Oligosaccharide and Glycoprotein Microarrays as Tools in HIV Glycobiology Glycan-Dependent gp120/Protein Interactions

AbstractDefining HIV envelope glycoprotein interactions with host factors or binding partners advances our understanding of the infectious process and provides a basis for the design of vaccines and agents that interfere with HIV entry. Here we employ carbohydrate and glycoprotein microarrays to analyze glycan-dependent gp120-protein interactions. In concert with new linking chemistries and synthetic methods, the carbohydrate arrays combine the advantages of microarray technology with the flexibility and precision afforded by organic synthesis. With these microarrays, we individually and competitively determined the binding profiles of five gp120 binding proteins, established the carbohydrate structural requirements for these interactions, and identified a potential strategy for HIV vaccine development

Solving Symbolic Equations with PRESS

We outline a program, PRESS (PRolog Equation Solving System) for solving symbolic, transcendental, non-differential equations. The methods used for solving equations are described, together with the service facilities. The principal technique, meta-level inference, appears to have applications in the broader field of symbolic and algebraic manipulation

Weyl's law and quantum ergodicity for maps with divided phase space

For a general class of unitary quantum maps, whose underlying classical phase space is divided into several invariant domains of positive measure, we establish analogues of Weyl's law for the distribution of eigenphases. If the map has one ergodic component, and is periodic on the remaining domains, we prove the Schnirelman-Zelditch-Colin de Verdiere Theorem on the equidistribution of eigenfunctions with respect to the ergodic component of the classical map (quantum ergodicity). We apply our main theorems to quantised linked twist maps on the torus. In the Appendix, S. Zelditch connects these studies to some earlier results on `pimpled spheres' in the setting of Riemannian manifolds. The common feature is a divided phase space with a periodic component.Comment: Colour figures. Black & white figures available at http://www2.maths.bris.ac.uk/~majm. Appendix by Steve Zelditc

Harmonising higher education and professional quality assurance processes for the assessment of learning outcomes in health

Maree O’Keefe, Amanda Henderson, Brian Jolly, Lindy McAllister, Louisa Remedios, Rebecca Chic

Threshold learning outcomes: a framework for incorporating professional accreditation and AQF standards into assessment blueprinting/mapping in healthcare disciplines

Maree O’Keefe, Amanda Henderson, Brian Jolly, Lindy McAllister, Louisa Remedios, Rebecca Chic

A test of the automaticity assumption of compliance tactics: discouraging undergraduate binge drinking by appealing to consistency and reciprocity

The mindfulness of compliance with requests making use of the commitment/consistency or the reciprocity principle was investigated. Participants (N = 129) received a foot-in-the-door (FITD) request (commitment/consistency application), a door-in-the-face (DITF) request (reciprocity application), or no request. Next, participants read either a weak or neutral message about the importance of moderate alcohol consumption then reported the likelihood of not drinking excessively for one week (target request). When accompanied by a weak message, the target request elicited less compliance if preceded by the DITF or FITD requests than by no initial request, suggesting compliance tactics sometimes increase thoughtfulness