Survey and Experimental Testing of Nongravimetric Mass Measurement Devices

Documentation presented describes the design, testing, and evaluation of an accelerated gravimetric balance, a low mass air bearing oscillator of the spring-mass type, and a centrifugal device for liquid mass measurement. A direct mass readout method was developed to replace the oscillation period readout method which required manual calculations to determine mass. A protoype 25 gram capacity micro mass measurement device was developed and tested

Electrical termination techniques

A technical review of high reliability electrical terminations for electronic equipment was made. Seven techniques were selected from this review for further investigation, experimental work, and preliminary testing. From the preliminary test results, four techniques were selected for final testing and evaluation. These four were: (1) induction soldering, (2) wire wrap, (3) percussive arc welding, and (4) resistance welding. Of these four, induction soldering was selected as the best technique in terms of minimizing operator errors, controlling temperature and time, minimizing joint contamination, and ultimately producing a reliable, uniform, and reusable electrical termination

Technology and Regional Development in the American Context

Many large cities in the developed countries have recently experienced a slow-down of growth, and in some cases, absolute contraction of their population size. These trends pertain in particular to old industrial agglomerations which often fail to adapt to the changing demands and locational requirements of modern production facilities and to differentiate their employment structure. Interrelations between industrial restructuring and urban regional change were among topics studied in the former Human Settlements and Services Area at IIASA. They are also of current research interest to the Regional and Urban Development Group. The paper by J. Rees, H. Stafford, R. Briggs and R. Oakey touches on several aspects of those interdependencies, especially the question of how do high-technology complexes develop over space. Part II of the paper has been done within a framework of an international collaboration project involving similar studies in the U.K. and F.R.G. and coordinated by Professor John Goddard of Newcastle, U.K

Measuring lateral heat flux across a thermohaline front: A model and observational test

We develop and test a method to observationally estimate lateral intrusive heat flux across a front. The model combines that of Joyce (1977), in which lateral cross-frontal advection by intrusions creates vertical temperature gradients, and Osborn and Cox (1972) in which vertical mixing of those gradients creates thermal microstructure that is dissipated by molecular conduction of heat. Observations of thermal microstructure dissipation χT are then used to estimate the production by intrusions, and hence the lateral heat flux and diffusivity. This method does not depend on the precise mechanism(s) of mixing, or on the dynamical mechanisms driving the frontal intrusions. It relies on several assumptions: (1) lateral cross-frontal advection produces diapycnal temperature gradients that are mixed locally, (2) thermal variance is dissipated locally and not exported, (3) intrusion scales are larger than turbulence scales, and (4) isotropy of temperature microstructure is assumed in order to estimate χT.The method is tested using microstructure observations in Meddy Sharon, where the erosion rate and associated lateral heat flux are known from successive mesoscale hydrographic observations (Hebert et al., 1990). An expression is developed for the production (lateral heat flux times lateral temperature gradient, expected to equal χT) in a front of steady shape that is eroding (detraining) at a steady rate; the production is proportional to the erosion speed and the square of the cross-frontal temperature contrast, both of which are well-known from observations. The qualitative structure and integrated value of the dissipation agree well with model assumptions and predictions: thermal variance produced by lateral intrusive heat flux is dissipated locally, dissipation in intrusive regions dominates total dissipation, and the total dissipation agrees with the observed erosion rate, all of which suggests that microstructure observations can be used to estimate intrusive heat flux. A direct comparison was made between lateral heat flux estimated from mesoscale Meddy structure plus the known rate of erosion, and lateral flux based on microscale temperature dissipation, with excellent agreement in the frontal zone and poorer agreement where lateral temperature gradient is too small to accurately measure

Chromosome-wide identification of novel imprinted genes using microarrays and uniparental disomies

Genomic imprinting refers to a specialized form of epigenetic gene regulation whereby the expression of a given allele is dictated by parental origin. Defining the extent and distribution of imprinting across genomes will be crucial for understanding the roles played by imprinting in normal mammalian growth and development. Using mice carrying uniparental disomies or duplications, microarray screening and stringent bioinformatics, we have developed the first large-scale tissue-specific screen for imprinted gene detection. We quantify the stringency of our methodology and relate it to previous non-tissue-specific large-scale studies. We report the identification in mouse of four brain-specific novel paternally expressed transcripts and an additional three genes that show maternal expression in the placenta. The regions of conserved linkage in the human genome are associated with the Prader–Willi Syndrome (PWS) and Beckwith–Wiedemann Syndrome (BWS) where imprinting is known to be a contributing factor. We conclude that large-scale systematic analyses of this genre are necessary for the full impact of genomic imprinting on mammalian gene expression and phenotype to be elucidated

Stirring by small-scale vortices caused by patchy mixing

Author Posting. © American Meteorological Society, 2005. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 35 (2005): 1245-1262, doi:10.1175/JPO2713.1.Evidence is presented that lateral dispersion on scales of 1–10 km in the stratified waters of the continental shelf may be significantly enhanced by stirring by small-scale geostrophic motions caused by patches of mixed fluid adjusting in the aftermath of diapycnal mixing events. Dye-release experiments conducted during the recent Coastal Mixing and Optics (CMO) experiment provide estimates of diapycnal and lateral dispersion. Microstructure observations made during these experiments showed patchy turbulence on vertical scales of 1–10 m and horizontal scales of a few hundred meters to a few kilometers. Momentum scaling and a simple random walk formulation were used to estimate the effective lateral dispersion caused by motions resulting from lateral adjustment following episodic mixing events. It is predicted that lateral dispersion is largest when the scale of mixed patches is on the order of the internal Rossby radius of deformation, which seems to have been the case for CMO. For parameter values relevant to CMO, lower-bound estimates of the effective lateral diffusivity by this mechanism ranged from 0.1 to 1 m2s−1. Revised estimates after accounting for the possibility of long-lived motions were an order of magnitude larger and ranged from 1 to 10 m2s−1. The predicted dispersion is large enough to explain the observed lateral dispersion in all four CMO dye-release experiments examined.The Coastal Mixing and Optics dye studies were funded by the Office of Naval Research under Grants N00014-95-1-0633 (tracer experiments) and N00014-95-1-1063 (AASERT fellowship). Additional analysis was also performed under ONR Grant N00014-01-1-0984

Estimation in a multiplicative mixed model involving a genetic relationship matrix

Genetic models partitioning additive and non-additive genetic effects for populations tested in replicated multi-environment trials (METs) in a plant breeding program have recently been presented in the literature. For these data, the variance model involves the direct product of a large numerator relationship matrix A, and a complex structure for the genotype by environment interaction effects, generally of a factor analytic (FA) form. With MET data, we expect a high correlation in genotype rankings between environments, leading to non-positive definite covariance matrices. Estimation methods for reduced rank models have been derived for the FA formulation with independent genotypes, and we employ these estimation methods for the more complex case involving the numerator relationship matrix. We examine the performance of differing genetic models for MET data with an embedded pedigree structure, and consider the magnitude of the non-additive variance. The capacity of existing software packages to fit these complex models is largely due to the use of the sparse matrix methodology and the average information algorithm. Here, we present an extension to the standard formulation necessary for estimation with a factor analytic structure across multiple environments