The c axis optical conductivity of layered systems in the superconducting state

In this paper, we discuss the c axis optical conductivity Re [sigma_c(omega)] in the high T_c superconductors, in the superconducting state. The basic premise of this work is that electrons travelling along the c axis between adjacent CuO_2 layers must pass through several intervening layers. In earlier work we found that, for weak inter-layer coupling, it is preferable for electrons to travel along the c axis by making a series of interband transitions rather than to stay within a single (and very narrow) band. Moreover, we found that many of the properties of the normal state optical conductivity, including the pseudogap could be explained by interband transitions. In this work we examine the effect of superconductivity on the interband conductivity. We find that, while the onset of superconductivity is clearly evident in the spectrum, there is no clear signature of the symmetry of the superconducting order parameter.Comment: 6 pages, 4 figure

How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse

Splice modulation therapy has shown great clinical promise in Duchenne muscular dystrophy, resulting in the production of dystrophin protein. Despite this, the relationship between restoring dystrophin to established dystrophic muscle and its ability to induce clinically relevant changes in muscle function is poorly understood. In order to robustly evaluate functional improvement, we used in situ protocols in the mdx mouse to measure muscle strength and resistance to eccentric contraction-induced damage. Here, we modelled the treatment of muscle with pre-existing dystrophic pathology using antisense oligonucleotides conjugated to a cell-penetrating peptide. We reveal that 15% homogeneous dystrophin expression is sufficient to protect against eccentric contraction-induced injury. In addition, we demonstrate a >40% increase in specific isometric force following repeated administrations. Strikingly, we show that changes in muscle strength are proportional to dystrophin expression levels. These data define the dystrophin restoration levels required to slow down or prevent disease progression and improve overall muscle function once a dystrophic environment has been established in the mdx mouse model

MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells

Background: Successful treatment of oesophageal cancer is hampered by recurrent drug resistant disease. We have previously demonstrated the importance of apoptosis and autophagy for the recovery of oesophageal cancer cells following drug treatment. When apoptosis (with autophagy) is induced, these cells are chemosensitive and will not recover following chemotherapy treatment. In contrast, when cancer cells exhibit only autophagy and limited Type II cell death, they are chemoresistant and recover following drug withdrawal. Methods: MicroRNA (miRNA) expression profiling of an oesophageal cancer cell line panel was used to identify miRNAs that were important in the regulation of apoptosis and autophagy. The effects of miRNA overexpression on cell death mechanisms and recovery were assessed in the chemoresistant (autophagy inducing) KYSE450 oesophageal cancer cells. Results: MiR-193b was the most differentially expressed miRNA between the chemosensitive and chemoresistant cell lines with higher expression in chemosensitive apoptosis inducing cell lines. Colony formation assays showed that overexpression of miR-193b significantly impedes the ability of KYSE450 cells to recover following 5-fluorouracil (5-FU) treatment. The critical mRNA targets of miR-193b are unknown but target prediction and siRNA data analysis suggest that it may mediate some of its effects through stathmin 1 regulation. Apoptosis was not involved in the enhanced cytotoxicity. Overexpression of miR-193b in these cells induced autophagic flux and non-apoptotic cell death. Conclusion: These results highlight the importance of miR-193b in determining oesophageal cancer cell viability and demonstrate an enhancement of chemotoxicity that is independent of apoptosis induction

TrES-1: The Transiting Planet of a Bright K0V Star

We report the detection of a transiting Jupiter-sized planet orbiting a relatively bright (V=11.79) K0V star. We detected the transit light-curve signature in the course of the TrES multi-site transiting planet survey, and confirmed the planetary nature of the companion via multicolor photometry and precise radial velocity measurements. We designate the planet TrES-1; its inferred mass is 0.75 +/- 0.07 Jupiter masses, its radius is 1.08 (+0.18/-0.04) Jupiter radii, and its orbital period is 3.030065 +/- 0.000008 days. This planet has an orbital period similar to that of HD 209458b, but about twice as long as those of the OGLE transiting planets. Its mass is indistinguishable from that of HD 209458b, but its radius is significantly smaller and fits the theoretical models without the need for an additional source of heat deep in the atmosphere, as has been invoked by some investigators for HD 209458b.Comment: 15 pages, 3 figures, 2 tables. To be published in Astrophysical Journal Letters. Ascii data in http://www.hao.ucar.edu/public/research/stare/data/TrES1.as

Management and Tillage Infl uence Barley Forage Productivity and Water Use in Dryland Cropping Systems

Annual cereal forages are resilient in water use (WU), water use efficiency (WUE), and weed control compared with grain crops in dryland systems. The combined influence of tillage and management systems on annual cereal forage productivity and WU is not well documented. We conducted a field study for the effects of tillage (no-till and tilled) and management (ecological and conventional) systems on WU and performance of forage barley (Hordeum vulgare L.) and weed biomass in two crop rotations (wheat [Triticum aestivum L.]–forage barley–pea [Pisum sativum L.] and wheat–forage barley–corn [Zea mays L.] –pea) from 2004 to 2010 in eastern Montana. Conventional management included recommended seeding rates, broadcast N fertilization, and short stubble height of wheat. Ecological management included 33% greater seeding rates, banded N fertilization at planting, and taller wheat stubble. Forage barley in ecological management had 28 more plants m–2, 2 cm greater height, 65 more tillers m–2, 606 kg ha–1 greater crop biomass, 3.5 kg ha–1 mm–1greater WUE, and 47% reduction in weed biomass at harvest than in conventional management. Pre-plant and post-harvest soil water contents were similar among tillage and management systems, but barley WU was 13 mm greater in 4-yr than 3-yr rotation. Tillage had little effect on barley performance and WU. Dryland forage barley with higher seeding rate and banded N fertilization in more diversified rotation produced more yield and used water more efficiently than that with conventional seeding rate, broadcast N fertilization, and less diversified rotation in the semiarid northern Great Plains

Nucleotide sequence of the structural gene (pyrB) that encodes the catalytic polypeptide of aspartate transcarbamoylase of Escherichia coli.

The deoxyribonucleotide sequence of pyrB, the cistron encoding the catalytic subunit of aspartate transcarbamoylase (carbamoylphosphate: L-aspartate carbamoyltransferase, EC 2.1.3.2), has been determined. The pyrB gene encodes a polypeptide of 311 amino acid residues initiated by an NH2-terminal methionine that is not present in the catalytically active polypeptide. The DNA sequence analysis revealed the presence of an eight-amino-acid sequence beginning at Met-219 that was not detected in previous analyses of amino acid sequence. This octapeptide sequence provides an additional component of the disordered loop in the equatorial domain of the catalytic polypeptide. It had been found previously that the catalytic polypeptide is expressed from a bicistronic operon that also produces the regulatory polypeptide encoded by pyrI. A single transcriptional control region precedes the structural gene of the catalytic polypeptide and a simple 15-base-pair region separates its COOH terminus from the structural gene of the regulatory polypeptide. The chain-terminating codon of the catalytic polypeptide may contribute to the ribosomal binding site for the regulatory polypeptide and thus assist coordinate expression of the two cistrons

A New Spectroscopic and Photometric Analysis of the Transiting Planet Systems TrES-3 and TrES-4

We report new spectroscopic and photometric observations of the parent stars of the recently discovered transiting planets TrES-3 and TrES-4. A detailed abundance analysis based on high-resolution spectra yields [Fe/H] $= -0.19\pm 0.08$, $T_\mathrm{eff} = 5650\pm 75$ K, and $\log g = 4.4\pm 0.1$ for TrES-3, and [Fe/H] $= +0.14\pm 0.09$, $T_\mathrm{eff} = 6200\pm 75$ K, and $\log g = 4.0\pm0.1$ for TrES-4. The accuracy of the effective temperatures is supported by a number of independent consistency checks. The spectroscopic orbital solution for TrES-3 is improved with our new radial-velocity measurements of that system, as are the light-curve parameters for both systems based on newly acquired photometry for TrES-3 and a reanalysis of existing photometry for TrES-4. We have redetermined the stellar parameters taking advantage of the strong constraint provided by the light curves in the form of the normalized separation $a/R_\star$ (related to the stellar density) in conjunction with our new temperatures and metallicities. The masses and radii we derive are M_\star=0.928_{-0.048}^{+0.028} M_{\sun},R_\star = 0.829_{-0.022}^{+0.015} R_{\sun}, and M_\star = 1.404_{-0.134}^{+0.066} M_{\sun}, R_\star=1.846_{-0.087}^{+0.096} R_{\sun} for TrES-3 and TrES-4, respectively. With these revised stellar parameters we obtain improved values for the planetary masses and radii. We find $M_p = 1.910_{-0.080}^{+0.075} M_\mathrm{Jup}$, $R_p=1.336_{-0.036}^{+0.031} R_\mathrm{Jup}$ for TrES-3, and $M_p=0.925 \pm 0.082 M_\mathrm{Jup}$, $R_p=1.783_{-0.086}^{+0.093} R_\mathrm{Jup}$ for TrES-4. We confirm TrES-4 as the planet with the largest radius among the currently known transiting hot Jupiters.Comment: 42 pages, 10 tables, 8 figures. Accepted for publication in the Astrophysical Journa

What is the evidence for giving chemoprophylaxis to children or students attending the same preschool, school or college as a case of meningococcal disease?

We performed a systematic literature review to assess the effectiveness of chemoprophylaxis for contacts of sporadic cases of invasive meningococcal disease (IMD) in educational settings. No studies directly compared IMD risk in contacts with/without chemoprophylaxis. However, compared to the background incidence, an elevated IMD risk was identified in settings without a general recommendation for chemoprophylaxis in pre-schools [pooled risk difference (RD) 58·2/10⁵, 95% confidence interval (CI) 27·3-89·0] and primary schools (pooled RD 4·9/10⁵, 95% CI 2·9-6·9) in the ~30 days after contact with a sporadic IMD case, but not in other educational settings. Thus, limited but consistent evidence suggests the risk of IMD in pre-school contacts of sporadic IMD cases is significantly increased above the background risk, but lower than in household contacts (pooled RD for household contacts with no chemoprophylaxis vs. background incidence: 480·1/10⁵, 95% CI 321·5-639·9). We recommend chemoprophylaxis for pre-school contacts depending on an assessment of duration and closeness of contact

S and D Wave Mixing in High TcT_c Superconductors

For a tight binding model with nearest neighbour attraction and a small orthorhombic distortion, we find a phase diagram for the gap at zero temperature which includes three distinct regions as a function of filling. In the first, the gap is a mixture of mainly $d$-wave with a smaller extended $s$-wave part. This is followed by a region in which there is a rapid increase in the $s$-wave part accompanied by a rapid increase in relative phase between $s$ and $d$ from 0 to $\pi$. Finally, there is a region of dominant $s$ with a mixture of $d$ and zero phase. In the mixed region with a finite phase, the $s$-wave part of the gap can show a sudden increase with decreasing temperature accompanied with a rapid increase in phase which shows many of the characteristics measured in the angular resolved photoemission experiments of Ma {\em et al.} in $\rm Bi_2Sr_2CaCu_2O_8$Comment: 12 pages, RevTeX 3.0, 3 PostScript figures uuencoded and compresse