Amelioration of aluminium-induced liver damage by vitamin E

Objective: To investigate the effects of aluminium sulphate on the microscopic morphology of the liver and on vitamin E amelioration of aluminium-induced liver damage. Methods: Rats were injected intraperitonally with aluminium sulphate alone or aluminium sulphate together with vitamin E, with saline injected rats used as the control group. The study took place in Pamukkale University Faculty of Medicine in 2005. Results: The rats exposed to aluminium showed morphological changes in addition to previously reported biochemical changes in the liver. Ihe anti-oxidant vitamin E significantly diminished the liver damage seen due to aluminium. Conclusion: There is an apparent protective effect of vitamin E on parenteral aluminium exposure

Transient Splenial Lesion of the Corpus Callosum Related to Migraine with Aura in a Pediatric Patient

Background: Transient splenial lesions of the corpus callosum are rare radiological findings first described in association with epilepsy, antiepileptic drugs and viral encephalitis. However, subsequently more cases were described associated with diverse clinical conditions. Case report: We describe a 13-year-old girl suffering from migraine with aura presenting with headache, right-sided hemiparesis and encephalopathy. Brain magnetic resonance imaging revealed an ovoid lesion in the splenium of the corpus callosum. The patient’s neurological symptoms resolved within 3 days without therapy and the lesion disappeared in follow up magnetic resonance images obtained 3 weeks after the onset of the symptoms. Results: Migraine with aura was considered to be the cause of the lesion. To our knowledge the present case is the first report of a pediatric patient with a diagnosis of migraine with aura presenting with hemiparesis and encephalopathy. Conclusions: A diagnosis of transient lesion of the corpus callosum should be suspected in patients with migraine with aura presenting with hemiparesis and encephalopathy. A mild course and a good prognosis might be expected in the presence of a splenial lesion of the corpus callosum

Histopathological and clinical evaluation of papulopustular lesions in Behcet's disease

Objective. Behcet's disease (BD) is a chronic inflammatory disorder characterised by aphthous stomatitis, genital ulcerations, erythema nodosum-like manifestations and papulopustular lesions. While a neutrophilic vasculitis accompanies most skin lesions it is usually regarded that the papulopustular lesions in BD are similar to acne vulgaris (AV). The aim of our current study was to further assess the clinical and histopathological features of papulopustular lesions in BD and how these features compared to those of AV

The effect of medroxyprogesterone acetate on bone marrow and testis during cytotoxic chemotherapy

The effect of medroxyprogesterone acetate (MPA) on the mitotic activity of bone marrow and testis during chemotherapy was investigated experimentally in an animal study. A total of 120 male Swiss albino mice were included in this study. Six groups were formed, each consisting of 20 mice. Low-dose MPA (LD-MPA) (15 mg/kg), high-dose MPA (HD-MPA) (100 mg/kg), LD-MPA plus cyclophosphamide (CP) (65 mg/kg), HD-MPA plus CP (65 mg/kg), and CP (65 mg/kg) were administered to the test groups and no drug was administered to the control group. Bone marrow samples and testis were examined for mitotic activity rate (MAR) on days 0, 18, 22, 26, and 30. In groups with regimens containing CP, MAR of hematopoietic cells in bone marrow was suppressed significantly (p 0.05). Mitotic activity rate of the testis cells was significantly suppressed in groups with regimens containing MPA (p <0.05). In conclusion, MPA inhibited mitotic activity of testis, but there was no effect on the mitotic activity of bone marrow. These data do not seem to confirm the hypothesis of a myeloprotective effect of MPA

DConfusion: A technique to allow cross study performance evaluation of fault prediction studies.

There are many hundreds of fault prediction models published in the literature. The predictive performance of these models is often reported using a variety of different measures. Most performance measures are not directly comparable. This lack of comparability means that it is often difficult to evaluate the performance of one model against another. Our aim is to present an approach that allows other researchers and practitioners to transform many performance measures back into a confusion matrix. Once performance is expressed in a confusion matrix alternative preferred performance measures can then be derived. Our approach has enabled us to compare the performance of 600 models published in 42 studies. We demonstrate the application of our approach on 8 case studies, and discuss the advantages and implications of doing this.Peer reviewe