Projecting prevalence by stage of care for prostate cancer and estimating future health service needs: protocol for a modelling study

Introduction Current strategies for the management of prostate cancer are inadequate in Australia. We will, in this study, estimate current service needs and project the future needs for prostate cancer patients in Australia. Methods and analysis First, we will project the future prevalence of prostate cancer for 2010-2018 using data for 1972-2008 from the New South Wales (NSW) Central Cancer Registry. These projections, based on modelled incidence and survival estimates, will be estimated using PIAMOD (Prevalence, Incidence, Analysis MODel) software. Then the total prevalence will be decomposed into five stages of care: initial care, continued monitoring, recurrence, last year of life and long-term survivor. Finally, data from the NSW Prostate Cancer Care and Outcomes Study, including data on patterns of treatment and associated quality of life, will be used to estimate the type and amount of services that will be needed by prostate cancer patients in each stage of care. In addition, Central Cancer Registry episode data will be used to estimate transition rates from localised or locally advanced prostate cancer to metastatic disease. Medicare and Pharmaceutical Benefits data, linked with Prostate Cancer Care and Outcomes Study data, will be used to complement the Cancer Registry episode data. The methods developed will be applied Australia-wide to obtain national estimates of the future prevalence of prostate cancer for different stages of clinical care. Ethics and dissemination This study was approved by the NSW Population and Health Services Research Ethics Committee. Results of the study will be disseminated widely to different interest groups and organisations through a report, conference presentations and peer-reviewed articles.This work is supported by the Prostate Cancer Foundation of Australia (grant number: PCFA – YI 0410). Both David Smith and Xue Qin Yu are supported by an Australian NHMRC Training Fellowship (Ref 1016598, 550002). Mark Clements is supported by an Australian NHMRC Career Development Award (Ref 471491)

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder

Mammalian microRNAs are emerging as key regulators of the development and function of the immune system. Here, we report a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide (LPS) correlated with granulocyte/monocyte (GM) expansion. Demonstrating the sufficiency of miR-155 to drive GM expansion, enforced expression in mouse bone marrow cells caused GM proliferation in a manner reminiscent of LPS treatment. However, the miR-155–induced GM populations displayed pathological features characteristic of myeloid neoplasia. Of possible relevance to human disease, miR-155 was found to be overexpressed in the bone marrow of patients with certain subtypes of acute myeloid leukemia (AML). Furthermore, miR-155 repressed a subset of genes implicated in hematopoietic development and disease. These data implicate miR-155 as a contributor to physiological GM expansion during inflammation and to certain pathological features associated with AML, emphasizing the importance of proper miR-155 regulation in developing myeloid cells during times of inflammatory stress

Investigating a predicted metallicity [Fe/H] variation in the Type II Globular Cluster NGC 362

NGC 362 is a non-common Type II Galactic globular cluster, showing a complex pseudo two-color diagram or 'chromosome map'. The clear separation of its stellar populations in the color-magnitude diagram and the distribution of the giant stars in the chromosome map strongly suggests that NGC 362 could host stars with both cluster-nominal as well as enhanced heavy-element abundances, and one of them could be iron. However, despite previous spectroscopic observations of NGC 362, no such iron variation has been detected. Our main goal is to confirm or disprove this result by searching for any internal variation of [Fe/H] which would give us insight into the formation and evolution of this interesting globular cluster. In this paper, we present the abundance analysis for a sample of 11 red giant branch members based on high-resolution and high S/N spectra obtained with the MIKE echelle spectrograph mounted at the Magellan-Clay telescope. HST and GAIA photometry and astrometry has been used to determine atmospheric parameters and membership. We obtained T$_{\text{eff}}$, log(g) and v$_{\text{t}}$ for our target stars and measured the mean iron content of the sample and its dispersion with three different methods, which lead to [Fe/H]$_1$=-1.10$\pm0.02$, [Fe/H]$_2$=-1.09$\pm0.01$ and [Fe/H]$_3$=-1.10$\pm0.01$, while the internal dispersion turned out to be $\sigma_{[\text{Fe/H}]_1}$=0.06$\pm0.01$, $\sigma_{[\text{Fe/H}]_2}$=0.03$\pm0.01$ and $\sigma_{[\text{Fe/H}]_3}$=0.05$\pm0.01$ respectively. The error analysis gives an internal dispersion due to observational error of 0.05 dex. Comparing the observed dispersion with the internal errors, we conclude that NGC 362 does not show any trace of an internal iron spread.Comment: 11 pages, 6 figure

Photodisintegration of Three-Body Nuclei with Realistic 2N and 3N Forces

Total photonuclear absorption cross sections of $^3$H and $^3$He are studied using realistic NN and NNN forces. Final state interactions are fully included. Two NN potential models, the AV14 and the r-space Bonn-A potentials, are considered. For the NNN forces the Urbana-VIII and Tucson-Melbourne models are employed. We find the cross section to be sensitive to nuclear dynamics. Of particular interest in this work is the effect which NNN forces have on the cross section. The addition of NNN forces not only lowers the peak height but increases the cross section beyond 70 MeV by roughly 15%. Cross sections are computed using the Lorentz integral transform method.Comment: Results for Bonn potential with model Bonn rA instead of model rB. The Bonn rB results contained a small inexactness. After the correction it turned out that Bonn rA is more suited for our purpose because it leads to a binding energy of 8.15 MeV (about 0.25 MeV more than Bonn rB). In addition the results for the other realistic potentials models are improved at low energies (HH expansion was not completely convergent for the low-energy results). LaTeX, 8 pages, 4 ps figure

Comparison of human uterine cervical electrical impedance measurements derived using two tetrapolar probes of different sizes

BACKGROUND We sought to compare uterine cervical electrical impedance spectroscopy measurements employing two probes of different sizes, and to employ a finite element model to predict and compare the fraction of electrical current derived from subepithelial stromal tissue. METHODS Cervical impedance was measured in 12 subjects during early pregnancy using 2 different sizes of the probes on each subject. RESULTS Mean cervical resistivity was significantly higher (5.4 vs. 2.8 Ωm; p < 0.001) with the smaller probe in the frequency rage of 4–819 kHz. There was no difference in the short-term intra-observer variability between the two probes. The cervical impedance measurements derived in vivo followed the pattern predicted by the finite element model. CONCLUSION Inter-electrode distance on the probes for measuring cervical impedance influences the tissue resistivity values obtained. Determining the appropriate probe size is necessary when conducting clinical studies of resistivity of the cervix and other human tissues

Reply to Comment on "Completely positive quantum dissipation"

This is the reply to a Comment by R. F. O'Connell (Phys. Rev. Lett. 87 (2001) 028901) on a paper written by the author (B. Vacchini, ``Completely positive quantum dissipation'', Phys.Rev.Lett. 84 (2000) 1374, arXiv:quant-ph/0002094).Comment: 2 pages, revtex, no figure