Status gizi berhubungan positif dengan derajat nyeri sendi penderita osteoartritis lutut = Nutritional status was positively associated with joint pain score in patients with knee osteoarthritis

Background: Knee osteoarthritis (OA) is a common disorder that is associated with significant morbidity, disability, and .medical costs, particularly in its advanced stages. While the cause of knee OA remains unclear, it has been associated with various risk factors, such as age, sex, genetic predisposition, biomechanical, and obesity. Pain in osteoarthritis occurs due to combination of various factors. Pain significantly increases the medical and non medical cost in OA. Data showed that obesity will increase the mechanical stress and pain of knee OA. However, uncertainty remains regarding potential relationship between body mass index (BMI) and pain in osteoarthritis. Moreover, since obesity is one of modifiable and preventable risk factors for the onset and progression of the disease, it is important to know the correlation between BMI and severity of pain in knee OA. Objective: To investigate the relationship between body mass index and severity of joint pain in knee osteoarthritis. Method: A cross sectional study was conducted and subjects were osteoarthritis patients in rheumatology clinic of Sardjito general hospital. Body mass index and visual analogue scale (VAS) score were measured. Correlation between BMI and VAS score were analyzed by bivariate correlation test. Results: There were 80 patients with osteoarthritis who participated in the study. Mean BMI was 26.36 ±4.23 kg/m2 and VAS score was 52.40±24.53 mm. The correlation test showed that there was a positive but non significant correlation between BMI and VAS scores (r = 0,11p = 0,33). Conclusion: There was a positive but non significant correlation between body mass index and the severity of joint pain in knee osteoarthritis

Status gizi berhubungan positif dengan derajat nyeri sendi penderita osteoartritis lutut

Background: Knee osteoarthritis (OA) is a common disorder that is associated with significant morbidity, disability, and medical costs, particularly in its advanced stages. While the cause of knee OA remains unclear, it has been associated with various risk factors, such as age, sex, genetic predisposition, biomechanical, and obesity. Pain in osteoarthritis occurs due to combination of various factors. Pain significantly increases the medical and non medical cost in OA. Data showed that obesity will increase the mechanical stress and pain of knee OA. However, uncertainty remains regarding potential relationship between body mass index (BMI) and pain in osteoarthritis. Moreover, since obesity is one of modifiable and preventable risk factors for the onset and progression of the disease, it is important to know the correlation between BMI and severity of pain in knee OA.Objectives: To investigate the relationship between body mass index and severity of joint pain in knee osteoarthritis.Methods: A cross sectional study was conducted and subjects were osteoarthritis patients in rheumatology clinic of Sardjito general hospital. Body mass index and visual analogue scale (VAS) score were measured. Correlation between BMI and VAS score were analyzed by bivariate correlation test.Results: There were 80 patients with osteoarthritis who participated in the study. Mean BMI was 26.36 +4.23 kg/m2 and VAS score was 52.40+24.53 mm. The correlation test showed that there was a positive but non significant correlation between BMI and VAS scores (r = 0,11; p = 0,33).Conclusion: There was a positive but non significant correlation between body mass index and the severity of joint pain in knee osteoarthritis

Kualitas hidup lansia hipertensi dengan overweight dan tidak overweight

The quality of life in elderly hypertension with overweight and non-overweightBackground: Indonesia will enter the period of aging and an increase in several elderlies with chronic diseases. The biggest health problems of the elderly are degenerative diseases, namely hypertension which significantly disrupts the quality of life both in terms of physical and mental health. One of the causal conditions associated with hypertension is overweight and obesity, which is known at this time the prevalence of obesity is growing progressively in old age. However, the results of research related to the influence of obesity on quality of life are still controversial.Objective: To determine differences in quality of life between hypertensive elderly who are overweight and non-overweight.Method: Cross-sectional study conducted in Yogyakarta City in Januari-April 2017 with a subject of 200 elderly people aged 60-74 years. Overweight was determined based on BMI measurements (>23 kg/m2) with an estimation of elderly height using depa length, quality of life of the elderly was measured using WHOQOL-BREF questionnaire, and compared the quality of life by age, gender, education, occupation, income, marital status, comorbidity, and disease history. Data analysis used independent t-test and linear regression.Results: Mean of environmental domain score was significantly higher (p=0,012) in elderly hypertension with overweight (26,69±3,28) compared to elderly hypertension non-overweight (25,44±3,58). Overweight protective effect on the low quality of life of the environment domain because it is influenced by other factors such as marital status, income, and education. Multivariate analysis shows that income and marital status are external factors that consistently influence the quality of life of the elderly both in total scores and per domain. High-income elderly people with married status have a better quality of life score.Conclusions: The mean score of the environmental domain is higher in elderly hypertension with overweight. Quality of life scores will be better in high income elderly and married

Studi Pharmacovigilance Obat Herbal Di Puskesmas Kasihan II Bantul

Kejadian Reaksi Obat yang Tidak Dikehendaki (ROTD) dari obat-obat herbal merupakan hal yang masih jarang diteliti di Indonesia. Gaya hidup kembali ke alam menjadi cukup popular saat ini, sehingga masyarakat kembali memanfaatkan berbagai bahan alam, termasuk pengobatan dengan tumbuhan obat atau herbal. Dengan meningkatnya penggunaan obat herbal di Indonesia, maka diperlukan pemantauan keamanan pada obat-obat herbal.  Tujuan penelitian ini adalah mengetahui gambaran kausalitas kejadian ROTD serta mengetahui kualitas hidup pasien yang mendapatkan resep obat herbal. Penelitian ini menggunakan rancangan observasional deskriptif, pengambilan data secara consecutive sampling secara prospektif. Pengambilan data selama dua bulan saat penelitian berlangsung, setelah itu dianalisis kejadian ROTD dan tanpa ROTD serta dinilai kualitas hidup pasien. Instrumen yang digunakan untuk menganalisis adalah algoritma Naranjo dan kuesioner SF-36. Hasil wawancara kepada 25 subyek penelitian pada pengamatan prospektif dan retrospektif, subyek yang melaporkan adanya kejadian ROTD sebanyak 3 subyek (12%). Sebanyak 2 subyek dengan kategori possible (mungkin) dan 1 subyek dengan kategori probable (cukup mungkin). ROTD yang muncul adalah gatal-gatal, nyeri pinggang, mual, ngantuk dan dada berdebar. Kesimpulan dari penelitian ini adalah terdapat kejadian ROTD pada pasien yang diberikan terapi herbal, gambaran kausalitas kejadian ROTD adalah kategori possible dan probable. Kata kunci: pharmacovigilance, reaksi obat yang tidak dikehendaki, obat herbal

Pengaruh Fisioterapi Terhadap Perbaikan Rasa Nyeri Pada Penderita Osteoartritis Lutut Yang Mendapat Terapi Parasetamol

Nyoman Kertia, Siti Nurdjanah - Impact of physiotherapy on pain improvement in patients with knee osteoarthritis who took paracetamol Background: Osteoarthritis (OA) of the knee is a disease caused by several etiologies but similar biology, morphology and clinical presentation. It doesn\u27t only affect joint cartilage, but also subchondral bone, ligament, capsule, membrane of joint and periarticular muscles. Chief complaints in OA of the knee are pain and physical disability. In OA of the knee there is lower limb weakness, particularly quadriceps muscles and the weakness severity is related to pain and disability. Objective: To know the combination of physiotherapy and paracetamol compound to paracetamol alone in OA of the knee. Methods: This study is a randomized controlled trial in OA of the knee in patients with moderate pain in Internal Medicine Department Outpatients Clinic, Dr. Sardjito Hospital, Yogyakarta. Patients were randomly divided into 2 groups. Treatment group (17 patients) took physiotherapy and paracetamol. Control group (19 patients) took paracetamol only. Physiotherapy was performed in Medical Rehabilitation Clinic with isometric exercise three times weekly and paracetamol 500 mg three times daily for 4 weeks. Pain intensity was measured by visual analogue scale (VAS) 100 mm before and after treatment. Result: There was significant decrease in the mean of pain intensity before and after treatment between treatment and control groups as much as 6.65 ± 5.134 mm (95% CI 32.14 to 41.15p < 0.0001) and 28.84 ± 8.760 mm (95% CI 26.37 to 31.32p < 0.0001), respectively. The decrease of pain intensity was significantly different between two goups (95% CI 3.004 to 12.606p=0.002) after 4 weeks of treatment. No serious adverse events were attributable resulted from paracetamol treatment. Conclusion: Pain intensity in OA of the knee patients who took paracetamol 500 mg three times daily and physiotherapy improved significantly than paracetamol only for 4 weeks of treatment. Key words: knee osteoarthritis, pain, VAS, physiotherapy, paracetamol

Maxillary Reconstruction Timing in Severe Systemic Lupus Erythematous (SLE) Patient with Bone Destruction due to Invasive Aspergillosis: Case Report

Severe Systemic Lupus Erythematosus patient was in the third of 28-days-cycle cyclophosphamide chemotherapy when the early symptoms of aspergillus infection occurred. This developed into extensive cranial bone damage. It was planned to get a biopsy and debridement for bone and soft tissue to diagnose and therapy palate osteonecrosis, followed by reconstruction surgery. This case report aimed to report the successful management of a severe patient on chemotherapy undergoing several operations so that the SLE aspergillosis is optimally managed

Efek Konsumsi Yogurt terhadap Glukosa Darah Puasa pada Penyandang Diabetes Mellitus Tipe 2

Background: Generally, patients with type 2 diabetes mellitus (T2D) have dysbiosis condition. Dysbiosis can increase oxidative stress that leads to hyperglycemia. Previous researches showed that yogurt consumption can reduce blood glucose in T2D, so it can be used as an alternative healthy snack for T2D patients. Objectives: To investigate the effects of probiotic and conventional yogurt with dosage 100ml/day on fasting blood glucose (FBG) in T2D patients Methods: Randomized controlled trial, double blind with pre-post group design. The 30 T2D patients from 3 publics health centre in Yogyakarta, were assigned to two groups. Each group, either control or intervention group, received 100 ml/d of yogurt for 4 weeks. FBG samples was assessed before and after intervention period Results: FBG significantly decreased in both group, which was -27 mg/dL in control group (p<0.05) and -19 mg/dL in intervention group (p<0.05). No significant difference in FBG change between intervention and control group, but control group has greater reduction in FBG compared to intervention group. Conclusion: Conventional yogurt has no significant difference effect in FBG change compared to probiotic yogurt

Diagnostic Criteria of Knee Osteoarthritis in Rheumatology Outpatient Clinic, Dr. Sardjito Hospital, YOGYAKARTA

Background: Osteoarthritis (OA) is a chronic condition characterized by the breakdown of joints cartilage. Approximately 25% of persons 55 years of age or older have knee pain on most days and about half of them have radiographic OA in the knee. Prevalence of knee OA increases with age and it is more common in women than men. It is not easy to establish the diagnosis of knee OA since other knee disorders have similar clinicalsigns and symptoms.Objective: The purpose of this study was to observe the diagnosis pattern of knee OA in rheumatology outpatient clinic at Dr. Sardjito Hospital based on clinical and radiographic criteria of American College of Rheumatology (ACR). Method: The design of this study was cross-sectional. Data of the patients with knee OA were investigated from their medical records. Results: There were 212 subjects diagnosed with knee OA during the year 2000–2010. Most of the subjects (90.56%) were more than 50 years old. Women were more frequent affected by OA than men. All of the subjects (100%) had knee pain. Crepitus was found in98.11% subjects. Morning stiffness less than 30 minutes was found in 86.79% subjects. Osteophyte appearances were found in 79.72% subjects.Conclusion: Knee pain, crepitus, and age more than 50 years old were the most frequent criteria used to diagnose knee OA. Morning stiffness less than 30 minutes and osteophyte appearances were also frequent in knee OA

Efek Konsumsi Yoghurt Probiotik Terhadap Kadar Low Density Lipoprotein Pada Penyandang Diabetes Mellitus Tipe 2

Background : As one of important markers of cardiovascular complication in patients with type 2 diabetes mellitus, low density lipoprotein (LDL) shall be maintained to be in normal range. Based on previous research, consumption of probiotic yogurt contains Lactobacillus acidophilus and Bifidobacterium animalis subsp. Lactis is presumed can improve LDL in patients with type 2 diabetes mellitus but the scientific evidence is still few. Objectives: To investigate the effect of probiotic yogurt on LDL in patients with type 2 diabetes. Methods: This study was double blinded randomized controlled trial which was conducted on 32 patientss with type 2 diabetes mellitus. Subjects were divided randomly into 2 groups and given 4 weeks intervention. Subjects in control group were given conventional yogurt while subjects in intervention group were given probiotic yogurt contains L. acidophilus LA5 and B. animalis subsp. Lactis Bb12. Food intake data was collected 4 times using 24-hour recall method during intervention period. LDL of subjects was measured before and after intervention. Results: There was no significant difference between LDL before and after intervention in control group (128 – 148.5 mg/dL) and intervention group (130 – 120.5 mg/dL). Meanwhile, LDL after intervention in control group and intervention group were significantly different (p<0.05). LDL between energy and macronutrients intake categories were not significantly different. Conclusion: Probiotic yogurt has a better LDL reduction effect in patients with type 2 diabetes mellitus than conventional yogurt, although the reduction is not significant