A Surprisingly Non-attractiveness of Commercial Poison Baits to Newly Established Population of White-Footed Ant, Technomyrmex brunneus (Hymenoptera: Formicidae), in a Remote Island of Japan

The white-footed ant, Technomyrmex brunneus, was newly introduced and established in a remote island of Japan and has caused unacceptable damage to the daily life of residents. To establish proper control measures, the present study investigated whether T. brunneus is effectively attracted to commercially available poison baits used to exterminate common household pest ants and the Argentine ant in Japan. Cafeteria experiments using three types of nontoxic baits and eight types of commercial poison baits for ants were conducted in the field, and the attractiveness was compared among the baits. The liquid poison bait “Arimetsu,” which consists of 42.6% water, 55.4% sugar, and 2.0% borate, and nontoxic 10% (w/v) sucrose water showed the highest attractiveness. On the other hand, other commercial poison baits were not as attractive. Therefore, sucrose liquid is the most effective attractive component to use in poison baits for T. brunneus

Afatinib Prolongs Survival Compared with Gefitinib in an Epidermal Growth Factor Receptor-Driven Lung Cancer Model

An irreversible ErbB family blocker is expected to inhibit tumors with activating epidermal growth factor receptor (EGFR) mutations more strongly than reversible EGFR tyrosine kinase inhibitors and to overcome acquired resistance to the T790M secondary mutation. Eleven-week-old transgenic mice with Egfr exon 19 deletion mutation were treated with afatinib, gefitinib, or vehicle for 4 weeks. All mice were sacrificed at 15 weeks of age, and the number of superficial left lung tumors with a long axis exceeding 1 mm was counted. The afatinib-treated group had significantly fewer tumors than the vehicle group (P < 0.01) and tended to have fewer tumors than the gefitinib-treated group (P = 0.06). Pathologically, gefitinib-treated mice had clearer, more nodular tumors than afatinib-treated mice. Immunoblotting showed that afatinib suppressed not only pEGFR but also pHER2, and induced apoptosis for longer periods than gefitinib. Subsequently, when each drug was administered 5 days per week until death, afatinib significantly enhanced mouse survival compared with gefitinib (median survival time: 456 days vs. 376.5 days; log-rank test, P < 0.01). Finally, the combination of afatinib with bevacizumab was found to be superior to either drug alone in exon 19 deletion/T790M and L858R/T790M xenograft tumors. Overall, afatinib was more potent than gefitinib in tumors harboring an exon 19 deletion mutation, and the combination of afatinib with bevacizumab efficiently suppressed tumors harboring the T790M secondary mutation

Effect of a Domain Wall on the Conductance Quantization in a Ferromagnetic Nanowire

The effect of the domain wall (DW) on the conductance in a ballistic ferromagnetic nanowire (FMNW) is revisited by exploiting a specific perturbation theory which is effective for a thin DW; the thinness is often the case in currently interested conductance measurements on FMNWs. Including the Hund coupling between carrier spins and local spins in a DW, the conductance of a FMNW in the presence of a very thin DW is calculated within the Landauer-B\"{u}ttiker formalism. It is revealed that the conductance plateaus are modified significantly, and the switching of the quantization unit from $e^2/h$ to ``about $2e^2/h$'' is produced in a FMNW by the introduction of a thin DW. This accounts well for recent observations in a FMNW.Comment: 5 pages, 2 figures, Corrected typos and added reference

Risk Management Function and Risk Communication in Hospital : Case of St. Marianna University School of Medicine Hospital

本稿では,近年,企業で取り組みが顕著となっている「リスクマネジメントの組織体制の構築」と「リスク情報の開示(リスク・コミュニケーション)」が医療機関においてどのように展開されているかについて検討を加える.まず第一に,理論的なフレームワークを提示する目的で,企業における「リスクマネジメントの組織体制構築」と「リスク情報の開示(リスク・コミュニケーション)」の動向をまとめる.第二に,企業リスクマネジメントのフレームワークにあてはめて,医療機関のリスクマネジメントについて検討を加える.第三に,聖マリアンナ医科大学病院における臓器移植体制構築の事例を考察する.In this study, we initially present the framework of business risk management mainly that of risk management function and risk information disclosure (risk communication). Secondly, based on the framework of business risk management, we analyze (1) how risk management function should be organized and (2) how risk communication should be carried out within the hospital. Lastly we present a case study of the organ transplant practice in St. Marianna University School of Medicine Hospital

An Evaluation of the Safety and Feasibility of Adenosine-assisted Clipping Surgery for Unruptured Cerebral Aneurysms: Study Protocol

The effectiveness of adenosine-induced flow arrest in surgical clipping for the cerebral aneurysms with difficulties in temporary clip placement to the proximal main trunk has been reported. This is the first clinical trial to evaluate the safety and feasibility of adenosine-assisted clipping surgery for unruptured cerebral aneurysms (UCAs) in Japan. The inclusion criteria are as follows: patients over 20 years old, patients who agree to be enrolled in this study after providing informed consent, patients who undergo clipping surgery for UCA in our institute, and patients in whom the surgeons (T.H. or I.D.) judge that decompression of the aneurysm is effective. The primary endpoint is a modified Rankin Scale (mRS) score 30 days after surgery. We plan to enroll 10 patients in this study. The original protocol of adenosine administration was established in this trial. Herein, we present the study protocol

Study of plastic scintillator based reactor neutrino detector

Recently nuclear power plant becomes one of the important electric power sources to reduce the greenhouse gasses emission. Nuclear reactor fuel consists of the uranium-235 (235U) enriched uranium and produces the thermal energy via nuclear fission process. Through the reactor operation, uranium-238 (238U) fission also produces the plutonium- 239 (239Pu), which should be strictly under controlled to avoid the diversion to the nuclear weapon for a nonproliferation and safeguard. At this point, monitoring of the nuclear power plant operation and its fuels exchange have important role for the peaceful nuclear energy usage. In this study, we produce the prototype of nuclear reactor monitor based on the plastic scintillator detecting anti-neutrinos, which produced through the several times of beta-decay from the nuclear fission products. In addition, we apply the monitoring performance simulation assuming the 1 ton size detector placed very closely to the reactor core

Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles

Recent studies have suggested that CD8+ liver-resident memory T (TRM) cells are crucial in the protection against liver-stage malaria. We used liver-directed mRNA-containing lipid nanoparticles (mRNA-LNPs) to induce liver TRM cells in a murine model. Single-dose intravenous injections of ovalbumin mRNA-LNPs effectively induced antigen-specific cytotoxic T lymphocytes in a dose-dependent manner in the liver on day 7. TRM cells (CD8+ CD44hi CD62Llo CD69+ KLRG1-) were induced 5 weeks after immunization. To examine the protective efficacy, mice were intramuscularly immunized with two doses of circumsporozoite protein mRNA-LNPs at 3-week intervals and challenged with sporozoites of Plasmodium berghei ANKA. Sterile immunity was observed in some of the mice, and the other mice showed a delay in blood-stage development when compared with the control mice. mRNA-LNPs therefore induce memory CD8+ T cells that can protect against sporozoites during liver-stage malaria and may provide a basis for vaccines against the disease