Kahler potentials for the MSSM inflation and the spectral index

Recently it has been argued that some of the fine-tuning problems of the MSSM inflation associated with the existence of a saddle point along a flat direction may be solved naturally in a class of supergravity models. Here we extend the analysis and show that the constraints on the Kahler potentials in these models are considerably relaxed when the location of the saddle point is treated as a free variable. We also examine the effect of supergravity corrections on inflationary predictions and find that they can slightly alter the value of the spectral index. As an example, for flat direction field values $|\bar{\phi}_0|=1\times10^{-4}M_P$ we find $n\sim0.92 ... 0.94$ while the prediction of the MSSM inflation without any corrections is $n\sim0.92$.Comment: 13 pages, one figure. Typos corrected and a reference adde

Partial duplication of the APBA2 gene in chromosome 15q13 corresponds to duplicon structures.

BackgroundChromosomal abnormalities affecting human chromosome 15q11-q13 underlie multiple genomic disorders caused by deletion, duplication and triplication of intervals in this region. These events are mediated by highly homologous segments of DNA, or duplicons, that facilitate mispairing and unequal cross-over in meiosis. The gene encoding an amyloid precursor protein-binding protein (APBA2) was previously mapped to the distal portion of the interval commonly deleted in Prader-Willi and Angelman syndromes and duplicated in cases of autism.ResultsWe show that this gene actually maps to a more telomeric location and is partially duplicated within the broader region. Two highly homologous copies of an interval containing a large 5' exon and downstream sequence are located approximately 5 Mb distal to the intact locus. The duplicated copies, containing the first coding exon of APBA2, can be distinguished by single nucleotide sequence differences and are transcriptionally inactive. Adjacent to APBA2 maps a gene termed KIAA0574. The protein encoded by this gene is weakly homologous to a protein termed X123 that in turn maps adjacent to APBA1 on 9q21.12; APBA1 is highly homologous to APBA2 in the C-terminal region and is distinguished from APBA2 by the N-terminal region encoded by this duplicated exon.ConclusionThe duplication of APBA2 sequences in this region adds to a complex picture of different low copy repeats present across this region and elsewhere on the chromosome

Symbiotic and genetic diversity of Rhizobium galegae isolates collected from the Galega orientalis gene center in the Caucasus

This paper explores the relationship between the genetic diversity of rhizobia and the morphological diversity of their plant hosts. Rhizobium galegae strains were isolated from nodules of wild Galega orientalis and Galega officinalis in the Caucasus, the center of origin for G. orientalis. All 101 isolates were characterized by genomic amplified fragment length polymorphism fingerprinting and by PCR-restriction fragment length polymorphism (RFLP) of the rRNA intergenic spacer and of five parts of the symbiotic region adjacent to nod box sequences. By all criteria, the R. galegae bv. officinalis and R. galegae bv. orientalis strains form distinct clusters. The nod box regions are highly conserved among strains belonging to each of the two biovars but differ structurally to various degrees between the biovars. The findings suggest varying evolutionary pressures in different parts of the symbiotic genome of closely related R. galegae biovars. Sixteen R. galegae bv. orientalis strains harbored copies of the same insertion sequence element; all were isolated from a particular site and belonged to a limited range of chromosomal genotypes. In all analyses, the Caucasian R. galegae bv. orientalis strains were more diverse than R. galegae bv. officinalis strains, in accordance with the gene center theory

Supergravity origin of the MSSM inflation

We consider the supergravity origin of the recently proposed MSSM inflationary model, which relies on the existence of a saddle point along a dimension six flat direction. We derive the conditions that the Kahler potential has to satisfy for the saddle point to exist irrespective of the hidden sector vevs. We show that these conditions are satisfied by a simple class of Kahler potentials, which we find to have a similar form as in various string theory compactifications. For these potentials, slow roll MSSM inflation requires no fine tuning of the soft supersymmetry breaking parameters.Comment: v3: 10 pages, no figures; version accepted for publication. Typos correcte

Pathogenic Variant Spectrum in Breast Cancer Risk Genes in Finnish Patients

Recurrent pathogenic variants have been detected in several breast and ovarian cancer (BC/OC) risk genes in the Finnish population. We conducted a gene-panel sequencing and copy number variant (CNV) analysis to define a more comprehensive spectrum of pathogenic variants in BRCA1, BRCA2, PALB2, CHEK2, ATM, BARD1, RAD51C, RAD51D, BRIP1, and FANCM genes in Finnish BC patients. The combined frequency of pathogenic variants in the BRCA1/2 genes was 1.8% in 1356 unselected patients, whereas variants in the other genes were detected altogether in 8.3% of 1356 unselected patients and in 12.9% of 699 familial patients. CNVs were detected in 0.3% of both 1137 unselected and 612 familial patients. A few variants covered most of the pathogenic burden in the studied genes. Of the BRCA1/2 carriers, 70.8% had 1 of 10 recurrent variants. In the other genes combined, 92.1% of the carrier patients had at least 1 of 11 recurrent variants. In particular, PALB2 c.1592delT and CHEK2 c.1100delC accounted for 88.9% and 82.9%, respectively, of the pathogenic variation in each gene. Our results highlight the importance of founder variants in the BC risk genes in the Finnish population and could be used in the designing of population screening for the risk variants

The Subdominant Curvaton

We present a systematic study of the amplitude of the primordial perturbation in curvaton models with self-interactions, treating both renormalizable and non-renormalizable interactions. In particular, we consider the possibility that the curvaton energy density is subdominant at the time of the curvaton decay. We find that large regions in the parameter space give rise to the observed amplitude of primordial perturbation even for non-renormalizable curvaton potentials, for which the curvaton energy density dilutes fast. At the time of its decay, the curvaton energy density may typically be subdominant by a relative factor of 10^-3 and still produce the observed perturbation. Field dynamics turns out to be highly non-trivial, and for non-renormalizable potentials and certain regions of the parameter space we observe a non-monotonous relation between the final curvature perturbation and the initial curvaton value. In those cases, the time evolution of the primordial perturbation also displays an oscillatory behaviour before the curvaton decay.Comment: Acknowledgments of financial support added, no further change