Changes in the human blood coagulating system during prolonged hypokinesia

Changes in the coagulating system of the blood were studied in six subjects during prolonged hypokinesia. Thrombogenic properties of the blood rose in all cases on the 8th day. These changes are explained by stress reaction due to unusual conditions for a healthy person. Changes in the blood coagulating system in the group subjected to physical exercise and without it ran a practically parallel course. Apparently physical exercise is insufficient to prevent such changes that appear in the coagulating system of the blood during prolonged hypokinesia

The Intelligent System of the Hearing Investigation

This paper describes a prototype of the intelligent system of the hearing investigation developed by the Tver State Technical University. The problem of automatic diagnostics, considered as the recognition problem of object not completely determined on set of the diseases classes’ descriptions, is discussed. The management strategy of the hearing investigation is proposed

Periodicity of professional pedagogical education within bachelor’s and master’s programmes in natural sciences

The article provides grounding and a methodological macro-development basis for a system periodic model of professional pedagogical education within bachelor's and master’s programmes in natural sciences. In the abovementioned context, periodicity is regarded as a universally applicable procedural basis for multilevel continuous professional pedagogical education in the sphere of natural sciences. A key category of system periodic model of professional pedagogical education within bachelor's and master’s programmes in natural sciences is a didactic cycle characterised by purposefulness, internal system integrity, dynamism, iterativity, controllability and hierarchy of levels based on phase logic. Didactic cycle is represented as a dual procedure of development of subject-subject relations oriented to correlation changes of self-balancing systems depending on quantitative augmentation in a form of grasping of content of professional pedagogical education within bachelor's and master’s programmes in natural sciences to qualitative personal transformations. Realisation of the hierarchy position is realised as macro-didactic, mesodidactic and micro-didactic cycles within the structure of a system model. Their attributive signs are goals, peculiarities of learning activity within the process of subject-subject dialogic interaction, types of solved tasks and performance. We have defined and characterised specificity of phases of didactic cycle: initiatives and perspectives, designing, implementation, assessment of results.peer-reviewe

"AHIMSA" principle in the religious and cultural practices of ancient and contemporary India

The paper is focused on the development of the ahimsa principle and its specifics in the ideology of ancient and contemporary India, in its religious and cultural practice

Physical constraints of cultural evolution of dialects in killer whales

Data collection was supported by a variety of organizations, including the Russian Fund for the Fundamental Research (Grant No. 15-04-05540), the Rufford Small Grants Fund, Whale and Dolphin Conservation, the Fundação para a Ciência e a Tecnologia (Grant No. SFRH/BD/30303/2006), Russell Trust Award of the University of St. Andrews, the Office of Naval Research, the Icelandic Research Fund (i. Rannsóknasjóður), the National Geographic Society Science and Exploration Europe (Grant No. GEFNE65-12), Vancouver Aquarium Marine Science Centre, the Canadian Ministry of Fisheries and Oceans, and the North Gulf Oceanic Society.Odontocete sounds are produced by two pairs of phonic lips situated in soft nares below the blowhole; the right pair is larger and is more likely to produce clicks, while the left pair is more likely to produce whistles. This has important implications for the cultural evolution of delphinid sounds: the greater the physical constraints, the greater the probability of random convergence. In this paper the authors examine the call structure of eight killer whale populations to identify structural constraints and to determine if they are consistent among all populations. Constraints were especially pronounced in two-voiced calls. In the calls of all eight populations, the lower component of two-voiced (biphonic) calls was typically centered below 4 kHz, while the upper component was typically above that value. The lower component of two-voiced calls had a narrower frequency range than single-voiced calls in all populations. This may be because some single-voiced calls are homologous to the lower component, while others are homologous to the higher component of two-voiced calls. Physical constraints on the call structure reduce the possible variation and increase the probability of random convergence, producing similar calls in different populations.PostprintPeer reviewe

Model of psychological and pedagogical diagnostics of integrative components of functional literacy In children with hearing and speech impaired

Статья посвящена вопросу психолого-педагогической диагностики функциональной грамотности у детей с нарушениями слуха и речи. В образовательных программах для детей с нарушениями слуха и речи основное внимание уделяется развитию интегративных компонентов функциональной грамотности, что связано с трудностями обучающихся в коммуникации с окружающими. Известно, что развитие интегративных компонентов функциональной грамотности возможно лишь в условиях целенаправленного педагогического воздействия с учетом особенностей интеллектуального и речевого развития каждого ученика. Авторами рассмотрена специфика формирования функциональной грамотности у детей с нарушениями слуха и речи, показана необходимость диагностики уровня ее развития.The article is devoted to the issue of psychological and pedagogical diagnostics of functional literacy in children with hearing and speech impairments. In educational programs for children with hearing and speech impairments, the main attention is paid to the development of integrative components of functional literacy, which is associated with the difficulties of students in communicating with others. It is known that the development of integrative components of functional literacy is possible only under the conditions of purposeful pedagogical influence, taking into account the peculiarities of the intellectual and speech development of each student. The authors considered the specificity of the formation of functional literacy in children with hearing and speech impairments, and showed the need to diagnose the level of its development

Use of information and communication technologies for counseling parents of children with disabilities

Статья посвящена проблеме консультирования родителей детей с ограниченными возможностями здоровья в условиях дистанционного обучения.The article is devoted to the problem of counseling parents of children with disabilities in the situation of distance learning

Lipoprotein(a) concentration and the blood content of INFγ-producing T-helpers 17 (Th17/1) in males with premature coronary artery disease

Aim. To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD).Material and methods. This retrospective cross-sectional study included 76 men aged 40 to 79 years. Patients were divided into following groups: main group — patients with CAD (58 [54;64] years, n=56) onset before the age of 55; control group — patients (62 [57;66] years, n=20) without CAD and obstructive CAD and peripheral arterial disease. Statins were taken by 51 (91%) and 9 (45%) patients in the main and control groups, respectively. In serum and plasma samples, lipid spectrum parameters and Lp(a) concentration were determined. Cellular phenotyping was performed by direct immunofluorescence in a culture of mononuclear leukocytes isolated from blood. To determine cytokines, cells were in vitro activated with inhibitor of intracellular transport of secretory proteins. Cell fluorescence was determined using flow cytometry.Results. Patients of both groups were comparable in age, body mass index, prevalence of hypertension and diabetes. Blood Lp(a) concentrations were higher in the CAD group than in the control group (49 [10;102] mg/dL vs 12 [4,3;32] mg/ dL, p<0,05). The content of INFγ-producing T-helpers 17 (Th17/1) was also higher in the CAD group (19 [15;24] vs 13 [11;22], % of Th17, p=0,05). Logistic regression revealed that elevated Lp(a) levels (≥30 mg/dL) and relative amounts of Th17/1 (>14% of Th17) independently of each other, atherogenic lipoprotein cholesterol levels, classical risk factors, and statin use were associated with premature CAD in the general group of patients with odds ratio (OR) of 4,6 (95% confidence interval (CI), 1,1-20,2) and 10,9 (2,1-56,7), p<0,05, respectively. The combination of Lp(a) >30 mg/dl and Th17/1 over 14% significantly increased the risk of premature CAD (OR, 28,0, 95% CI, 4,31-181,75, p=0,0005).Conclusion. We have shown for the first time that an increased Lp(a) concentration with an increased Th17/1 content is associated with the premature CAD in men