A cost minimisation analysis of NOACs compared to warfarin to attain therapeutic anticoagulation amongst AF patients, pre- and post-cardioversion

Atrial fibrillation can be managed with anticoagulation and restoration of normal sinus rhythm using direct current cardioversion (DCCV). To reduce the risk of thromboembolism anticoagulation pre-and-post DCCV is recommended. This study investigates the cost effectiveness of using NOACs compared to warfarin to attain therapeutic anticoagulation amongst AF patients pre-and-post DCCV. Propensity score matching revealed no statistically significant difference in outcomes from using NOACs and Warfarin. A cost minimisation study was performed; demonstrating a cost differential of €209 between those administered NOACs and warfarin pre and post DCCV. This study demonstrates how using NOACs compared to warfarin to attain therapeutic anticoagulation amongst AF patients preand-post DCCV is cost effective

The significance of grassroots and inclusive innovation in harnessing social entrepreneurship and urban regeneration

Purpose: The purpose of this study is to examine the dimensions of inclusive and grassroots innovations operationalised by a social enterprise and the impact of these activities on urban regeneration. To this end, the case of Homebaked in Liverpool, UK, is presented and discussed. Design/methodology/approach: Face-to-face interviews with members of Homebaked’s management, staff and volunteers were conducted; the interviews were complemented with on-site observations and review of archival information of the social enterprise. Findings: The data gathered revealed the organisation’s involvement in both types of innovation as a means to achieve long-term urban regeneration related goals. For instance, innovative, strategic and human dimensions, together with the human dimension emerged as key ways of innovating. The impacts of innovative practices comprised encouraging inclusiveness among residents and non-residents, with approaches including hands-on training workshops, job and volunteering opportunities being predominant. Originality/value: First, the study advances the theoretical and applied understanding of grassroots and inclusive innovation in the context of a social enterprise. For instance, an innovative/strategic and human dimension emerged as predominant ways in which grassroots and inclusive innovation elements were manifested. These dimensions were based on technology uptake, implementation of new product/service concepts or harnessing the skills of local and non-local individuals. Similarly, four dimensions associated with the impacts of these types of innovation were revealed. Second, the study addresses acknowledged gaps in the literature, particularly regarding the limited contributions illuminating processes and determinants of innovation among social enterprises. © 2020, Emerald Publishing Limited

Protein-DNA charge transport: Redox activation of a DNA repair protein by guanine radical

DNA charge transport (CT) chemistry provides a route to carry out oxidative DNA damage from a distance in a reaction that is sensitive to DNA mismatches and lesions. Here, DNA-mediated CT also leads to oxidation of a DNA-bound base excision repair enzyme, MutY. DNA-bound Ru(III), generated through a flash/quench technique, is found to promote oxidation of the [4Fe-4S](2+) cluster of MutY to [4Fe-4S](3+) and its decomposition product [3Fe-4S](1+). Flash/quench experiments monitored by EPR spectroscopy reveal spectra with g = 2.08, 2.06, and 2.02, characteristic of the oxidized clusters. Transient absorption spectra of poly(dGC) and [Ru(phen)(2)dppz](3+) (dppz = dipyridophenazine), generated in situ, show an absorption characteristic of the guanine radical that is depleted in the presence of MutY with formation instead of a long-lived species with an absorption at 405 nm; we attribute this absorption also to formation of the oxidized [4Fe-4S](3+) and [3Fe4S](1+) clusters. In ruthenium-tethered DNA assemblies, oxidative damage to the 5'-G of a 5'-GG-3' doublet is generated from a distance but this irreversible damage is inhibited by MutY and instead EPR experiments reveal cluster oxidation. With ruthenium-tethered assemblies containing duplex versus single-stranded regions, MutY oxidation is found to be mediated by the DNA duplex, with guanine radical as an intermediate oxidant; guanine radical formation facilitates MutY oxidation. A model is proposed for the redox activation of DNA repair proteins through DNA CT, with guanine radicals, the first product under oxidative stress, in oxidizing the DNA-bound repair proteins, providing the signal to stimulate DNA repair

Erratum: “Seed layer technique for high quality epitaxial manganite films” [AIP Advances 6, 085109 (2016)]

No abstract available

Bayesian Analysis of Solar Oscillations

A Bayesian probability based approach is applied to the problem of detecting and parameterizing oscillations in the upper solar atmosphere for the first time. Due to its statistical origin, this method provides a mechanism for determining the number of oscillations present, gives precise estimates of the oscillation parameters with a self-consistent statistical error analysis, and allows the oscillatory model signals to be reconstructed within these errors. A highly desirable feature of the Bayesian approach is the ability to resolve oscillations with extremely small frequency separations. The code is applied to SOHO/CDS (Solar and Heliospheric Observatory/Coronal Diagnostic Spectrometer) O V 629A observations and resolves four distinct P4, P5, P6 and P7 p-modes within the same sunspot transition region. This suggests that a spectrum of photospheric p-modes is able to propagate into the upper atmosphere of the Sun and Sun-like stars, and places precise observational constraints on models of umbral eigen modes.Comment: Accepted for publication in The Astrophysical Journal. It is scheduled for the ApJ July 20, 2008, v682n 1 issu

Optical bistability in Er-Yb co-doped phosphate glass microspheres at room temperature

We experimentally demonstrate optical bistability in Er3+-Yb3+ phosphate glass microspheres at 295 K. Bistability is associated with both Er3+ fluorescence and lasing behavior, and chromatic switching. The chromatic switching results from an intrinsic mechanism exploiting the thermal coupling of closely-spaced energy levels, and occurs simultaneously with the intensity switching. A contrast ratio of 3.2 has been obtained for chromatic switching, and the intensity switching shows ratios of 2.4 for 550 nm and, 1.8 for the 660 nm fluorescence emissions, and 11 for the IR lasing at 1.5 um. Concurrent with these observations, we investigate a temperature dependent absorption of pump power which exhibits bistable behavior. The influences of the host matrix on lasing and fluorescence mechanisms are highlighted.Comment: 22 pages, 6 figure

Ballistic-electron-emission spectroscopy of Al<SUB>x</SUB>Ga<SUB>1-x</SUB>As/GaAs heterostructures: conduction-band offsets, transport mechanisms, and band-structure effects

We report an extensive investigation of semiconductor band-structure effects in single-barrier AlxGa1-xAs/GaAs heterostructures using ballistic-electron-emission spectroscopy (BEES). The transport mechanisms in these single-barrier structures were studied systematically as a function of temperature and Al composition over the full compositional range (0&#8804;x&#8804;1). The initial (&#915;) BEES thresholds for AlxGa1-xAs single barriers with 0&#8804;x&#8804;0.42 were extracted using a model which includes the complete transmission probability of the metal-semiconductor interface and the semiconductor heterostructure. Band offsets measured by BEES are in good agreement with previous measurements by other techniques which demonstrates the accuracy of this technique. BEES measurements at 77 K give the same band-offset values as at room temperature. When a reverse bias is applied to the heterostructures, the BEES thresholds shift to lower voltages in good agreement with the expected bias-induced band-bending. In the indirect band-gap regime (x&gt;0.45), spectra show a weak ballistic-electron-emission microscopy current contribution due to intervalley scattering through AlxGa1-xAs X valley states. Low-temperature spectra show a marked reduction in this intervalley current component, indicating that intervalley phonon scattering at the GaAs/AlxGa1-xAs interface produces a significant fraction of this X valley current. A comparison of the BEES thresholds with the expected composition dependence of the AlxGa1-xAs &#915;, L, and X points yields good agreement over the entire composition range

The need for calcium imaging in nonhuman primates: New motor neuroscience and brain-machine interfaces

A central goal of neuroscience is to understand how populations of neurons coordinate and cooperate in order to give rise to perception, cognition, and action. Nonhuman primates (NHPs) are an attractive model with which to understand these mechanisms in humans, primarily due to the strong homology of their brains and the cognitively sophisticated behaviors they can be trained to perform. Using electrode recordings, the activity of one to a few hundred individual neurons may be measured electrically, which has enabled many scientific findings and the development of brain-machine interfaces. Despite these successes, electrophysiology samples sparsely from neural populations and provides little information about the genetic identity and spatial micro-organization of recorded neurons. These limitations have spurred the development of all-optical methods for neural circuit interrogation. Fluorescent calcium signals serve as a reporter of neuronal responses, and when combined with post-mortem optical clearing techniques such as CLARITY, provide dense recordings of neuronal populations, spatially organized and annotated with genetic and anatomical information. Here, we advocate that this methodology, which has been of tremendous utility in smaller animal models, can and should be developed for use with NHPs. We review here several of the key opportunities and challenges for calcium-based optical imaging in NHPs. We focus on motor neuroscience and brain-machine interface design as representative domains of opportunity within the larger field of NHP neuroscience

ADGO 2.0: interpreting microarray data and list of genes using composite annotations

ADGO 2.0 is a web-based tool that provides composite interpretations for microarray data comparing two sample groups as well as lists of genes from diverse sources of biological information. Some other tools also incorporate composite annotations solely for interpreting lists of genes but usually provide highly redundant information. This new version has the following additional features: first, it provides multiple gene set analysis methods for microarray inputs as well as enrichment analyses for lists of genes. Second, it screens redundant composite annotations when generating and prioritizing them. Third, it incorporates union and subtracted sets as well as intersection sets. Lastly, users can upload their own gene sets (e.g. predicted miRNA targets) to generate and analyze new composite sets. The first two features are unique to ADGO 2.0. Using our tool, we demonstrate analyses of a microarray dataset and a list of genes for T-cell differentiation. The new ADGO is available at http://www.btool.org/ADGO2