Improved AURA k-Nearest Neighbour approach

The k-Nearest Neighbour (kNN) approach is a widely-used technique for pattern classification. Ranked distance measurements to a known sample set determine the classification of unknown samples. Though effective, kNN, like most classification methods does not scale well with increased sample size. This is due to their being a relationship between the unknown query and every other sample in the data space. In order to make this operation scalable, we apply AURA to the kNN problem. AURA is a highly-scalable associative-memory based binary neural-network intended for high-speed approximate search and match operations on large unstructured datasets. Previous work has seen AURA methods applied to this problem as a scalable, but approximate kNN classifier. This paper continues this work by using AURA in conjunction with kernel-based input vectors, in order to create a fast scalable kNN classifier, whilst improving recall accuracy to levels similar to standard kNN implementations

The fat and the thin - a survey of nutritional status and disease patterns among urbanized Black South Africans

The nutritional status of and disease patterns in 449 healthy and 803 hospitalized urbanized Blacks in Durban were surveyed. While unemployed males were generally less fat than controls, obesity (i.e. weight 40% over that expected) was extremely common among female factory (33%) and female hospital 'domestic' (65%) employees. Undernutrition was significantly more common among patients and more marked in males, 82% having significantly reduced fat stores. Disease patterns were similar in malnourished male and female patients, with infective and respiratory diseases predominating. However, the pattern was different in overweight male and female patients, non-ischaemic cardiovascular diseases, particularly hypertension, predominating. The most common cause of death in males was respiratory disease, and in females cardiovascular disease. Overall, malnutrition was most common in the subgroup (N = 212) of patients who died. The results confirm the known associations between undernutrition and increased susceptibility to infection and mortality, and also between overnutrition and hypertensive cardiovascular disease. The observation that malnutrition and obesity can coexist within rapidly urbanized communities stresses the need for concurrent education on nutrition. The high incidence of 'hospital malnutri-tion' observed emphasizes the need for nutritional support in acutely ill patients

Impact of comet Shoemaker-Levy 9 on Jupiter

Three-dimensional numerical simulations of the impact of Comet Shoemaker-Levy 9 on Jupiter and the resulting vapor plume expansion were conducted using the Smoothed Particle Hydrodynamics (SPH) method. An icy body with a diameter of 2 km can penetrate to an altitude of -350 km (0 km = 1 bar) and most of the incident kinetic energy is transferred to the atmosphere between -100 km to -250 km. This energy is converted to potential energy of the resulting gas plume. The unconfined plume expands vertically and has a peak radiative power approximately equal to the total radiation from Jupiter's disc. The plume rises a few tens of atmospheric scale heights in ∼10² seconds. The rising plume reaches the altitude of ∼3000 km, but no atmospheric gas is accelerated to the escape velocity (∼60 km/s)

DNA Methylation of the ABO Promoter Underlies Loss of ABO Allelic Expression in a Significant Proportion of Leukemic Patients

Background: Loss of A, B and H antigens from the red blood cells of patients with myeloid malignancies is a frequent occurrence. Previously, we have reported alterations in ABH antigens on the red blood cells of 55% of patients with myeloid malignancies. Methodology/Principal Findings: To determine the underlying molecular mechanisms of this loss, we assessed ABO allelic expression in 21 patients with ABH antigen loss previously identified by flow cytometric analysis as well as an additional 7 patients detected with ABH antigen changes by serology. When assessing ABO mRNA allelic expression, 6/12 (50%) patients with ABH antigen loss detected by flow cytometry and 5/7 (71%) of the patients with ABH antigen loss detected by serology had a corresponding ABO mRNA allelic loss of expression. We examined the ABO locus for copy number and DNA methylation alterations in 21 patients, 11 with loss of expression of one or both ABO alleles, and 10 patients with no detectable allelic loss of ABO mRNA expression. No loss of heterozygosity (LOH) at the ABO locus was observed in these patients. However in 8/11 (73%) patients with loss of ABO allelic expression, the ABO promoter was methylated compared with 2/10 (20%) of patients with no ABO allelic expression loss (P = 0.03). Conclusions/Significance: We have found that loss of ABH antigens in patients with hematological malignancies is associated with a corresponding loss of ABO allelic expression in a significant proportion of patients. Loss of ABO allelic expression was strongly associated with DNA methylation of the ABO promoter.Tina Bianco-Miotto, Damian J. Hussey, Tanya K. Day, Denise S. O'Keefe and Alexander Dobrovi

Local transformations of the hippocampal cognitive map

Grid cells are neurons active in multiple fields arranged in a hexagonal lattice and are thought to represent the “universal metric for space.” However, they become nonhomogeneously distorted in polarized enclosures, which challenges this view. We found that local changes to the configuration of the enclosure induce individual grid fields to shift in a manner inversely related to their distance from the reconfigured boundary. The grid remained primarily anchored to the unchanged stable walls and showed a nonuniform rescaling. Shifts in simultaneously recorded colocalized grid fields were strongly correlated, which suggests that the readout of the animal’s position might still be intact. Similar field shifts were also observed in place and boundary cells—albeit of greater magnitude and more pronounced closer to the reconfigured boundary—which suggests that there is no simple one-to-one relationship between these three different cell types

Weyl's law and quantum ergodicity for maps with divided phase space

For a general class of unitary quantum maps, whose underlying classical phase space is divided into several invariant domains of positive measure, we establish analogues of Weyl's law for the distribution of eigenphases. If the map has one ergodic component, and is periodic on the remaining domains, we prove the Schnirelman-Zelditch-Colin de Verdiere Theorem on the equidistribution of eigenfunctions with respect to the ergodic component of the classical map (quantum ergodicity). We apply our main theorems to quantised linked twist maps on the torus. In the Appendix, S. Zelditch connects these studies to some earlier results on `pimpled spheres' in the setting of Riemannian manifolds. The common feature is a divided phase space with a periodic component.Comment: Colour figures. Black & white figures available at http://www2.maths.bris.ac.uk/~majm. Appendix by Steve Zelditc

Intermediate statistics in quantum maps

We present a one-parameter family of quantum maps whose spectral statistics are of the same intermediate type as observed in polygonal quantum billiards. Our central result is the evaluation of the spectral two-point correlation form factor at small argument, which in turn yields the asymptotic level compressibility for macroscopic correlation lengths

A plesiosaur containing an ichthyosaur embryo as stomach contents from the Sundance Formation of the Bighorn Basin, Wyoming

Herein we report the discovery of an ichthyosaur embryo from the Upper Member of the Sundance Formation (Oxfordian) of the Bighorn Basin, Wyoming. The specimen is the first known ichthyosaur embryo from the Upper Jurassic, and is the first Jurassic ichthyosaur embryo from North America. The embryo was discovered in close association with the abdomen of an articulated partial plesiosaur skeleton, and several lines of evidence support the interpretation of the embryo as plesiosaur stomach contents. The small size and extremely poor ossification of the embryo indicate that the animal was probably not a neonate. Although the taxonomic affinities of the fossil are unknown, the large ichthyosaurian (sensu stricto) Opthalmosaurus natans is the only known ichthyosaur from the Sundance Formation, and the embryo may belong to that taxon

Characterization of the seismic environment at the Sanford Underground Laboratory, South Dakota

An array of seismometers is being developed at the Sanford Underground Laboratory, the former Homestake mine, in South Dakota to study the properties of underground seismic fields and Newtonian noise, and to investigate the possible advantages of constructing a third-generation gravitational-wave detector underground. Seismic data were analyzed to characterize seismic noise and disturbances. External databases were used to identify sources of seismic waves: ocean-wave data to identify sources of oceanic microseisms, and surface wind-speed data to investigate correlations with seismic motion as a function of depth. In addition, sources of events contributing to the spectrum at higher frequencies are characterized by studying the variation of event rates over the course of a day. Long-term observations of spectral variations provide further insight into the nature of seismic sources. Seismic spectra at three different depths are compared, establishing the 4100-ft level as a world-class low seismic-noise environment.Comment: 29 pages, 16 figure