Influence of beta-blockers on mechanical dyssynchrony and cardiac remodeling in patients with ischemic chronic heart failure in the setting of revascularization

Diastolic dysfunction (DD) and cardiac dyssynchrony (DS) are involved in the progression of chronic heart failure (CHF). A comparative analysis was conducted of the effect of a 6-month course of nebivolol and bisoprolol on DD, DS and metalloproteinase-9 (MMP-9) level in patients with ischemic chronic heart failure with preserved ejection fraction (HFpEF) and with midrange ejection fraction (HFmrEF), as well as in patients with comorbid type 2 diabetes mellitus (T2DM) in the setting of coronary artery bypass grafting (CABG) after 6 months of therap

The legal status of assistants to the judges in Ukraine and in Poland (comparative analysis)

In the light of the ongoing judicial reform aimed at bringing Ukraine's legal proceedings in line with European standards, the issue of organizational support for the activities of courts as one of the guarantees of the independence of judges becomes of paramount importance. Recommendations for the effective implementation of the Basic Principles of Independence of the Judiciary adopted by the resolution of the Economic and Social Council of 1989/60 and approved by UN General Assembly resolution 44/162 on 15 December 1989, namely Recommendation 5, stipulate that the State should pay special attention to the need provision of certain resources necessary for the functioning of the judicial system, taking into account the appointment of a sufficient number of judges for the level of detention, providing the courts with the necessary personnel and equipment, and providing judges with a decent level of personal security, retirement and wages [1]

Narrative Polyphony in Novel “Savely’s Days” by G. Sluzhitel

The narrative structure of the novel “Savely’s Days” by G. Sluzhitel is considered. It is determined that a polyphonic system of narrative instances is expressed in the novel, and the relationship between them is established. Methods of creating a subjective versatility of the text have been studied. It is noted that the genre of memories as a whole retains constant features, which include the methods of creating a chronotope. It embodys the image of a hero, while it is the very feature of the protagonist, who is an unreliable narrator, that leads to the transformation of the classical narration of memories and to the emergence of several subject-speech plans. The relevance of the study is due to the need to study the narrative instances and the originality of their relationship in order to comprehend the narrative space of a work of art. The novelty is seen in the fact that the methods of creating the effect of polyphonic narration are determined on the basis of the material of the modern novel. The observation of the modern writer style formation is carried out. It has been proved that the polyphony of narrative images arises in the novel due to the fact that, technically, the story cannot be conducted only from the point of view of the cat-narrator, since this will significantly limit the discourse. The purpose of polyphony is to look at a modern person from different points of view, including a detached one

Features of Anthropomorphic Narrative in Modern Prose

The narrative structures of novels written by Ye. CheshirKo and O. Roy are considered. The author characterizes the narrative polyphony: the voice of subjectivized unreliable narrator is supplemented by the voice of an objectified narrator or the voices of other characters, which leads to transformations of the genre basis of the work. It is established that the narrative on behalf of the nonhuman character causes the appearance of the features of magical realism which consist of a special binary chronotope including the characteristics of the contemporary real world and the alternative one, a distinct type of character who is either a representative of the alternative world or a mediator between two worlds. The relevance of the research lies in the need to study narrative instances in the modern prose. The novelty of the study is seen in the fact that on the basis of the modern novels, united by several features, the narrative polyphony and the ways of its creation are characterized. The author explores the stylistic features of the aforementioned novels which have not previously been the subject of thorough literary analysis. It is proved that the polyphony of narrative images expands the possibilities of the plot, style, as well as the view of a person as the subject of the image. The comparative method and the method of intertextual analysis are used in the article

Magical Realism through the Prism of Artistic Conflict

The question of the conflict in the works of magic realism is considered. It is reported that works of magical realism spread in the twentieth century in the literature of different countries and took a strong position in Russian literature in recent decades. Attention is paid to iconic works in modern Russian literature, written in the  mainstream of magical realism. The results of the analysis of binary oppositions at the level of the chronotope and the system of characters in the works of M. Petrosyan “House in which ...” and E. Nekrasova “Kalechin-Malechin” are presented. With the help of comparative and intertextual methods, it has been proved that the traditional neorealistic conflict of two worlds, characteristic of the literature of the twentieth century, is depicted in works of magical realism, proceeding not from the principle of opposing two worlds, but on the basis of their interpenetration and the dominance of noumenal reality over the fantastic. It is proved that the commonality of  antinomies and binary oppositions paradigmatically unites these works, this allows us to conclude about the unity of the artistic world of magic realism as a reflection of the author’s position. The typological approach, the search for intertextual connections determine the relevance of the study for modern literary criticism. The novelty of the research lies in the fact that the comparison of texts allows one to see the ways of modeling the conflict in its variants, taking into account the specifics of works of magical realism, in addition, both texts have not yet become an object of analysis through the prism of conflict

Choice of antihypertensive therapy in hypertensive patients with critical coronary artery stenosis

Sixty patients with stages II-III AH were studied. ABPM was performed in all the patients. DBPP was assessed by the degree of nocturnal BP lowering. Patients were randomized into groups receiving perindopril or losartan potassium. Perindopril was prescribed at a dose of 4 mg/day with subsequent rising up to 8 mg/day during 7 days. The initial dose of losartan potassium was 25 mg with subsequent rising up to 50 mg 2 times a day. The duration of observation was 8 weeks. Thus, perindopril therapy in hypertensive patients in the preoperative CABG period increased the number of people with normal BP profileyesБелгородский госуниверсите

Pharmacological correction of immune disorders in patients with chronic heart failure and ischemic heart disease

Currently, there are few data on the effect of cardiovascular drugs on the immune status of patients with heart failure (HF). This paper provides information on the impact of ß-adrenergic blocking agent (BAB), angiotensin-converting enzyme inhibitors (ACEI) on the maintenance of markers of immune inflammation in the blood, as well as on inhibition of synthesis of tumor necrosis factor-α (TNF-α) and on blocking of interaction between TNF-α and membrane receptor

Professional standard – peg professional work of teachers professional training

This article discusses the relevance of the development and implementation of the professional standard of vocational training of the teacher, its significance, characteristics and procedure for the development and use opportunitiesРассматриваются актуальность разработки и внедрения профессионального стандарта педагога профессионального обучения, его значимость, особенности и процедура разработки, а также возможности использовани

Teaching practice of bachelors of vocational training in modern conditions

The article describes the main approaches to the preparation of bachelors in the framework of pedagogical practice. The author identifies the stages of teaching practice. The features of the organization of teaching practice in modern conditionsВ статье рассмотрены основные подходы к подготовке бакалавров в рамках педагогической практики; выделены этапы прохождения педагогической практики; отражены особенности организации педагогической практики в современных условия

Competence-oriented teaching practice bachelors in terms of networking

In article the authors considers the relevance to pedagogical practice with the changes in modern Russian education. Focuses on the specifics of networking. The author offers im-plementation and introduction of this system into the educational spaceВ статье авторами была рассмотрена актуальность организации педагогической практики с учетом изменений в современном российском образовании. Акцентируется внимание на специфике сетевого взаимодействия. Автором предложены варианты реализации и внедрения данной системы в образовательное пространств