The incidence of the postoperative peritonitis in digestive surgery in children. Clinical and therapeutical aspects

Postoperative peritonitis are the result of the defects a first surgical intervention and therefore they are a complication of the digestive surgery. In pediatric surgery they appear in the digestive surgery in new-born and infant or as a complication in the postoperative evolution of a acute appendicitis in small children or teenagers, ussuallly, after interventios in the emergency department or other surgical departments. The authors are analyzing the incidence and the causes of the postoperative peritonitis admitted and treated in the pediatric surgery department in the last 25 years

Molecular dynamics and physical stability of amorphous nimesulide drug and its binary drug-polymer systems

yesIn this paper we study the effectiveness of three well known polymers: inulin, Soluplus and PVP in stabilizing amorphous form of nimesulide (NMS) drug. The re-crystallization tendency of pure drug as well as measured drug-polymer systems were examined at isothermal conditions by using broadband dielectric spectroscopy (BDS), and at non-isothermal conditions by differential scanning calorimetry (DSC). Our investigation has shown that the crystallization half-life time of pure NMS at 328 K is equal to 33 minutes. We found that this time can be prolonged to 40 years after adding to NMS 20% of PVP polymer. This polymer proved to be the best NMS’s stabilizer, while the worst stabilization effect was found after adding the inulin to NMS. Additionally, our DSC, BDS and FTIR studies indicate that for suppression of NMS’s re-crystallization in NMS-PVP system, the two mechanisms are responsible: the polymeric steric hindrances as well as the antiplastization effect excerted by the excipient.The authors J.K., Z.W., K.G. and M.P., are grateful for the financial support received within the Project No. 2015/16/W/NZ7/00404 (SYMFONIA 3) from the National Science Centre, Poland. H.M. and L.T. are supported by Science Foundation Ireland under grant No. 12/RC/2275 (Synthesis and Solid State Pharmaceuticals Centre)

Orofacial clefts in children - clinical and terapeutical aspects

Orofacial clefts are the most encountered facial malformation and they represent a congenital malformation with a particular impact, not only from the aesthetic point of view, but also from the functional point of view, with profound repercussions on the child’s psychosomatic development. The therapeutic approach to these congenital defects of the cranio-facial structures requires a close collaboration between the pediatric surgeon, the orthodontist, the logoped, and it is often necessary even a psychological approach to these cases. The authors are presenting the experience of the Pediatric Surgery Clinic of the Craiova Emergency County Hospital in the surgical approach of the cases of orofacial clefts in the last ten years

Physical function improvements and relief from fatigue and pain are associated with increased productivity at work and at home in rheumatoid arthritis patients treated with certolizumab pegol

Objectives. To evaluate the association between improvements in physical function, fatigue and pain and improvements in productivity at work and at home in patients treated with certolizumab pegol (CZP) in combination with MTX

Methods for creativity stimulation of students in Math courses

The purpose of the present paper is to highlight, using a comparative study, different methods for the stimulation of the creativity of students taking part in classes of Algebra, Geometry, Differential Equations, Special Mathematics. It is analyzed and exemplified the development of the students’ creativity with: scientific contents taught at mentioned disciplines; the teaching and learning methods used at courses and seminars having the goal of teaching this content; the employed methods and evaluation tools; other approached strategies of differentiate instruction. The creativity of the teacher is also taken into consideration

ECONOMIC BURDEN OF AXIAL SPONDYLOARTHRITIS RELATED TO PAID WORK AND HOUSEHOLD PRODUCTIVITY AT BASELINE IN THE RAPID-AXSPA STUDY: DIFFERENCES AND SIMILARITIES BETWEEN ANKYLOSING SPONDYLITIS AND NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS

Pathophysiology and treatment of rheumatic disease