Reprint of: CAA Broadband Noise Prediction for Aeroacoustic Design

AbstractThe current status of a hybrid RANS/CAA approach for the simulation of broadband sound generation is presented. The method rests on the use of steady Reynolds Averaged Navier-Stokes (RANS) simulation to prescribe the time-averaged motion of turbulent flow. By means of synthetic turbulence the steady one-point statistics (e.g. turbulent kinetic energy) and turbulent length- and time-scales of RANS are translated into fluctuations of turbulent velocity (or vorticity), whose statistics very accurately reproduce the spatial target distributions of RANS. The synthetic fluctuations are used to prescribe sound sources which drive linear acoustic perturbation equations. The whole approach represents a methodology to solve statistical noise theories with state-of-the-art Computational Aeroacoustics (CAA) tools in the time-domain. A brief overview of the synthetic turbulence model and its numerical discretization in terms of the Random Particle-Mesh (RPM) and Fast Random Particle-Mesh (FRPM) method is given. Results are presented for trailing edge, slat, jet, and combustion noise. Some problems related to the formulation of vortex sound sources are discussed

Estudio de la autoasociacion del benceno y del tolueno en solución en ciclohexano

Se determinan los coeficientes de reparto del benceno y del tolueno entre el ciciohexano y el agua a 25°C y los calores de mezcla para los sistemas benceno-ciciohexano y tolueno-ciclohexano. La dependencia marcada de los coeficientes de reparto con la concentración es interpretada en términos de autoasociación del hidrocarburo aromático en la fase orgánica. El fenómeno de la autoasociación es analizado empleando tres modelos distintos: a) dimerización simple; b) autoasociación en cadena de acuerdo a Mecke-Kempter y c) autoasociación en cadena con dos constantes, k^ para la dimerización y k„ para la polimerización. Se halla que este último modelo describe adecuadamente el fenómeno hasta concentraciones de 2mol/I. Los valores hallados para la constante de dimerización, kj = 0,096 I/mol (benceno) y 0,031 I/mol (tolueno) y para la constante de polimerización, kp = 0,087 I/mol (benceno) y 0,043 I/mol (tolueno)muestran la baja estabilidad de los asociados implicados e indican que la polimerización no se halla particularmente favorecida. La combinación de los datos de autoasociación provenientes de los estudios de reparto con los resultados calorimétricos permiten establecer la entalpia promedia de autoasociación, A H = -5,52 KJ/mol y - 5,61 KJ/mol para el benceno y el tolueno respectivamente Se evalúan además las energías libre y entropías de autoasociación. Finalmente se discute la importancia relativa de las interacciones soluto-soluto en la fase orgánica frente a las Interacciones soluto-soluto en el agua

Diseño, construcción y calibración de un calorímetro de solución de precisión media

Se descrit)en los criterios de diseño, la construcción y la calibración de un calorímetro isoperit and gt; ólico de solución de precisión media y de bajo costo. Se miden los cambios térmicos mediante un termistor de 15.000 otimios a 293 K, cuya calibración permite encontrar la expresión AT = -52,495 log,o (Rf/Ri) para el cambio de temperatura en función de la resistencia, en el rango de trabajo, 297 a 299 K, La sensibilidad termométríca es 0,00158 K/otimio. El error relativo máximo en las medidas calorimétricas con el sistema de calibración benceno-cíclotiexano es de 3%. el de la capacidad calorífica es de 2,74% y el correspondiente a la diferencia de temperatura es de 1,66%, Se encuentran problemas por la gran pendiente de pérdidas de calor, 0,048 K/mln. (valor máximo observado). El coeficiente de transferencia de calor de las paredes del vaso calorimétrico resultó elevado aunque cumple las especificaciones exigidas

Problems of modern programming used in the technology of transport processes

It is well known that information technologies are the most rapidly developing areas of modern life. New technology, designs, names and abbreviations appear almost every day.While creating the products application programming, depending on the industry in which a project is, at the forefront come priority challenges that require extraordinary solutions. This could be accuracy of the solution in the physics-mathematical calculations, the speed of calculations in the programs that implement the reaction or improved interface in products aimed for users, as well as solutions for tasks that implement specific requirements for group work.Mankind has shown interest in the search of the optimal route of application programming and mathematical solution of transportation tasks, allowing to calculate the best route at the lowest cost

Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage

Core regulatory transcription factors (CR TFs) establish enhancers with logical ordering during embryogenesis and development. Here we report that in fusion-positive rhabdomyosarcoma, a cancer of the muscle lineage, the chief oncogene PAX3-FOXO1 is driven by a translocated FOXO1 super enhancer (SE) restricted to a late stage of myogenesis. Using chromatin conformation capture techniques, we demonstrate that the extensive FOXO1 cis-regulatory domain interacts with PAX3. Furthermore, RNA sequencing and chromatin immunoprecipitation sequencing data in tumors bearing rare PAX translocations implicate enhancer miswiring across all fusion-positive tumors. HiChIP of H3K27ac showed connectivity between the FOXO1 SE, additional intra-domain enhancers, and the PAX3 promoter. We show that PAX3-FOXO1 transcription is diminished when this network of enhancers is ablated by CRISPR. Our data reveal a hijacked enhancer network that disrupts the stepwise CR TF logic of normal skeletal muscle development (PAX3 to MYOD to MYOG), replacing it with an "infinite loop" enhancer logic that locks rhabdomyosarcoma in an undifferentiated stage

Restauração ecológica de paisagens degradadas por meio da produção agroecológica em sistemas agroflorestais.

bitstream/item/120203/1/CT.-346-Seoane.pd

Road Traffic Noise and Incident Myocardial Infarction: A Prospective Cohort Study

BACKGROUND Both road traffic noise and ambient air pollution have been associated with risk for ischemic heart disease, but only few inconsistent studies include both exposures. METHODS In a population-based cohort of 57 053 people aged 50 to 64 years at enrolment in 1993-1997, we identified 1600 cases of first-ever MI between enrolment and 2006. The mean follow-up time was 9.8 years. Exposure to road traffic noise and air pollution from 1988 to 2006 was estimated for all cohort members from residential address history. Associations between exposure to road traffic noise and incident MI were analysed in a Cox regression model with adjustment for air pollution (NO(x)) and other potential confounders: age, sex, education, lifestyle confounders, railway and airport noise. RESULTS We found that residential exposure to road traffic noise (L(den)) was significantly associated with MI, with an incidence rate ratio IRR of 1.12 per 10 dB for both of the two exposure windows: yearly exposure at the time of diagnosis (95% confidence interval (CI): 1.02-1.22) and 5-years time-weighted mean (95% CI: 1.02-1.23) preceding the diagnosis. Visualizing of the results using restricted cubic splines showed a linear dose-response relationship. CONCLUSIONS Exposure to long-term residential road traffic noise was associated with a higher risk for MI, in a dose-dependent manner

Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage.

Core regulatory transcription factors (CR TFs) establish enhancers with logical ordering during embryogenesis and development. Here we report that in fusion-positive rhabdomyosarcoma, a cancer of the muscle lineage, the chief oncogene PAX3-FOXO1 is driven by a translocated FOXO1 super enhancer (SE) restricted to a late stage of myogenesis. Using chromatin conformation capture techniques, we demonstrate that the extensive FOXO1 cis-regulatory domain interacts with PAX3. Furthermore, RNA sequencing and chromatin immunoprecipitation sequencing data in tumors bearing rare PAX translocations implicate enhancer miswiring across all fusion-positive tumors. HiChIP of H3K27ac showed connectivity between the FOXO1 SE, additional intra-domain enhancers, and the PAX3 promoter. We show that PAX3-FOXO1 transcription is diminished when this network of enhancers is ablated by CRISPR. Our data reveal a hijacked enhancer network that disrupts the stepwise CR TF logic of normal skeletal muscle development (PAX3 to MYOD to MYOG), replacing it with an "infinite loop" enhancer logic that locks rhabdomyosarcoma in an undifferentiated stage