Traitement du signal audio-visuel et visiophone personne libre

Les informations visuelles et acoustiques sont au coeur de la (télé)communication entre les personnes. Le visage est la principale source d'information. Des techniques de détection du mouvement et de la teinte de la peau délimitent des régions d'intérêt où peuvent se trouver des visages. Un réseau de neurones détecte le visage et fournit la position et l'échelle du visage. Le visage repéré est suivi, en temps réel, par une caméra motorisée et par une antenne acoustique qui génère un lobe orientable. La prise de vue et la prise de son sont ainsi centrées en permanence sur l'utilisateur qui est libre de se déplacer et libre de tout équipement spécifique. Le traitement du signal audio-visuel sont intégrées à LISTEN, démonstrateur du visiophone "personne libre"

ENDOGLIN is dispensable for vasculogenesis, but required for vascular endothelial growth factor-induced angiogenesis

ENDOGLIN (ENG) is a co-receptor for transforming growth factor-β (TGF-β) family members that is highly expressed in endothelial cells and has a critical function in the development of the vascular system. Mutations in Eng are associated with the vascular disease known as hereditary hemorrhagic telangiectasia type l. Using mouse embryonic stem cells we observed that angiogenic factors, including vascular endothelial growth factor (VEGF), induce vasculogenesis in embryoid bodies even when Eng deficient cells or cells depleted of Eng using shRNA are used. However, ENG is required for the stem cell-derived endothelial cells to organize effectively into tubular structures. Consistent with this finding, fetal metatarsals isolated from E17.5 Eng heterozygous mouse embryos showed reduced VEGF-induced vascular network formation. Moreover, shRNA-mediated depletion and pharmacological inhibition of ENG in human umbilical vein cells mitigated VEGF-induced angiogenesis. In summary, we demonstrate that ENG is required for efficient VEGF-induced angiogenesis

Murine embryonic stem cell in vitro differentiation: applications to the study of vascular development

The present review summarizes knowledge accumulated during the last decade concerning in vitro endothelial differentiation from embryonic stem (ES) cells. There is now growing evidence that ES cells may provide a powerful model system to determine the cellular and molecular mechanisms of vascular development. ES cells differentiate into the endothelial lineage by successive maturation steps recapitulating in vivo events observed in the embryo. Further maturation of ES-derived embryoid bodies either in three dimensional gels or in confrontation cultures with tumor spheroids can also provide a model of physiological or tumoral angiogenesis. The data obtained from experimental in vitro differentiation of genetically modified mouse ES cells highlight the potential and the complementarity of this model system to in vivo gene knock out studies. We also consider and discuss some of the potential applications of ES cell technology in vascular biology for future directions in basic research and medicine, by manipulation of differentiation and the generation of cell populations for analysis and transplantation for therapeutic use