285 research outputs found
Atmospheric Concentrations of Alternaria, Cladosporium, Ganoderma and Didymella Spores Monitored in Cork (Ireland) and Worcester (England) During the Summer of 2010
This study represents the first international intercomparison of fungal spore observations since 1990, focusing on atmospheric concentrations of Alternaria, Cladosporium, Ganoderma and Didymella spores. The campaigns were performed at sites located in Cork (Ireland) and Worcester (England) during summer 2010. Observations were made using Hirst-type volumetric spore traps and corresponding optical identification at the genus level by microscope. The measurements at both sites (including meteorological parameters) were compared and contrasted. The relationships between the fungal spore concentrations with selected meteorological parameters were investigated using statistical methods and multivariate regression trees (MRT). The results showed high correlations between the two sites with respect to daily variations. Statistically significant higher spore concentrations for Alternaria, Cladosporium and Ganoderma were monitored at the Worcester site. This result was most likely due to the differences in precipitation and local fungal spore sources at the two sites. Alternaria and Cladosporium reached their maxima a month earlier in Cork than in Worcester, and Didymella with Ganoderma peaked simultaneously with similar diurnal trends found for all the investigated spore types. MRT analysis helped to determine threshold values of the meteorological parameters that exerted most influence on the presence of spores: they were found to vary at the two sites. Our results suggest that the aeromycological profile is quite uniform over the British Isles, but a description of bioaerosols with respect to overall load and daily concentration can be quite diverse although the geographical difference between sites is relatively small. These variations in the concentrations therefore need to be explored at the national leve
Coarse-Graining and Renormalization Group in the Einstein Universe
The Kadanoff-Wilson renormalization group approach for a scalar
self-interacting field theor generally coupled with gravity is presented. An
average potential that monitors the fluctuations of the blocked field in
different scaling regimes is constructed in a nonflat background and explicitly
computed within the loop-expansion approximation for an Einstein universe. The
curvature turns out to be dominant in setting the crossover scale from a
double-peak and a symmetric distribution of the block variables. The evolution
of all the coupling constants generated by the blocking procedure is examined:
the renormalized trajectories agree with the standard perturbative results for
the relevant vertices near the ultraviolet fixed point, but new effective
interactions between gravity and matter are present. The flow of the conformal
coupling constant is therefore analyzed in the improved scheme and the infrared
fixed point is reached for arbitrary values of the renormalized parameters.Comment: 18 pages, REVTex, two uuencoded figures. (to appear in Phys. Rev.
D15, July) Transmission errors have been correcte
Automated Generation of User Guidance by Combining Computation and Deduction
Herewith, a fairly old concept is published for the first time and named
"Lucas Interpretation". This has been implemented in a prototype, which has
been proved useful in educational practice and has gained academic relevance
with an emerging generation of educational mathematics assistants (EMA) based
on Computer Theorem Proving (CTP).
Automated Theorem Proving (ATP), i.e. deduction, is the most reliable
technology used to check user input. However ATP is inherently weak in
automatically generating solutions for arbitrary problems in applied
mathematics. This weakness is crucial for EMAs: when ATP checks user input as
incorrect and the learner gets stuck then the system should be able to suggest
possible next steps.
The key idea of Lucas Interpretation is to compute the steps of a calculation
following a program written in a novel CTP-based programming language, i.e.
computation provides the next steps. User guidance is generated by combining
deduction and computation: the latter is performed by a specific language
interpreter, which works like a debugger and hands over control to the learner
at breakpoints, i.e. tactics generating the steps of calculation. The
interpreter also builds up logical contexts providing ATP with the data
required for checking user input, thus combining computation and deduction.
The paper describes the concepts underlying Lucas Interpretation so that open
questions can adequately be addressed, and prerequisites for further work are
provided.Comment: In Proceedings THedu'11, arXiv:1202.453
Renormalization-Group Improved Effective Potential for Interacting Theories with Several Mass Scales in Curved Spacetime
The renormalization group (RG) is used in order to obtain the RG improved
effective potential in curved spacetime. This potential is explicitly
calculated for the Yukawa model and for scalar electrodynamics, i.e. theories
with several (namely, more than one) mass scales, in a space of constant
curvature. Using the -theory on a general curved spacetime
as an example, we show how it is possible to find the RG improved effective
Lagrangian in curved spacetime. As specific applications, we discuss the
possibility of curvature induced phase transitions in the Yukawa model and the
effective equations (back-reaction problem) for the -theory
on a De Sitter background.Comment: 18 pages, LaTeX file, UB-ECM-PF 93/2
GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse
Background: The sperm protein IZUMO1 (Izumo sperm-egg fusion 1) and its recently identified binding partner on the oolemma, IZUMO1R, are among the first ligand-receptor pairs shown to be essential for gamete recognition and adhesion. However, the IZUMO1-IZUMO1R interaction does not appear to be directly responsible for promoting the fusion of the gamete membranes, suggesting that this critical phase of the fertilization cascade requires the concerted action of alternative fusogenic machinery. It has therefore been proposed that IZUMO1 may play a secondary role in the organization and/or stabilization of higher-order heteromeric complexes in spermatozoa that are required for membrane fusion. Results: Here, we show that fertilization-competent (acrosome reacted) mouse spermatozoa harbor several high molecular weight protein complexes, a subset of which are readily able to adhere to solubilized oolemmal proteins. At least two of these complexes contain IZUMO1 in partnership with GLI pathogenesis-related 1 like 1 (GLIPR1L1). This interaction is associated with lipid rafts and is dynamically remodeled upon the induction of acrosomal exocytosis in preparation for sperm adhesion to the oolemma. Accordingly, the selective ablation of GLIPR1L1 leads to compromised sperm function characterized by a reduced ability to undergo the acrosome reaction and a failure of IZUMO1 redistribution. Conclusions: Collectively, this study characterizes multimeric protein complexes on the sperm surface and identifies GLIPRL1L1 as a physiologically relevant regulator of IZUMO1 function and the fertilization process.Avinash S. Gaikwad, Amanda L. Anderson, D. Jo Merriner, Anne E. O’Connor, Brendan J. Houston, R. John Aitken, Moira K. O’Bryan, and Brett Nixo
Improved Effective Potential in Curved Spacetime and Quantum Matter - Higher Derivative Gravity Theory
\noindent{\large\bf Abstract.} We develop a general formalism to study the
renormalization group (RG) improved effective potential for renormalizable
gauge theories ---including matter--gravity--- in curved spacetime. The
result is given up to quadratic terms in curvature, and one-loop effective
potentials may be easiliy obtained from it. As an example, we consider scalar
QED, where dimensional transmutation in curved space and the phase structure of
the potential (in particular, curvature-induced phase trnasitions), are
discussed. For scalar QED with higher-derivative quantum gravity (QG), we
examine the influence of QG on dimensional transmutation and calculate QG
corrections to the scalar-to-vector mass ratio. The phase structure of the
RG-improved effective potential is also studied in this case, and the values of
the induced Newton and cosmological coupling constants at the critical point
are estimated. Stability of the running scalar coupling in the Yukawa theory
with conformally invariant higher-derivative QG, and in the Standard Model with
the same addition, is numerically analyzed. We show that, in these models, QG
tends to make the scalar sector less unstable.Comment: 23 pages, Oct 17 199
Computation of the winding number diffusion rate due to the cosmological sphaleron
A detailed quantitative analysis of the transition process mediated by a
sphaleron type non-Abelian gauge field configuration in a static Einstein
universe is carried out. By examining spectra of the fluctuation operators and
applying the zeta function regularization scheme, a closed analytical
expression for the transition rate at the one-loop level is derived. This is a
unique example of an exact solution for a sphaleron model in spacetime
dimensions.Comment: Some style corrections suggested by the referee are introduced
(mainly in Sec.II), one reference added. To appear in Phys.Rev.D 29 pages,
LaTeX, 3 Postscript figures, uses epsf.st
Computer modeling of diabetes and Its transparency: a report on the Eighth Mount Hood Challenge
Objectives
The Eighth Mount Hood Challenge (held in St. Gallen, Switzerland, in September 2016) evaluated the transparency of model input documentation from two published health economics studies and developed guidelines for improving transparency in the reporting of input data underlying model-based economic analyses in diabetes.
Methods
Participating modeling groups were asked to reproduce the results of two published studies using the input data described in those articles. Gaps in input data were filled with assumptions reported by the modeling groups. Goodness of fit between the results reported in the target studies and the groups’ replicated outputs was evaluated using the slope of linear regression line and the coefficient of determination (R2). After a general discussion of the results, a diabetes-specific checklist for the transparency of model input was developed.
Results
Seven groups participated in the transparency challenge. The reporting of key model input parameters in the two studies, including the baseline characteristics of simulated patients, treatment effect and treatment intensification threshold assumptions, treatment effect evolution, prediction of complications and costs data, was inadequately transparent (and often missing altogether). Not surprisingly, goodness of fit was better for the study that reported its input data with more transparency. To improve the transparency in diabetes modeling, the Diabetes Modeling Input Checklist listing the minimal input data required for reproducibility in most diabetes modeling applications was developed.
Conclusions
Transparency of diabetes model inputs is important to the reproducibility and credibility of simulation results. In the Eighth Mount Hood Challenge, the Diabetes Modeling Input Checklist was developed with the goal of improving the transparency of input data reporting and reproducibility of diabetes simulation model results
Mechanisms underlying a thalamocortical transformation during active tactile sensation
During active somatosensation, neural signals expected from movement of the sensors are suppressed in the cortex, whereas information related to touch is enhanced. This tactile suppression underlies low-noise encoding of relevant tactile features and the brain’s ability to make fine tactile discriminations. Layer (L) 4 excitatory neurons in the barrel cortex, the major target of the somatosensory thalamus (VPM), respond to touch, but have low spike rates and low sensitivity to the movement of whiskers. Most neurons in VPM respond to touch and also show an increase in spike rate with whisker movement. Therefore, signals related to self-movement are suppressed in L4. Fast-spiking (FS) interneurons in L4 show similar dynamics to VPM neurons. Stimulation of halorhodopsin in FS interneurons causes a reduction in FS neuron activity and an increase in L4 excitatory neuron activity. This decrease of activity of L4 FS neurons contradicts the "paradoxical effect" predicted in networks stabilized by inhibition and in strongly-coupled networks. To explain these observations, we constructed a model of the L4 circuit, with connectivity constrained by in vitro measurements. The model explores the various synaptic conductance strengths for which L4 FS neurons actively suppress baseline and movement-related activity in layer 4 excitatory neurons. Feedforward inhibition, in concert with recurrent intracortical circuitry, produces tactile suppression. Synaptic delays in feedforward inhibition allow transmission of temporally brief volleys of activity associated with touch. Our model provides a mechanistic explanation of a behavior-related computation implemented by the thalamocortical circuit
Association of Nonobstructive Chronic Bronchitis with Respiratory Health Outcomes in Adults
Importance: Chronic bronchitis has been associated with cigarette smoking as well as with e-cigarette use among young adults, but the association of chronic bronchitis in persons without airflow obstruction or clinical asthma, described as nonobstructive chronic bronchitis, with respiratory health outcomes remains uncertain. Objective: To assess whether nonobstructive chronic bronchitis is associated with adverse respiratory health outcomes in adult ever smokers and never smokers. Design, Setting, and Participants: This prospective cohort study included 22325 adults without initial airflow obstruction (defined as the ratio of forced expiratory volume in the first second [FEV1] to forced vital capacity [FVC] of <0.70) or clinical asthma at baseline. The National Heart, Lung, and Blood Institute (NHLBI) Pooled Cohorts Study harmonized and pooled data from 9 US general population-based cohorts. Thus present study is based on data from 5 of these cohorts. Participants were enrolled from August 1971 through May 2007 and were followed up through December 2018. Exposures: Nonobstructive chronic bronchitis was defined by questionnaire at baseline as both cough and phlegm for at least 3 months for at least 2 consecutive years. Main Outcomes and Measures: Lung function was measured by prebronchodilator spirometry. Hospitalizations and deaths due to chronic lower respiratory disease and respiratory disease-related mortality were defined by events adjudication and administrative criteria. Models were stratified by smoking status and adjusted for anthropometric, sociodemographic, and smoking-related factors. The comparison group was participants without nonobstructive chronic bronchitis. Results: Among 22325 adults included in the analysis, mean (SD) age was 53.0 (16.3) years (range, 18.0-95.0 years), 58.2% were female, 65.9% were non-Hispanic white, and 49.6% were ever smokers. Among 11082 ever smokers with 99869 person-years of follow-up, participants with nonobstructive chronic bronchitis (300 [2.7%]) had accelerated decreases in FEV1 (4.1 mL/y; 95% CI, 2.1-6.1 mL/y) and FVC (4.7 mL/y; 95% CI, 2.2-7.2 mL/y), increased risks of chronic lower respiratory disease-related hospitalization or mortality (hazard ratio [HR], 2.2; 95% CI, 1.7-2.7), and greater respiratory disease-related (HR, 2.0; 95% CI, 1.1-3.8) and all-cause mortality (HR, 1.5; 95% CI, 1.3-1.8) compared with ever smokers without nonobstructive chronic bronchitis. Among 11243 never smokers with 120004 person-years of follow-up, participants with nonobstructive chronic bronchitis (151 [1.3%]) had greater rates of chronic lower respiratory disease-related hospitalization or mortality (HR, 3.1; 95% CI, 2.1-4.5) compared with never smokers without nonobstructive chronic bronchitis. Nonobstructive chronic bronchitis was not associated with FEV1:FVC decline or incident airflow obstruction. The presence of at least 1 of the component symptoms of nonobstructive chronic bronchitis (ie, chronic cough or phlegm), which was common in both ever smokers (11.0%) and never smokers (6.7%), was associated with adverse respiratory health outcomes. Conclusions and Relevance: The findings suggest that nonobstructive chronic bronchitis is associated with adverse respiratory health outcomes, particularly in ever smokers, and may be a high-risk phenotype suitable for risk stratification and targeted therapies
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