Prevalência de fatores de risco coronariano em praticantes de futebol recreacional

Verificar a prevalência dos fatores de risco coronariano em praticantes de futebol recreacional e comparar o risco coronariano de acordo com a faixa etária. Avaliaram- se 201 homens que praticavam futebol recreacionalmente, com idade média de 25.3 ± 6.0 anos. Todos responderam ao questionário RISKO, que é um questionário contendo 8 fatores de risco, sendo o risco coronariano representado pela soma dos escores obtidos nos 8 fatores de risco. O tratamento estatístico constou da exploração descritiva e da ANOVA oneway, com post hoc Tuckey, para comparação entre as faixas etárias. Adotou- se um nível de significância de p < 0.05. O escore médio de risco coronariano encontrado foi de 18.22 ± 3.49 pontos (12- 29 pontos), classificado como risco médio. Em relação às faixas etárias o risco coronariano médio obtido foi de: 16.58 ± 3.11 pontos para os indivíduos entre 18- 20 anos; 18.21 ± 3.08 pontos para aqueles entre 21- 30 anos; 20.58 ± 3.89 pontos para os sujeitos entre 31- 40 anos; e 21.00 ± 4.53 para aqueles com idade superior a 40 anos. Em relação a cada fator de risco isoladamente, as prevalências observadas, em ordem decrescente, foram: excesso de peso (44.78%), sedentarismo (38.31%), hipercolesterolemia (24.38%), tabagismo (17.41%), hereditariedade (12.94%) e hipertensão (8.46%). Os fatores de risco coronariano mais prevalentes nos praticantes de futebol recreacional foram o excesso de peso, o sedentarismo e a hipercolesterolemia, apresentando classificação de risco médio e crescimento com o aumento da idade, sobretudo após os 31 anos.Investigar la prevalencia de factores de riesgo coronario en jugadores recreacionales de fútbol y comparar el riesgo coronario según grupo de edad. Métodos: Se evaluaron 201 hombres que practicaban fútbol de forma recreativa, con edad media de 25.3 ± 6.0 años. Todos respondieron el cuestionario RISKO, que contiene 8 factores de riesgo y representándose el riesgo coronario por la suma de las puntuaciones obtenidas en los 8 factores. El análisis estadístico incluyó descripción de los datos y ANOVA one way, con post hoc Tukey, para comparaciones entre grupos de edad, con nivel de significación de p < 0.05. Se encontró una media de puntuación de riesgo coronario de 18.22 ± 3.49 puntos (12- 29 puntos), que se clasifica como riesgo medio. En cuanto a grupos de edad el riesgo coronario reportado fue de 16.58 ± 3.11 puntos para los individuos del grupo 18- 20 años, 18.21 ± 3.08 puntos para 21- 30 años, 20.58 ± 3.89 puntos para 31- 40 años, y 21.00 ± 4.53 para los mayores de 40 años. Para cada factor de riesgo, la prevalencia observada, en orden descendente, fue: sobrepeso (44.78%), inactividad física (38.31%), hipercolesterolemia (24.38%), tabaquismo (17.41%), herencia (12.94%) e hipertensión (8.46%). Los factores de riesgo coronario de mayor prevalencia en los jugadores recreacionales de fútbol fueron la inactividad física, el sobrepeso y la hipercolesterolemia, con una clasificación de riesgo medio y con aumento del riesgo con la edad, especialmente después de 31 años.To determine the prevalence of coronary risk factors in recreational soccer players and compare the coronary risk according to age. Methods: 201 men who practiced soccer recreationally eere evaluated, with a mean age of 25.26 ± 5.96 years. All individuals answered the questionnaire RISKO, which is a questionnaire containing eight risk factors. The coronary risk is represented by the sum of the scores obtained in the eight risk factors. Statistical analysis consisted of descriptive exploration and one way ANOVA with post hoc Tukey, to compare coronary risk between age groups. We adopted a significance level of p < 0.05. The mean coronary risk was 18.22 ± 3.49 points (12- 29 points), classified as medium risk. Regarding age groups the mean coronary risk obtained was: 16.58 ± 3.11 points for individuals between 18 and 20 years; 18.21 ± 3.08 points for those between 21 and 30 years, 20.58 ± 3.89 points for subjects between 31 and 40 years, and 21.00 ± 4.53 for those aged over 40 years. For each risk factor, the prevalence observed in descending order, was: overweight (44.78%), physical inactivity (38.31%), hypercholesterolemia (24.38%), smoking (17.41%), inheritance (12.94%) and hypertension (8.46%). The coronary risk factors more prevalent in recreational soccer players were overweight, physical inactivity and hypercholesterolemia, showing increased with increasing age, especially after 31 years

Desempenho do consórcio entre repolho e rabanete com pré-cultivo de crotalária, sob manejo orgânico.

Foram conduzidos dois experimentos no Sistema Integrado de Produção Agroecológica, em Seropédica, (RJ), durante dois anos consecutivos. O objetivo foi avaliar o desempenho do consórcio entre as culturas de repolho e rabanete com pré-cultivo de crotalária, sob manejo orgânico. Usou-se delineamento experimental de blocos ao acaso com sete repetições, em parcelas subdivididas, representando um fatorial 2 x 3, sendo o primeiro fator o pré-cultivo, com Crotalaria juncea e pousio (vegetação espontânea); e o segundo fator o sistema de cultivo (consórcio entre repolho e rabanete e os respectivos monocultivos). Não houve diferença significativa no tocante à produtividade do repolho ou rabanete, entre C. juncea e pousio, independentemente do tipo de manejo (monocultivos ou consórcio). O desenvolvimento do repolho não foi influenciado pela presença do rabanete, no consórcio entre essas espécies sob cultivo orgânico. O rabanete sob consórcio apresentou redução no diâmetro médio, massa média e produtividade de raízes, sem, contudo,desqualificar o padrão comercial das raízes colhidas. Considerando a média dos dois anos experimentais, o IEA atingiu 1,59, o que indicou a viabilidade do consórcio, otimizando práticas culturais, incluindo adubação,capina e irrigação

Electrochemical behavior of Ti/Al2O3 interfaces produced by diffusion bonding

In the field of biomedical applications a special interest exists regarding the study of the physicochemical and mechanical behaviour of materials, with special focus on the electrochemical degradation of metal/ceramic interfaces. In fact, etal/ceramic interfaces may be present in several biomedical devices, ranging from external or implantable sensors, to dental implants. Diffusion bonding represents an important technique since, in opposition to other production technologies, such as active metal brazing, avoid the possible liberation of certain chemical components harmful to health. The aim of this work is to study the electrochemical degradation of the interface formed between commercially pure Ti and Al2O3 produced by diffusion bonding, in contact with a physiological solution. The present approach included the evaluation of the contribution of individual and pairs of interfacial layers on the global degradation processes. For this propose d.c. electrochemical techniques were used to monitor the open-circuit potential, and to perform potentiodynamic polarization and galvanic corrosion evaluation. Also, electrochemical impedance spectroscopy was used as a complementary technique of the corrosion behaviour of the interface. Chemical composition and morphology of samples and corrosion products were evaluated by SEM and EDS analysis. According to experimental results, two principal reaction layers were formed in the interface: TiAl and Ti3Al. The TiAl layer appears to be the responsible for the strong increase in corrosion rate of the interface.Fundação para a Ciência e Tecnologia -POCTI/CTM/33384/2000; SFRH/BPD/ 5518/2001

The holographic superconductors in higher-dimensional AdS soliton

We explore the behaviors of the holographic superconductors at zero temperature for a charged scalar field coupled to a Maxwell field in higher-dimensional AdS soliton spacetime via analytical way. In the probe limit, we obtain the critical chemical potentials increase linearly as a total dimension $d$ grows up. We find that the critical exponent for condensation operator is obtained as 1/2 independently of $d$, and the charge density is linearly related to the chemical potential near the critical point. Furthermore, we consider a slightly generalized setup the Einstein-Power-Maxwell field theory, and find that the critical exponent for condensation operator is given as $1/(4-2n)$ in terms of a power parameter $n$ of the Power-Maxwell field, and the charge density is proportional to the chemical potential to the power of $1/(2-n)$.Comment: LaTeX, 16 pages, 5 figures, typos corrected, one reference added, version to appear in European Physical Journal

Metabolic Alterations in Experimental Autoimmune Encephalomyelitis in Mice: Effects of Prior Physical Exercise

Experimental autoimmune encephalomyelitis (EAE) induces significant reduction of the body mass concomitant to sickness behavior and anorexia. We investigated whether regular physical exercise prevents metabolic alterations associated with loss of the body mass occurring during an EAE inflammatory peak. Female C57BL/6 mice were assigned to the unexercised and exercise-trained groups. In four weeks, EAE was induced in half of the animals in each group, and the exercise protocol was maintained onto 10 days post-induction (10 dpi) completing 6 weeks of regular exercise (forced swimming). At 14 dpi, the relative mass of metabolic tissues, serum levels of triglycerides, cholesterol, and glucose, glycogen contents in the muscle and liver, and muscle levels of cytokines were measured. A significantly decreased clinical score associated with attenuation of the body mass loss in exercised EAE animals, as compared to the non-exercised ones, were observed. The associated metabolic parameters were not modified by this approach, although negative correlations between some parameters and clinical score at 14 dpi were observed. Although the prior program of aerobic exercise is capable of decreasing clinical score and body mass loss, it is not sufficient to crucially modify metabolic outcomes associated with inflammation at the EAE peak.Експериментальний аутоімунний енцефаломієліт (ЕАЕ) викликає істотне зменшення маси тіла, зумовлене хворобливою поведінкою та анорексією. Ми досліджували, чи можуть регулярні фізичні вправи запобігати метаболічним змінам і втраті маси тіла в перебігу запального періоду ЕАЕ. Миші-самиці лінії C57BL/6 були поділені на «нетреновану» та «треновану» групи. Через чотири тижні у половини тварин кожної групи індукували ЕАЕ, і протокол тренувань підтримувався ще 10 днів після індукції цього захворювання. Як тренування використовували примусове плавання. На 14-й день після індукції ЕАЕ у відповідній групі всі миші піддавались евтаназії; вимірювали відносну масу метаболічнозалежних тканин, рівні тригліцеридів, холестеролу та глюкози в сироватці крові, вміст глікогену в м’язах та печінці та рівні цитокінів у м’язах. У «тренованих» тварин з ЕАЕ виявлялося вірогідне зменшення оцінки інтенсивності захворювання порівняно з відповідним значенням у «нетренованих» мишей; це було асоційоване з обмеженням втрати маси тіла. У використаному варіанті експерименту зміни метаболічних параметрів у «тренованих» і «нетренованих» тварин істотно не розрізнялись, але на 14-й день спостерігалися негативні кореляції між деякими параметрами та клінічними оцінками. Отже, програма попереднього аеробного тренування здатна забезпечувати зменшення як клінічної інтенсивності ЕАЕ, так і відносної втрати маси тіла. Проте цей захід не є достатнім, щоб кардинально модифікувати метаболічні наслідки, пов’язані із запаленням на максимумі ЕАЕ

Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome

Noncoding RNAs play regulatory roles in physiopathology, but their involvement in neurodevelopmental diseases is poorly understood. Rett syndrome is a severe, progressive neurodevelopmental disorder linked to loss-of-function mutations of the MeCP2 gene for which no cure is yet available. Analysis of the noncoding RNA profile corresponding to the brain-abundant circular RNA (circRNA) and transcribed-ultraconserved region (T-UCR) populations in a mouse model of the disease reveals widespread dysregulation and enrichment in glutamatergic excitatory signaling and microtubule cytoskeleton pathways of the corresponding host genes. Proteomic analysis of hippocampal samples from affected individuals confirms abnormal levels of several cytoskeleton-related proteins together with key alterations in neurotransmission. Importantly, the glutamate receptor GRIA3 gene displays altered biogenesis in affected individuals and in vitro human cells and is influenced by expression of two ultraconserved RNAs. We also describe post-transcriptional regulation of SIRT2 by circRNAs, which modulates acetylation and total protein levels of GluR-1. As a consequence, both regulatory mechanisms converge on the biogenesis of AMPA receptors, with an effect on neuronal differentiation. In both cases, the noncoding RNAs antagonize MeCP2-directed regulation. Our findings indicate that noncoding transcripts may contribute to key alterations in Rett syndrome and are not only useful tools for revealing dysregulated processes but also molecules of biomarker value