Situasi Filariasis Setelah Pengobatan Massal Tahun Ketiga di Kabupaten Mamuju Utara

Mass Drug Administration (MDA) of lymphatic filariasis has been carried out for three years in North of Mamuju District. However, achievement of efficacy of this programme was unknown. The implementation of mass treatment to filariasis have been conducted for three years in the District of North Mamuju, but achievement of efficacy of this activity were not known yet. To determine the change of filarial situation as well as knowledge, attitude and behavior of the people to filariasis, after three years mass drug treatment, studies were conducted in March-November 2015, the activities were to collect mass blood fingerprick and interview to the local community. The blood fingerprick was conducted to two selected villages do to age 5 years up old (≥ 5 years), and interviewed was conducted to thirty selected villages do to age 15 years up old (≥ 15 years). The results showed that microfilaria rate in North Mamuju district was 1,39%, and the species was Brugiamalayi. Interviewed to 1,586 respondents indicated that knowledge of filariasis disease and the mass treatment it self were low, similary with the behavior related prevention to drug consumption. On the other hand their behave to prevention, control and filariasis treatment were positif. Microfilaria rate was still higher than 1%, as well as knowledge, attitude and behavior related to prevention and mass drug consumption were particularly still low, those indicated that after three years of mass drug treatment implementation the result did not showed as excpected. It suggested that mass drug implementation in North Mamuju need to be continued until five years,with right procedures and seriously monitoring to the area with chronic and microfilaria positive cases

Activation of Type 1 Cannabinoid Receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures

The endocannabinoid system has been implicated in the modulation of adult neurogenesis. Here, we describe the effect of type 1 cannabinoid receptor (CB1R) activation on self-renewal, proliferation and neuronal differentiation in mouse neonatal subventricular zone (SVZ) stem/progenitor cell cultures. Expression of CB1R was detected in SVZ-derived immature cells (Nestin-positive), neurons and astrocytes. Stimulation of the CB1R by (R)-(+)-Methanandamide (R-m-AEA) increased self-renewal of SVZ cells, as assessed by counting the number of secondary neurospheres and the number of Sox2+/+ cell pairs, an effect blocked by Notch pathway inhibition. Moreover, R-m-AEA treatment for 48 h, increased proliferation as assessed by BrdU incorporation assay, an effect mediated by activation of MAPK-ERK and AKT pathways. Surprisingly, stimulation of CB1R by R-m-AEA also promoted neuronal differentiation (without affecting glial differentiation), at 7 days, as shown by counting the number of NeuN-positive neurons in the cultures. Moreover, by monitoring intracellular calcium concentrations ([Ca2+](i)) in single cells following KCl and histamine stimuli, a method that allows the functional evaluation of neuronal differentiation, we observed an increase in neuronal-like cells. This proneurogenic effect was blocked when SVZ cells were co-incubated with R-m-AEA and the CB1R antagonist AM 251, for 7 days, thus indicating that this effect involves CB1R activation. In accordance with an effect on neuronal differentiation and maturation, R-m-AEA also increased neurite growth, as evaluated by quantifying and measuring the number of MAP2-positive processes. Taken together, these results demonstrate that CB1R activation induces proliferation, self-renewal and neuronal differentiation from mouse neonatal SVZ cell cultures.Fundacao para a Ciencia e a Tecnologia - Portugal [POCTI/SAU-NEU/68465/2006, PTDC/SAU-NEU/104415/2008, PTDC/SAU-NEU/101783/2008, POCTI/SAU-NEU/110838/2009]; Fundacao Calouste Gulbenkian [96542]; Fundacao para a Ciencia e Tecnologiainfo:eu-repo/semantics/publishedVersio

The three main monotheistic religions and gm food technology: an overview of perspectives

Abstract Background Public acceptance of genetically modified crops is partly rooted in religious views. However, the views of different religions and their potential influence on consumers' decisions have not been systematically examined and summarized in a brief overview. We review the positions of the Judaism, Islam and Christianity – the three major monotheistic religions to which more than 55% of humanity adheres to – on the controversies aroused by GM technology. Discussion The article establishes that there is no overarching consensus within the three religions. Overall, however, it appears that mainstream theology in all three religions increasingly tends towards acceptance of GM technology per se, on performing GM research, and on consumption of GM foods. These more liberal approaches, however, are predicated on there being rigorous scientific, ethical and regulatory scrutiny of research and development of such products, and that these products are properly labeled. Summary We conclude that there are several other interests competing with the influence exerted on consumers by religion. These include the media, environmental activists, scientists and the food industry, all of which function as sources of information and shapers of perception for consumers

Capsaicin-Induced Changes in LTP in the Lateral Amygdala Are Mediated by TRPV1

The transient receptor potential vanilloid type 1 (TRPV1) channel is a well recognized polymodal signal detector that is activated by painful stimuli such as capsaicin. Here, we show that TRPV1 is expressed in the lateral nucleus of the amygdala (LA). Despite the fact that the central amygdala displays the highest neuronal density, the highest density of TRPV1 labeled neurons was found within the nuclei of the basolateral complex of the amygdala. Capsaicin specifically changed the magnitude of long-term potentiation (LTP) in the LA in brain slices of mice depending on the anesthetic (ether, isoflurane) used before euthanasia. After ether anesthesia, capsaicin had a suppressive effect on LA-LTP both in patch clamp and in extracellular recordings. The capsaicin-induced reduction of LTP was completely blocked by the nitric oxide synthase (NOS) inhibitor L-NAME and was absent in neuronal NOS as well as in TRPV1 deficient mice. The specific antagonist of cannabinoid receptor type 1 (CB1), AM 251, was also able to reduce the inhibitory effect of capsaicin on LA-LTP, suggesting that stimulation of TRPV1 provokes the generation of anandamide in the brain which seems to inhibit NO synthesis. After isoflurane anesthesia before euthanasia capsaicin caused a TRPV1-mediated increase in the magnitude of LA-LTP. Therefore, our results also indicate that the appropriate choice of the anesthetics used is an important consideration when brain plasticity and the action of endovanilloids will be evaluated. In summary, our results demonstrate that TRPV1 may be involved in the amygdala control of learning mechanisms

Implications of COVID-19 on the Labor Market of Saudi Arabia: The Role of Universities for a Sustainable Workforce

Governments all over the world are taking preventive measures to contain the spread of COVID-19. However, these measures have caused both long- and short-term effects on the socioeconomic situation of many countries. Due to lockdowns and business shutdowns, people are becoming unemployed or are working on reduced wages, creating a unique type of career shock in the global job market. Moreover, this phenomenon also produces a negative reflux among workers, encouraging a new skill set for this unprecedented time. The present study aimed to investigate the implications of COVID-19 on the labor market of Saudi Arabia. Data were collected with the help of a questionnaire from both public and private sector employers (n = 234) to inquire about their perceptions of the new skill set required in the changing business environment during and after pandemics. The data were analyzed with the help of descriptive statistics as well as simple and companion regression. The results indicate that the healthcare, service and education sectors have quickly transformed themselves from conventional to remote forms of working and consider virtual skills, autonomous working and effective communication the most important skills for their workforce during the current and the postpandemic scenarios. Interviews were then conducted with educational leaders to develop a conceptual framework by integrating both qualitative and quantitative analysis of the surveys. The results of the study are beneficial for the educational leadership of higher education institutions (HEIs) to better align their educational programs with changing market needs. By doing so, they not only increase the sustainability of the workforce but also minimize the impact of COVID-19 on the Saudi labor market

Goal Programming and Mathematical Modelling for Developing a Capacity Planning Decision Support System-Based Framework in Higher Education Institutions

Achieving the Saudi Kingdom’s vision 2030 in the higher education sector requires higher education institutions to make a significant simultaneous change in their current practices. This encompasses the transitioning of government-funded educational institutions to be financially independent. Therefore, a prompt, agile transition is required while maintaining a positive socioeconomic impact, entrepreneurship and innovation, and high-quality education. This necessitates the transition to lean processes and the review of current practices. One of the most vital processes in educational institutions is student admission/enrollment capacity planning. This study puts forward a capacity planning decision support system (DSS)-based framework for university student enrollment. The framework was applied to the case of KAU, where current practice and challenges are presented, and from which data were collected. A top-down/bottom-up approach was followed and applied using the goal programming technique and a developed mathematical model, respectively. Results show that the proposed framework effectively affects student admission/enrollment capacity planning on strategic and operational levels. Moreover, it can be used in other planning aspects of higher education in universities, such as human resources planning, teaching load planning, faculty-to-student ratios, accreditation, quality requirements, lab capacity planning, equipment/teaching aids procurement, and financial planning, to mention a few. The implications of this study include assisting decision-makers in higher education institutions in matching their admission/enrollment capacity of student numbers between the macro-strategic and the micro-operational level

Goal Programming and Mathematical Modelling for Developing a Capacity Planning Decision Support System-Based Framework in Higher Education Institutions

Achieving the Saudi Kingdom’s vision 2030 in the higher education sector requires higher education institutions to make a significant simultaneous change in their current practices. This encompasses the transitioning of government-funded educational institutions to be financially independent. Therefore, a prompt, agile transition is required while maintaining a positive socioeconomic impact, entrepreneurship and innovation, and high-quality education. This necessitates the transition to lean processes and the review of current practices. One of the most vital processes in educational institutions is student admission/enrollment capacity planning. This study puts forward a capacity planning decision support system (DSS)-based framework for university student enrollment. The framework was applied to the case of KAU, where current practice and challenges are presented, and from which data were collected. A top-down/bottom-up approach was followed and applied using the goal programming technique and a developed mathematical model, respectively. Results show that the proposed framework effectively affects student admission/enrollment capacity planning on strategic and operational levels. Moreover, it can be used in other planning aspects of higher education in universities, such as human resources planning, teaching load planning, faculty-to-student ratios, accreditation, quality requirements, lab capacity planning, equipment/teaching aids procurement, and financial planning, to mention a few. The implications of this study include assisting decision-makers in higher education institutions in matching their admission/enrollment capacity of student numbers between the macro-strategic and the micro-operational level

Population pharmacokinetics of intramuscular gentamicin administered to young infants with suspected severe sepsis in Kenya

Aims To determine the population pharmacokinetics of intramuscular (i.m.) gentamicin in African infants with suspected severe sepsis. Methods Samples were withdrawn 1 h after a single i.m. injection of 8 mg kg(-1) gentamicin and the next morning prior to any further dosing. Concentration-time data were analysed with the population pharmacokinetic package NONMEM. Data were fitted using a one-compartment model with a log-normal model for interindividual variability and an additive residual error model. The influence of a range of clinical characteristics was tested on the pharmacokinetics of intramuscular gentamicin and the effect of incorporating interindividual variability on bioavailability was examined. Results The data set comprised 107 patients and 203 concentrations. Peak concentrations ranged from 3.0 mg L-1 to 19.8 mg L-1 (median 10.6 mg L-1) and 'next day' samples from 0.3 mg L-1 to 6.2 mg L-1 .The best models were clearance/bioavailability (CL) (L h(-1)) = 0.0913 x weight (kg) x (age (days) + 1)/11)(0.130) and volume of distribution/bioavailability (V) = 2.02 x (1 + 0.277 x (weight -3)). Therefore, an infant with the median weight of 3 kg and age 10 days would have a predicted CL of 0.274 L h(-1) and V of 2.02 L. Interindividual variability in CL was 40% and in V was 42%. This model required a term for covariance between CL and V. When variability in bioavailability was introduced as an alternative model, interindividual variability in CL was 22%, in V 18% and in relative bioavailability 36%. Conclusions Intramuscular administration of 8 mg kg(-1) gentamicin daily to infants gives mean 1 h peak concentration of 10.6 mg L-1 and a trough concentration of less than 2 mg L-1. Wide variability in the peak concentration may reflect variable absorption rate or bioavailability