209 research outputs found
R&D Status of Nuclear Emulsion For Directional Dark Matter Search
In this study, we are doing R&D for directional dark matter search with
nuclear emulsion. First of all, higher resolution nuclear emulsion with fine
silver halide crystals was developed in the production facility of emulsion at
Nagoya university, and we confirmed that it can detect the expected nuclear
recoil tracks. The readout of submicron tracks was required the new technology.
We developed the expansion technique, and could readout the signal by shape
analysis with optical microscopy. The two dimensional angular resolution is 36
degrees at the original track length of range from 150nm to 200nm with optical
microscopy. Finally we demonstrated by using recoiled nuclei induced by 14.8MeV
neutron, and confirmed the technique.Moreover, we developed the X-ray
microscope system with SPring-8 as final check with higher resolution of
selected candidate tracks with optical microscopy. The angular resolution was
improved from 31 degrees with optical microscopy to 17degrees with X-ray
microscopy at the track length of range from 150nm to 250nm. We are developing
the practical system and planning for start of the test running with prototype
detector.Comment: Proceedings of the 3rd International conference on Directional
Detection of Dark Matter (CYGNUS 2011), Aussois, France, 8-10 June 201
Chaos and its quantization in dynamical Jahn-Teller systems
We investigate the Jahn-Teller system for the purpose to
reveal the nature of quantum chaos in crystals. This system simulates the
interaction between the nuclear vibrational modes and the electronic motion in
non-Kramers doublets for multiplets of transition-metal ions. Inclusion of the
anharmonic potential due to the trigonal symmetry in crystals makes the system
nonintegrable and chaotic. Besides the quantal analysis of the transition from
Poisson to Wigner level statistics with increasing the strength of
anharmonicity, we study the effect of chaos on the electronic orbital angular
momentum and explore the magnetic -factor as a function of the system's
energy. The regular oscillation of this factor changes to a rapidly-decaying
irregular oscillation by increasing the anharmonicity (chaoticity).Comment: 8 pages, 6 figure
First events from the CNGS neutrino beam detected in the OPERA experiment
The OPERA neutrino detector at the underground Gran Sasso Laboratory (LNGS)
was designed to perform the first detection of neutrino oscillations in
appearance mode, through the study of nu_mu to nu_tau oscillations. The
apparatus consists of a lead/emulsion-film target complemented by electronic
detectors. It is placed in the high-energy, long-baseline CERN to LNGS beam
(CNGS) 730 km away from the neutrino source. In August 2006 a first run with
CNGS neutrinos was successfully conducted. A first sample of neutrino events
was collected, statistically consistent with the integrated beam intensity.
After a brief description of the beam and of the various sub-detectors, we
report on the achievement of this milestone, presenting the first data and some
analysis results.Comment: Submitted to the New Journal of Physic
Phytotoxin produced by the netted scab pathogen, Streptomyces turgidiscabies strain 65, isolated in Sweden
“Quem ensina também aprende” : a formação pela prática de professores primários na província do Paraná
Talaromyces atroroseus, a new species efficiently producing industrially relevant red pigments
Some species of Talaromyces secrete large amounts of red pigments. Literature has linked this character to species such as Talaromyces purpurogenus, T. albobiverticillius, T. marneffei, and T. minioluteus often under earlier Penicillium names. Isolates identified as T. purpurogenus have been reported to be interesting industrially and they can produce extracellular enzymes and red pigments, but they can also produce mycotoxins such as rubratoxin A and B and luteoskyrin. Production of mycotoxins limits the use of isolates of a particular species in biotechnology. Talaromyces atroroseus sp. nov., described in this study, produces the azaphilone biosynthetic families mitorubrins and Monascus pigments without any production of mycotoxins. Within the red pigment producing clade, T. atroroseus resolved in a distinct clade separate from all the other species in multigene phylogenies (ITS, β-tubulin and RPB1), which confirm its unique nature. Talaromyces atroroseus resembles T. purpurogenus and T. albobiverticillius in producing red diffusible pigments, but differs from the latter two species by the production of glauconic acid, purpuride and ZG-1494α and by the dull to dark green, thick walled ellipsoidal conidia produced. The type strain of Talaromyces atroroseus is CBS 133442
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA polymerase II, causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the severe consequence of these transcription-blocking lesions. However, the exact mechanism and factors involved remain largely unknown. Here, using a genome-wide CRISPR-Cas9 screen, we identified the elongation factor ELOF1 as an important factor in the transcription stress response following DNA damage. We show that ELOF1 has an evolutionarily conserved role in transcription-coupled nucleotide excision repair (TC-NER), where it promotes recruitment of the TC-NER factors UVSSA and TFIIH to efficiently repair transcription-blocking lesions and resume transcription. Additionally, ELOF1 modulates transcription to protect cells against transcription-mediated replication stress, thereby preserving genome stability. Thus, ELOF1 protects the transcription machinery from DNA damage via two distinct mechanisms
Involvement of Girdin in the Determination of Cell Polarity during Cell Migration
Cell migration is a critical cellular process that determines embryonic development and the progression of human diseases. Therefore, cell- or context-specific mechanisms by which multiple promigratory proteins differentially regulate cell migration must be analyzed in detail. Girdin (girders of actin filaments) (also termed GIV, Gα-interacting vesicle associated protein) is an actin-binding protein that regulates migration of various cells such as endothelial cells, smooth muscle cells, neuroblasts, and cancer cells. Here we show that Girdin regulates the establishment of cell polarity, the deregulation of which may result in the disruption of directional cell migration. We found that Girdin interacts with Par-3, a scaffolding protein that is a component of the Par protein complex that has an established role in determining cell polarity. RNA interference-mediated depletion of Girdin leads to impaired polarization of fibroblasts and mammary epithelial cells in a way similar to that observed in Par-3-depleted cells. Accordingly, the expression of Par-3 mutants unable to interact with Girdin abrogates cell polarization in fibroblasts. Further biochemical analysis suggests that Girdin is present in the Par protein complex that includes Par-3, Par-6, and atypical protein kinase C. Considering previous reports showing the role of Girdin in the directional migration of neuroblasts, network formation of endothelial cells, and cancer invasion, these data may provide a specific mechanism by which Girdin regulates cell movement in biological contexts that require directional cell movement
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