The Workshop Classroom format and its impact on the motivation, learning and achievement of primary school children

La falta de motivación en los niños el desinterés, el desgano, promueven bajos resultados académicos y conducen al fracaso escolar, la repetición y la deserción. Ello exige modificaciones en el formato escuela y la construcción de metodologías innovadoras (Teriggi y Peraza, 2006). En esta investigación describiremos la importancia del formato Aula Taller con el objetivo de analizar la influencia del mismo en la motivación y en el aprendizaje en educación primaria. El impacto se verá también en los docentes quienes configurarán sus propuestas atendiendo a las necesidades reales de sus alumnos. En el contexto uruguayo se registran escasos estudios en el nivel primario y ninguno que ponga énfasis en el impacto de logros según la metodología áulica, por ello su estudio y relevancia. Los resultados serán sometidos al juicio de la comunidad académica nacional e internacional generando intercambios que permitan avanzar en la construcción del conocimiento sobre nuevos formatos escolares. Además se pone en la agenda de discusión académica ciertas cuestiones en relación a: la incidencia de la motivación en los aprendizajes de los niños, la adaptación de la enseñanza a las necesidades de aprendizaje de los alumnos, modelos escolares obsoletos y necesidad de innovaciones.Lack of motivation in children disinterest, lack of interest, promote low academic results and lead to school failure, repetition and desertion. This requires changes in the school format and the construction of innovative methodologies (Terigi, F. y Perazza, R. 2006) In this research we will describe the importance of the Aula Taller format with the objective of analyzing the influence of the same on motivation and learning in primary education. The impact will also be seen in the teachers who will configure their proposals taking into account the real needs of their students. In the Uruguayan context there are few studies at the primary level and none that emphasize the impact of achievements according to the aulic methodology, for that reasons its study and relevance. The results will be submitted to the judgment of the national and international academic community generating exchanges that allow advance in the construction of the knowledge on new school formats. In addition, certain issues are included in the academic discussion agenda: the incidence of motivation in children's learning, the adaptation of teaching to students' learning needs, obsoletes school models and the need for innovation.Fil: Nuñez Soler, Nancy. Universidad Internacional Iberoamericana; EspañaFil: Gonzalez, Mariela Lourdes. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentin

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old