Оценка клинической эффективности щадящей и стандартной панретинальной лазеркоагуляции сетчатки при непролиферативной диабетической ретинопатии

We have shown that the classical panretinal laser coagulation is a rather traumatic procedure, damaging all layers of the retina, leadingbto a narrowing of visual fields and decrease the electrical activityof the retina that can impair quality of life. Using sparing laser coagulation is a highly effective metod of prolonged of visual function.Проведено сравнительное исследование вариантов лазеркоагуляции сетчатки при сахарном диабете. Установлено, что стандартная панретинальная лазеркоагуляция является достаточно травматичной процедурой, повреждающей все слои сетчатки, приводящей к сужению полей зрения и снижению электрической активности сетчатки, ухудшающим качество жизни пациента. Щадящая (субпороговая) лазеркоагуляция сетчатки является высокоэффективным методом длительного сохранения зрительных функций

Project-oriented technology for formation of professional competence due to interdisciplinary connections

На примере одной из дисциплин архитектурно-градостроительного направления творческого вуза демонстрируется применение проектно-ориентированных технологий, опирающихся на обширную коллекцию трехмерных моделей реального предприятия. Это позволяет установить межпредметные связи для формирования профессиональных компетенций.On the example of one of the disciplines of Architecture and urban areas we show the usage of project-oriented technologies, based on an extensive collection of three-dimensional models of real company. This approach allows to set the interdisciplinary communication for the formation of professional competencies

The Orbital Order Parameter in La0.95Sr0.05MnO3 probed by Electron Spin Resonance

The temperature dependence of the electron-spin resonance linewidth in La0.95Sr0.05MnO3 has been determined and analyzed in the paramagnetic regime across the orbital ordering transition. From the temperature dependence and the anisotropy of linewidth and $g$-value the orbital order can be unambiguously determined via the mixing angle of the wave functions of the $e_{\rm g}$-doublet. The linewidth shows a similar evolution with temperature as resonant x-ray scattering results

Математические аспекты течения внутриглазной жидкости

It is shown that the process of establishing the equilibrium concentration of ions is exponential. But very small value of exponent leads to the fact that the ion concentration practically does not change at all reasonable times the values of diffusion, the possible changes as it lies within the experimental error of measurement.В работе показано, что процесс установления равновесной концентрации ионов носит экспоненциальный характер. Однако очень малое значение показателя экспоненты приводит к тому, что концентрация ионов практически не меняется при всех разумных значениях времен диффузии, возможные же ее изменения лежат в пределах экспериментальной погрешности измерения

Medicine and improvement in the Scots Magazine; and Edinburgh Literary Miscellany, 1804-17

Megan Coyer’s chapter engages with periodical print as a vehicle for an improving medical culture in Scotland, concentrating on the second series of the Scots Magazine. Coyer demonstrates how the Scottish press often complemented improving civic initiatives like the Edinburgh Lunatic Asylum campaign. She focuses attention on the distinctive national dynamics associated with medical improvement efforts in early nineteenth-century Scotland, with the Scots Magazine ‘providing a public forum for the expression of a national medical identity’. This identity, as Coyer shows, had an ideology of improvement at its core. This work recovers the cultural significance of the Scots Magazine as ‘the third major player in popular periodical culture in Romantic-era Scotland’; a status overshadowed by the recent critical attention devoted to the second Edinburgh Review and Blackwood’s in Scottish Romantic studies. Coyer also shows how the efforts of public health reformers highlight the complexity of improvement as both a material and moral process. She argues that print efforts dedicated to improving public health represent a ‘discursive strand in the magazine identifying a lack of cleanliness … as a moral and material blight on an otherwise improving Scottish society’. This bringing together of moral and practical aspects of improvement in the Scots also finds expression in the magazine’s series of Scottish medical biographies, whose narratives, Coyer notes, provide ‘ideal exemplars of lives dedicated to a culture of improvement’

СИНДРОМ АЛАЖИЛЛЯ В КЛИНИЧЕСКОЙ ПРАКТИКЕ

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Current status and future opportunities for serial crystallography at MAX IV Laboratory

Over the last decade, serial crystallography, a method to collect complete diffraction datasets from a large number of microcrystals delivered and exposed to an X-ray beam in random orientations at room temperature, has been successfully implemented at X-ray free-electron lasers and synchrotron radiation facility beamlines. This development relies on a growing variety of sample presentation methods, including different fixed target supports, injection methods using gas-dynamic virtual-nozzle injectors and high-viscosity extrusion injectors, and acoustic levitation of droplets, each with unique requirements. In comparison with X-ray free-electron lasers, increased beam time availability makes synchrotron facilities very attractive to perform serial synchrotron X-ray crystallography (SSX) experiments. Within this work, the possibilities to perform SSX at BioMAX, the first macromolecular crystallography beamline at MAX IV Laboratory in Lund, Sweden, are described, together with case studies from the SSX user program: an implementation of a high-viscosity extrusion injector to perform room temperature serial crystallography at BioMAX using two solid supports - silicon nitride membranes (Silson, UK) and XtalTool (Jena Bioscience, Germany). Future perspectives for the dedicated serial crystallography beamline MicroMAX at MAX IV Laboratory, which will provide parallel and intense micrometre-sized X-ray beams, are discussed

New Assembly, Reannotation and Analysis of the Entamoeba histolytica Genome Reveal New Genomic Features and Protein Content Information

Entamoeba histolytica is an anaerobic parasitic protozoan that causes amoebic dysentery. The parasites colonize the large intestine, but under some circumstances may invade the intestinal mucosa, enter the bloodstream and lead to the formation of abscesses such amoebic liver abscesses. The draft genome of E. histolytica, published in 2005, provided the scientific community with the first comprehensive view of the gene set for this parasite and important tools for elucidating the genetic basis of Entamoeba pathogenicity. Because complete genetic knowledge is critical for drug discovery and potential vaccine development for amoebiases, we have re-examined the original draft genome for E. histolytica. We have corrected the sequence assembly, improved the gene predictions and refreshed the functional gene assignments. As a result, this effort has led to a more accurate gene annotation, and the discovery of novel features, such as the presence of genome segmental duplications and the close association of some gene families with transposable elements. We believe that continuing efforts to improve genomic data will undoubtedly help to identify and characterize potential targets for amoebiasis control, as well as to contribute to a better understanding of genome evolution and pathogenesis for this parasite