Научно-образовательная и организаторская деятельность профессора М. И. Стуковенкова

У статті висвітлюються основні віхи життя та діяльності визначного дерматовенеролога, директора київської дерматологічної клініки ординарного професора імператорського університету Святого Володимира М.І. Стуковенкова за період 1842–1897 рр.The article highlights the most significant achievements of an eminent scientist, dermatovenereologist, Director of Kiev dermatological clinic, Professor of St. Vladimir imperial university M.I. Stukovenkov (1842 – 1897).В статье освещаются основные вехи жизни и деятельности выдающегося дерматовенеролога, директора киевской дерматологической клиники, ординарного профессора императорского университета Св. Владимира М. И. Стуковенкова (за период 1842 – 1897 гг.)

Науково-освітня та організаційна діяльність професора М.І. Стуковенкова

У статті висвітлюються основні віхи життя та діяльності визначного дерматовенеролога, директора київської дерматологічної клініки ординарного професора імператорського університету Святого Володимира М.І. Стуковенкова за період 1842–1897 рр

Minimum living wage as a basic aspect for managing the population’s life quality in Russia

The purpose of this research is to analyze the problem of incompliance of the minimum living wage (MLW) and the subsistence level. The consumer baskets of the Moscow residents and Europeans are compared. The MLW in Russia and countries of the Eurozone is aligned. Social aspects of raising the MLW to the level of the subsistence level are considered. Positive and negative consequences are formulated. The dynamics of the MLW and subsistence level are studied in detail. The factors influencing the quality of the population’s life are regulated. Positive and negative consequences of raising the MLW are formulated. Conclusions about the quality of the Russian population’s life are made. The article is based on a comprehensive study of regulatory and legislative documents that establish the MLW amount, the subsistence level, the consumer basket, as well as on studying the works of national and foreign researchers.peer-reviewe

Organizational and pedagogical activity of the teacher in training at the training center of the enterprise

In the article presents a system of methodological principles and organizational and pedagogical conditions aimed at the formation of a high level of knowledge of students in the working profession in the working profession. Authors descriptions of learning process including: the resources of educational, scientific and industrial structuresВ статье представлена система методических принципов и организационно-педагогических условий, направленных на формирование высокого уровня знаний обучающихся по рабочей профессии в условиях производственной среды наукоемких производств. Приведено описание процесса обучения, включающего ресурсы образовательных, научных и производственных структур, позволяющих обеспечить участие обучающихся по рабочей профессии в научно-инновационной деятельност

БАТАРЕЙНЫЕ СИСТЕМЫ НАКОПЛЕНИЯ ЭЛЕКТРИЧЕСКОЙ ЭНЕРГИИ ДЛЯ ИСПОЛЬЗОВАНИЯ В ИНТЕЛЛЕКТУАЛЬНЫХ ЭНЕРГЕТИЧЕСКИХ СИСТЕМАХ

The main features of battery electric energy storage systems (BESS) are considered in this paper . The functions and the recommended range of installed capacity of BESS are specified depending on their point of connection to energy system. The topologies of a hybrid battery system, which may be used in a range of small, medium and large capacity are given. Different control strategies for hybrid storage system that provide the recommend charge/discharge times of BESS elements are presented. References 30, figures 7.Рассмотрены особенности батарейных систем накопления электрической энергии (БСНЭ). Указаны функции БСНЭ, диапазон рекомендуемой установленной мощности и энергоемкости систем в зависимости от точки их подключения. Приведены структурные схемы гибридных батарейных систем, которые могут применяться в диапазоне малых, средних и больших мощностей. Предложен метод управления гибридной системой накопления, обеспечивающий работу элементов БСНЭ с рекомендуемыми временами заряда-разряда. Библ. 30, рис. 7.Розглянуто особливості батарейних систем накопичення електричної енергії (БСНЕ). Вказані функції БСНЕ, діапазон встановленої потужності та енергоємності систем, що рекомендується в залежності від точки їх підключення. Наведено структурні схеми гібридних батарейних систем, що можуть використовуватись в діапазоні малих, середніх та великих потужностей. Запропоновано метод управління гібридною системою накопичення, що забезпечує роботу елементів БСНЕ з часом заряду-розряду, що рекомендується. Бібл. 30, рис. 7

Discrimination between Streptococcus pneumoniae and Streptococcus mitis based on sorting of their MALDI mass spectra

AbstractAccurate species-level identification of alpha-hemolytic (viridans) streptococci (VGS) is very important for understanding their pathogenicity and virulence. However, an extremely high level of similarity between VGS within the mitis group (S. pneumoniae, S. mitis, S. oralis and S. pseudopneumoniae) often results in misidentification of these organisms. Earlier, matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) has been suggested as a tool for the rapid identification of S. pneumoniae. However, by using Biotyper 3.0 (Bruker) or Vitek MS (bioMérieux) databases, Streptococcus mitis/oralis species can be erroneously identified as S. pneumoniae. ClinProTools 2.1 software was used for the discrimination of MALDI-TOF mass spectra of 25 S. pneumoniae isolates, 34 S. mitis and three S. oralis. Phenotypical tests and multilocus gene typing schemes for the S. pneumoniae (http://spneumoniae.mlst.net/) and viridans streptococci (http://viridans.emlsa.net/) were used for the identification of isolates included in the study. The classifying model was generated based on different algorithms (Genetic Algorithm, Supervised Neural Network and QuickClassifier). In all cases, values of sensitivity and specificity were found to be equal or close to 100%, allowing discrimination of mass spectra of different species. Three peaks (6949, 9876 and 9975 m/z) were determined conferring the maximal statistical weight onto each model built. We find this approach to be promising for viridans streptococci discrimination

Dupilumab: basic aspects and applications to T2-mediated diseases

The asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), atopic dermatitis (AD), eosinophilic esophagitis and other diseases based on T2-inflammation are a widespread in the world. It has led to the development of genetically engineered drugs aimed at individual and specific components of inflammation. One of the leading positions in the pathogenesis of T2-mediated diseases is occupied by interleukin (IL)-4 and IL-13, which explains the prospects of studying these cytokines for the creation of anti-IL-4/IL-13 monoclonal antibodies. The first immunobiological drug was registered to directe against the α subunit of the IL-4 receptor (IL-4Ra), common to both IL-4 and IL-4/IL-13 receptor complexes is dupilumab which is a fully human monoclonal antibody. Dupilumab targets the IL-4 receptor alpha chain (IL-4Rα), common to both IL-4R complexes: type 1 (IL-4Rα/γc; IL-4 specific) and type 2 (IL-4Rα/IL-13Rα1; IL-4 and IL-13 specific). Because the IL-4/IL-13/STAT6 signaling pathway plays a significant role in T2 inflammation. IL-4 and IL-13 are secreted by several cells and, along with other T2 cytokines, as well as with the participation of IL-33, IL-25 and TSLP can stimulate cells to further secrete pro-inflammatory cytokines, contributing to the maintenance of the inflammatory process. Currently, dupilumab has been studied in at least 3,000 patients with asthma, AD, CRSwNP and eosinophilic esophagitis. The results of investigation show an acceptable safety profile in placebo-controlled studies worldwide. In this article, we have highlighted the results of numerous clinical studies and observations that have proven the effectiveness and safety of the use of dupilumab in asthma, AD, CRSwNP, prurigo, eosinophilic esophagitis and eosinophilic pneumonia

Glycyrrhetinic acid and its derivatives as inhibitors of poly(ADP-ribose)polymerases 1 and 2, apurinic/apyrimidinic endonuclease 1 and DNA polymerase β

Aim. For strengthening the efficiency of monofunctional alkylating antineoplastic drugs it is important to lower the capacity of base excision repair (BER) system which corrects the majority of DNA damages caused by these reagents. The objective was to create inhibitors of the key BER enzymes (PARP1, PARP2, DNA polymerase β, and APE1) by the directed modification of glycyrrhetinic acid (GA). Methods. Amides of GA were produced from the GA acetate by formation of the corresponding acyl chloride, amidation with the appropriate amine and subsequent deacylation. Small library of 2-cyano substituted derivatives of GA methyl esters was obtained by the structural modification of GA framework and carboxylic acid group. The inhibitory capacity of the compounds was estimated by comparison of the enzyme activities in specific tests in the presence of compounds versus their absence. Results. None of tested compounds inhibits PARP1 significantly. Unmodified GA and its morpholinic derivative were shown to be weak inhibitors of PARP2. The derivatives of GA containing keto-group in 11 triterpene framework were shown to be moderate inhibitors of pol β. Compound 3, containing 12-oxo-9(11)-en moiety in the ring C, was shown to be a single inhibitor of APE1 among all compounds studied. Conclusions. The class of GA derivatives, selective pol β inhibitors, was found out. The selective inhibitor of APE1 and weak selective inhibitor of PARP2 were also revealed

TRANSFORMATION OF APPROACHES AND MEANS OF DIAGNOSING RISKS OF INVESTMENT PROJECTS AND GOVERNMENT TARGETED PROGRAMS

The article is devoted to the problem of risk assessment in the development of state programs and the implementation of investment projects, analysis of methods and techniques of risk management applied in this area today. The authors theoretically describe the place of evaluation in risk analysis and management as a new emerging function of government bodies. The article opens the scientific discussion on new challenges facing the scientific community in the field of methodological support and support of the processes of modernization of public administration in the field of risk management. The authors summarize the Ukrainian practice of risk assessment in the development of state target programs, designate areas for further research on the stated problem.Key words: risk management, government targeted programs, public administration, investment project

THE DIDACTIC-TECHNOLOGICAL SUPPORT FOR THE PRACTICE-BASED CLUSTER FOR STUDENTS IN VOCATIONAL PEDAGOGICAL UNIVERSITY

The article considers the possibilities of using didactic and technological support for the organization of practice-oriented training of students in the conditions of a professional pedagogical university.В статье рассматриваются возможности применения дидактико-технологического обеспечения для организации практико-ориентированной подготовки студентов в условиях профессионально-педагогического вуза