Noise reduction evaluation of grids in a supersonic air stream with application to Space Shuttle

Near field acoustic measurements were obtained for a model supersonic air jet perturbed by a screen. Noise reduction potential in the vicinity of the space shuttle vehicle during ground launch when the rocket exhaust flow is perturbed by a grid was determined. Both 10 and 12 mesh screens were utilized for this experiment, and each exhibited a noise reduction only at very low frequencies in the near field forward arc. A power spectrum analysis revealed that a modest reduction of from 3 to 5 decibels exists below a Strouhal number S sub t = 0.11. Above S sub t = 0.11 screen harmonics increased the observed sound pressure level. The favorable noise reductions obtained with screens for S sub t 0.11 may be of substantial interest for the space shuttle at ground launch

An evaluation of linear acoustic theory for a hovering rotor

Linear acoustic calculations are compared with previously reported data for a small-scale hovering rotor operated at high tip Mach numbers. A detailed calculated description of the distributions of blade surface pressure and shear stress due to skin friction is presented. The noise due to skin friction and loading, in the rotor disk plane, is small compared to thickness noise. The basic conclusions of Boxwell et al about the importance of nonlinear effects are upheld. Some approximations involved in the current theories for the inclusion of nonlinear effects are discussed. Using a model nonlinear problem, it is shown that to use the acoustic analogy, good knowledge of the flowfield is required

In Vitro Evaluation of Non-Protein Adsorbing Breast Cancer Theranostics Based on 19F-Polymer Containing Nanoparticles

Eight fluorinated nanoparticles (NPs) are synthesized, loaded with doxorubicin (DOX), and evaluated as theranostic delivery platforms to breast cancer cells. The multifunctional NPs are formed by self-assembly of either linear or star-shaped amphiphilic block copolymers, with fluorinated segments incorporated in the hydrophilic corona of the carrier. The sizes of the NPs confirm that small circular NPs are formed. The release kinetics data of the particles reveals clear hydrophobic core dependence, with longer sustained release from particles with larger hydrophobic cores, suggesting that the DOX release from these carriers can be tailored. Viability assays and flow cytometry evaluation of the ratios of apoptosis/necrosis indicate that the materials are non-toxic to breast cancer cells before DOX loading; however, they are very efficient, similar to free DOX, at killing cancer cells after drug encapsulation. Both flow cytometry and confocal microscopy confirm the cellular uptake of NPs and DOX-NPs into breast cancer cells, and in vitro 19F-MRI measurement shows that the fluorinated NPs have strong imaging signals, qualifying them as a potential in vivo contrast agent for 19F-MRI

Hepatitis e Virus Genotype 3 Genomes from RNA-Positive but Serologically Negative Plasma Donors Have CUG as the Start Codon for ORF3

Hepatitis E virus (HEV) is a pathogen that causes hepatitis worldwide. Molecular studies have identified HEV RNA in blood products although its significance is not understood. This study was undertaken to characterize HEV genomes in asymptomatic plasma donors from Sweden and Germany lacking anti-HEV. Complete open reading frames (ORFs) were obtained from HEV strains in 5 out of 18 plasma donors who tested positive for HEV RNA. All strains had CUG as the start codon of ORF3, while 147 GenBank strains all had AUG as the start codon (p < 0.0001). This substitution was found in both interrelated and unrelated strains belonging to different phylogenetic clades. The HEV strains from the seronegative plasma donors had no other substitution in common, which may be why the CUG substitution seems to explain the seronegativity

Normal calcium-activated anion secretion in a mouse selectively lacking TMEM16A in intestinal epithelium

Calcium-activated anion secretion is expected to ameliorate cystic fibrosis, a genetic disease that carries an anion secretory defect in exocrine tissues. Human patients and animal models of the disease that present a mild intestinal phenotype have been postulated to bear a compensatory calcium-activated anion secretion in the intestine. TMEM16A is calcium-activated anion channel whose presence in the intestinal epithelium is contradictory. We aim to test the functional expression of TMEM16A using animal models with Cftr and/or Tmem16a intestinal silencing. Expression of TMEM16A was studied in a wild type and intestinal Tmem16a knockout mice by mRNA-seq, mass-spectrometry, q-PCR, Western blotting and immunolocalization. Calcium-activated anion secretion was recorded in the ileum and proximal colon of these animals including intestinal Cftr knockout and double mutants with dual Tmem16a and Cftr intestinal ablation. Mucus homeostasis was studied by immune-analysis of Mucin-2 (Muc2) and survival curves were recorded. Tmem16a transcript was found in intestine. Nevertheless, protein was barely detected in colon samples. Electrophysiological measurements demonstrated that the intestinal deletion of Tmem16a did not change calcium-activated anion secretion induced by carbachol or ATP in ileum and proximal colon. Muc2 architecture was not altered by Tmem16a silencing as was observed when Cftr was deleted from mouse intestine. Tmem16a silencing neither affected animal survival nor modified the lethality observed in the intestinal Cftr-null mouse. Our results demonstrate that TMEM16A function in the murine intestine is not related to electrogenic calcium-activated anion transport and does not affect mucus homeostasis and survival of animals

Pupil size and pupillary light reflex in early infancy: heritability and link to genetic liability to schizophrenia

Background: Measures based on pupillometry, such as the pupillary light reflex (PLR) and baseline pupil size, reflect physiological responses linked to specific neural circuits that have been implicated as atypical in some psychiatric and neurodevelopmental conditions. Methods: We investigated the contribution of genetic and environmental factors to the baseline pupil size and the PLR in 510 infant twins assessed at 5 months of age (281 monozygotic and 229 dizygotic pairs), and its associations with common genetic variants associated with neurodevelopmental (autism spectrum disorder and attention deficit hyperactivity disorder) and mental health (bipolar disorder, major depressive disorder and schizophrenia) conditions using genome-wide polygenic scores (GPSs). Results: Univariate twin modelling showed high heritability at 5 months for both pupil size (h2 = .64) and constriction in response to light (h2 = .62), and bivariate twin modeling indicated substantial independence between the genetic factors influencing each (rG = .38). A statistically significant positive association between infant tonic pupil size and the GPS for schizophrenia was found (β = .15, p = .024), while there was no significant association with the GPS for autism or any other GPSs. Conclusions: This study shows that some pupil measures are highly heritable in early infancy, although substantially independent in their genetic etiologies, and associated with common genetic variants linked to schizophrenia. It illustrates how genetically informed studies of infants may help us understand early physiological responses associated with psychiatric disorders which emerge much later in life

Low-lying level structure of 56^{56}Cu and its implications on the rp process

The low-lying energy levels of proton-rich $^{56}$Cu have been extracted using in-beam $\gamma$-ray spectroscopy with the state-of-the-art $\gamma$-ray tracking array GRETINA in conjunction with the S800 spectrograph at the National Superconducting Cyclotron Laboratory at Michigan State University. Excited states in $^{56}$Cu serve as resonances in the $^{55}$Ni(p,$\gamma$)$^{56}$Cu reaction, which is a part of the rp-process in type I x-ray bursts. To resolve existing ambiguities in the reaction Q-value, a more localized IMME mass fit is used resulting in $Q=639\pm82$~keV. We derive the first experimentally-constrained thermonuclear reaction rate for $^{55}$Ni(p,$\gamma$)$^{56}$Cu. We find that, with this new rate, the rp-process may bypass the $^{56}$Ni waiting point via the $^{55}$Ni(p,$\gamma$) reaction for typical x-ray burst conditions with a branching of up to $\sim$40$\%$. We also identify additional nuclear physics uncertainties that need to be addressed before drawing final conclusions about the rp-process reaction flow in the $^{56}$Ni region.Comment: 8 pages, accepted for Phys. Rev.

Absolute Flux Density Calibration of the Greenland Telescope Data for Event Horizon Telescope Observations

Starting from the observing campaign in April 2018, the Greenland Telescope (GLT) has been added as a new station of the Event Horizon Telescope (EHT) array. Visibilities on baselines to the GLT, particularly in the North-South direction, potentially provide valuable new constraints for the modeling and imaging of sources such as M87*. The GLT's location at high Northern latitudes adds unique challenges to its calibration strategies. Additionally, the performance of the GLT was not optimal during the 2018 observations due to it being only partially commissioned at the time. This document describes the steps taken to estimate the various parameters (and their uncertainties) required for the absolute flux calibration of the GLT data as part of the EHT. In particular, we consider the non-optimized status of the GLT in 2018, as well as its improved performance during the 2021 EHT campaign.Comment: 17 pages, 4 figures, EHT Memo Series 2023-L1-0

Attacker Control and Impact for Confidentiality and Integrity

Language-based information flow methods offer a principled way to enforce strong security properties, but enforcing noninterference is too inflexible for realistic applications. Security-typed languages have therefore introduced declassification mechanisms for relaxing confidentiality policies, and endorsement mechanisms for relaxing integrity policies. However, a continuing challenge has been to define what security is guaranteed when such mechanisms are used. This paper presents a new semantic framework for expressing security policies for declassification and endorsement in a language-based setting. The key insight is that security can be characterized in terms of the influence that declassification and endorsement allow to the attacker. The new framework introduces two notions of security to describe the influence of the attacker. Attacker control defines what the attacker is able to learn from observable effects of this code; attacker impact captures the attacker's influence on trusted locations. This approach yields novel security conditions for checked endorsements and robust integrity. The framework is flexible enough to recover and to improve on the previously introduced notions of robustness and qualified robustness. Further, the new security conditions can be soundly enforced by a security type system. The applicability and enforcement of the new policies is illustrated through various examples, including data sanitization and authentication

Thermodynamic theory of epitaxial ferroelectric thin films with dense domain structures

A Landau-Ginsburg-Devonshire-type nonlinear phenomenological theory is presented, which enables the thermodynamic description of dense laminar polydomain states in epitaxial ferroelectric thin films. The theory explicitly takes into account the mechanical substrate effect on the polarizations and lattice strains in dissimilar elastic domains (twins). Numerical calculations are performed for PbTiO3 and BaTiO3 films grown on (001)-oriented cubic substrates. The "misfit strain-temperature" phase diagrams are developed for these films, showing stability ranges of various possible polydomain and single-domain states. Three types of polarization instabilities are revealed for polydomain epitaxial ferroelectric films, which may lead to the formation of new polydomain states forbidden in bulk crystals. The total dielectric and piezoelectric small-signal responses of polydomain films are calculated, resulting from both the volume and domain-wall contributions. For BaTiO3 films, strong dielectric anomalies are predicted at room temperature near special values of the misfit strain.Comment: 19 pages, 8 figure