Paul
- Bernasconi Corrado
- Beutler A.
- Bingham Clifton
- Bingham Sarah J.
- Blackler Laura
- Blunn Karina J.
- Bolce R.
- Breedveld Ferdinand C.
- Breslin Anne
- Buch Maya
- Burgos-Vargas Ruben
- Burke Laura
- Burkhardt Harald
- Burmester Gerd
- Bykerk Vivian P.
- Chai Akiko
- Chernajovsky Yuti
- Chung Carol Y.
- Cifaldi Mary
- Cohen Roger
- Cohen Stanley B.
- Conaghan P. G.
- Covucci Allison
- Curtis Jeffrey
- Curtis Jeffrey
- Curtis Jeffrey
- Dass Shouvik
- Davies Rebecca
- De Bari Cosimo
- De Silva Chulanie
- Decktor D.
- Dehoratius R.
- Delaet Ingrid
- Dell'Accio Francesco
- Dennison Elaine
- Dougados Maxime
- Dougados Maxime
- Doyle M. K.
- Dudler Jean
- Durez Patrick
- Ehrenstein Michael R.
- El-Kadi H.
- Elashoff M.
- Elegbe Ayanbola
- Ellis Shawn D.
- Eltawil Noha
- Emery P.
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Emery Paul
- Eveslage Maria
- Fan H.
- Farmer Pamela
- Faurholm Bjarne
- Fichtner Andreas
- Fleischmann R.
- Fleischmann R.
- Fleischmann R.
- Fleischmann Roy
- Fleischmann Roy M.
- Fleischmann Roy M.
- Fuji Takeshi
- Furst Dan
- Furst Daniel E.
- Furst Daniel E.
- Galloway James
- Genant Harry
- Genovese M.
- Genovese M. C.
- Genovese M. C.
- Genovese Mark C.
- Genovese Mark C.
- Goldman J.
- Goldring Mary
- Gomez-Reino Juan
- Gould David
- Gujrathi Sheila
- Gullick Nicola J.
- Gullick Nicola J.
- Guo Yonghua
- Guérette Benoit
- Guérette Benoit
- Guérette Benoit
- Guérette Benoit
- Guérette Benoit
- Hamilton Jennifer
- Haraoui Boulos
- Haraoui Boulos
- Heatley Rebecca
- Herzer Peter
- Heycock Carol
- Hochberg Marc
- Hogan Vanessa
- Holweg Cecile
- Hsia E. C.
- Hsia E. C.
- Hsia E. C.
- Hughes Chris
- Hutchinson David G.
- Hyrich Kimme
- Hyrich Kimme L.
- Iaremenko Oleg
- Ince Akgun
- Jameson Karen
- Jones Tim
- Kahan Andre
- Kary Sonja
- Kavanaugh Arthur
- Kavanaugh Arthur
- Kavanaugh Arthur
- Kavanaugh Arthur
- Kellner H.
- Kelly Clive
- Kelly Sheila
- Keystone E.
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Keystone Edward
- Khan Nadar
- Khanna Dinesh
- Khraishi Majed
- Kiely Patrick
- Kim L.
- Kirkham Bruce
- Kirkham Bruce W.
- Kirkham Bruce W.
- Kleinert Stefan
- Knight Gregory D.
- Koehm Michaela
- Kremer J.
- Kremer Joel M.
- Krummel-Lorenz Brigitte
- Kummerfeld Sarah
- Kupper Hartmut
- Kupper Hartmut
- Kvien Tore
- Landewe Robert
- Landewe Robert
- Landewe Robert
- Lawson Richard
- Le Bars Manuela
- Lehane Patricia
- Leirisalo-Repo M.
- Li Tracy
- Liebhaber Anke
- Listing Joachim
- Liu H.
- Lloyd Lois A.
- Long Simon G.
- Luggen Michael
- Lugli Helena
- Luijtens Kristel
- Luijtens Kristel
- Lunt Mark
- Lunt Mark
- Luo Allison
- Macey Katherine M.
- Malamet Raymond
- Malik Saadia
- Manzo Antonio
- Mariette Xavier
- Marrelli Alessandra
- Matteson E. L.
- Matteson E. L.
- Matteson Eric L.
- Matucci Cerenic Marco
- McDowell Jackie
- Mela Christopher M.
- Mendelsohn A.
- Mikitenko Ganna
- Mistlin Alan
- Moreland Larry
- Mozaffarian Neelufar
- Mozaffarian Neelufar
- Nikiphorou Elena
- Nishikawa Masataka
- Nissim Ahuva
- Notley Clare A.
- Nurmohamed Michael T.
- Oakley Stephen
- Oezer Uemit
- Owaki Hajime
- Owen Catherine
- Panayi Gabriel
- Pappu Ramesh
- Patra Kaushik
- Patra Kaushik
- Patra Kaushik
- Patra Kaushik
- Pavelka Karel
- Pavelka Karel
- Potempa Jan
- Qi Keqin
- Quirke Anne-Marie
- Rahman M. U.
- Rees Jonathon
- Reiss William
- Reynard Mark
- Reynolds Alan
- Ritchlin C.
- Rizzo Warren
- Robles Manuel
- Roy Sanjoy
- Rynne Martin
- Sague S.
- Saravanan Vadivelu
- Scharbatke Eva C.
- Schechtman Joy
- Schiff Michael
- Schiff Michael
- Seed Michael
- Shah Devron
- Shaw Tim
- Sibilia Jean
- Smolen Josef
- Smolen Josef
- Smolen Josef
- Smolen Josef
- Soliman Moetaza M.
- Stancati Andrea
- Strand Vibeke
- Strangfeld Anja
- Subang Christina
- Sweetser Marianne
- Sweetser Marianne T.
- Symmons Deborah
- Taylor Monet
- Taylor Peter
- Taylor Peter
- Teng Onno
- Tony Hans-Peter
- Torbeyns Anne
- Townsend Michael
- Unnebrink Kristina
- van der Heijde D.
- van der Heijde Désirée
- van der Heijde Désirée
- van der Heijde Désirée
- van der Heijde Désirée
- van der Heijde Désirée
- van Laar Jacob M.
- van Vollenhoven Ronald
- van Vollenhoven Ronald
- van Vollenhoven Ronald
- van Vollenhoven Ronald
- Venables Patrick
- Vencovsky Jiri
- Vernon Emma
- Vernon Emma
- Vital Edward M.
- Walsh Claire
- Walsh David A.
- Wang J.
- Wasco M. C.
- Watson Kath
- Watson Kath D.
- Watson Kath D.
- Wegner Natalia
- Weinblatt Michael
- Weinblatt Michael
- Westhovens Rene
- Westhovens Rene
- Weyer Gerd
- Williams Richard
- Williams Richard B.
- Williams Sarah
- Winyard Paul
- Xu W.
- Yazici Yusuf
- Young Adam
- Young Adam
- Zain Amir
- Zanetakis E.
- Zink Angela
- Ălvaro-Gracia Jose
- Ăstör Andrew
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: In Japan, more than 20 rheumatoid arthritis (RA) patients died of interstitial pneumonia (IP) caused by leflunomide (LEF) were reported, but many of them were considered as the victims of opportunistic infection currently. In this paper, efficacy and safety of low-dose LEF classified by body weight (BW) were studied. Methods: Fifty-nine RA patients were started to administrate LEF from July 2007 to July 2009. Among them, 25 patients were excluded because of the combination with tacrolimus, and medication modification within 3 months before LEF. Remaining 34 RA patients administered 20 to 50âmg/week of LEF were followed up for 1 year and enrolled in this study. Dose of LEF was classified by BW (50âmg/week for over 50âkg, 40âmg/week for 40 to 50âkg and 20 to 30âmg/week for under 40âkg). The average age and RA duration of enrolled patients were 55.5 years old and 10.2 years. Prednisolone (PSL), methotrexate (MTX) and etanercept were used in 23, 28 and 2 patients, respectively. In case of insufficient response or adverse effect, dosage change or discontinuance of LEF were considered. Failure was defined as dosages up of PSL and MTX, or dosages down or discontinuance of LEF. Last observation carried forward method was used for the evaluation of failed patients at 1 year. Results: At 1 year after LEF start, good/ moderate/ no response assessed by the European League Against Rheumatism (EULAR) response criteria using Disease Activity Score, including a 28-joint count (DAS28)-C reactive protein (CRP) were showed in 14/ 10/ 10 patients, respectively. The dosage changes of LEF at 1 year were dosage up: 10, same dosage: 5, dosage down: 8 and discontinuance: 11 patients. The survival rate of patients in this study was 23.5% (24 patients failed) but actual LEF continuous rate was 67.6% (11 patients discontinued) at 1 year. The major reason of failure was liver dysfunction, and pneumocystis pneumonia was occurred in 1 patient resulted in full recovery. One patient died of sepsis caused by decubitus ulcer infection. DAS28-CRP score was decreased from 3.9 to 2.7 significantly. Although CRP was decreased from 1.50 to 0.93âmg/dl, it wasn't significant. Matrix metalloproteinase (MMP)-3 was decreased from 220.0 to 174.2âng/ml significantly. Glutamate pyruvate transaminase (GPT) was increased from 19 to 35 U/l and number of leukocyte was decreased from 7832 to 6271 significantly. DAS28-CRP, CRP, and MMP-3 were improved significantly with MTX, although they weren't without MTX. Increase of GPT and leukopenia were seen significantly with MTX, although they weren't without MTX. Conclusions: It was reported that the risks of IP caused by LEF in Japanese RA patients were past IP history, loading dose administration and low BW. Addition of low-dose LEF is a potent safe alternative for the patients showing unsatisfactory response to current medicines, but need to pay attention for liver function and infection caused by leukopenia, especially with MTX. Disclosure statement: The authors have declared no conflicts of interes
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
- Dolman Rozzie
- Domingo-Marco Joana
- Donadee Chenell
- Donaldson Kate
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dos Santos Filipa
- Douillard Thomas
- Drake Chelsea
- Drapola Debra
- Drayss Maria
- Drummond Andrew
- Drury Kay
- Duan Erick
- Duberley Stephen
- Duffy Eamon
- Duffy Oscar
- Duke Graeme
- Duke Zoe
- Duncan Tracy
- Dunsavage Janice
- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
- Elhassan Munzir
- Ellervee Anneli
- Ellis Chiara
- Ellis Christine
- Ellis Yvette
- Elmahi Einas
- Elsefi Tarek
- Eltayeb Ayaa
- Elvira Evangeline
- England Jenna
- Englert Sarah
- English Shane
- Epelmanž Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
- Evans Andrew
- Evans Debra
- Evans Gabrielle
- Everitt Robert
- Evers Mirjam
- Evetts George
- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
- Fagbodun Elizabeth
- Farahi Neda
- Fareed Komal
- Farnell-Ward Sarah
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazla Fathima
- Featherstone Peter
- Felton Tim
- Fennessy Gerard
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- Hall Alistair S
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- Hernandez Erik
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- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
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- Hilldrith Anette
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- Hindle Grace
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- Hodge Christopher
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- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
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- Irving Ben
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- Jan Hassing Robert
- Janin Pierre
- Jarczak Dominik
- Jarman Claire
- Jayakumar Deva
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- Jean-Pierre Eraldi
- Jeblaoui Asma
- Jenkins Samuel
- Jenkins Sarah
- Jenkins Steve
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- Jepson Eleanor
- Jerenec Katja
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- Jha Avinash
- Jha Rajeev
- Jhanji Shaman
- Jin Xia
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- Jongebloed Katherine
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- Keeler Sheryl
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- Khoud Ahmed
- Khwaja Kosar
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- Kiiski Heikki
- Kilner Mari
- Kim Edy Y.
- Kimpton Sarah
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- Kirk Jill
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- Kit Barbara
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- Klein Daniela
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- Kochert Erik
- Koelink Maaike
- Koirala Kanchan
- Koirala Sabin
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- Kolovou Angeliki
- Konecny Pam
- Kong Jing
- Koopmans Matty
- Kosa Alma
- Kremling Julius
- KreĂ Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kumar Rohit
- Kummerlen Christine
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- Kunz Kevin
- Kurenda Catherine
- Kutsogiannis Demetrios
- Kuybida Yuriy
- Kwan Yvonne
- Kyeremeh Lynsey
- Kyle Laura
- L?Hotellier Sylvie
- Labbe Vincent
- Laffan Mike
- Laffey John
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- Lamontagne Francois
- Lampro Lamprini
- Landais Michaël
- Landoni Giovanni
- Landsiedel-Mechenbier Elke
- Lang Eva
- Langridge Emma
- Latham Victoria
- Latino Reece
- Laudi Svenja
- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
- Le Guen LenaĂŻg
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- Leaf David E.
- Lean Richard
- Leaver Susannah
- Leavis Helen
- Leblond Julie
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- Lee Kelvin
- Lee Stephanie
- Lee Stephen
- Lefevre Montaine
- Leffelaar Evelien
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- Lemaire-Brunel Delphine
- Lembo Rosalba
- Leparco CĂ©cile
- Leroyer Marie-Helene
- Lesona Eden
- Levett Chris
- Lewis Joanne
- Lewis Roger J.
- Lewis Sarah
- LewisProsser Lorraine
- Liao Angela
- Lim Rosario
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- Lindergard Gabriella
- Linnett Vanessa
- Linstrum Kelsey M.
- Litton Ed
- Litton Edward
- Liu Theresa
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- Lockett Teresa
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- Maquigneau Natacha
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- Marroquin Oscar
- Marsden Tracy
- Marsh Emma
- Marshall John C.
- Marshall Lucy
- Marten Nicole
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- Martin Emma
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- Massey Natalie
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- Mayak Katelyn
- Mayangao Irving
- Maynard Victoria
- Mayr Florian
- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
- McClintock Declan
- McConnochie Rachael
- McCracken Phoebe
- McCreary Erin
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- McCullagh Liz
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- McCullough James
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- McEldrew Ben
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- McGarry Karen
- McGhee Christopher
- McGlothlin Anna
- McGloughlin Steve
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- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
- McIntyre Lauralyn
- McKee Madeleine
- McKenna Shirley
- McKenna Sonia
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- Mclaughlan Danielle
- McMaster Moyra
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- McMillan Catherine
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- McMorrow Liam
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- McQuilten Zoe
- McVerry Bryan J.
- McWilliam Stephen
- Medhurst Laura
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- Meermeier Werner
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- Mehrtens Jan
- Mehta Reena
- Meijer Karina
- Menon David
- Mercier Emmanuelle
- Mercier Romain
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- Mew Louise
- Meyer Jason
- Mezher Chaouki
- Meziani Ferhat
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- Mguni Nhlanhla
- Michael Angiy
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- Morgan Matt
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- Mouncey Paul R.
- Mowery Brent
- Mrad Aymen
- Mtuwa Shelia
- Mukherjee Dipak
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- Naeem Anas
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- Naim Giulia
- Nair Priya
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- Nee Jens
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- Newman Julie
- Newman Tabitha
- Ng Anthony
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- Nguyen-Valat Thi-My-Hue
- Nichol Alistair D.
- Nicholier Tiphaine
- Nicholson Andrew
- Nicholson Anne
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- Oza Deepali
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- Panwar Rakshit
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- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
- Parker Jane C.
- Parker Lorraine
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- Raj Ashok
- Ralston Maximillian
- Ramakrishnan N
- Ramali Mohamed
- Ramamurthi Balaji
- Ramanan Mahesh
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- Rowan Kathryn M.
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- Sara Treena
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- Sathianathan Kushaharan
- Sathianathan Prasannakumari
- Saull Michelle
- Saunders Christina T.
- Saunderson Paula
- Sauras-ColĂłn Esther
- Saxena Manoj
- Sayada Sarah
- Sayehli Cyrus
- Scanlan Jeremy
- Scano Riccardo
- Schaaf Bernhard
- Schlegel Christian
- Schmidhofer Mark
- Schneider Francis
- Schoenling Andrew
- Scholl Denise
- Schotsman Joost
- Schouten Jeroen
- Schueler Robert
- Schuster-Bruce Martin
- Schutgens Roger
- Schweikert Sacha
- Scott Kathryn
- Scott Zoe
- Scully Michael
- Seaman Rebecca
- Seidel Antje
- Seidu Fatima
- Seigne Patick
- Sekiwala Rose
- Sellers Katharine
- Selmi Carlo
- Sement Arnaud
- Senya Ho
- Seppelt Ian
- Sernicola Elisa
- Serri Karim
- Sevilla Chanthou
- Seymour Christopher W.
- Shah Faraaz
- Shahid Tasnin
- Shaikh Arif
- Shaikh Mohiuddin
- Shakya Roshni
- Shankar-Hari Manu
- Sharma Deepak
- Shaw David
- Shaw Deborah
- Shaw Joanne
- Shearer Audrey
- Sheath Ben
- Sheffield Jonathan
- Shehabi Yahya
- Shekar Kiran
- Shelton Sarah
- Sherwood Nick
- Shetty Varun
- Shields Fiona
- Shimabukuro-Vornhagen Alexander
- Shintani Ayumi
- Shirley Kim
- Shovelton Charmaine
- Shree Madhu
- Shrestha Namrata
- Shrestha Sabita
- Shrestha Tapaswi
- Shu Ki Lok Jennifer
- Shyamsundar Murali
- Siami Shidasp
- Sibin Sindhu
- Sicat Christine
- Siddiqui Atif
- Siddiqui Ayesha
- Sidéris Georgios
- Siewerski Chris
- Siika Wangari
- Sikondari Nyma
- Silversides Jon
- Sim Malcolm
- Simmonds Catherine
- Simons Koen
- Simpson Benjamin
- Simpson Joanna
- Simpson Scott
- Simpson Tom
- Sinclair Julie-Ann
- Singh Jayaprakash
- Singh Rajeev
- Singh Vanessa
- Singler Karen
- Singleton Jo
- Sinha Pratik
- Skinner Denise
- Skinner Tabitha
- Skorko Agnieszka
- Skrtich Aimee
- Slaughter Melanie
- Slieker Kitty
- Sligl Wendy
- Sloan Andrew
- Sloots-Cuppen Sonja
- Small Charlotte
- Smallshaw Karen
- Smallwood Andrew
- Smee Joanna
- Smit Albertine
- Smith Alex
- Smith Catherine
- Smith Eleanor
- Smith Emma
- Smith John
- Smith Judith
- Smith Julie
- Smith Kerry
- Smith Lucie
- Smith Matthew
- Smith Natalie
- Smith Oliver
- Smith Paul
- Smith Simon
- Smith Tim
- Smuts Sara
- Smyth Kirsty
- Smyth Michelle
- Smyth Naoise
- Soar Natalie
- Solesbury Amanda
- Somerville Alastair
- Song Rima
- Soukup Jens
- Southern David
- Southin Sara
- Spain Sandra
- Speight Holly
- Spencer Kayleigh
- Spencer Stephen
- Spencer Thomas
- Speyer Rebecca
- Spiers Catriona
- Spittle Nick
- Spivey Michael
- Spong Adam
- Sprinckmoller Stefan
- Squires Rebecca
- Stambaugh Martha
- Stammers Katie
- Stanciu Delia
- Stanley Timothy
- Stanworth Simon
- Stapleton Liana
- Starke Lisa
- Stavor Dara
- Stedman Roger
- Steffen Melanie
- Stephanie Gelinotte
- Stephens Deanna
- Stevenson Lesley
- Stewart Richard
- Stienstra Riejanne
- Stone Sarah
- Stowe Bethan
- Stratton Emma
- Stronach Lucy
- Suber Tomeka
- Sukuraman Anila
- Summerfield Anna
- Summers Charlotte
- Sundaram Radha
- Sundaran Dhinesh
- Sunkara Krishna
- Surti Zuhra
- Sutherland Helen
- Sutherland Sara-Beth
- Sutterlin Laetitia
- Sutton Joanne
- Sutu Mihaela
- Sven?ek Franc
- Svit?kar Nikolai
- Swabe Jacqueline
- Sweet Katie
- Sy Eric
- Szakmany Tamas
- Szawarski Piotr
- Tai Charlotte
- Tait Jennifer
- Talia Nadine
- Tallott Mandy
- Tamm Tina
- Tamme Kadri
- Taqdees Huda
- Tarr Esther
- Tate Margaret
- Tatham Kate
- Tavares Silvia
- Taylor Holly
- Taylor Melanie
- Taylor Sian
- Tee Ameila
- Templeton Maie
- Teo Hoon
- Terrill Lenae
- The Stephanie
- Thedinga Karen
- Thomas Amy
- Thomas Ashly
- Thomas Emma
- Thomas Helen
- Thomas Matt
- Thomas Vicky
- Thompson Patricia
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Thurairatnam Saranya
- Tierney Carey
- Tinmouth Alan
- Tirot Patrice
- Tlayjeh Haytham
- Toffalo Sue
- Tolppa Timo
- Tomasi Enrico
- Tomlinson Helen
- Tong Steve
- Tong Steven
- Tony Kiran
- Totzke Juliane
- Touma Omar
- Towns Miriam
- Trapani Tony
- Trask Kara
- Traverse Eleanor
- Trickey Jemma
- Trim Fiona
- Trimmer Ken
- Triulzi Darrell
- Troeman Darren
- Trues Estefania
- Truman Nicholas
- Tsakiridou Kyriaki
- Tsang Jennifer
- Tsinaslanidis Georgios
- Tuckwell Caroline
- Tully Redmond
- Tully Riona
- Tung Raymond
- Tupper-Carey Daryl
- Turgeon Alexis F.
- Turki Salah
- Turner Anne M.
- Turner Elizabeth
- Turner Keri
- Turner-Bone Ian
- Turns Margaret
- TV Bharath
- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Ullmann Hannah
- Umrani Zulfiqar
- Unsworth Adam
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- Van Der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Haren Frank
- Van Hecke Jolien
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Zanten Arthur
- van Zuylen Tamara
- Van?t Hoff William
- Vandewoestyne Sophie
- Vanjak Christian
- Vanmali Piyush
- van Opdorp Marjolein
- van Vonderen Marit
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Veillard Marion
- Venkatesh Bala
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Vermont - van der Staaij Janine
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
- Viehman Alex
- Vieillard-Baron Antoine
- Vignesh C
- Villot Solenne
- VilĂĄ Clara
- Vincent Rachel
- Virdee Satwinder
- Visentin Elisa
- Visser Yorik
- Vita Tina
- Vivier Dominique
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Volkov Lev
- Voza Gennaro
- Vuylsteke Alain
- Wada Asako
- Waddington Natalia
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walker Susan
- Walsh Joanne
- Walsh Tim
- Walsham James
- Walton Catherine
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Watts Angela
- Waugh Victoria
- Webb Steve A.
- Weber Lisa
- Webster Denise
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Alan
- Wells Colin
- Wells Karen
- Welters Ingeborg
- West Lauren
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wijewardena Gayathri
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
- Williams Karen
- Williams Marie
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Surface topography induces 3D self-orientation of cells and extracellular matrix resulting in improved tissue function
- Author
- Alexandre Deschambeault
- Auger
- Bettinger
- Bhatia
- Bo Cui
- Brunette
- Bush
- Carrier
- Claude J. Giasson
- Cox
- Emmanuel Roy
- Endler
- Fay
- Francois A. Auger
- Gerecht
- Germain
- Girton
- Glawe
- Grenier
- Grenier
- Guido
- Guo
- Kalath
- Kaplan
- Komai
- Ksander
- Langer
- Laplante
- Lucie Germain
- LâHeureux
- Mandy B. Esch
- Maurice
- Maxime D. Guillemette
- Mehmet Toner
- Meier
- Michel Dumoulin
- Oakley
- OâConnell
- Patrick Carrier
- Pietak
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- Robert Gauvin
- Teixeira
- Teixeira
- Teodor Veres
- Vrana
- Zhao
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/2009
- Field of study
Elementos institucionais e desempenho da logĂstica de uma rede pĂșblica de assistĂȘncia farmacĂȘutica
- Author
- ABBAD GardĂȘnia
- BARNEY Jay
- BOLAND Tony
- BOWERSOX Donald J.
- BRESSER-PEREIRA Luiz Carlos
- BROUTHERS Keith D.
- CAI Shaohan
- CARONNA Carol A
- CASILE Maureen
- CHOPRA Sunil
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- COHEN Morris A.
- COSTA Gustavo P
- CROUCH Colin
- DEEG Richard
- DIMAGGIO Paul J.
- Dornier Philippe-Pierre
- GREENWOOD Royston
- HAIR Joseph F.
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- HE Xinming
- HENSELER Jörg
- HENSELER Jörg
- HUBER George P
- HULT G.
- HULT G.
- HURLEY Robert F.
- INOUE Keiko
- JACKSON Gregory
- KRAUSE Daniel R.
- LIANG Huigang
- MARTIN Graham P.
- MEEPETCHDEE Yongyut
- MEIXELL Mary J.
- MESQUITA Arlan M.
- MEYER John W.
- MEYER John W.
- MIEMCZYK Joe
- OAKLEY Christine
- OLIVER Christine
- POWELL Walter W
- PRADO Henrique S. A
- Regina CĂ©lia Nazar Fialho
- Ricardo S. Martins
- RINGLE Christian M.
- ROY Claude
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- SCOTT W
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- SELZNICK Philip
- SIMCHI-LEVI David
- TOLBERT Pamela S.
- TRIDAPALLI Juarez P.
- WEICK Karl E
- WETZELS Martin
- ZHANG Cheng
- ZHU Qinghua
- ZUCKER Lynne G
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
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- Van Oostayen Jacques A.
- Van Oostenbrugge Robert J
- Van Oostenbrugge Robert J.
- Van Rooij Willem Jan J.
- Van Vemde Gina
- Van Walderveen Marianne Aa
- Van Zwam Wim H
- Van Zwam Wim H.
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- Velasco Stephane
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- Vitello Nicolas
- Voguet Charlotte
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- Von Weitzel Mudersbach P
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- Vuillier Fabrice
- Wagner A
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- Wakhloo A
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- Wang Adrien
- Wanke I
- Wardlaw Joanna
- Watson Tw
- Watt M
- Watts M
- Weaver M
- Wechsler L
- Wechsler L
- Weill A
- Weill A
- Weimar C
- Weinstein C
- Weisman Dc
- Wermer Marieke Jh
- Weymayr F
- Whaley M
- Whelan R
- White Philip
- White Philip
- Wiegner R
- Wiertlewski Sandrine
- Wiese C
- Wiggam I
- Wijeratne Tissa
- Williams D
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- Williams J
- Willinsky Ra
- Willinsky Ra
- Wisco D
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- Wodarg F
- Wolff Valérie
- Wong Andrew
- Wong Jh
- Wong Jh
- Wong Kitty
- Wortmann G
- Wright Mr
- Wright Mr
- Wu Teddy Y
- Wunderlich S
- Yan Bernard
- Yanase L
- Yang V
- Yassi Nawaf
- Yavagal D
- Yavagal Dileep R
- Yavagal Dileep R.
- Yeo Ta
- Yger Marion
- Yoo Albert J
- Yoo J
- You Sj
- Young Dennis
- Yu Y
- Zacharatos H
- Zaidat O
- Zaidi S
- Zavanone Chiara
- Zech M
- Zegarac V
- Zerlauth Jean-baptiste
- Zimmel L
- Zuniga Paolo
- Zurasky J
- Publication venue
- 'Elsevier BV'
- Publication date
- 16/12/2017
- Field of study
Background:
General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care.
Methods:
For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered.
Findings:
Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09â2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75â3·10, p<0·0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1·53, 95% CI 1·14â2·04, p=0·0044). The risk of bias and variability between studies was assessed to be low.
Interpretation:
Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons
Effect of Antiplatelet Therapy on Survival and Organ SupportâFree Days in Critically Ill Patients With COVID-19
- Author
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Aguilar-Dano April
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Amri Ali
- Al Enezi Farhan
- Al Qasim Eman
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderink Bashar
- Alderman Meera
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Farisha
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Alqahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Amatya Sameena
- Ambrosino Richard
- Anders Jeanette
- Anderson Thomas
- Andreae Mark
- Andric Zdravko
- Angus Derek
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Apte Yogesh
- Arabi Yaseen
- Arachchige Malka
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Aryal Diptesh
- Asif Namra
- Aspinwall Angelique
- Attanayaka Udara
- Attokaran Antony
- Attwood Ben
- Au Carly
- Austin Karen
- Austin Pauline
- Avard Bronwyn
- Awan Sidra
- Azaiz Amine
- Azergui Nora
- Azzaui Harun
- Babel JakĆĄa
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Baillie Kenneth
- Bain William
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barbazza Leanne
- Barber Russell
- Barbier François
- Barge Deborah
- Bari Sara
- Bariola Ryan
- Barker Gareth
- Barnes Nicky
- Baron Rebecca
- Barreau Amelie
- Bart Robert
- Bartholdy Roland
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastola Sirjana
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- Bates Michelle
- Bates Samantha
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- Bauchmuller Kris
- Bean Sarah
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- Beer Deborah
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- Bergin Colin
- Berry Lindsay
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- Bewley Jeremy
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- de Bus Liesbet
- de Courcy-Golder Kim
- de Jong Menno
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- de Keulenaer Adrian
- de la Fuente Carmen
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- de Neef Mark
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- del Prado Michael
- del Sorbo Lorenzo
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- Duplaix Mathilde
- Dushianthan Ahilanandan
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- Ebenezer R
- Edwards Alexandra
- Effelaar Evelien
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eichinger Fred
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- Golden David
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- Homes Jennifer
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- Jayakumar Deva
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- Jenkins Samuel
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- Jha Avinash
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- Juhaz Vera
- Kadam Umesh
- Kalchko-Veyssal Selver
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- Kalogirou Michael
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- Katary Amro
- Kayani Abdul
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- Keeler Sheryl
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- Keet Owen
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- Kell Kay
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- Kendrick Sara
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- KovĂĄcs SĂĄndor
- Krajinovic Vladimir
- Kremling Julius
- KreĂ Gabriele
- Krishnamurthy Vinodh
- Krishnaoorthy S
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
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- Kwakkenbos-Craanen Marion
- Kyeremeh Lynsey
- Kyle Laura
- Labbe Vincent
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- Landsiedel-Mechenbier Elke
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- Lee Stephanie
- Lee Stephen
- Lefevre Montaine
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- Lemaire-Brunel Delphine
- Leparco CĂ©cile
- Lesona Eden
- Leszkoven JĂĄnos
- Lewis Joanne
- Lewis Roger
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- Liao Angela
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- Lother Sylvain
- Lowe Benjamin
- Lowery Maryalyce
- Lowrey Julie
- Lucas Rachael
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- Masood Sobia
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- Newman Sally
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- Yang Yang
- Yarad Elizabeth
- Yates David
- Yealy Donald
- Young Chelsea
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- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Äimoti Renata
- Publication venue
- American Medical Association
- Publication date
- 05/04/2022
- Field of study
International audienc
Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
- Author
- A Aceituno
- A Adams
- A Aghaebrahim
- A Alseraya
- A Anderson
- A Azizi
- A Balgude
- A Bauer
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- A Bhatt
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- Ludo F.M. Beenen
- Ludovic Morin
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- Lukas C. van Dijk
- M Alexandrou
- M AlHazzaa
- M Almekhlafi
- M Bain
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- M Bellew
- M Bendszus
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- M Boulton
- M Calderon-Arnulphi
- M Charif
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- M Cronquist
- M Crowe
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- M Dietzold
- M Eesa
- M Eesa
- M Eesa
- M Elhammady
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- M Guglielmetti
- M Hamberger
- M Hammer
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- M HernĂĄndez-PĂ©rez
- M HjĂžrringgaard
- M Hogan
- M Holtmannspötter
- M Horton
- M Howk
- M Jiménez
- M Jumaa
- M Kate
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- M Killer-Oberpfalzer
- M Kowarik
- M Lapierre
- M Lazzaro
- M Lindner
- M Lorenz
- M Martin
- M MartĂnez GaldĂĄmez
- M Maxwell
- M McCusker
- M McManus
- M MillĂĄn
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- M Möhlenbruch
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- M Weaver
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- Manon Kappelhof
- Marc Bintner
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- Mariana Sarov
- Marianne AA van Walderveen
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- Marie-HĂ©lĂšne Dugay
- Marie-HĂ©lĂšne Mahagne
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- Marieke JH Wermer
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- Mathieu Bataille
- Mathieu Sevin-Allouet
- Matthias Lamy
- Maurice Giroud
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- Michaël Obadia
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- Miriam Priglinger
- MJ Lee
- ML Koch
- Mohamed Aggour
- Monica Badve
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- N Akhtar
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- N Pitiyanuvath
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- N Rao
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- Nogueira
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- O Imoukhuede
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- P Beck
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- S Adatia
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- S Crandall
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- S Decesare
- S Dehkharghani
- S Dharmadhikari
- S Doppelheuer
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- S Streib
- S Subramaniam
- S Tateshima
- S Taudorf
- S Wunderlich
- S Zaidi
- S-I Sohn
- Sabrina Debruxelles
- Sal Lamin
- Sandra Felix
- Sandrine Deltour
- Sandrine Wiertlewski
- Sanjeev Nayak
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- Saver
- Saver
- SB Coutts
- Scott Brown
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- Sebastiaan F. de Bruijn
- Serge Bakchine
- Serge Bracard
- Serge Evrard
- Servane Mouton
- Sherisse Celestino
- Silvan Licher
- Silvia Pistocchi
- Simon Salinas
- SJ Kim
- SJ You
- Sjoerd F.M. Jenniskens
- Skye Coote
- SolĂšne De Gaalon
- Sophie Crozier
- Sophie Godard Ducceschi
- SR Belagaje
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- Stefan Vinken
- Stefanie Schipperen
- Steff Lewis
- Stephane Velasco
- Stephen M Davis
- Stephen M Davis
- Susan Day
- Sylvain Lachaud
- Sylvie Godon-Hardy
- SĂ©bastien Richard
- SĂ©bastien Richard
- SĂ©verine Debiais
- T Boeckh-Behrens
- T Coughlan
- T Daly
- T Daly
- T Davis
- T Devlin
- T Devlin
- T Galvin
- T Harbo
- T Hendrickson
- T Hyldal
- T Jeerakathil
- T Kahles
- T Krings
- T Larson
- T Lowenkopf
- T Lynch
- T Marotta
- T Meindl
- T Musuka
- T Nguyen
- T Reiff
- T Roberts
- T Sajobi
- T Sajobi
- T Scheibe-Mirek
- T Stavngaard
- T Stewart
- T Stewart
- T Stewart
- T Walsh
- TA Yeo
- Tae-Hee Cho
- Tanya Frost
- TB Kotylak
- Teddy Y Wu
- TG Jovin
- Thanh Phan
- Theo Stijnen
- Thibaud Lebouvier
- Thierry Moulin
- Thomas J Oxley
- Thomas Liebig
- Thomas Ritzenthaler
- Thomas Ronziere
- Thompson Robinson
- Tiemen van Boxtel
- Timo Krings
- Timothy Ang
- Timothy J Harrington
- Timothy J Kleinig
- Tiphaine Rouaud
- Tissa Wijeratne
- Tobien H.C.M.L. Schreuder
- Tommy Andersson
- Tony Goddard
- TS Field
- Tudor G Jovin
- Tudor G. Jovin
- TW Watson
- U Grzyska
- V Biberacher
- V Chang
- V Costalat
- V Deshmukh
- V Dubuc
- V Kalugdan
- V Nambiar
- V Obach
- V Pandey
- V Patel
- V Reddy
- V Snyder
- V Szeder
- V Totoraitis
- V Totoraitis
- V Yang
- V Zegarac
- VA Coté
- Valérie Domigo
- Valérie Wolff
- Vasdev Ashok
- Vincent Cahagne
- Vincent Costalat
- Vincent Guiraud
- Violaine Rouaud Jaffrenou
- Vitor Mendes Pereira
- VK Reddy
- W Clark
- W Holloway
- W Maloney
- W Montanera
- W Morgan
- W Pfeilschifer
- W Poon
- W Tekle
- Wade Smith
- Werner Hacke
- WF Morrish
- WF Morrish
- Willem Jan J. van Rooij
- Willy Struijk
- Wilma Pellikaan
- Wim H van Zwam
- Wim H. van Zwam
- Winston Chong
- Wintermark
- WJ Hicks
- WJ Montanera
- WJ Montanera
- Wouter J Schonewille
- X Ayrignac
- X Urra
- Xavier Barreau
- Xavier Ducrocq
- Xavier Leclerc
- Y Deschaintre
- Y Li
- Y Yu
- Yannick Bejot
- YD Kim
- Yince Loh
- Yves Chau
- Yves Samson
- Yvo B W E M Roos
- Yvo B.W.E.M. Roos
- Z El-Zammar
- Z Khawaja
- Zofia Ross
- Zoltan Szatmary
- Zwenneke Flach
- Publication venue
- 'Elsevier BV'
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