Quality assurance of the solar UV network in the Antarctic

Measuring ultraviolet radiation in the Antarctic region, where weather conditions are extremely challenging, is a demanding task. Proper quality control of the measurements and quality assurance of the data, which are the basis of all scientific use of data, has to be especially well planned and executed. In this paper we show the importance of proper quality assurance and describe the methods used to successfully operate the NILU-UV multichannel radiometers of the Antarctic network stations at Ushuaia, 54S, and Marambio, 64S. According to our experience, even though multichannel instruments are supposed to be rather stable as a function of time, severe drifts can occur in the sensitivity of the channels under these harsh conditions. During 2000–2003 the biggest drifts were 35%, both at Ushuaia and Marambio, with the sensitivity of the channels dropping at different rates. Without proper corrections in the data, this would have seriously affected the calculated UV dose rates. As part of the quality assurance of the network a traveling reference NILU-UV, which was found to be stable, was used to transfer the desired irradiance scale to the site NILU-UV data. Relative lamp tests were used to monitor the stability of the instruments. Each site NILU-UV was scaled channel by channel to the traveling reference by performing solar comparisons. The method of scaling each channel separately was found to be successful, even though the differences between the raw data of the site NILU-UV and the reference instruments were, before the data correction, as much as 40%. After the correction, the mean ratios of erythemally weighted UV dose rates measured during the solar comparisons in 2000–2003 between the reference NILU-UV and the site NILU-UV were 1.007 ± 0.011 and 1.012 ± 0.012 for Ushuaia and Marambio, respectively, when the solar zenith angle varied up to 80. These results make possible the scientific use of NILU-UV data measured simultaneously at quite different locations, e.g., the Antarctic and Arctic, and the method presented is also practicable for other multichannel radiometer networks.S, and Marambio, 64S. According to our experience, even though multichannel instruments are supposed to be rather stable as a function of time, severe drifts can occur in the sensitivity of the channels under these harsh conditions. During 2000–2003 the biggest drifts were 35%, both at Ushuaia and Marambio, with the sensitivity of the channels dropping at different rates. Without proper corrections in the data, this would have seriously affected the calculated UV dose rates. As part of the quality assurance of the network a traveling reference NILU-UV, which was found to be stable, was used to transfer the desired irradiance scale to the site NILU-UV data. Relative lamp tests were used to monitor the stability of the instruments. Each site NILU-UV was scaled channel by channel to the traveling reference by performing solar comparisons. The method of scaling each channel separately was found to be successful, even though the differences between the raw data of the site NILU-UV and the reference instruments were, before the data correction, as much as 40%. After the correction, the mean ratios of erythemally weighted UV dose rates measured during the solar comparisons in 2000–2003 between the reference NILU-UV and the site NILU-UV were 1.007 ± 0.011 and 1.012 ± 0.012 for Ushuaia and Marambio, respectively, when the solar zenith angle varied up to 80. These results make possible the scientific use of NILU-UV data measured simultaneously at quite different locations, e.g., the Antarctic and Arctic, and the method presented is also practicable for other multichannel radiometer networks.S. According to our experience, even though multichannel instruments are supposed to be rather stable as a function of time, severe drifts can occur in the sensitivity of the channels under these harsh conditions. During 2000–2003 the biggest drifts were 35%, both at Ushuaia and Marambio, with the sensitivity of the channels dropping at different rates. Without proper corrections in the data, this would have seriously affected the calculated UV dose rates. As part of the quality assurance of the network a traveling reference NILU-UV, which was found to be stable, was used to transfer the desired irradiance scale to the site NILU-UV data. Relative lamp tests were used to monitor the stability of the instruments. Each site NILU-UV was scaled channel by channel to the traveling reference by performing solar comparisons. The method of scaling each channel separately was found to be successful, even though the differences between the raw data of the site NILU-UV and the reference instruments were, before the data correction, as much as 40%. After the correction, the mean ratios of erythemally weighted UV dose rates measured during the solar comparisons in 2000–2003 between the reference NILU-UV and the site NILU-UV were 1.007 ± 0.011 and 1.012 ± 0.012 for Ushuaia and Marambio, respectively, when the solar zenith angle varied up to 80. These results make possible the scientific use of NILU-UV data measured simultaneously at quite different locations, e.g., the Antarctic and Arctic, and the method presented is also practicable for other multichannel radiometer networks.. These results make possible the scientific use of NILU-UV data measured simultaneously at quite different locations, e.g., the Antarctic and Arctic, and the method presented is also practicable for other multichannel radiometer networks.Fil: Lakkala, K.. Finnish Meteorological Institute; FinlandiaFil: Redondas, A.. Instituto Nacional de Meteorología; EspañaFil: Meinander, O.. Finnish Meteorological Institute; FinlandiaFil: Torres ,Carlos. Instituto Nacional de Meteorología; EspañaFil: Koskela, T.. Finnish Meteorological Institute; FinlandiaFil: Cuevas, Eduardo. Instituto Nacional de Meteorología; EspañaFil: Taalas, P.. Finnish Meteorological Institute; FinlandiaFil: Dahlback, A.. University of Oslo; NoruegaFil: Deferrari, Guillermo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Edvardsen, K.. Instituto Noruego de Investigación del Aire; NoruegaFil: Ochoa, H.. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; Argentin

Evidence-based approach to thrombophilia testing

Thrombophilia can be identified in about half of all patients presenting with VTE. Testing has increased tremendously for various indications, but whether the results of such tests help in the clinical management of patients has not been settled. I use evidence from observational studies to conclude that testing for hereditary thrombophilia generally does not alter the clinical management of patients with VTE, with occasional exceptions for women at fertile age. Because testing for thrombophilia only serves limited purpose this should not be performed on a routine basis

Antibodies to Serine Proteases in the Antiphospholipid Syndrome

It is generally accepted that the major autoantigen for antiphospholipid antibodies (aPL) in the antiphospholipid syndrome (APS) is β2-glycoprotein I (β2GPI). However, a recent study has revealed that some aPL bind to certain conformational epitope(s) on β2GPI shared by the homologous enzymatic domains of several serine proteases involved in hemostasis and fibrinolysis. Importantly, some serine protease–reactive aPL correspondingly hinder anticoagulant regulation and resolution of clots. These results extend several early findings of aPL binding to other coagulation factors and provide a new perspective about some aPL in terms of binding specificities and related functional properties in promoting thrombosis. Moreover, a recent immunological and pathological study of a panel of human IgG monoclonal aPL showed that aPL with strong binding to thrombin promote in vivo venous thrombosis and leukocyte adherence, suggesting that aPL reactivity with thrombin may be a good predictor for pathogenic potentials of aPL

The Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved Structure

Plasmodium falciparum malaria parasites, living in red blood cells, express proteins of the erythrocyte membrane protein-1 (PfEMP1) family on the red blood cell surface. The binding of PfEMP1 molecules to human cell surface receptors mediates the adherence of infected red blood cells to human tissues. The sequences of the 60 PfEMP1 genes in each parasite genome vary greatly from parasite to parasite, yet the variant PfEMP1 proteins maintain receptor binding. Almost all parasites isolated directly from patients bind the human CD36 receptor. Of the several kinds of highly polymorphic cysteine-rich interdomain region (CIDR) domains classified by sequence, only the CIDR1α domains bind CD36. Here we describe the CD36-binding portion of a CIDR1α domain, MC179, as a bundle of three α-helices that are connected by a loop and three additional helices. The MC179 structure, containing seven conserved cysteines and 10 conserved hydrophobic residues, predicts similar structures for the hundreds of CIDR sequences from the many genome sequences now known. Comparison of MC179 with the CIDR domains in the genome of the P. falciparum 3D7 strain provides insights into CIDR domain structure. The CIDR1α three-helix bundle exhibits less than 20% sequence identity with the three-helix bundles of Duffy-binding like (DBL) domains, but the two kinds of bundles are almost identical. Despite the enormous diversity of PfEMP1 sequences, the CIDR1α and DBL protein structures, taken together, predict that a PfEMP1 molecule is a polymer of three-helix bundles elaborated by a variety of connecting helices and loops. From the structures also comes the insight that DBL1α domains are approximately 100 residues larger and that CIDR1α domains are approximately 100 residues smaller than sequence alignments predict. This new understanding of PfEMP1 structure will allow the use of better-defined PfEMP1 domains for functional studies, for the design of candidate vaccines, and for understanding the molecular basis of cytoadherence

State of the climate in 2013

In 2013, the vast majority of the monitored climate variables reported here maintained trends established in recent decades. ENSO was in a neutral state during the entire year, remaining mostly on the cool side of neutral with modest impacts on regional weather patterns around the world. This follows several years dominated by the effects of either La Niña or El Niño events. According to several independent analyses, 2013 was again among the 10 warmest years on record at the global scale, both at the Earths surface and through the troposphere. Some regions in the Southern Hemisphere had record or near-record high temperatures for the year. Australia observed its hottest year on record, while Argentina and New Zealand reported their second and third hottest years, respectively. In Antarctica, Amundsen-Scott South Pole Station reported its highest annual temperature since records began in 1957. At the opposite pole, the Arctic observed its seventh warmest year since records began in the early 20th century. At 20-m depth, record high temperatures were measured at some permafrost stations on the North Slope of Alaska and in the Brooks Range. In the Northern Hemisphere extratropics, anomalous meridional atmospheric circulation occurred throughout much of the year, leading to marked regional extremes of both temperature and precipitation. Cold temperature anomalies during winter across Eurasia were followed by warm spring temperature anomalies, which were linked to a new record low Eurasian snow cover extent in May. Minimum sea ice extent in the Arctic was the sixth lowest since satellite observations began in 1979. Including 2013, all seven lowest extents on record have occurred in the past seven years. Antarctica, on the other hand, had above-average sea ice extent throughout 2013, with 116 days of new daily high extent records, including a new daily maximum sea ice area of 19.57 million km2 reached on 1 October. ENSO-neutral conditions in the eastern central Pacific Ocean and a negative Pacific decadal oscillation pattern in the North Pacific had the largest impacts on the global sea surface temperature in 2013. The North Pacific reached a historic high temperature in 2013 and on balance the globally-averaged sea surface temperature was among the 10 highest on record. Overall, the salt content in nearsurface ocean waters increased while in intermediate waters it decreased. Global mean sea level continued to rise during 2013, on pace with a trend of 3.2 mm yr-1 over the past two decades. A portion of this trend (0.5 mm yr-1) has been attributed to natural variability associated with the Pacific decadal oscillation as well as to ongoing contributions from the melting of glaciers and ice sheets and ocean warming. Global tropical cyclone frequency during 2013 was slightly above average with a total of 94 storms, although the North Atlantic Basin had its quietest hurricane season since 1994. In the Western North Pacific Basin, Super Typhoon Haiyan, the deadliest tropical cyclone of 2013, had 1-minute sustained winds estimated to be 170 kt (87.5 m s-1) on 7 November, the highest wind speed ever assigned to a tropical cyclone. High storm surge was also associated with Haiyan as it made landfall over the central Philippines, an area where sea level is currently at historic highs, increasing by 200 mm since 1970. In the atmosphere, carbon dioxide, methane, and nitrous oxide all continued to increase in 2013. As in previous years, each of these major greenhouse gases once again reached historic high concentrations. In the Arctic, carbon dioxide and methane increased at the same rate as the global increase. These increases are likely due to export from lower latitudes rather than a consequence of increases in Arctic sources, such as thawing permafrost. At Mauna Loa, Hawaii, for the first time since measurements began in 1958, the daily average mixing ratio of carbon dioxide exceeded 400 ppm on 9 May. The state of these variables, along with dozens of others, and the 2013 climate conditions of regions around the world are discussed in further detail in this 24th edition of the State of the Climate series. © 2014, American Meteorological Society. All rights reserved

Overvåking av ozonlaget. Et norsk og et globalt perspektiv.

Rapporten beskriver den observerte svekkingen av ozonlaget. Det blir fokusert på globale endringer og på endringer over Europa og Norge. Utviklingen av atmosfærens innhold av klor og brom, som bryter ned ozonlaget, blir diskutert

Overvåking av ozonlaget. Årsrapport 1993.

Rapporten presenterer måledata fra norske bakkestasjoner i 1993