42 research outputs found
Gravitational lensing in the weak field limit by a braneworld black hole
Braneworld black holes existing today may be of primordial origin, or may
even be produced in high energy particle collisions in the laboratory and in
cosmic ray showers as well. These black holes obey a modified mass-radius
relationship compared to standard Schwarzschild black holes. Using the
variational principle we calculate the bending angle of a light ray near the
horizon of a braneworld black hole in the weak field limit. We next derive the
expressions of several lensing quantities like the Einstein radius and the
magnification for a point light source. These expressions are modified compared
to the lensing quantities for standard Schwarzschild black holes and contain
the scale of the extra dimensions.Comment: 5 pages, 1 eps figure, discussion on the mass range for applicability
of weak field gravitational lensin
Explainable AI based Interventions for Pre-season Decision Making in Fashion Retail
Future of sustainable fashion lies in adoption of AI for a better
understanding of consumer shopping behaviour and using this understanding to
further optimize product design, development and sourcing to finally reduce the
probability of overproducing inventory. Explainability and interpretability are
highly effective in increasing the adoption of AI based tools in creative
domains like fashion. In a fashion house, stakeholders like buyers,
merchandisers and financial planners have a more quantitative approach towards
decision making with primary goals of high sales and reduced dead inventory.
Whereas, designers have a more intuitive approach based on observing market
trends, social media and runways shows. Our goal is to build an explainable new
product forecasting tool with capabilities of interventional analysis such that
all the stakeholders (with competing goals) can participate in collaborative
decision making process of new product design, development and launch
Particle motion and gravitational lensing in the metric of a dilaton black hole in a de Sitter universe
We consider the metric exterior to a charged dilaton black hole in a de
Sitter universe. We study the motion of a test particle in this metric.
Conserved quantities are identified and the Hamilton-Jacobi method is employed
for the solutions of the equations of motion. At large distances from the black
hole the Hubble expansion of the universe modifies the effective potential such
that bound orbits could exist up to an upper limit of the angular momentum per
mass for the orbiting test particle. We then study the phenomenon of strong
field gravitational lensing by these black holes by extending the standard
formalism of strong lensing to the non-asymptotically flat dilaton-de Sitter
metric. Expressions for the various lensing quantities are obtained in terms of
the metric coefficients.Comment: 8 pages, RevTex, 1 eps figures; discussion improved; typos corrected;
references adde
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
A study to assess the existing cultural beliefs and associate practices regarding newborn care among mothers in Chandu Village at Gurugram, Haryana
Introduction: Culture is defined as a shared system of beliefs, values and behavioural expectations that provide social structure for daily living. Not all customs and beliefs are harmful. Some of them have positive values while others may be of no role or positively harmful for the baby’s health in various forms like physical, psychological, social development. The objective of the study was to explore the cultural beliefs and associate practices in new born care among mothers. Statement Of The Problem:“ A study to assess the existing cultural beliefs and associate practices regarding newborn care among mothers in Chandu Village at Gurugram, Haryana”. Method: Research approach used was quantitative, a descriptive design was used. targeted population of newborn babies were’100 mothers. Purposive sampling technique was used to collect the data. The data was collected by structured knowledge questionnaire and analysed and interpretation by descriptive and interferential statics. Result: Result shows that 98%mothers follow the cultural associate practices whereas 2% do not follow. Overall mean value was13.19±1.978. Conclusion: The finding of the study concluded that the mothers with the average knowledge scores regarding cultural beliefs and associate practices of newborn babies are more as compared to the low cultural beliefs and practices
Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck cancer
The prevalence of head and neck squamous cell carcinoma, HNSCC, continues to grow. Change in the expression of TP53 in HNSCC affects its downstream miRNAs and their gene targets, anomalously altering the expressions of the five genes, MEIS1, AGTR1, DTL, TYMS and BAK1. These expression alterations follow the repression of TP53 that upregulates miRNA-107, miRNA- 215, miRNA-34 b/c and miRNA-125b,
but downregulates miRNA-155. The above five so far unreported genes are the targets of these miRNAs. Meta-analyses of microarray and RNA-Seq data followed by qRT-PCR validation unravel these new ones in HNSCC. The regulatory roles of TP53 on miRNA-155 and miRNA-125b differentiate the expressions of AGTR1 and BAK1in HNSCC vis-a`-vis other carcinogenesis. Expression changes alter cell cycle regulation, angiogenic and blood cell formation, and apoptotic modes in affliction. Pathway analyses establish the resulting systems-level functional and mechanistic insights into the etiology of HNSCC
Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck
Background: Alteration of chromosome 9q22.3 region is an early and frequent event in head and neck squamous cell carcinoma (HNSCC). The aim of this study was to understand the association of candidate tumor suppressor genes PHF2, FANCC, PTCH1, and XPA located in this region in the development of HNSCC. Methods: The alterations (deletion, promoter methylation, mutation, expression) of these genes were analyzed in 65 dysplastic head and neck lesions and 84 primary HNSCC samples. Clinicopathologic correlations were made with alterations of the genes. Results: Overall alterations (deletion, promoter methylation) of FANCC and PTCH1 were high in mild dysplasia and comparable in subsequent stages of tumor progression. However, PHF2 alteration was low in mild dysplasia, but increased in moderate and severe dysplasias. Alterations (deletion, promoter methylation) of FANCC and PTCH1 showed association with each other. Two novel mutations in GLI binding sites of PTCH1 promoter and a novel microsatellite marker hmPTCH1 with four alleles at immediate upstream of the gene were identified. In a case-control study, the (CGG)7 allele of hmPTCH1 was found to be susceptible for HNSCC development. Concordance was seen in the expression (RNA, protein) of these genes with their molecular alterations. Conclusions: Alterations of FANCC and PTCH1 could be used as molecular marker for early diagnosis and prognosis of HNSCC