The efficacy of cinacalcet in the treatment of hyperparathyroidism in Turkish hemodialysis patient population

WOS: 000393291900012OBJECTIVE: Cinacalcet reduces parathyroid hormone levels by increasing the sensitivity of the parathyroid gland to calcium. in this study, we firstly aimed to evaluate the efficacy of cinacalcet in Turkish hemodialysis patients. MATERIAL and METHODS: 4483 hemodialysis patients were screened and 469 patients who had used cinacalcet were included in the study. the patients were divided into 4 groups according to drug usage durations (Group 1: 3 months, Group 2: 6 months, Group 3: 9 months and Group 4: 12 months). the patients' Parathormone, Ca, P and CaxP levels at the 3rd, 6th, 9th and 12th months were compared to the start of treatment and previous months. RESULTS: the levels of Parathormone, Ca, P and CaxP significantly decreased compared to their initial levels in all groups (from 1412 pg/ml to 1222 pg/mL for Parathormone, p< 0,001) in the 3rd month. However, this reduction was not continued in the subsequent months (Parathormone: 1381 pg/ml for the 12th month). CONCLUSION: Cinacalcet may not provide adequate benefit in control of hyperparathyroidism in Turkish hemodialysis patient population

Sorption of acid dyes from aqueous solution by using non-ground ash and slag

The sorption of two acid dyes (Acid Yellow 99 and Acid Red 183) into locally available industrial waste materials, namely, Granulated Blast Furnace Slag (GBFS) and Furnace Bottom Ash (FBA), has been investigated by performing batch equilibrium experiments with pH, ionic conductivity, initial dye concentration and temperature as variables. The kinetic sorption data indicated that the sorption capacity of GBFS for these dyes was almost zero. On the other hand, the color removal efficiency for FBA could reach 50% depending on the initial dye concentration. It was also found that the kinetics of sorption of Acid Yellow 99 and Acid Red 183 onto the surface of FBA at different operating conditions were best described by the Elovich kinetic model. In addition, the adsorption equilibrium data were analyzed using various adsorption isotherm models and the results have shown that the sorption behaviors of the studied dyes could be best described by the Langmuir model. © 2010 Elsevier B.V

ÇOCUKLUK ÇAĞI OVER KAYNAKLI SOLİD TÜMÖRLERDE CERRAHİ DENEYİMLERİMİZ

Amaç: Over kaynaklı solid tümörler çocukluk yaş grubunda nadirdir, ancak tespit edildiğinde hem hasta hem deailesi için önemli bir endişe kaynağıdır. Bu çalışmanın amacı çocukluk çağında solid over tümörü saptananhastalardaki deneyimimizin sunulmasıdır.Yöntem: Ocak 2010 ile Ocak 2023 yılları arasında solid over tümörü saptanan 0-18 yaş arası hastalar retrospektifolarak değerlendirildi. Hastaların demografik özellikleri, ek hastalıkları, tanıda kullanılan yöntemler, tümörbelirteçleri, risk temelli uygulanan cerrahi yöntem, tümör tipi ve özellikleri, uygulanan tedavi ve nüks varlığıkaydedildi.Bulgular: Çalışmamızda 67 olgu değerlendirmeye alındı. Olguların 51’i (%76,1) benign kitlelerdi (en sık matürkistik teratom). Bu olguların ortanca yaşı 13,0 (10,0-15,0) idi. En sık taraf sağ (%58,8) iken kitlelerin ortanca boyutu8,0 (5,0-11,0) cm idi. Ameliyat sonrası hastanede kalış süresi 2,0 (2,0-3,0) gündü. Malign kitle saptanan 16 (%23,9)olgunun ortanca yaşı 11,5 (7,5-15,0) idi. En sık taraf sol (%56,3) iken en sık tanı immatür teratomdu (%43,8).Kitlelerin ortanca boyutu 15,0 cm (8,0-22,7) idi. Ameliyat sonrası hastanede kalış süresi ise 3,0 (3,0-4,0) gündü.Cerrahi yöntemler değerlendirildiğinde benign kitlelerde en sık kullanılan yöntem laparoskopi (%58,8) ve overkoruyucu cerrahiydi (%80,4). Her iki tercihte de en etkili faktör kitle boyutuydu (p=0,000 ve p=0,001). Malignkitlelerde en sık tercih edilen yöntem laparotomi (%93,8) ve ooferektomiydi (%87,5).Benign ve malign kitleler arasında kitle boyutu, ameliyat sonrası takip süreleri, uygulanan cerrahi tipi, over koruyucucerrahi açısından istatiksel anlamlı fark bulundu (p&lt;0,05).Sonuç: Çocukluk çağında over kitleleri erişkinden farklı olarak genellikle germ hücreli tümörlerdir. Çalışmamızdagösterildiği üzere malign karakterli kitlelerde tümör yayılımı ve evreleme açısından laparotomi sıklıkla tercih edilsede benign karakterli kitlelerde laparoskopi ve over koruyucu cerrahi en çok tercih edilen yöntemlerdi. Bu tercihlerinbelirlenmesinde en önemli faktörler ise kitlenin özellikleri ve boyutuydu.&nbsp

The Treatment of Recurrent Urothelial Tumors of the Upper Urinary System and at Urostomy Site following Radical Cystectomy with Intraureteral Bacillus Calmette-Guérin and Cryotherapy.

Urinary bladder carcinoma is the second most common cancer of the urinary system. The recurrence rate in the upper urinary system (UUS) for urothelial cancers is around 3% following radical cystectomy. The followup generally consists of imaging studies and urinary cytology, although there are no prospective data on the frequency, the mode, and the duration of followup. In patients carefully selected according to risk factors, kidney-sparing minimally invasive methods (ureteroscopic procedures, percutaneous approach, and local drug instillation) appear as contemporary alternatives for low-grade and low-stage primary UUS. In this paper, we present the patient who underwent radical cystectomy with urinary diversion ureterocutaneostomy, was diagnosed with widespread bilateral UUS tumors and recurrent tumor at the urostomy site at active followup, for which he was given local Bacillus Calmette-Guérin (BCG) and cryotherapy, and was followed by disease-free for 2 years thereafter