1,543 research outputs found
Effects of past and current crop management on leaching losses, soil microbial community composition and activity
A lysimeter experiment was conducted to investigate the effect of past and current management practices on soil microbial biomass, activity and community composition. Intact monolith lysimeters were taken from sites of the same soil type that had been under long-term organic and conventional crop management. They were subjected to the same crop rotation and managed according to best organic and conventional practices. Mineral N loss was determined in leachates and soil samples taken before the experiment and after 30 months were analysed for biological soil properties, including microbial diversity. Results indicated that leaching losses were similar for all treatments and that crop was the main influence on microbial biomass composition and size, while microbial activity was determined by management history
Abnormal connectivity between the default mode and the visual system underlies the manifestation of visual hallucinations in Parkinson’s disease:A task-based fMRI study
Background: The neural substrates of visual hallucinations remain an enigma, due primarily to the difficulties associated with directly interrogating the brain during hallucinatory episodes. Aims: To delineate the functional patterns of brain network activity and connectivity underlying visual hallucinations in Parkinson’s disease. Methods: In this study, we combined functional magnetic resonance imaging (MRI) with a behavioral task capable of eliciting visual misperceptions, a confirmed surrogate for visual hallucinations, in 35 patients with idiopathic Parkinson’s disease. We then applied an independent component analysis to extract time series information for large-scale neuronal networks that have been previously implicated in the pathophysiology of visual hallucinations. These data were subjected to a task-based functional connectivity analysis, thus providing the first objective description of the neural activity and connectivity during visual hallucinations in patients with Parkinson’s disease. Results: Correct performance of the task was associated with increased activity in primary visual regions; however, during visual misperceptions, this same visual network became actively coupled with the default mode network (DMN). Further, the frequency of misperception errors on the task was positively correlated with the strength of connectivity between these two systems, as well as with decreased activity in the dorsal attention network (DAN), and with impaired connectivity between the DAN and the DMNs, and ventral attention networks. Finally, each of the network abnormalities identified in our analysis were significantly correlated with two independent clinical measures of hallucination severity. Conclusions: Together, these results provide evidence that visual hallucinations are due to increased engagement of the DMN with the primary visual system, and emphasize the role of dysfunctional engagement of attentional networks in the pathophysiology of hallucinations
Wave energy in Europe: Views on experiences and progress to date
publisher: Elsevier articletitle: Wave energy in Europe: Views on experiences and progress to date journaltitle: International Journal of Marine Energy articlelink: http://dx.doi.org/10.1016/j.ijome.2015.09.001 content_type: article copyright: © 2015 Elsevier Ltd. All rights reserved
p38 δ
p38δ mitogen activated protein kinase (MAPK) is a unique stress responsive protein kinase. While the p38 MAPK family as a whole has been implicated in a wide variety of biological processes, a specific role for p38δ MAPK in cellular signalling and its contribution to both physiological and pathological conditions are presently lacking. Recent emerging evidence, however, provides some insights into specific p38δ MAPK signalling. Importantly, these studies have helped to highlight functional similarities as well as differences between p38δ MAPK and the other members of the p38 MAPK family of kinases. In this review we discuss the current understanding of the molecular mechanisms underlying p38δ MAPK activity. We outline a role for p38δ MAPK in important cellular processes such as differentiation and apoptosis as well as pathological conditions such as neurodegenerative disorders, diabetes, and inflammatory disease. Interestingly, disparate roles for p38δ MAPK in tumour development have also recently been reported. Thus, we consider evidence which characterises p38δ MAPK as both a tumour promoter and a tumour suppressor. In summary, while our knowledge of p38δ MAPK has progressed somewhat since its identification in 1997, our understanding of this particular isoform in many cellular processes still strikingly lags behind that of its counterparts
Political and Economic Opening as a Post-Crisis Strategy for Japan
In economics literature, the sources of economic growth in general and in Japan in particular have been appraised either from the supply-side, with the emphasis on capital accumulation, labour, total factor productivity and – given the advent of the new growth models – on technological change, or from the demand side. The study on Japanese growth by Chenery et al. (1962) was an early demand-based study that looked at the drivers of economic growth and structural change over the period 1914-1954. Using input-output methods and taking into account the contribution of technological change11 over this long-time period, the authors found two distinct early sub-periods of economic growth: the 1914-1935 and the 1935-1954 sub-periods. The first (1914-1935) is characterised by a rise in domestic income (by 4.5 per cent per annum) with large increases in exports. The second (1935-1954) is marked by the loss of colonial supplies of raw materials and by a substantial fall in exports; this second sub-period is also marked by import substitution policies and by the rising importance of technological change. The findings for the first sub-period mirror Japan’s emergence as an economic and geostrategic power, affirming first its colonial ambitions in East-Asia through the development of its many manufacturing networks, in the region as a whole and in Korea in particular (Inkster, 2001)
Representing Terrain With Mathematical Operators
This work describes a mathematical representation of terrain data consisting of a novel operation, the “drill”. It facilitates the representation of legal terrains, capturing the richness of the physics of the terrain’s generation by digging channels in the surface. Given our current reliance on digital map data, hand-held devices, and GPS navigation systems, the accuracy and compactness of terrain data representations are becoming increasingly important. Representing a terrain as a series of operations that can procedurally regenerate the terrains allows for compact representation that retains more information than height fields, TINs, and other popular representations. Our model relies on the hydrography information extracted from the terrain, and so drainage information is retained during encoding. To determine the shape of the drill along each channel in the channel network, a cross section of the channel is extracted, and a quadratic polynomial is fit to it. We extract the drill representation from a mountainous dataset, using a series of parameters (including size and area of influence of the drill, as well as the density of the hydrography data), and present the accuracy calculated using a series of metrics. We demonstrate that the drill operator provides a viable and accurate terrain representation that captures both the terrain shape and the richness of its generation
Physical Education Pedagogies Built upon Theories of Movement Learning: How Can Environmental Constraints Be Manipulated to Improve Children’s Executive Function and Self-Regulation Skills?
Physical education in schools has been marginalised across the globe, and as a result, children are missing out on opportunities to develop and acquire the foundation skills needed to lead a physically active life. The squeeze on physical education in schools, particularly in some western countries (United Kingdom, Australia and America), has been justified on the grounds that core subjects such as English and mathematics need more curriculum time, as this will lead to higher cognitive and academic performance. The aim of this paper is to highlight how physical education lessons in early childhood, underpinned by either of two major theories of motor learning, can support teachers in the creation of learning environments, as well as guide their pedagogical practice to facilitate children’s development of key cognitive skills, in particular executive function and self-regulation skills. These skills are crucial for learning and development and have been found to be a higher predictor of academic achievement than IQ. They also enable positive behaviour and allow us to make healthy choices for ourselves and others, therefore providing further evidence that the development of movement skills has the potential to secure positive attitudes and outcomes towards physical activity across the lifespan
USING BIRD STRIKE DATA TO MONITOR BIRD-HAZARD CONTROL
An effective definition of a bird strike is the basis for quantifying the scale of bird hazard problems. Here we present a working definition of a bird strike, which in turn forms the basis of an analysis of 32 years’ data collected at Dublin Airport, Ireland. A variety of datasets are analysed including the number of bird strikes per ten thousand aircraft movements, the mass of the bird species being struck, the time of year at which bird strikes occur and the dimensions of the aircraft utilising the airfield. In addition, we have analysed the mean number of strikes per year and the mean number of birds struck per bird strike. Following a very serious incident involving a Boeing 737-200 which struck a flock of gulls in the mid -1980’s, a new regime of control measures was put in place. Therefore our study permits us to evaluate the effectiveness of this management programme. The results suggest that the most significant impact of control measures is to reduce the number of birds being struck per bird strike
Impact of different unconditional monetary incentives on survey response rates in men with prostate cancer: A 2-arm randomised trial
Background: Men are often viewed as a difficult group to recruit for psychological research, including in psycho-oncology. Whilst research has demonstrated the effectiveness of small monetary incentives for encouraging research participation, little research has examined different large unconditional incentive amounts. Larger unconditional incentives may result in increased participation of men in psychological research. This randomised study within a case–control trial of men diagnosed with early-stage prostate cancer aimed to investigate whether (a) response rates to a 30-min questionnaire completed via mail, online, or phone would vary with different unconditional incentive amounts, and (b) demographics would vary in those who responded within the different incentive groups. Methods: We conducted this randomised study within a case–control cross-sectional study aiming to identify the social-ecological factors influencing treatment discontinuation in prostate cancer patients. A total of 238 participants from the cross-sectional study were randomised to receive one of two unconditional incentives (n = 121 received AUD 20) with the study materials (consent form and survey). Results: Overall, 113 (47 %) responded; n = 61/121 (50.4 %) in the AUD 20 group. No evidence of a difference was found in response rates by incentive group (odds ratio 1.27, 95 % CI = 0.76 – 2.12, p = 0.36). Additionally, there were no evident differences in the demographics of the responders vs. non-responders within each incentive group (all p \u3e 0.05). Conclusions: Unlike previous research, we were unable to show that higher monetary incentives were more effective for increasing response rates. An AUD $20 unconditional incentive may be no more effective than a lesser amount for encouraging prostate cancer survivors to participate in research involving long questionnaires. Future research should consider the cost-benefits of providing large unconditional incentives, as non-responses will result in lost resources perhaps better utilised in other engagement strategies
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