The effects of sheep manure application time and rates on yield and botanical composition of secondary succession rangeland

This experimental study was conducted in Samsun/Turkey on a secondary succession rangeland during 2006 - 2008. Botanical composition of the experimental area consists of 28% legumes, 64% grasses, and 8% of other species. Target rates of sheep manure were 0, 25.0, 50.0, 75.0, and 100 kg total N ha–1, based on the manure analyses results (according to N rates in sheep manure). The sheep manure was applied at two different times. Means of 3 years of experimental period and total dry matteryield was obtained from the manure treatment of 75.0 kg N ha-1 and 50 + 50 kg N ha-1 (4153 kg ha-1, and 3813 kg ha-1, respectively). With respect to the three-year average, ratios of legumes, grasses, and otherplants ranged from 20.8 to 40.7%, 41.6 to 66.9%, and 10.7 to 20.7%, respectively. Although ratios of legumes, and other plants increased in the all of the treatments, grass ratios decreased. The crude protein content of obtained rangeland hay ranged between 107.0 and 143.0 g kg-1 in 2006, 93.0 and 123.4 g kg-1 in 2007, 116.3 and 166.4 g kg-1 in 2008. The maximum benefit was provided from the application of 75.0 kg N ha-1 with a sum of 971.2 ha-1

The inexorable resistance of inertia determines the initial regime of drop coalescence

Drop coalescence is central to diverse processes involving dispersions of drops in industrial, engineering and scientific realms. During coalescence, two drops first touch and then merge as the liquid neck connecting them grows from initially microscopic scales to a size comparable to the drop diameters. The curvature of the interface is infinite at the point where the drops first make contact, and the flows that ensue as the two drops coalesce are intimately coupled to this singularity in the dynamics. Conventionally, this process has been thought to have just two dynamical regimes: a viscous and an inertial regime with a crossover region between them. We use experiments and simulations to reveal that a third regime, one that describes the initial dynamics of coalescence for all drop viscosities, has been missed. An argument based on force balance allows the construction of a new coalescence phase diagram

EFFECTS OF ORTHODONTIC ADHESIVE MATERIALS ON S. MUTANS AND LACTOBACILLI LEVELS IN HUMAN SALIVA

ABSTRAC

Boundary Integral Equations and the Dirichlet Problem

The standard boundary element method applied to a problem with Dirichlet boundary conditions leads to a Fredholm integral equation of the first kind. A stable second kind equation results from a hypersingular equation formulation of the problem, obtained by differentiating the original boundary integral statement. The evaluation of the hypersingular integral requires that the coefficient function multiplying the hypersingular kernel be differentiable. For two dimensional problems, Overhauser elements are a very convenient basis set for obtaining the necessary smoothness. Test calculations with the Laplace equation demonstrate (a) the stability of the hypersingular approach for the Dirichlet problem and (b) that the hypersingular approach yields results that are more accurate than those obtained with the standard approach

Gefitinib (ZD1839, Iressa™) as palliative treatment in recurrent or metastatic head and neck cancer

To assess the level of activity and toxicity of gefitinib (ZD1839, Iressa™) in a population of patients with locally recurrent and/or metastatic head and neck cancer. Patients were recruited into an expanded access programme through the multidisciplinary head and neck clinics at the Royal Marsden and St George's Hospitals. Patients were required to have received at least one course of standard systemic chemotherapy or radiation therapy, or be medically unfit for chemotherapy. Patients were commenced on single-agent gefitinib at a dose of 500 mg day−1. Clinical, symptomatic and radiological response, time to progression (TTP), survival and toxicity were recorded. A total of 47 patients were enrolled (35 male and 12 female) with a median age of 62 years (range 18–93 years). The observed clinical response rate was 8% with a disease control rate (complete response, partial response, stable disease) of 36%. In all, 34% of patients experienced an improvement in their symptoms. The median TTP and survival were 2.6 and 4.3 months, respectively. Acneiform folliculitis was the most frequent toxicity observed (76%) but the majority of cases were grade 1 or 2. Only four patients experienced grade 3 toxicity of any type (all cases of folliculitis). Gefitinib was well tolerated and yielded symptomatic improvement in one-third of patients. However, this agent appeared to possess limited antitumour activity in this group of patients with head and neck cancer in whom the objective response rate, median TTP and survival were all lower than has been reported in a previous study

Global Perspectives on Task Shifting and Task Sharing in Neurosurgery.

BACKGROUND: Neurosurgical task shifting and task sharing (TS/S), delegating clinical care to non-neurosurgeons, is ongoing in many hospital systems in which neurosurgeons are scarce. Although TS/S can increase access to treatment, it remains highly controversial. This survey investigated perceptions of neurosurgical TS/S to elucidate whether it is a permissible temporary solution to the global workforce deficit. METHODS: The survey was distributed to a convenience sample of individuals providing neurosurgical care. A digital survey link was distributed through electronic mailing lists of continental neurosurgical societies and various collectives, conference announcements, and social media platforms (July 2018-January 2019). Data were analyzed by descriptive statistics and univariate regression of Likert Scale scores. RESULTS: Survey respondents represented 105 of 194 World Health Organization member countries (54.1%; 391 respondents, 162 from high-income countries and 229 from low- and middle-income countries [LMICs]). The most agreed on statement was that task sharing is preferred to task shifting. There was broad consensus that both task shifting and task sharing should require competency-based evaluation, standardized training endorsed by governing organizations, and maintenance of certification. When perspectives were stratified by income class, LMICs were significantly more likely to agree that task shifting is professionally disruptive to traditional training, task sharing should be a priority where human resources are scarce, and to call for additional TS/S regulation, such as certification and formal consultation with a neurosurgeon (in person or electronic/telemedicine). CONCLUSIONS: Both LMIC and high-income countries agreed that task sharing should be prioritized over task shifting and that additional recommendations and regulations could enhance care. These data invite future discussions on policy and training programs

Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

Peer reviewe