Chemical composition of seeds and green beans of common bean varieties, breeded in Omsk State Agrarian University under conditions of southern forest-steppe zone of Western Siberia

ArticleThe article considers the biochemical composition of green beans and seeds of common beans varieties, breeded in Omsk State Agrarian University named after P.A. Stolypin (OmSAU). The research was conducted in 2014–2016. Varieties of locally breeded beans, in comparison with the standards, have advantages in the content of protein, zinc, iodine, calcium, iron, sugar; green bean technological properties and tenderizing of seeds during cooking, which becomes an indispensable component of the diet

Familial Mediterranean fever in Russia: Experience of the Federal Rheumatology Center

The paper gives the experience of the V.A. Nasonova Research Institute of Rheumatology in identifying and managing patients with familial Mediterranean fever (FMF). Objective: to describe the features of the disease in patients with FMF in Russia and to compare them with the data obtained in the study of Turkish and Armenian populations with a high incidence of this disease. Patients and methods. The investigation enrolled 23 patients with a documented diagnosis of FMF who met the Turkish pediatric criteria (F. Yalcinkaya et al.) and/or the criteria described by A. Livnech et al. and had two identical mutations (homozygosity) or two different mutations (compound heterozygosity) in the MEFV gene. Among the patients there were 9 men and 14 women. The age of the patients at the time of treatment was 4.5 to 36 years. Their age at onset of FMF was 2 months to 15 years (mean age, 3.2±2.3 years). Results. The examination established that 18 (78.3%) patients were Armenians, 3 were representatives of the North Caucasus peoples (a Darghin woman, an Avar man, and an Ingush/Kabardian man), a man from mixed (Greek/Georgian) marriage, and a Russian woman whose ancestors were Armenian and Jewish. The most common manifestation of FMF were recurrent episodes of fever (22; 95.7%); abdominal pain with fever ranked second (19; 82.6%), followed by chest pain (11; 47.8%), locomotor apparatus lesion (16; 69.6%), and skin lesions (7; 30.4%). The episodes were accompanied by increased levels of acutephase markers in 100% of the patients. There were a high proportion of patients, in whom FMF was concurrent with other rheumatic and autoinflammatory diseases (juvenile chronic arthritis, chronic recurrent multifocal osteomyelitis, and acute rheumatic fever) (7; 30.4%). Twenty-two (95.6%) patients received colchicine; the tumor necrosis factor inhibitor etanercept was prescribed in 2 (8.7%) patients with comorbidity; there was a pronounced therapeutic effect. Conclusion. Although the majority of our patients were Armenians, the disease was also identified in those belonging to the peoples of the North Caucasus and Transcaucasia and in one Russian female patient. There has generally been a fairly typical picture of the disease. The considerable frequency of joint damage and the high proportion of patients with comorbid rheumatic diseases have engaged our attention. From a diagnostic point of view, of importance is the elevated level of acutephase markers during a disease attack, which in combination with the clinical and ethnic characteristics of patients allows the diagnosis of FMF to be suspected

Superbase ionic liquids for effective cellulose processing from dissolution to carbonisation

This is the author accepted manuscript. The final version is available from Royal Society of Chemistry via the DOI in this recordA range of superbase derived ionic liquids (SILs) was synthesised and characterised. Their ability to dissolve cellulose and the characteristics of the produced fibres were correlated to their specific structural and solvent properties. 17 ionic liquids (ILs) (including 9 novel) were analysed and six ILs were selected to produce fibres: 1-ethyl-3-methylimidazolium acetate [C2C1im][OAc], 1-ethyl-3-methylimidazolium diethyl phosphate [C2C1im][DEP] and the SILs 1-ethyl-1,8-diazabicyclo[5.4.0]undec-7-enium diethylphosphate [DBUEt][DEP], 1,8-diazabicyclo[5.4.0]undec-7-enium acetate [DBUH][OAc], 1,5-diazabicyclo[4.3.0]non-5-enium acetate [DBNH][OAc] and 1-ethyl-1,5-diazabicyclo[4.3.0]non-5-enium diethylphsophate [DBNEt][DEP]. The mechanical properties of these fibres were investigated. The obtained fibres were then carbonised to explore possible application as carbon fibre precursors. The fibres obtained using a mixture of 1,5-diazabicyclo[4.3.0]non-5-enium based SILs with acetate and hexanoate anions (9 : 1), [DBNH][OAc][Hex], showed a promising combination of strength, stiffness and strain at failure values for applications in textiles and fibre reinforcement in renewable composites. Using Raman spectroscopy it is demonstrated that these fibres exhibit a relatively high degree of structural order, with fewer defects than the other materials. On the other hand, analogous fibres based on imidazolium cation with acetate and hexanoate anions (9 : 1), [C2C1im][OAc][Hex] showed a decline in the quality of the produced fibres compared to the fibres produced from [C2C1im][OAc], [C2C1im][DEP] or [DBNH][OAc][Hex].We would like to thank the EPSRC grant number EP/L017679/01 for financial support (AERO RB1717)

Architectural and Spiritual Monuments of the City in the Fate of Human

The article presents the biography of the architect and restorer, Anatoly Andreyevich Kuzmin, who devoted his whole life to preserving the spiritual heritage of the city of Nizhny Tagil – temple buildings. The story is told by the artist's granddaughter.В статье представлена биография архитектора и реставратора Анатолия Андреевича Кузьмина, посвятившего всю жизнь сохранению духовного наследия города Нижнего Тагила – храмовым постройкам. История рассказана внучкой художника

THE ROLE OF CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROME AFTER THE EMERGENCE OF MORE POWERFUL INHIBITORS OF P2Y12 RECEPTOR

The role of P2Y12 receptor blocker clopidogrel after the introduction into clinical practice of new, more powerful and stable operating drugs belonging to this class of antiplatelet agents is discussed. The advantages and disadvantages of each of the currently used antiplatelet drugs that block the receptor P2Y12 are reviewed. On the basis of the analysis concludes that, despite the emergence of new antiplatelet agents clopidogrel, appears to be widely used for a long time in the treatment of patients with acute coronary syndrome and / or after coronary stenting. This is primarily due to the presence of large evidence base, and confirmation of safety of long-term therapy clopidogrel.</p

Семейная средиземноморская лихорадка в России (опыт работы Федерального ревматологического центра)

The paper gives the experience of the V.A. Nasonova Research Institute of Rheumatology in identifying and managing patients with familial Mediterranean fever (FMF). Objective: to describe the features of the disease in patients with FMF in Russia and to compare them with the data obtained in the study of Turkish and Armenian populations with a high incidence of this disease. Patients and methods. The investigation enrolled 23 patients with a documented diagnosis of FMF who met the Turkish pediatric criteria (F. Yalcinkaya et al.) and/or the criteria described by A. Livnech et al. and had two identical mutations (homozygosity) or two different mutations (compound heterozygosity) in the MEFV gene. Among the patients there were 9 men and 14 women. The age of the patients at the time of treatment was 4.5 to 36 years. Their age at onset of FMF was 2 months to 15 years (mean age, 3.2±2.3 years). Results. The examination established that 18 (78.3%) patients were Armenians, 3 were representatives of the North Caucasus peoples (a Darghin woman, an Avar man, and an Ingush/Kabardian man), a man from mixed (Greek/Georgian) marriage, and a Russian woman whose ancestors were Armenian and Jewish. The most common manifestation of FMF were recurrent episodes of fever (22; 95.7%); abdominal pain with fever ranked second (19; 82.6%), followed by chest pain (11; 47.8%), locomotor apparatus lesion (16; 69.6%), and skin lesions (7; 30.4%). The episodes were accompanied by increased levels of acutephase markers in 100% of the patients. There were a high proportion of patients, in whom FMF was concurrent with other rheumatic and autoinflammatory diseases (juvenile chronic arthritis, chronic recurrent multifocal osteomyelitis, and acute rheumatic fever) (7; 30.4%). Twenty-two (95.6%) patients received colchicine; the tumor necrosis factor inhibitor etanercept was prescribed in 2 (8.7%) patients with comorbidity; there was a pronounced therapeutic effect. Conclusion. Although the majority of our patients were Armenians, the disease was also identified in those belonging to the peoples of the North Caucasus and Transcaucasia and in one Russian female patient. There has generally been a fairly typical picture of the disease. The considerable frequency of joint damage and the high proportion of patients with comorbid rheumatic diseases have engaged our attention. From a diagnostic point of view, of importance is the elevated level of acutephase markers during a disease attack, which in combination with the clinical and ethnic characteristics of patients allows the diagnosis of FMF to be suspected. Представлен опыт ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» по выявлению и ведению пациентов с семейной средиземноморской лихорадкой – ССЛ (Familial Mediterranean Fever, FMF). Цель исследования – описать особенности течения заболевания у пациентов с ССЛ в России и сопоставить их с данными, полученными при изучении турецкой и армянской популяций, в которых наблюдается высокая частота этого заболевания. Пациенты и методы. В исследование включено 23 пациента с достоверным диагнозом ССЛ, удовлетворявших турецким педиатрическим критериям (F. Yalcinkaya и соавт.) и/или критериям А. Livnech и соавт. и имевших две одинаковые мутации (гомозиготность) или две разные мутации (компаунд-гетерозиготность) гена MEFV. Пациентов мужского пола было 9, женского пола – 14. Возраст больных на момент обращения составил от 4,5 до 36 лет. Возраст дебюта ССЛ – от 2 мес до 15 лет (в среднем – 3,2±2,3 года). Результаты. При обследовании установлено, что 18 (78,3%) пациентов были армянами, 3 – представителями народов Северного Кавказа (1 – даргинка, 1 – аварец, 1 – ингуш/кабардинец), 1 – грек/грузин и 1 – русская, имевшая предков армян и евреев. Самым частым проявлением ССД были повторяющиеся эпизоды лихорадки – 22 (95,7%) пациента, второе место занимала сопровождавшая лихорадку боль в животе – 19 (82,6%), далее следовали боль в грудной клетке – 11 (47,8%), поражение опорно-двигательного аппарата – 16 (69,6%), поражение кожи – 7 (30,4%). У всех пациентов атаки сопровождались повышением уровня острофазовых показателей. Отмечена высокая доля пациентов, у которых ССЛ сочеталась с другими ревматическими и аутовоспалительными заболеваними (ювенильным хроническим артритом, хроническим рецидивирующим мультифокальным остеомиелитом, острой ревматической лихорадкой) – 7 (30,4%). 22 (95,6%) пациента получали колхицин. 2 (8,7%) больным с коморбидной патологией был назначен ингибитор фактора некроза опухоли этанерцепт, отмечался выраженный терапевтический эффект. Выводы. Хотя большинство наших пациентов были армяне, заболевание выявлено также у лиц, относящихся к народам Северного Кавказа и Закавказья, и 1 русской пациентки. В целом наблюдалась достаточно типичная картина заболевания. Обращали на себя внимание значительная частота поражения суставов и высокая доля пациентов с коморбидной ревматической патологией. Важным с диагностической точки зрения является повышение уровня острофазовых маркеров во время атаки заболевания, что в сочетании с клинической картиной и этнической характеристикой пациентов позволяет заподозрить диагноз ССЛ. 

Современные подходы к диагностике , лечению и мониторингу пациенто в с криопирин-ассоциированными периодическими синдромами (CAPS)

Cryopyrin-associated periodic syndromes (CAPS) are the most prominent representatives of monogenic autoinflammatory diseases (AIDs). They are characterized by a concurrence of fever, rash, and other symptoms that are accompanied by disabling or life-threatening complications. Based on the current guidelines for the management of patients with AIDs and on their own experience, the authors have elaborated a diagnostic algorithm for CAPS, which can optimize their differential diagnosis with systemic juvenile arthritis and other AIDs and the early use of effective therapy and management tactics. Interleukin-1 inhibitors are target agents, by which one can monitor activity and prevent complications. The given algorithm will be able to improve the timely diagnosis of CAPS and to optimize treat-to-target treatment and management in patients.Криопирин-ассоциированные периодические синдромы (Cryopyrin-Associated Periodic Syndromes, CAPS) являются наиболее яркими представителями моногенных аутовоспалительных заболеваний (АВЗ). Они характеризуются сочетанием лихорадки, сыпи и других симптомов, сопровождающихся формированием потенциально инвалидизирующих или жизнеугрожающих осложнений. На основе современных рекомендаций по ведению пациентов с АВЗ, а также нашего собственного опыта разработан алгоритм диагностики CAPS, позволяющий оптимизировать их дифференциальную диагностику с системным ювенильным артритом и другими АВЗ, раннее назначение эффективной терапии, а также тактику ведения пациентов. Ингибиторы интерлейкина 1 являются таргетными средствами, с помощью которых можно контролировать активность и предупреждать развитие осложнений. Представленный алгоритм позволит улучшить своевременную диагностику CAPS, оптимизировать лечение и ведение пациентов в рамках стратегии «Treat to target»