10,618 research outputs found
Group Strategyproof Pareto-Stable Marriage with Indifferences via the Generalized Assignment Game
We study the variant of the stable marriage problem in which the preferences
of the agents are allowed to include indifferences. We present a mechanism for
producing Pareto-stable matchings in stable marriage markets with indifferences
that is group strategyproof for one side of the market. Our key technique
involves modeling the stable marriage market as a generalized assignment game.
We also show that our mechanism can be implemented efficiently. These results
can be extended to the college admissions problem with indifferences
OptFROG — Analytic signal spectrograms with optimized time–frequency resolution
A Python package for the calculation of spectrograms with optimized time and frequency resolution for application in the analysis of numerical simulations on ultrashort pulse propagation is presented. Gabor’s uncertainty principle prevents both resolutions from being optimal simultaneously for a given window function employed in the underlying short-time Fourier analysis. Our aim is to yield a time–frequency representation of the input signal with marginals that represent the original intensities per unit time and frequency similarly well. As a use-case, we demonstrate the implemented functionality for the analysis of simulations on ultrashort pulse propagation in a nonlinear waveguide
Do effective properties for unsaturated weakly layered porous media exist? An experimental study
International audienceIn a multi-step outflow experiment we found that a weak heterogeneity within a sand column prevents the estimated effective hydraulic parameters from being unique. We compared vertical water content profiles calculated from these parameters with profiles measured by x-ray attenuation. A layered material model based on x-ray data was able to reproduce the outflow curve and also the water content distribution inside the column. We also calculated effective parameters for the layered model turned upside down and obtained large differences to the set of values of the original sample
Spin-Orbit-Induced Kondo Size Effect in Thin Films with 5/2-spin Impurities
Recently, for spin impurities quite different size dependence of the
Kondo contribution to the resistivity was found experimentally than for S=2.
Therefore previous calculation about the effect of the spin-orbit-induced
magnetic anisotropy on the Kondo amplitude of the resistivity is extended to
the case of impurity spin which differs from the integer spin case as
the ground state is degenerated. In this case the Kondo contribution remains
finite when the sample size goes to zero and the thickness dependence in the
Kondo resistivity is much weaker for Cu(Mn). The behavior of the Kondo
coefficient as a function of the thickness depends on the Kondo temperature,
that is somewhat stronger for larger . Comparing our results with a recent
experiment in thin Cu(Mn) films, we find a good agreement.Comment: 8 pages, ReVTeX + 4 figures (Postscript
Neoadjuvant radiochemotherapy for locally advanced gastric cancer: a phase I-II study
Background: To study in a phase I-II trial the maximum tolerated dose, the toxicity, and the tolerance of adding radiotherapy to systemic chemotherapy administered preoperatively in patients with locoregionally advanced gastric adenocarcinoma. Patients and methods: Patients with adenocarcinoma of the stomach (T3-4Nany or TanyN+), performance status ≤1, normal hematological, hepatic and renal functions received two cycles of cisplatin 100 mg/m2 on day 1, 5-FU 800 mg/m2 on days 1 to 4 and leucovorin 60 mg b.i.d. on days 1 to 4 q3w, concomitantly with radiation therapy escalated in three dose tiers (31.2, 38.4 and 45.6 Gy). Results: Nineteen patients were accrued and 18 completed neoadjuvant therapy. Major toxicity consisted of grade 3/4 leucopenia and mucositis in 89% and 36% of the patients, respectively. Only one episode of febrile neutropenia was recorded. Dose level number 2 (38.4 Gy) with the chemotherapy given q4w is the recommended dose level. All patients were subsequently operated and no fatalities occurred. Pathological assessment showed one complete and eight partial responses. Two- and 3-year relapse-free survival rates were 57% and 50%, respectively. Only one patient relapsed locally. The peritoneum was the most frequent site of relapse. Conclusions: This neoadjuvant therapeutic program is relatively well tolerated, does not seem to increase the operative risk, and might increase the locoregional control of the disease. The frequency of peritoneal involvement in relapsing patients underscores the need for a more effective systemic treatmen
GRB070125: The First Long-Duration Gamma-Ray Burst in a Halo Environment
We present the discovery and high signal-to-noise spectroscopic observations
of the optical afterglow of the long-duration gamma-ray burst GRB070125. Unlike
all previously observed long-duration afterglows in the redshift range 0.5 < z
1.0 A) absorption
features in the wavelength range 4000 - 10000 A. The sole significant feature
is a weak doublet we identify as Mg II 2796 (W = 0.18 +/- 0.02 A), 2803 (W =
0.08 +/- 0.01) at z = 1.5477 +/- 0.0001. The low observed Mg II and inferred H
I column densities are typically observed in galactic halos, far away from the
bulk of massive star formation. Deep ground-based imaging reveals no host
directly underneath the afterglow to a limit of R > 25.4 mag. Either of the two
nearest blue galaxies could host GRB070125; the large offset (d >= 27 kpc)
would naturally explain the low column density. To remain consistent with the
large local (i.e. parsec scale) circum-burst density inferred from broadband
afterglow observations, we speculate GRB070125 may have occurred far away from
the disk of its host in a compact star-forming cluster. Such distant stellar
clusters, typically formed by dynamical galaxy interactions, have been observed
in the nearby universe, and should be more prevalent at z>1 where galaxy
mergers occur more frequently.Comment: 8 pages, accepted in Ap
Hierarchical model for the scale-dependent velocity of seismic waves
Elastic waves of short wavelength propagating through the upper layer of the
Earth appear to move faster at large separations of source and receiver than at
short separations. This scale dependent velocity is a manifestation of Fermat's
principle of least time in a medium with random velocity fluctuations. Existing
perturbation theories predict a linear increase of the velocity shift with
increasing separation, and cannot describe the saturation of the velocity shift
at large separations that is seen in computer simulations. Here we show that
this long-standing problem in seismology can be solved using a model developed
originally in the context of polymer physics. We find that the saturation
velocity scales with the four-third power of the root-mean-square amplitude of
the velocity fluctuations, in good agreement with the computer simulations.Comment: 7 pages including 3 figure
Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed complications. However, the mechanisms underlying blood-brain barrier opening are poorly understood. Here we demonstrate the role of the neurotransmitter glutamate in modulating early barrier permeability in vivo Using intravital microscopy, we show that recurrent seizures and the associated excessive glutamate release lead to increased vascular permeability in the rat cerebral cortex, through activation of NMDA receptors. NMDA receptor antagonists reduce barrier permeability in the peri-ischemic brain, whereas neuronal activation using high-intensity magnetic stimulation increases barrier permeability and facilitates drug delivery. Finally, we conducted a double-blind clinical trial in patients with malignant glial tumors, using contrast-enhanced magnetic resonance imaging to quantitatively assess blood-brain barrier permeability. We demonstrate the safety of stimulation that efficiently increased blood-brain barrier permeability in 10 of 15 patients with malignant glial tumors. We suggest a novel mechanism for the bidirectional modulation of brain vascular permeability toward increased drug delivery and prevention of delayed complications in brain disorders.
SIGNIFICANCE STATEMENT:
In this study, we reveal a new mechanism that governs blood-brain barrier (BBB) function in the rat cerebral cortex, and, by using the discovered mechanism, we demonstrate bidirectional control over brain endothelial permeability. Obviously, the clinical potential of manipulating BBB permeability for neuroprotection and drug delivery is immense, as we show in preclinical and proof-of-concept clinical studies. This study addresses an unmet need to induce transient BBB opening for drug delivery in patients with malignant brain tumors and effectively facilitate BBB closure in neurological disorders
How chemistry controls electron localization in 3d1 perovskites: A Wannier-function study
In the series of 3d1 t2g perovskites, SrVO3--CaVO3--LaTiO3--YTiO3 the
transition-metal d electron becomes increasingly localized and undergoes a Mott
transition between CaVO3 and LaTiO3. By defining a low-energy Hubbard
Hamiltonian in the basis of Wannier functions for the t2g LDA band and solving
it in the single-site DMFT approximation, it was recently shown[1] that
simultaneously with the Mott transition there occurs a strong suppression of
orbital fluctuations due to splitting of the t2g levels. The present paper
reviews and expands this work, in particular in the direction of exposing the
underlying chemical mechanisms by means of ab initio LDA Wannier functions
generated with the NMTO method. The Wannier functions for the t2g band exhibit
covalency between the transition-metal t2g, the large cation-d, and the
oxygen-p states; this covalency, which increases along the series, turns out to
be responsible not only for the splittings of the t2g levels, but also for
non-cubic perturbations of the hopping integrals, both of which are decisive
for the Mott transition. We find good agreement with the optical and
photoemission spectra, with the crystal-field splittings and orbital
polarizations recently measured for the titanates, and with the metallization
volume for LaTiO3. The metallization volume for YTiO3 is predicted. Using
super-exchange theory, we reproduce the observed magnetic orders in LaTiO3 and
YTiO3, but the results are sensitive to detail, in particular for YTiO3 which,
without the Jahn-Teller distortion, would be AFM C- or A-type, rather than FM.
Finally, we show that it possible to unfold the orthorhombic t2g LDA
bandstructure to a pseudocubic zone. In this zone, the lowest band is separated
from the two others by a direct gap and has a width, W_I, which is
significantly smaller than that, W, of the entire t2g band. The progressive
GdFeO3-type distortion favours electron localization by decreasing W, by
increasing the splitting of the t2g levels and by decreasing W_I. Our
conclusions concerning the roles of GdFeO3-type and JT distortions agree with
those of Mochizuki and Imada [2].Comment: Published version, final. For high resolution figures see
http://www.fkf.mpg.de/andersen/docs/pub/abstract2004+/pavarini_02.pd
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