5,299 research outputs found
CAMMD: Context Aware Mobile Medical Devices
Telemedicine applications on a medical practitioners mobile device should be context-aware. This can vastly improve the effectiveness of mobile applications and is a step towards realising the vision of a ubiquitous telemedicine environment. The nomadic nature of a medical practitioner emphasises location, activity and time as key context-aware elements. An intelligent middleware is needed to effectively interpret and exploit these contextual elements. This paper proposes an agent-based architectural solution called Context-Aware Mobile Medical Devices (CAMMD). This framework can proactively communicate patient records to a portable device based upon the active context of its medical practitioner. An expert system is utilised to cross-reference the context-aware data of location and time against a practitioners work schedule. This proactive distribution of medical data enhances the usability and portability of mobile medical devices. The proposed methodology alleviates constraints on memory storage and enhances user interaction with the handheld device. The framework also improves utilisation of network bandwidth resources. An experimental prototype is presented highlighting the potential of this approach
Logarithmic behavior of degradation dynamics in metal--oxide semiconductor devices
In this paper the authors describe a theoretical simple statistical modelling
of relaxation process in metal-oxide semiconductor devices that governs its
degradation. Basically, starting from an initial state where a given number of
traps are occupied, the dynamics of the relaxation process is measured
calculating the density of occupied traps and its fluctuations (second moment)
as function of time. Our theoretical results show a universal logarithmic law
for the density of occupied traps , i.e., the degradation is logarithmic and its amplitude depends on the
temperature and Fermi Level of device. Our approach reduces the work to the
averages determined by simple binomial sums that are corroborated by our Monte
Carlo simulations and by experimental results from literature, which bear in
mind enlightening elucidations about the physics of degradation of
semiconductor devices of our modern life
The problem of interpretation in vignette methodology in research with young people
In this paper we explore how interpretation is dealt with by researchers using a vignette methodology. Researchers using vignette methodology often struggle with interpretation: how to interpret the responses when participants shift between discussing the vignettes as themselves, taking the perspective of the character in the vignette and commenting on what ‘ought’ to happen. We argue that by foregrounding a consideration of the method with an explicitly articulated theoretical position of dialogicality, issues inherent in interpretation become a valuable addition to the research rather than an obstacle to be overcome. In the paper we discuss ‘Louise’ a young carer, detailing the various positions she takes in her talk about the vignette of Mary, a fictitious young carer, to illustrate how a perspective based in dialogical theory contributed to the analysis of her various moves through different identity positions
On the Influence of Magnetic Fields on the Structure of Protostellar Jets
We here present the first results of fully three-dimensional (3-D) MHD
simulations of radiative cooling pulsed (time-variable) jets for a set of
parameters which are suitable for protostellar outflows. Considering different
initial magnetic field topologies in approximate with the
thermal gas, i.e., (i) a longitudinal, and (ii) a helical field, both of which
permeating the jet and the ambient medium; and (iii) a purely toroidal field
permeating only the jet, we find that the overall morphology of the pulsed jet
is not very much affected by the presence of the different magnetic field
geometries in comparison to a nonmagnetic calculation. Instead, the magnetic
fields tend to affect essentially the detailed structure and emission
properties behind the shocks at the head and at the pulse-induced internal
knots, particularly for the helical and toroidal geometries. In these cases, we
find, for example, that the emissivity behind the internal knots can
be about three to four times larger than that of the purely hydrodynamical jet.
We also find that some features, like the nose cones that often develop at the
jet head in 2-D calculations involving toroidal magnetic fields, are smoothed
out or absent in the 3-D calculations.Comment: 13 pages, 3 figures, Accepted by ApJ Letters after minor corrections
(for high resolution figures, see http://www.iagusp.usp.br/~adriano/h.tar
Systematic Errors in Cosmic Microwave Background Interferometry
Cosmic microwave background (CMB) polarization observations will require
superb control of systematic errors in order to achieve their full scientific
potential, particularly in the case of attempts to detect the B modes that may
provide a window on inflation. Interferometry may be a promising way to achieve
these goals. This paper presents a formalism for characterizing the effects of
a variety of systematic errors on interferometric CMB polarization
observations, with particular emphasis on estimates of the B-mode power
spectrum. The most severe errors are those that couple the temperature
anisotropy signal to polarization; such errors include cross-talk within
detectors, misalignment of polarizers, and cross-polarization. In a B mode
experiment, the next most serious category of errors are those that mix E and B
modes, such as gain fluctuations, pointing errors, and beam shape errors. The
paper also indicates which sources of error may cause circular polarization
(e.g., from foregrounds) to contaminate the cosmologically interesting linear
polarization channels, and conversely whether monitoring of the circular
polarization channels may yield useful information about the errors themselves.
For all the sources of error considered, estimates of the level of control that
will be required for both E and B mode experiments are provided. Both
experiments that interfere linear polarizations and those that interfere
circular polarizations are considered. The fact that circular experiments
simultaneously measure both linear polarization Stokes parameters in each
baseline mitigates some sources of error.Comment: 19 pages, 9 figures, submitted to Phys. Rev.
Mosaicking with cosmic microwave background interferometers
Measurements of cosmic microwave background (CMB) anisotropies by
interferometers offer several advantages over single-dish observations. The
formalism for analyzing interferometer CMB data is well developed in the
flat-sky approximation, valid for small fields of view. As the area of sky is
increased to obtain finer spectral resolution, this approximation needs to be
relaxed. We extend the formalism for CMB interferometry, including both
temperature and polarization, to mosaics of observations covering arbitrarily
large areas of the sky, with each individual pointing lying within the flat-sky
approximation. We present a method for computing the correlation between
visibilities with arbitrary pointing centers and baselines and illustrate the
effects of sky curvature on the l-space resolution that can be obtained from a
mosaic.Comment: 9 pages; submitted to Ap
Self-field effects upon the critical current density of flat superconducting strips
We develop a general theory to account self-consistently for self-field
effects upon the average transport critical current density Jc of a flat
type-II superconducting strip in the mixed state when the bulk pinning is
characterized by a field-dependent depinning critical current density Jp(B),
where B is the local magnetic flux density. We first consider the possibility
of both bulk and edge-pinning contributions but conclude that bulk pinning
dominates over geometrical edge-barrier effects in state-of-the-art YBCO films
and prototype second-generation coated conductors. We apply our theory using
the Kim model, JpK(B) = JpK(0)/(1+|B|/B0), as an example. We calculate Jc(Ba)
as a function of a perpendicular applied magnetic induction Ba and show how
Jc(Ba) is related to JpK(B). We find that Jc(Ba) is very nearly equal to
JpK(Ba) when Ba > Ba*, where Ba* is the value of Ba that makes the net flux
density zero at the strip's edge. However, Jc(Ba) is suppressed relative to
JpK(Ba) at low fields when Ba < Ba*, with the largest suppression occurring
when Ba*/B0 is of order unity or larger.Comment: 9 pages, 4 figures, minor revisions to add four reference
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Image segmentation techniques for granular materials
To improve understanding of the mechanical behavior of granular materials it is important to be able to quantify the relative arrangement of the grains, i.e. the fabric. This can be done, for example, by measuring the orientations of the particles (e.g. the long axis orientation) or by considering the orientations of the vectors normal to each grain‐grain contact. In two dimensional (2D) analyses this information can be obtained by digital image analysis of images of thin sections obtained from an optical microscope. While such data is useful, granular materials of engineering interest are three dimensional (3D) materials and quantification of the 3D fabric is necessary. Micro Computed‐Tomography (μCT) together with 3D image analysis has emerged as a promising technique for obtaining the 3D data required. This paper aims to highlight the challenges associated with using image analysis to provide quantitative information on fabric. While automated image segmentation has proved to produce reasonable results in some cases, it is sometimes less successful when dealing with highly irregular and angular soil grains. This paper evaluates the effectiveness of 2D and 3D segmentation techniques that rely on the watershed segmentation algorithm. The primary material considered is Reigate Silver Sand, a natural quartzitic sand with grain diameters in the range of 150–300 μm. While the sand considered is primarily of interest to geotechnical engineers, the results of this study will be of interest to anyone seeking to quantify granular material fabric using either 2D microscopy data or μCT 3D data sets
Analysis of margin classification systems for assessing the risk of local recurrence after soft tissue sarcoma resection
Purpose:
To compare the ability of margin classification systems to determine local recurrence (LR) risk after soft tissue sarcoma (STS) resection.
Methods:
Two thousand two hundred seventeen patients with nonmetastatic extremity and truncal STS treated with surgical resection and multidisciplinary consideration of perioperative radiotherapy were retrospectively reviewed. Margins were coded by residual tumor (R) classification (in which microscopic tumor at inked margin defines R1), the R+1mm classification (in which microscopic tumor within 1 mm of ink defines R1), and the Toronto Margin Context Classification (TMCC; in which positive margins are separated into planned close but positive at critical structures, positive after whoops re-excision, and inadvertent positive margins). Multivariate competing risk regression models were created.
Results:
By R classification, LR rates at 10-year follow-up were 8%, 21%, and 44% in R0, R1, and R2, respectively. R+1mm classification resulted in increased R1 margins (726 v 278, P < .001), but led to decreased LR for R1 margins without changing R0 LR; for R0, the 10-year LR rate was 8% (range, 7% to 10%); for R1, the 10-year LR rate was 12% (10% to 15%) . The TMCC also showed various LR rates among its tiers (P < .001). LR rates for positive margins on critical structures were not different from R0 at 10 years (11% v 8%, P = .18), whereas inadvertent positive margins had high LR (5-year, 28% [95% CI, 19% to 37%]; 10-year, 35% [95% CI, 25% to 46%]; P < .001).
Conclusion:
The R classification identified three distinct risk levels for LR in STS. An R+1mm classification reduced LR differences between R1 and R0, suggesting that a negative but < 1-mm margin may be adequate with multidisciplinary treatment. The TMCC provides additional stratification of positive margins that may aid in surgical planning and patient education
Ticarcillin hypersusceptibility in pseudomonas aeruginosa in cystic fibrosis
Background: A subpopulation of Pseudomonas aeruginosa (PsA) exists in cysticfibrosis (CF) patients that is hypersusceptible to ticarcillin, a carboxypenicillin, in vitro (Tichs strain) defined as a minimum inhibitory concentration (MIC) ≤4μg/ml. Methods: In a retrospective cohort study, isolates of PsA from CF (23), non-cystic fibrosis bronchiectasis (NCFB) (17) and control (18) patients were analysed. MICs for each isolate were determined using agar dilution against six antibiotics and interpreted using EUCAST breakpoints. Prevalence of Tichs in each cohort was calculated. A point prevalence survey was conducted in CF to review the patients’ clinical progress following PsA isolation. Results: Prevalence of the Tichs strain in PsA was 48%, 76% and 0% in the CF, NCFB and control cohorts respectively. A statistically significant difference in geometric mean MIC was seen between the Tichs and non-Tichs cohorts in CF for ticarcillin (as expected) and temocillin (p=0.041and p=0.036 respectively). A similar trend was observed in NCFB for ticarcillin (p=0.038) and temocillin (p=0.067), although statistical significance was not reached for the latter.In CF, the Tichs strain demonstrated lower MICs to all antibiotics tested apart from gentamicin compared to their non-Tichs counterparts. Those who had the Tichs strain in CF had fewer antibiotics (13.9 days versus 23.5 days, Tichs and non-Tichs respectively) although this result was not statistically significant p=0.202. Conclusion: Our data supports the existence of a Tichs strain of PsA in our CF and NCFB patient populations. This strain correlated with reduced MICs to temocillin in CF, to which PsA would normally be resistant, which may be of clinical relevance.</p
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