Hydrochimie des eaux de surface de la région d’Adiaké (sud-est côtier de la Côte d’Ivoire)

Objectif : Évaluer la qualité physicochimique des eaux de surface de la région d’Adiaké (sud-est côtier de la Côte d’Ivoire) et expliquer les phénomènes à l’origine de la minéralisation de ces eaux.Méthodologie and résultats : Dix-sept paramètres physico-chimiques sont déterminés pour chacun des 7 échantillons d’eaux. Les résultats sont traités à l’aide de méthodes hydrochimiques (diagramme de Piper) pour l’étude de la typologie des eaux et des techniques d’analyse statistique multivariée. L’Analyse en Composantes Principales Normées (ACPN) et l’analyse en Classification Hiérarchique Ascendante (CHA) sont utilisées pour mettre en évidence respectivement les phénomènes à l’origine de la minéralisation des eaux et les liens entre ces eaux. Les eaux étudiées sont acides (5,09 pH 7,43) et très faiblement minéralisées (CE100 JScm-1). Les teneurs des paramètres chimiques sont inférieurs aux normes OMS ; excepté, la silice (15,8 mg/L à 56,8 mg/L) et les éléments métalliques en traces : le fer (0,31 à 3,82 mg/L), le manganèse (0,019 à 0,264 mg/L) et l’aluminium (0,02 à 0,232 mg/L). Les eaux sont dans la majorité chlorurées sodi-potassiques. Trois phénomènes sont à l’origine de la minéralisation des eaux : les apports des activités anthropogéniques, le pluviolessivage des sols et le contact eau-roche (principal mécanisme de production d’ions). Trois groupes d’eaux sont obtenus. La Bia se distingue des autres eaux par son importante composition chimique.Conclusion et applications : Cette étude révèle que 43% des eaux de surface de la région d’Adiaké subissent une pollution anthropique importante. En dehors de la contamination bactérienne non traitée, cette étude montre que les eaux du Toumanguié, de l’Ehania et de la lagune Ehy peuvent représenter d’importantes réserves pour l’approvisionnement en eau potable de la région.Mots-clés : Eaux de surface, Paramètres physico-chimique, Éléments Métalliques en Traces, région d’Adiaké, Côte d’Ivoire

Composition chimique d’un extrait aqueux de bridelia ferruginea benth. (euphorbiaceae) et études de ses effets toxicologique et pharmacologique chez les mammifères.

La caractérisation des constituants chimiques de l’extrait aqueux de Bridelia ferruginea (SEA) a révélé la présence de quinones, de tanins catéchiques et galliques, d’alcaloïdes, de stérols, de polyterpènes, de polyphénols, de composés réducteurs, de flavonoïdes et de saponosides.L’étude de la toxicité aiguë de SEA, réalisée sur des souris, a montré que l’extrait aqueux de Bridelia ferruginea administré par voie orale est modérément toxique (DL50 égale à 3568,88 ± 308,45 mg/kg PC). En revanche, la même substance est très toxique (DL50 égale à 111,38 ± 29,3 mg/kg PC) lorsqu’elle est administrée par voie intrapéritonéale. Pour des doses comprises entre 5.10-3 g/kg de PC et 4.10-2 g/kg de PC, SEA provoque une hypotension dose-dépendante chez le lapin. Cette hypotension étant inhibée par l’atropine, l’extrait aqueux de Bridelia ferruginea contiendrait probablement des substances cholinomimétiques de type muscarinique.Mots-clés : Bridelia ferruginea, toxicologie, phytochimie, pharmacologie

PPROC, an ontology for transparency in'public procurement

Public procurement or tendering refers to the process followed by public authorities for the procurement of goods and services. In most developed countries, the law requires public authorities to provide online information to ensure competitive tendering as far as possible, for which the adequate announcement of tenders is an essential requirement. In addition, transparency laws being proposed in such countries are making the monitoring of public contracts by citizens a fundamental right. This paper describes the PPROC ontology, which has been developed to give support to both processes, publication and accountability, by semantically describing public procurement processes and contracts. The PPROC ontology is extensive, since it covers not only the usual data about the tender, its objectives, deadlines and awardees, but also details of the whole process, from the initial contract publication to its termination. This makes it possible to use the ontology for both open data publication purposes and for the overall management of the public contract procurement process

Etude de la culture en couloirs de manioc (Manihot esculenta CRANTZ) à base de Gliricidia sepium en Côte d’Ivoire

L’objectif de l’étude est de recommander aux paysans un système de production de manioc à la fois rentable et préservatrice de l’environnement. Pour atteindre cet objectif, deux systèmes améliorés de culture en couloirs (manioc amélioré Yavo/soja vert (Mung bean)/Gliricidia sepium avec un apport de fumure de fond minérale_200 kg/ha de NPK_10-18-18 ou organique_10 t/ha de fiente de poule) ont été mis en compétition avec le système traditionnel (association manioc local/arachide). Les systèmes de culture en couloirs ont bien couvert le sol comparativement au système traditionnel. Les taux moyens de débourrage du manioc ont varié de 80,15 à 82,03% pour la variété locale et de 80,11 à 75,08% pour la variété Yavo. Ces taux ont montré des interactions site x variété significatives et des interactions année x site très hautement significatifs. La culture en couloirs a enregistré un rendement moyen général en racines tubéreuses fraîches de 40 t/ha contre 13 t/ha dans le système traditionnel. Elle a permis d’augmenter le rendement du manioc de 27 t/ha. La culture en couloirs pourrait constituer une solution intéressante de remplacement du système traditionnel. Il est donc possible d’obtenir des rendements élevés à l’unité de surface grâce à la culture en couloirs de manioc.Mots-clés : manioc, Yavo, gliricidia sepium, soja vert, culture en couloirs, Côte d’Ivoire

Effects of cattle and poultry manures on organic matter content and adsorption complex of a sandy soil under cassava cultivation (Manihot esculenta, Crantz)

This study examined the A and B horizons of deep, developed and moderately unsaturated sandy ferrallitic soils amended with cattle and poultry manures under cassava (Manihot esculenta Crantz) cultivation. Therefore, a plot experiment was carried out by using a randomized complete blocks design in 4 replications and fields treatments which included unfertilized (control) and one dose (10 t/ha) of both manures. The study of the different fractions of animal manures showed that the poultry had the greatest content of C (organic carbon), N (nitrogen), P (phosphorus), K (potassium), Ca (calcium) and C:N ratio (p < 0.01). However, the value of Mg (magnesium) in the studied manures was not significantly different (p < 0.01). The manure treatment significantly increased the soil organic matter contents from 0.46 to 2.8 and 1.1% respectively with poultry and cattle manures (p < 0.01). Organic fertilizer significantly increased the cation exchange capacity from 1.7 to 12.75 and 3.8 me:100 g and the bases saturation content from 47 to 80 and to 76% respectively with the poultry and cattle manures (p < 0.01). The organic fertilizer showed significant effect on earthworms populations Hyperiodrilus africanus (Oligochaeta, Eudrilidae) in the soil, with 128 and 85% respectively about the poultry and cattle manures compared to the control (p < 0.01).Key words: Cattle manure, poultry manure, cassava, organic matter, cation exchange capacity, basessaturation content

Nocardiosis in a Kidney-Pancreas Transplant

34-year-old man with chronic renal and pancreas failure in complicated diabetic disease received a kidney-pancreas transplantation. On the 32nd postoperative day, an acute kidney rejection occurred and resolved with OKT3 therapy. The patient also presented refractory urinary infection by E. Fecalis and M. Morganii, and a focal bronchopneumonia in the right-basal lobe resolved with elective chemotherapy. During the 50th post-operative day, an intense soft tissue inflammation localized in the first left metatarsal-phalangeal articulation occurred (Figure 1) followed by an abscess with a cutaneous fistula and extension to the almost totality of foot area. The radiological exam revealed a small osteo-lacunar image localized in the proximal phalanx head of the first finger foot. From the cultural examination of the purulent material, N. Asteroides was identified. An amoxicillin-based treatment was started and continued for three months, with the complete resolution of infection This case is reported for its rarity in our casuistry, and for its difficult differential diagnosis with other potentially serious infections

Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting complex i activity

The fine regulation of mitochondrial function has proved to be an essential metabolic adaptation to fluctuations in oxygen availability. During hypoxia, cells activate an anaerobic switch that favors glycolysis and attenuates the mitochondrial activity. This switch involves the hypoxia-inducible transcription factor-1 (HIF-1). We have identified a HIF-1 target gene, the mitochondrial NDUFA4L2 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2). Our results, obtained employing NDUFA4L2-silenced cells and NDUFA4L2 knockout murine embryonic fibroblasts, indicate that hypoxia-induced NDUFA4L2 attenuates mitochondrial oxygen consumption involving inhibition of Complex I activity, which limits the intracellular ROS production under low-oxygen conditions. Thus, reducing mitochondrial Complex I activity via NDUFA4L2 appears to be an essential element in the mitochondrial reprogramming induced by HIF-1This work was supported by Ministerio de Ciencia e Innovación (SAF 2007-06592, SAF2010-14851), Comunidad Autónoma de Madrid (SAL 2006/ 0311), Metoxia Project-Health (F2 2009-222741), and Recava Network (RD 06/0014/0031) to M.O.L.; PS09/00101 and CP07/00143 to A.M.-R.; PI060701, PS09/00116, and CP08/00204 to S.C.; BFU2008-03407/BMC to J.A.; SAF2009-08007 to J.A.E.; and CSD2007-00020 to A.M.-R. and J.A.E. The CNIC is supported by the Instituto de Salud Carlos III-MICINN and the Pro-CNIC Foundation. We are grateful to Mike Murphy (Mitochondrial Biology Unit, MRC, Cambridge, UK) for the gift of MitoQ. We also thank Stephen Y. Chan and Joseph Loscalzo (Harvard Medical School, Boston, MA) for providing us ISCU expression vector

Internet of Tangible Things: Workshop on Tangible Interaction with the Internet of Things

The rise of the Internet of Things (IoT) brings abundant new opportunities to create more effective and pleasing tangible user interfaces that capitalize on intuitive interaction in the physical world, whilst utilizing capabilities of sensed data and Internet connectivity. However, with these new opportunities come new challenges; little is still known how to best design tangible IoT interfaces that simultaneously provide engaging user experiences and foster a sense of understanding about the often-complex functionality of IoT systems. How should we map previous taxonomies and design principles for tangible interaction into the new landscape of IoT systems? This workshop will bring together a community of researchers from the fields of IoT and tangible interaction, in order to explore and discuss how parallels between tangible interaction and the properties of IoT systems can best be capitalised on as HCI research moves increasingly toward the Internet of Tangible Things (IoTT). Through ideation and discussion, the workshop will function as a springboard for the community to begin creating new taxonomies and design considerations for the emerging IoTT

OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism

Analysis of variants in three genes encoding oxysterol-binding protein (OSBP) homologues (OSBPL2, OSBPL9, OSBPL10) in Finnish families with familial low high-density lipoprotein (HDL) levels (N = 426) or familial combined hyperlipidemia (N = 684) revealed suggestive linkage of OSBPL10 single-nucleotide polymorphisms (SNPs) with extreme end high triglyceride (TG; >90th percentile) trait. Prompted by this initial finding, we carried out association analysis in a metabolic syndrome subcohort (Genmets) of Health2000 examination survey (N = 2,138), revealing association of multiple OSBPL10 SNPs with high serum TG levels (>95th percentile). To investigate whether OSBPL10 could be the gene underlying the observed linkage and association, we carried out functional experiments in the human hepatoma cell line Huh7. Silencing of OSBPL10 increased the incorporation of [3H]acetate into cholesterol and both [3H]acetate and [3H]oleate into triglycerides and enhanced the accumulation of secreted apolipoprotein B100 in growth medium, suggesting that the encoded protein ORP10 suppresses hepatic lipogenesis and very-low-density lipoprotein production. ORP10 was shown to associate dynamically with microtubules, consistent with its involvement in intracellular transport or organelle positioning. The data introduces OSBPL10 as a gene whose variation may contribute to high triglyceride levels in dyslipidemic Finnish subjects and provides evidence for ORP10 as a regulator of cellular lipid metabolism

Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics

Cardiovascular disease is a common complication of diabetes and the leading cause of death among people with diabetes. Because of the huge premature morbidity and mortality associated with diabetes, prevention of vascular complications is a key issue. Although the exact mechanism by which vascular damage occurs in diabetes in not fully understood, numerous studies support the hypothesis of a causal relationship of non-enzymatic glycation with vascular complications. In this review, data which point to an important role of Amadori-modified glycated proteins and advanced glycation endproducts in vascular disease are surveyed. Because of the potential role of early- and advanced non-enzymatic glycation in vascular complications, we also described recent developments of pharmacological inhibitors that inhibit the formation of these glycated products or the biological consequences of glycation and thereby retard the development of vascular complications in diabetes