14,470 research outputs found
Prospects for Discovering Supersymmetry at the LHC
Supersymmetry is one of the best-motivated candidates for physics beyond the
Standard Model that might be discovered at the LHC. There are many reasons to
expect that it may appear at the TeV scale, in particular because it provides a
natural cold dark matter candidate. The apparent discrepancy between the
experimental measurement of g_mu - 2 and the Standard model value calculated
using low-energy e+ e- data favours relatively light sparticles accessible to
the LHC. A global likelihood analysis including this, other electroweak
precision observables and B-decay observables suggests that the LHC might be
able to discover supersymmetry with 1/fb or less of integrated luminosity. The
LHC should be able to discover supersymmetry via the classic missing-energy
signature, or in alternative phenomenological scenarios. The prospects for
discovering supersymmetry at the LHC look very good.Comment: 8 pages, 11 figure
Stochastic compartmental analysis - Some applications and examples of estimation in a pulse labelled system
Stochastic compartmental analysis with examples of estimation in pulse labelled syste
Cell-free prediction of protein expression costs for growing cells
Translating heterologous proteins places significant burden on host cells, consuming expression resources leading to slower cell growth and productivity. Yet predicting the cost of protein production for any given gene is a major challenge, as multiple processes and factors combine to determine translation efficiency. To enable prediction of the cost of gene expression in bacteria, we describe here a standard cell-free lysate assay that provides a relative measure of resource consumption when a protein coding sequence is expressed. These lysate measurements can then be used with a computational model of translation to predict the in vivo burden placed on growing E. coli cells for a variety of proteins of different functions and lengths. Using this approach, we can predict the burden of expressing multigene operons of different designs and differentiate between the fraction of burden related to gene expression compared to action of a metabolic pathway
Revisiting the Higgs Mass and Dark Matter in the CMSSM
Taking into account the available accelerator and astrophysical constraints,
the mass of the lightest neutral Higgs boson h in the minimal supersymmetric
extension of the Standard Model with universal soft supersymmetry-breaking
masses (CMSSM) has been estimated to lie between 114 and ~ 130 GeV. Recent data
from ATLAS and CMS hint that m_h ~ 125 GeV, though m_h ~ 119 GeV may still be a
possibility. Here we study the consequences for the parameters of the CMSSM and
direct dark matter detection if the Higgs hint is confirmed, focusing on the
strips in the (m_1/2, m_0) planes for different tan beta and A_0 where the
relic density of the lightest neutralino chi falls within the range of the
cosmological cold dark matter density allowed by WMAP and other experiments. We
find that if m_h ~ 125 GeV focus-point strips would be disfavoured, as would
the low-tan beta stau-chi and stop -chi coannihilation strips, whereas the
stau-chi coannihilation strip at large tan beta and A_0 > 0 would be favoured,
together with its extension to a funnel where rapid annihilation via
direct-channel H/A poles dominates. On the other hand, if m_h ~ 119 GeV more
options would be open. We give parametrizations of WMAP strips with large tan
beta and fixed A_0/m_0 > 0 that include portions compatible with m_h = 125 GeV,
and present predictions for spin-independent elastic dark matter scattering
along these strips. These are generally low for models compatible with m_h =
125 GeV, whereas the XENON100 experiment already excludes some portions of
strips where m_h is smaller.Comment: 24 pages, 9 figure
A supersymmetric D-brane Model of Space-Time Foam
We present a supersymmetric model of space-time foam with two stacks of eight
D8-branes with equal string tensions, separated by a single bulk dimension
containing D0-brane particles that represent quantum fluctuations in the
space-time foam. The ground state configuration with static D-branes has zero
vacuum energy. However, gravitons and other closed-string states propagating
through the bulk may interact with the D0-particles, causing them to recoil and
the vacuum energy to become non zero. This provides a possible origin of dark
energy. Recoil also distorts the background metric felt by energetic massless
string states, which travel at less than the usual (low-energy) velocity of
light. On the other hand, the propagation of chiral matter anchored on the D8
branes is not affected by such space-time foam effects.Comment: 33 pages, latex, five figure
Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis
BACKGROUND
Mechanisms regulating breast cancer lymph node metastasis are unclear. Staining of CLEVER-1 (common lymphatic endothelial and vascular endothelial receptor-1) in human breast tumors was used, along with in vitro techniques, to assess involvement in the metastatic process.
METHODS
148 sections of primary invasive breast cancers, with 10 yr follow-up, were stained with anti-CLEVER-1. Leukocyte infiltration was assessed, along with involvement of specific subpopulations by staining with CD83 (mature dendritic cells, mDC), CD209 (immature DC, iDC) and CD68 (macrophage, Mϕ). In vitro expression of CLEVER-1 on lymphatic (LEC) and blood endothelial cells (BEC) was examined by flow cytometry.
RESULTS
In vitro results showed that although both endothelial cell types express CLEVER-1, surface expression was only evident on LEC. In tumour sections CLEVER-1 was expressed in blood vessels (BV, 61.4% of samples), lymphatic vessels (LV, 18.2% of samples) and in Mϕ/DCs (82.4% of samples). However, only CLEVER-1 expression in LV was associated with LN metastasis (p = 0.027) and with Mϕ indices (p = 0.021). Although LV CLEVER-1 was associated with LN positivity there was no significant correlation with recurrence or overall survival, BV CLEVER-1 expression was, however, associated with increased risk of recurrence (p = 0.049). The density of inflammatory infiltrate correlated with CLEVER-1 expression in BV (p < 0.001) and LV (p = 0.004).
CONCLUSIONS
The associations between CLEVER-1 expression on endothelial vessels and macrophage/leukocyte infiltration is suggestive of its regulation by inflammatory conditions in breast cancer, most likely by macrophage-associated cytokines. Its upregulation on LV, related surface expression, and association with LN metastasis suggest that it may be an important mediator of tumor cell metastasis to LN
What if Supersymmetry Breaking Unifies beyond the GUT Scale?
We study models in which soft supersymmetry-breaking parameters of the MSSM
become universal at some unification scale, , above the GUT scale,
\mgut. We assume that the scalar masses and gaugino masses have common
values, and respectively, at . We use the
renormalization-group equations of the minimal supersymmetric SU(5) GUT to
evaluate their evolutions down to \mgut, studying their dependences on the
unknown parameters of the SU(5) superpotential. After displaying some generic
examples of the evolutions of the soft supersymmetry-breaking parameters, we
discuss the effects on physical sparticle masses in some specific examples. We
note, for example, that near-degeneracy between the lightest neutralino and the
lighter stau is progressively disfavoured as increases. This has the
consequence, as we show in planes for several different values
of , that the stau coannihilation region shrinks as
increases, and we delineate the regions of the plane
where it is absent altogether. Moreover, as increases, the focus-point
region recedes to larger values of for any fixed and
. We conclude that the regions of the plane that are
commonly favoured in phenomenological analyses tend to disappear at large
.Comment: 24 pages with 11 eps figures; references added, some figures
corrected, discussion extended and figure added; version to appear in EPJ
Noncommutative 6D Gauge Higgs Unification Models
The influence of higher dimensions in noncommutative field theories is
considered. For this purpose, we analyze the bosonic sector of a recently
proposed 6 dimensional SU(3) orbifold model for the electroweak interactions.
The corresponding noncommutative theory is constructed by means of the
Seiberg-Witten map in 6D. We find in the reduced bosonic interactions in 4D
theory, couplings which are new with respect to other known 4D noncommutative
formulations of the Standard Model using the Seiberg-Witten map.
Phenomenological implications due to the noncommutativity of extra dimensions
are explored. In particular, assuming that the commutative model leads to the
standard model values, a bound -5.63 10^{-8} GeV^{-2}< theta <1.06
10^{-7}GeV^{-2} on the corresponding noncommutativity scale is derived from
current experimental constraints on the S and T oblique parameters. This bound
is used to predict a possibly significant impact of noncommutativity effects of
extra dimensions on the rare Higgs boson decay H-> gamma gamma.Comment: Latex file, 11 pages, 1 figur
On the Significance of the Weyl Curvature in a Relativistic Cosmological Model
The Weyl curvature includes the Newtonian field and an additional field, the
so-called anti-Newtonian. In this paper, we use the Bianchi and Ricci
identities to provide a set of constraints and propagations for the Weyl
fields. The temporal evolutions of propagations manifest explicit solutions of
gravitational waves. We see that models with purely Newtonian field are
inconsistent with relativistic models and obstruct sounding solutions.
Therefore, both fields are necessary for the nonlocal nature and radiative
solutions of gravitation.Comment: 15 pages, incorporating proof correction
Transport and cooling of singly-charged noble gas ion beams
The transport and cooling of noble gas singly-charged ion beams by means of a
Radio Frequency Quadrupole Cooler Buncher (RFQCB) have been studied at the
LIMBE low energy beam line of the GANIL facility. Ions as light as
have been cooled and stored before their extraction in bunches using as
buffer gas. Bunches characteristics have been studied as a function of the
parameters of the device. Sizeable transmissions of up to 10 have been
obtained. A detailed study of the lifetime of ions inside the buncher has been
performed giving an estimate of the charge exchange cross-section. Results of a
microscopic Monte-Carlo transport code show reasonable agreement with
experimental data.Comment: 13 figure
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