925 research outputs found
A two-fluid model for tissue growth within\ud a dynamic flow environment
We study the growth of a tissue construct in a perfusion bioreactor, focussing on its response to the mechanical environment. The bioreactor system is modelled as a two-dimensional channel containing a tissue construct through which a flow of culture medium is driven. We employ a multiphase formulation of the type presented by G. Lemon, J. King, H. Byrne, O. Jensen and K. Shakesheff in their study (Multiphase modelling of tissue growth using the theory of mixtures. J. Math. Biol. 52(2), 2006, 571â594) restricted to two interacting fluid phases, representing a cell population (and attendant extracellular matrix) and a culture medium, and employ the simplifying limit of large interphase viscous drag after S. Franks in her study (Mathematical Modelling of Tumour Growth and Stability. Ph.D. Thesis, University of Nottingham, UK, 2002) and S. Franks and J. King in their study (Interactions between a uniformly proliferating tumour and its surrounding: Uniform material properties. Math. Med. Biol. 20, 2003, 47â89).\ud
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The novel aspects of this study are: (i) the investigation of the effect of an imposed flow on the growth of the tissue construct, and (ii) the inclusion of a mechanotransduction mechanism regulating the response of the cells to the local mechanical environment. Specifically, we consider the response of the cells to their local density and the culture medium pressure. As such, this study forms the first step towards a general multiphase formulation that incorporates the effect of mechanotransduction on the growth and morphology of a tissue construct. The model is analysed using analytic and numerical techniques, the results of which illustrate the potential use of the model to predict the dominant regulatory stimuli in a cell population
The Properties and Gaseous Environments of Powerful Classical Double Radio Galaxies
The properties of a sample of 31 very powerful classical double radio
galaxies with redshifts between zero and 1.8 are studied. The source
velocities, beam powers, ambient gas densities, total lifetimes, and total
outflow energies are presented and discussed. The rate of growth of each side
of each source were obtained using a spectral aging analysis. The beam power
and ambient gas density were obtained by applying the strong shock jump
conditions to the ends of each side of the source. The total outflow lifetime
was obtained by applying the power-law relationship between the beam power and
the total source lifetime derived elsewhere for sources of this type, and the
total outflow energy was obtained by combining the beam power and the total
source lifetime. Composite profiles were constructed by combining results
obtained from each side of each source. The composite profiles indicate that
the ambient gas density falls with distance from the central engine. The source
velocities, beam powers, total lifetimes, and total energies seem to be
independent of radio source size. This is consistent with the standard model in
which each source grows at a roughly constant rate during which time the
central engine puts out a roughly constant beam power. The fact that the total
source lifetimes and energies are independent of radio source size indicates
that the sources are being sampled at random times during their lifetimes.Comment: 7 pages, 5 figures, to appear in "Extragalactic Jets: Theory and
Observation from Radio to Gamma Ray", eds. T. A. Rector and D. S. De Young,
ASP conference series, Replaced version has minor textual correction
Spreading dynamics on spatially constrained complex brain networks
The study of dynamical systems defined on complex networks provides a natural framework with which to investigate myriad features of neural dynamics and has been widely undertaken. Typically, however, networks employed in theoretical studies bear little relation to the spatial embedding or connectivity of the neural networks that they attempt to replicate. Here, we employ detailed neuroimaging data to define a network whose spatial embedding represents accurately the folded structure of the cortical surface of a rat brain and investigate the propagation of activity over this network under simple spreading and connectivity rules. By comparison with standard network models with the same coarse statistics, we show that the cortical geometry influences profoundly the speed of propagation of activation through the network. Our conclusions are of high relevance to the theoretical modelling of epileptic seizure events and indicate that such studies which omit physiological network structure risk simplifying the dynamics in a potentially significant way
Ytterbium-doped tantalum pentoxide waveguide lasers
We have demonstrated a Yb:Ta2O5 waveguide laser fabricated by RF magnetron sputtering on oxidised silicon. The waveguide laser was end-pumped with a laser diode at 977 nm and lasing was observed between 1015 and 1020 nm. The launched pump power threshold and slope efficiency were measured to be ~25 mW and 1.78 %, respectively
Quasars, their host galaxies, and their central black holes
We present the final results from our deep HST imaging study of the hosts of
radio-quiet quasars (RQQs), radio-loud quasars (RLQs) and radio galaxies (RGs).
We describe new WFPC2 R-band observations for 14 objects and model these images
in conjunction with the data already reported in McLure et al (1999). We find
that spheroidal hosts become more prevalent with increasing nuclear luminosity
such that, for nuclear luminosities M_V < -23.5, the hosts of both radio-loud
and radio-quiet AGN are virtually all massive ellipticals. Moreover we
demonstrate that the basic properties of these hosts are indistinguishable from
those of quiescent, evolved, low-redshift ellipticals of comparable mass. This
result kills any lingering notion that radio-loudness is determined by
host-galaxy morphology, and also sets severe constraints on evolutionary
schemes which attempt to link low-z ULIRGs with RQQs. Instead, we show that our
results are as expected given the relationship between black-hole and spheroid
mass established for nearby galaxies, and apply this relation to estimate the
mass of the black hole in each object. The results agree very well with
completely-independent estimates based on nuclear emission-line widths; all the
quasars in our sample have M(bh) > 5 x 10^8 solar masses, while the radio-loud
objects are confined to M(bh) > 10^9 solar masses. This apparent mass-threshold
difference, which provides a natural explanation for why RQQs outnumber RLQs by
a factor of 10, appears to reflect the existence of a minimum and maximum level
of black-hole radio output which is a strong function of black-hole mass.
Finally, we use our results to estimate the fraction of massive
spheroids/black-holes which produce quasar-level activity. This fraction is
\~0.1% at the present day, rising to > 10% at z = 2-3.Comment: Revised version accepted for publication in Monthly Notices of the
Royal Astronomical Society. 46 pages, the final 19 of which comprise an
Appendix. 15 figures in main text. A further 14 4-panel greyscale plots and
14 line plots which appear in the Appendix have been reproduced here with
reduced quality due to space limitations. A full resolution copy of the
manuscript can be obtained via ftp://ftp.roe.ac.uk/pub/jsd/dunlop2002.ps.g
Atomic hydrogen in the one-sided "compact double" radio galaxy 2050+364
European VLBI Network spectral imaging of the "compact double" radio source
2050+364 in the UHF band at 1049 MHz has resolved the HI absorbing region, and
has shown a faint continuum component to the North (N), in addition to the
well-known East-West double (E, W). Re-examination of VLBI continuum images at
multiple frequencies suggests that 2050+364 may well be a one-sided core-jet
source, which appears as a double over a limited frequency range. One of the
dominant features, W, would then be the innermost visible portion of the jet,
and could be at or adjacent to the canonical radio core. The other, E, is
probably related to shocks at a sudden bend of the jet, towards extended
steep-spectrum region N. A remarkably deep and narrow HI absorption line
component extends over the entire projected extent of 2050+364. It coincides in
velocity with the [OIII] optical doublet lines to within 10 km/s. This HI
absorption could arise in the atomic cores of NLR clouds, and the motion in the
NLR is then remarkably coherent both along the line-of-sight and across a
projected distance of > 300 pc on the plane of the sky. Broader, shallower HI
absorption at lower velocities covers only the plausible core area W. This
absorption could be due to gas which is either being entrained by the inner jet
or is flowing out from the accretion region; it could be related to the BLR.Comment: 10 pages, 7 figures. Accepted in A&
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